AR063790A1 - Diaril ,dipiridinil y arilpiridinilderivados y usos de los mismos - Google Patents

Diaril ,dipiridinil y arilpiridinilderivados y usos de los mismos

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Publication number
AR063790A1
AR063790A1 ARP070105033A ARP070105033A AR063790A1 AR 063790 A1 AR063790 A1 AR 063790A1 AR P070105033 A ARP070105033 A AR P070105033A AR P070105033 A ARP070105033 A AR P070105033A AR 063790 A1 AR063790 A1 AR 063790A1
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AR
Argentina
Prior art keywords
hydrogen
halo
alkyl
benzene ring
alkoxy
Prior art date
Application number
ARP070105033A
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English (en)
Inventor
George Tetteh Magnus-Aryitey
Roger Benjamin Ruggeri
Benjamin Aaron Thuma
Original Assignee
Pfizer Prod Inc
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Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR063790A1 publication Critical patent/AR063790A1/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/06—Antihyperlipidemics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1) en el que: R es hidrógeno o R tornado junto con R1 y el nitrógeno al que están unidos forman una pirrolidina opcionalmente condensada con un anillo bencénico o un anillo de piperidina opcionalmente condensada con un anillo bencénico, donde dicha pirrolidina, dicha pirrolidina condensada con un anido bencénico, dicha piperidina y dicha piperidina condensada con un anillo bencénico se sustituyen opcionalmente con 1 a 3 sustituyentes seleccionados cada uno independientemente de metilo, halo, -OH o C(O)-O-alquilo C1-4; R1 es: (a) alquilo C3-8, (b) alquenilo C3-8, (c) carbociclo C5-6 parcial o totalmente saturado opcionalmente condenando con un anillo bencénico, (d) heterociclo de 5 a 6 miembros, parcial o totalmente saturado, que contiene 1 a 2 heteroátomos seleccionados independientemente de O, S o N, opcionalmente condensado con un anillo bencénico o (e) alquilo C1-3 sustituido con un resto químico seleccionado del grupo que consiste en: (i) carbociclo C3-6 parcial o totalmente saturado, opcionalmente condensado con un anillo bencénico, (ii) alcoxi C1-4, (iii) heterociclo de 5 a 6 miembros, parcial o totalmente saturado, que contiene 1 a 2 heteroátomos seleccionados independientemente de O, S o N, opcionalmente condensado con un anillo bencénico, (iv) heteroarilo de 5 a 6 miembros, que contiene 1 a 3 heteroátomos seleccionados independientemente de O, S o N, opcionalmente condensado con un anillo bencénico, (v) fenilo opcionalmente condensado con un heterociclo de 5 a 6 miembros, que contiene 1 a 2 heteroátomos seleccionados independientemente de O, S o N, (vi) naftilo, (vii) fenoxi y (viii) 2-oxo-2,3-dihidrobenzimidazolilo, donde dichos sustituyentes (a) a (e) y dichos restos químicos (i) a (viii) están cada uno opcionalmente sustituidos con uno a tres sustituyentes seleccionados independientemente de: hidroxilo, halo, metilo u HO-alquilo C1-3, R2a y R2b son cada uno hidrógeno; R3 es: hidrógeno, halo, alquilo C1-3, hidroxilo, alcoxi C1-3 o benciloxi, R4 es: hidrógeno, halo, alquilo C1-3, hidroxilo, alcoxi C1-3 o metilo fluorosustituido; V es nitrógeno o C-R5, donde R5 es: hidrógeno, halo, alquilo C1-3, hidroxilo, alcoxi C1-3, metilo fluorosustituido o benciloxi; R6 es: hidrógeno, alquilo C1-3, hidroxilo, alcoxi C1-3 o halo; R7 es -C(O)NH2, -NHSO2-alquilo C1-4 o 1H-1,2,4-triazol-5-ilo y R8 es hidrógeno, flúor u -OH o R7 es: hidrógeno, flúor u -OH y R8 es: -C(O)NH2. -NHSO2alquilo C1-4 o 1H-1,2,4-triazol-5-ilo; R9 es: hidrógeno, hidroxilo, alquilo C1-3; metilo fluorosustituido, alcoxi C1-3 o halo y W es C-R10 y X es nitrógeno, o W es nitrógeno y X es C-R11, o W es C-R10 y X es C-R11, donde R10 es: hidrógeno, alquilo C1-3, hidroxilo, alcoxi C1-3, metilo fluorosustituido, ciano o halo y R11 es: hidrógeno, alquilo C1-3, hidroxilo, alcoxi C1-3 o halo; una sal farmacéuticamente aceptable del mismo o un solvato o hidrato de dicho compuesto o dicha sal.
ARP070105033A 2006-11-13 2007-11-12 Diaril ,dipiridinil y arilpiridinilderivados y usos de los mismos AR063790A1 (es)

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US86547906P 2006-11-13 2006-11-13

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CA2669311A1 (en) 2008-05-22
CL2007003198A1 (es) 2008-02-15
KR20090064478A (ko) 2009-06-18
WO2008059335A1 (en) 2008-05-22
NO20091649L (no) 2009-05-20
TW200826927A (en) 2008-07-01
AU2007320906A1 (en) 2008-05-22
JP2010509392A (ja) 2010-03-25
UY30706A1 (es) 2008-07-03
IL198236A0 (en) 2009-12-24
US20080167371A1 (en) 2008-07-10
MX2009004314A (es) 2009-05-05
EP2084127A1 (en) 2009-08-05
CN101583593A (zh) 2009-11-18

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