AR070361A1 - Compuestos heterociclicos antiviricos - Google Patents

Compuestos heterociclicos antiviricos

Info

Publication number
AR070361A1
AR070361A1 ARP090100481A ARP090100481A AR070361A1 AR 070361 A1 AR070361 A1 AR 070361A1 AR P090100481 A ARP090100481 A AR P090100481A AR P090100481 A ARP090100481 A AR P090100481A AR 070361 A1 AR070361 A1 AR 070361A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
hydrogen
acyl
optionally substituted
Prior art date
Application number
ARP090100481A
Other languages
English (en)
Inventor
Francisco Xavier Talamas
Robert James Weikert
Clara Jeou Jen Lin
Sharada Shenvi Labadie
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40521706&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR070361(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR070361A1 publication Critical patent/AR070361A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Son inhibidores de la polimerasa NS5b del virus de la hepatitis C. Se describen también composiciones y métodos para tratar una infeccion del HCV y para inhibir la replicacion del HCV. Reivindicacion1: Un compuesto de la formula (1) en la que A1 es fenileno o piridinileno; A2 es fenilo o piridinilo opcionalmente sustituidos por 1-3 grupos elegidos con independencia entre el grupo formado por halogeno, alquilo C1-6, haloalquilo C1-6, ciano y alcoxi C1-6; R1 es hidrogeno, alquilo C1-10, cicloalquilo C3-7, alcoxi C1-10 o halogeno; Y es NR2R3, hidroxialquilo C1-6, acilo C1-6 o heteroarilo elegido entre el grupo formado por pirrolilo, pirazolilo o isoxazolilo, dicho heteroarilo está opcionalmente sustituido por uno o dos grupos elegidos entre alquilo C1-3, haloalquilo C1-3, alcoxi C1-3, halogeno o pirrolidinilo, en el que el átomo de nitrogeno está opcionalmente sustituido por acilo C1-6 o alquilsulfonilo C1-6; en la que (i) R2 es (a) hidrogeno, (b) alquilo C1-10, (c) alquilo C1-10 sustituido de una a cuatro veces por restos elegidos con independencia entre hidroxi, NR7bR8b, alcoxi C1-3, halogeno y ciano; (d) R11S(=O)m[C(R5)2]1-6 en el que R11 es alquilo C1-6 o NR7cR8c;8; (e) alquilo C1-3-S(=O)2NH-[C(R5)2]1-6; (f) R7bR8bNC(=O)-[C(R5)2]1-6; (g) cicloalquilo C3-6 opcionalmente sustituido por -OH, alcoxi C1-3 o -NR7bR8b; (h) heterociclilo; (i) heterociclil-alquilo C1-6, (j) heteroaril-alquilo C1-6, (k) acilo C1-6 opcionalmente sustituido por alquilsulfonilo C1-6; (l) (CH2)pCOX3 en el que p es un numero de uno a seis y X3 es hidroxi, alcoxi C1-6 o NR7cR8c; en el que dicho resto heterociclilo es oxetanilo, tetrahidrofuranilo, tetrahidropiranilo, azetidinilo, pirrolidinilo o piperidinilo, oxazolidin-2-on-4-ilo y dicho resto heteroarilo es piridinilo o pirimidinilo y dichos grupos heterociclilo o heteroarilo están opcionalmente sustituidos por -OH, alcoxi C1-3, alquilo C1-3 o -NR7bR8b; R3 es hidrogeno, alquilo C1-10, S(O)2R6, S(=O)2NR7aR8a, acilo C1-6 o C(=O)NR7aR8a; o bien (ii) R2 y R3 juntos son (CH2)2X1(CH2)2, (CH2)3-4S(=O)2, (CH2)2-3NR10S(=O)2; R4 y R5 son con independencia hidrogeno, alquilo C1-6 o cicloalquilo C3-7; R6 es alquilo C1-6 o cicloalquilo C3-7; R7a y R8a son (i) con independencia hidrogeno, alquilo C1-6, hidroxialquilo C1-6, haloalquilo C1-6 o bien (ii) R7a y R8a juntos son (CH2)2X1(CH2)2; R7b, R8b y R10 son con independencia hidrogeno, alquilo C1-6, acilo C1-6 o alquilsulfonilo C1-6, R7c y R8c son con independencia hidrogeno o alquilo C1-3; R9 es hidrogeno, acilo C1-3, alquilsulfonilo C1-3 o alquilo C1-3; R10 es hidrogeno o alquilo C1-6; X1 es -O-, -NR9-, -S(O)m, (CH2)n; X2 es NHR5 u O; m y n son con independencia un numero entero de 0 a 2; o, una sal farmacéuticamente aceptables del mismo.
ARP090100481A 2008-02-14 2009-02-12 Compuestos heterociclicos antiviricos AR070361A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2862908P 2008-02-14 2008-02-14
US13860308P 2008-12-18 2008-12-18

Publications (1)

Publication Number Publication Date
AR070361A1 true AR070361A1 (es) 2010-03-31

Family

ID=40521706

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100481A AR070361A1 (es) 2008-02-14 2009-02-12 Compuestos heterociclicos antiviricos

Country Status (18)

Country Link
US (1) US8071797B2 (es)
EP (1) EP2245023B1 (es)
JP (1) JP2011512341A (es)
KR (1) KR20100117073A (es)
CN (1) CN101910145A (es)
AR (1) AR070361A1 (es)
AT (1) ATE539070T1 (es)
AU (1) AU2009214194B2 (es)
BR (1) BRPI0907885A2 (es)
CA (1) CA2714254A1 (es)
CL (1) CL2009000305A1 (es)
ES (1) ES2377280T3 (es)
IL (1) IL204736A0 (es)
MX (1) MX2010004623A (es)
PE (1) PE20091458A1 (es)
RU (1) RU2010137635A (es)
TW (1) TW200936573A (es)
WO (1) WO2009101022A1 (es)

Families Citing this family (40)

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US8293909B2 (en) 2008-09-11 2012-10-23 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8048887B2 (en) * 2008-09-11 2011-11-01 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8198449B2 (en) 2008-09-11 2012-06-12 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7994171B2 (en) 2008-09-11 2011-08-09 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
JP2013505912A (ja) * 2009-09-24 2013-02-21 エフ．ホフマン−ラ ロシュ アーゲー 複素環式抗ウイルス化合物
US8324212B2 (en) 2010-02-25 2012-12-04 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8354410B2 (en) 2010-03-11 2013-01-15 Bristol-Meyers Squibb Company Compounds for the treatment of hepatitis C
JP2013522192A (ja) * 2010-03-11 2013-06-13 ブリストル−マイヤーズ スクイブ カンパニー Ｃ型肝炎の処置のための化合物
US8324239B2 (en) 2010-04-21 2012-12-04 Novartis Ag Furopyridine compounds and uses thereof
US8445497B2 (en) 2010-06-30 2013-05-21 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
MX2013004655A (es) 2010-10-26 2013-08-27 Presidio Pharmaceuticals Inc Inhibidores del virus de la hepatitis c.
US8507683B2 (en) 2010-12-09 2013-08-13 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
EP2744342B1 (en) 2011-08-17 2019-04-24 GlaxoSmithKline LLC Therapeutic methods
WO2013028371A1 (en) * 2011-08-19 2013-02-28 Glaxo Group Limited Benzofuran compounds for the treatment of hepatitis c virus infections
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
US9303020B2 (en) 2012-02-08 2016-04-05 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
WO2013148620A1 (en) 2012-03-27 2013-10-03 Bristol-Myers Squibb Company Benzofuran derivatives for the treatment of hepatitis c
JP2016505011A (ja) * 2013-01-10 2016-02-18 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎の治療用の大環状ベンゾフランおよびアザベンゾフラン化合物
US8962651B2 (en) 2013-03-13 2015-02-24 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
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EP3119769A1 (en) * 2014-03-21 2017-01-25 Bristol-Myers Squibb Pharma Company Cyanoamino (aza)benzofuran compounds for the treatment of hepatitis c
ES2688147T3 (es) 2014-03-21 2018-10-31 Bristol-Myers Squibb Company Compuestos de 6H-furo[2,3-e]indol para el tratamiento de la hepatitis C
AR099820A1 (es) 2014-03-21 2016-08-17 Bristol Myers Squibb Co Ciano que contiene compuestos de azabenzofuran para el tratamiento de la hepatitis c
