PE20050950A1 - Derivados de triazol sustituidos como antagonistas de oxitocina - Google Patents
Derivados de triazol sustituidos como antagonistas de oxitocinaInfo
- Publication number
- PE20050950A1 PE20050950A1 PE2004000912A PE2004000912A PE20050950A1 PE 20050950 A1 PE20050950 A1 PE 20050950A1 PE 2004000912 A PE2004000912 A PE 2004000912A PE 2004000912 A PE2004000912 A PE 2004000912A PE 20050950 A1 PE20050950 A1 PE 20050950A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- nr7r8
- metoxypyridin
- metoximethyl
- nr7c
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Pregnancy & Childbirth (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS 1,2,4-TRIAZOLES SUSTITUIDOS DE FORMULA (I), EN DONDE V, W, X E Y SON INDEPENDIENTEMENTE, C-R6 O N; Z ES C-H O N; R1 ES FENILO SUSTITUIDO CON DOS O MAS SUSTITUYENTES COMO HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6), CIANO, C(O)NR7R8, NR7R8, NR7C(O)R10 Y N[C(O)R10]2; O PIRIDINILO O N-OXIDO DE PIRIDINILO CADA UNO SUSTITUIDOS; R2 ES H, OH, OR9, NR7R8, NR7C(O)R10 Y N[C(O)R10]2, HETEROCICLO DE 5 A 7 MIEMBROS O ALQUILO(C1-C6), OPCIONALMENTE SUSTITUIDOS; R3 ES H, ALQUILO(C1-C6); R4 ES H, ALQUILO(C1-C6) Y OR9; R5 ES HALO, ALQUILO(C1-C6), ALCOXI(C1-C6), NR7R8, NR7C(O)R10 Y N[C(O)R10]2. SON COMPUESTOS PREFERIDOS: 2-(4-FLUORO-2-METILFENIL)-5-(5-METOXIMETIL-4-(6-METOXIPIRIDIN-3-IL)-4H-[1,2,4]TRIAZOL-3-IL)-PIRIDINA, 2-(2,3-DIMETOXIFENIL-5-{5-METOXIMETIL-4-(6-METOXIPIRIDIN-3-IL)-4H-[1,2,4]TRIAZOL-3-IL]-PIRAZINA, 2-(4-CIANO-2-METILFENIL)-5-[5-METOXIMETIL-4-(6-METOXIPIRIDIN-3-IL)4H-[1,2,4]TRIAZOL-3-IL]-PIRAZINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON ANTAGONISTAS DE OXITOCINA POR LO QUE SON UTILES EN EL TRATAMIENTO DE DISFUNCION SEXUAL, PARTICULARMENTE LA EYACULACION PRECOZ
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0322159A GB0322159D0 (en) | 2003-09-22 | 2003-09-22 | New substituted triazoles for use as novel pharmaceuticals |
GB0403150A GB0403150D0 (en) | 2004-02-12 | 2004-02-12 | Novel pharmaceuticals |
GB0415110A GB0415110D0 (en) | 2004-07-05 | 2004-07-05 | Substituted triazole derivatives as oxytocin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050950A1 true PE20050950A1 (es) | 2005-11-11 |
Family
ID=34381637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004000912A PE20050950A1 (es) | 2003-09-22 | 2004-09-20 | Derivados de triazol sustituidos como antagonistas de oxitocina |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1673355A1 (es) |
JP (1) | JP2007505888A (es) |
AR (1) | AR045791A1 (es) |
BR (1) | BRPI0414663A (es) |
CA (1) | CA2539297C (es) |
MX (1) | MXPA06003158A (es) |
NL (1) | NL1027084C2 (es) |
PA (1) | PA8613001A1 (es) |
PE (1) | PE20050950A1 (es) |
TW (1) | TW200526606A (es) |
UY (1) | UY28524A1 (es) |
WO (1) | WO2005028452A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7745630B2 (en) | 2003-12-22 | 2010-06-29 | Justin Stephen Bryans | Triazolyl piperidine arginine vasopressin receptor modulators |
CN103554042B (zh) * | 2004-11-18 | 2016-08-10 | Synta医药公司 | 调节hsp90活性的三唑化合物 |
AP2007004047A0 (en) * | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
DE602006003416D1 (de) * | 2005-03-21 | 2008-12-11 | Pfizer Ltd | Substituierte triazolderivate als oxytocinantagonisten |
EP1863484A1 (en) * | 2005-03-21 | 2007-12-12 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
CA2614746C (en) | 2005-07-09 | 2011-05-10 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
