AR045791A1 - Derivados de triazol sustituidos como antagonistas de oxitocina - Google Patents
Derivados de triazol sustituidos como antagonistas de oxitocinaInfo
- Publication number
- AR045791A1 AR045791A1 ARP040103392A ARP040103392A AR045791A1 AR 045791 A1 AR045791 A1 AR 045791A1 AR P040103392 A ARP040103392 A AR P040103392A AR P040103392 A ARP040103392 A AR P040103392A AR 045791 A1 AR045791 A1 AR 045791A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- nr7r8
- alkoxy
- nr7c
- triazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto de fórmula (1) en la que V, W, X e Y, que pueden ser iguales o diferentes, representan C-R6 o N; Z es C-H o N; R1 se selecciona entre: (i) un anillo fenilo sustituido con 2 o más sustituyentes, que pueden ser iguales o diferentes, cada uno seleccionado independientemente entre halo, alquilo C1-6, alcoxi C1-6, ciano, C(O)NR7R8, NR7R8, NR7C(O)R10 y N[C(O)R10]2; y (ii) un anillo heterocíclico aromático de 5 a 7 miembros que contiene 1-3 heteroátomos seleccionados entre N, O y S y los N-óxidos del mismo; estando dicho anillo opcionalmente sustituido con 2 o más sustituyentes, que pueden ser iguales o diferentes, seleccionados entre halo, alquilo C1-6. alcoxi C1-6, ciano, C(O)NR7R8, NR7R8, NR7C(O)R10 y N[C(O)R10]2; R2 se selecciona entre: (i) H, OH, OR9, NR7R8, NR7C(O)R10 y N[C(O)R10]2; (ii) un heterociclo de 5-7 miembros unido a N, que contiene 1-3 heteroátomos seleccionados entre N, O y S; estando dicho anillo opcionalmente sustituido con 1 o más grupos seleccionados entre alquilo C1-6, alcoxi C1-6 y C(O)NR7R8; y (iii) alquilo C1-6 opcionalmente sustituido con un heterociclo de 5-7 miembros unido a N, que contiene 1-3 heteroátomos seleccionados entre N, O y S; R3 se selecciona entre H y alquilo c1- 6; R4 se selecciona entre H, alquilo C1-6 y OR9; R5 se selecciona entre halo, alquilo C1-6, alcoxi C1-6, NR7R8, NR7C(O)R10 y N[C(O)R10]2; R6 se selecciona entre H, halo, alquilo C1-6, alcoxi C1-6, ciano, NR7R8, NR7C(O)R10, N[C(O)R10]2 y C(O)NR7R8; R7 y R8, que pueden ser iguales o diferentes, se seleccionan entre H y alquilo C1-6; R9 es alquilo C1-6, que está opcionalmente sustituido con 1 o más grupos, cada uno seleccionado independientemente entre alcoxi C1-6 y un heterociclo de 5-7 miembros unido a N, que contiene 1-3 heteroátomos seleccionados entre N, O y S; y R10 se selecciona entre alquilo C1-6 y alcoxi C1-6; un tautómero de los mismos o una sal farmacéuticamente aceptable, solvato o polimorfo de dicho compuesto o tautómero; con la condición de que el compuesto de fórmula (1)no sea: 3-etil-5-(4-imidazol-1-ilfenil)-4-(4-metoxifenil)-4H-[1,2,4]triazol, 3-(3´,5´-diclorobifenil-4-il)-4-(2-metoxifenil)-5-metil-4H-[1,2,4]triazol, 3-(3´,5´-bis-trifluorometilbifenil- 4-il)-4-(2-fluorofenil)-5-metil-4H-[1,2,4]triazol o 3-(3´,5´-bis-trifluorometilbifenil-4-il)-5-metil-4-(3-trifluorometilbifenil)-4H-[1,2,4]triazol.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0322159A GB0322159D0 (en) | 2003-09-22 | 2003-09-22 | New substituted triazoles for use as novel pharmaceuticals |
GB0403150A GB0403150D0 (en) | 2004-02-12 | 2004-02-12 | Novel pharmaceuticals |
GB0415110A GB0415110D0 (en) | 2004-07-05 | 2004-07-05 | Substituted triazole derivatives as oxytocin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045791A1 true AR045791A1 (es) | 2005-11-16 |
Family
ID=34381637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040103392A AR045791A1 (es) | 2003-09-22 | 2004-09-21 | Derivados de triazol sustituidos como antagonistas de oxitocina |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1673355A1 (es) |
JP (1) | JP2007505888A (es) |
AR (1) | AR045791A1 (es) |
BR (1) | BRPI0414663A (es) |
CA (1) | CA2539297C (es) |
MX (1) | MXPA06003158A (es) |
NL (1) | NL1027084C2 (es) |
PA (1) | PA8613001A1 (es) |
PE (1) | PE20050950A1 (es) |
TW (1) | TW200526606A (es) |
UY (1) | UY28524A1 (es) |
WO (1) | WO2005028452A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7745630B2 (en) | 2003-12-22 | 2010-06-29 | Justin Stephen Bryans | Triazolyl piperidine arginine vasopressin receptor modulators |
JP4954083B2 (ja) * | 2004-11-18 | 2012-06-13 | シンタ ファーマスーティカルズ コーポレイション | Hsp90活性を調節するトリアゾール化合物 |
AP2007004047A0 (en) | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
JP2008533192A (ja) * | 2005-03-21 | 2008-08-21 | ファイザー・リミテッド | オキシトシンアンタゴニストとしての置換されたトリアゾール誘導体 |
JP2008533193A (ja) * | 2005-03-21 | 2008-08-21 | ファイザー・リミテッド | オキシトシン拮抗薬としての置換トリアゾール誘導体 |
JP4651714B2 (ja) | 2005-07-09 | 2011-03-16 | アストラゼネカ アクチボラグ | 糖尿病の治療においてglk活性化剤として使用するためのヘテロアリールベンズアミド誘導体 |
CA2618103A1 (en) * | 2005-08-10 | 2007-02-15 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
FR2903985B1 (fr) | 2006-07-24 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
FR2904316B1 (fr) | 2006-07-31 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique. |
DE102006059710A1 (de) * | 2006-12-18 | 2008-06-19 | Freie Universität Berlin | Substituierte 4-Hydroxypyridine |
FR2910473B1 (fr) | 2006-12-26 | 2009-02-13 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique. |
US8536185B2 (en) | 2008-09-22 | 2013-09-17 | Cayman Chemical Company, Incorporated | Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases |
EP3501533A1 (en) | 2014-12-22 | 2019-06-26 | Ferring B.V. | Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies |
KR20190094187A (ko) | 2016-12-21 | 2019-08-12 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 축합 고리기 아자시클로부틸 트리아졸 유도체, 이의 제조 방법 및 의약에서의 이의 용도 |
US20210040073A1 (en) | 2016-12-28 | 2021-02-11 | Jiangsu Hengrui Medicine Co., Ltd. | Azabicyclo-substituted triazole derivative, preparation method thereof, and application of same in medicine |
TW202016091A (zh) * | 2018-06-20 | 2020-05-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種otr抑制劑的可藥用鹽、晶型及製備方法 |
CN113004250B (zh) * | 2019-12-19 | 2022-07-26 | 上海森辉医药有限公司 | 一种制备取代的三唑衍生物的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000063363A (ja) * | 1998-08-12 | 2000-02-29 | Yamanouchi Pharmaceut Co Ltd | 新規なトリアゾール誘導体 |
WO2001058880A1 (fr) * | 2000-02-08 | 2001-08-16 | Yamanouchi Pharmaceutical Co., Ltd. | Derives de triazole |
BR0110961A (pt) * | 2000-05-19 | 2004-06-29 | Merck Patent Gmbh | Derivados de triazol |
ES2240661T3 (es) * | 2001-07-05 | 2005-10-16 | Pfizer Products Inc. | Sulfonil-heteroaril-triazoles como agentes antiinflamatorios y analgesicos. |
CA2469042A1 (en) * | 2001-12-20 | 2003-07-03 | Applied Research Systems Ars Holding N.V. | Triazoles as oxytocin antagonists |
-
2004
- 2004-09-10 MX MXPA06003158A patent/MXPA06003158A/es active IP Right Grant
- 2004-09-10 EP EP04769366A patent/EP1673355A1/en not_active Withdrawn
- 2004-09-10 WO PCT/IB2004/002977 patent/WO2005028452A1/en active Application Filing
- 2004-09-10 JP JP2006526721A patent/JP2007505888A/ja active Pending
- 2004-09-10 BR BRPI0414663-8A patent/BRPI0414663A/pt not_active IP Right Cessation
- 2004-09-10 CA CA2539297A patent/CA2539297C/en not_active Expired - Fee Related
- 2004-09-20 PE PE2004000912A patent/PE20050950A1/es not_active Application Discontinuation
- 2004-09-20 UY UY28524A patent/UY28524A1/es not_active Application Discontinuation
- 2004-09-21 PA PA20048613001A patent/PA8613001A1/es unknown
- 2004-09-21 TW TW093128603A patent/TW200526606A/zh unknown
- 2004-09-21 AR ARP040103392A patent/AR045791A1/es unknown
- 2004-09-22 NL NL1027084A patent/NL1027084C2/nl not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
UY28524A1 (es) | 2005-04-29 |
NL1027084A1 (nl) | 2005-03-24 |
WO2005028452A1 (en) | 2005-03-31 |
CA2539297A1 (en) | 2005-03-31 |
TW200526606A (en) | 2005-08-16 |
JP2007505888A (ja) | 2007-03-15 |
PA8613001A1 (es) | 2005-08-04 |
CA2539297C (en) | 2010-07-20 |
NL1027084C2 (nl) | 2006-01-24 |
EP1673355A1 (en) | 2006-06-28 |
PE20050950A1 (es) | 2005-11-11 |
BRPI0414663A (pt) | 2006-11-21 |
MXPA06003158A (es) | 2006-06-05 |
WO2005028452A9 (en) | 2005-07-21 |
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Legal Events
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