US9840511B2 (en) 2014-05-21 2017-12-12 Bristol-Meyers Squibb Company 2-(aryl or heteroaryl-)phenyl (AZA)benzofuran compounds for the treatment of hepatitis C
US10214534B2 (en) 2014-06-11 2019-02-26 Bristol-Myers Squibb Company Substituted 2-phenyl (AZA)benzofuran compounds for the treatment of hepatitis C
WO2016022513A1 (en) 2014-08-05 2016-02-11 Bristol-Myers Squibb Company Furopyridine compounds for the treatment of hepatitis c
BR112017006117A2 (pt) 2014-09-26 2017-12-19 Changzhou Yinsheng Pharmaceutical Co Ltd análogo de benzofurano como inibidor de ns4b
EP3201202A1 (en) 2014-10-02 2017-08-09 Bristol-Myers Squibb Company Macrocyclic benzofuran compounds for the treatment of hepatitis c
US10131645B2 (en) 2015-02-19 2018-11-20 Bristol-Myers Squibb Company Benzofurans substituted with primary benzamide as HCV inhibitors
WO2016133961A1 (en) 2015-02-19 2016-08-25 Bristol-Myers Squibb Company Benzofurans substituted with bicyclic secondary benzamide as hcv inhibitors
US10125111B2 (en) 2015-02-19 2018-11-13 Bristol-Myers Squibb Company Benzofuran compounds for the treatment of hepatitis C
WO2016133963A1 (en) 2015-02-19 2016-08-25 Bristol-Myers Squibb Company Benzofurans substituted with secondary benzamide as hcv inhibitors
WO2016133972A1 (en) 2015-02-19 2016-08-25 Bristol-Myers Squibb Company Substituted benzofuran compounds for the treatment of hepatitis c
TWI731854B (zh) 2015-03-23 2021-07-01 美商共結晶製藥公司 Ｃ型肝炎病毒聚合酶之抑制劑
CN105732602B (zh) * 2015-09-23 2017-04-19 常州寅盛药业有限公司 作为ns4b抑制剂的苯并呋喃类似物
BR112018007876B1 (pt) * 2015-11-19 2023-10-17 Shanghai Hengrui Pharmaceutical Co., Ltd. Derivado de benzofurano, seus usos e seu processo de preparação, e composição farmacêutica
EP3380199A4 (en) 2015-11-24 2019-05-22 L'oreal DEVICE FOR TREATING HAIR

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HN2003000348A (es) * 2002-11-01 2008-10-14 Viropharma Inc Compuestos de benzofurano, composiciones y metodos para tratamiento y profilaxis de infeccion virales de hepatitis c y enfermedades asociadas.
CL2007000361A1 (es) * 2006-02-09 2008-01-25 Wyeth Corp Combinacion que comprende un inhibidor de la arn polimerasa del virus de la hepatitis c (vhc) y un inhibidor de la proteasa del vhc; composicion farmaceutica que la comprende; y uso de la combinacion para tratar trastornos asociados con vhc.
MX2009008439A (es) * 2007-02-12 2009-08-13 Intermune Inc Nuevos inhibidores de la replicacion del virus de hepatitis c.

Also Published As

Publication number Publication date
MX2010004623A (es) 2010-06-07
CN101910145A (zh) 2010-12-08
IL204736A0 (en) 2010-11-30
WO2009101022A1 (en) 2009-08-20
EP2245023A1 (en) 2010-11-03
TW200936573A (en) 2009-09-01
PE20091458A1 (es) 2009-09-24
CL2009000305A1 (es) 2010-02-19
AU2009214194A1 (en) 2009-08-20
US8071797B2 (en) 2011-12-06
RU2010137635A (ru) 2012-03-20
CA2714254A1 (en) 2009-08-20
US20090208449A1 (en) 2009-08-20
AU2009214194B2 (en) 2012-05-17
KR20100117073A (ko) 2010-11-02
ATE539070T1 (de) 2012-01-15
EP2245023B1 (en) 2011-12-28
BRPI0907885A2 (pt) 2015-07-21
JP2011512341A (ja) 2011-04-21
ES2377280T3 (es) 2012-03-26

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