CA2618103A1 (en) * | 2005-08-10 | 2007-02-15 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
FR2903985B1 (fr) | 2006-07-24 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
FR2904316B1 (fr) | 2006-07-31 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique. |
DE102006059710A1 (de) * | 2006-12-18 | 2008-06-19 | Freie Universität Berlin | Substituierte 4-Hydroxypyridine |
FR2910473B1 (fr) | 2006-12-26 | 2009-02-13 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique. |
AP3272A (en) | 2008-09-22 | 2015-05-31 | Cayman Chem Co | Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prosaglandin D2 mediated diseases |
ES2716862T3 (es) | 2014-12-22 | 2019-06-17 | Ferring Bv | Terapia con antagonistas del receptor de oxitocina en la fase lútea para la implantación y embarazo en mujeres que se someten a tecnologías de reproducción asistida |
RU2019118993A (ru) * | 2016-12-21 | 2021-01-22 | Цзянсу Хэнжуй Медицин Ко., Лтд. | Производное азациклобутилтриазола с конденсированной кольцевой группой, способ его получения и его применение в медицине |
CN113149961B (zh) | 2016-12-28 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 氮杂双环基取代的三唑类衍生物、其制备方法及其在医药上的应用 |
WO2019242642A1 (zh) * | 2018-06-20 | 2019-12-26 | 江苏恒瑞医药股份有限公司 | 一种otr抑制剂的可药用盐、晶型及制备方法 |
CN113004250B (zh) * | 2019-12-19 | 2022-07-26 | 上海森辉医药有限公司 | 一种制备取代的三唑衍生物的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000063363A (ja) * | 1998-08-12 | 2000-02-29 | Yamanouchi Pharmaceut Co Ltd | 新規なトリアゾール誘導体 |
AU2000223275A1 (en) * | 2000-02-08 | 2001-08-20 | Yamanouchi Pharmaceutical Co..Ltd. | Novel triazole derivatives |
CZ20023763A3 (cs) * | 2000-05-19 | 2003-03-12 | Merck Patent Gmbh | Derivát triazolu |
EP1273580B1 (en) * | 2001-07-05 | 2005-06-15 | Pfizer Products Inc. | Sulfonyl heteroaryl triazoles as anti-inflammatory and analgesic agents |
AU2002364291B2 (en) * | 2001-12-20 | 2007-08-02 | Merck Serono Sa | Triazoles as oxytocin antagonists |
-
2004
- 2004-09-10 EP EP04769366A patent/EP1673355A1/en not_active Withdrawn
- 2004-09-10 BR BRPI0414663-8A patent/BRPI0414663A/pt not_active IP Right Cessation
- 2004-09-10 WO PCT/IB2004/002977 patent/WO2005028452A1/en active Application Filing
- 2004-09-10 MX MXPA06003158A patent/MXPA06003158A/es active IP Right Grant
- 2004-09-10 CA CA2539297A patent/CA2539297C/en not_active Expired - Fee Related
- 2004-09-10 JP JP2006526721A patent/JP2007505888A/ja active Pending
- 2004-09-20 UY UY28524A patent/UY28524A1/es not_active Application Discontinuation
- 2004-09-20 PE PE2004000912A patent/PE20050950A1/es not_active Application Discontinuation
- 2004-09-21 AR ARP040103392A patent/AR045791A1/es unknown
- 2004-09-21 PA PA20048613001A patent/PA8613001A1/es unknown
- 2004-09-21 TW TW093128603A patent/TW200526606A/zh unknown
- 2004-09-22 NL NL1027084A patent/NL1027084C2/nl not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2539297C (en) | 2010-07-20 |
AR045791A1 (es) | 2005-11-16 |
NL1027084A1 (nl) | 2005-03-24 |
CA2539297A1 (en) | 2005-03-31 |
WO2005028452A9 (en) | 2005-07-21 |
JP2007505888A (ja) | 2007-03-15 |
MXPA06003158A (es) | 2006-06-05 |
UY28524A1 (es) | 2005-04-29 |
WO2005028452A1 (en) | 2005-03-31 |
TW200526606A (en) | 2005-08-16 |
EP1673355A1 (en) | 2006-06-28 |
NL1027084C2 (nl) | 2006-01-24 |
PA8613001A1 (es) | 2005-08-04 |
BRPI0414663A (pt) | 2006-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |