AR086290A1 - Inhibidores del virus de la hepatitis c - Google Patents

Inhibidores del virus de la hepatitis c

Info

Publication number
AR086290A1
AR086290A1 ARP120101594A AR086290A1 AR 086290 A1 AR086290 A1 AR 086290A1 AR P120101594 A ARP120101594 A AR P120101594A AR 086290 A1 AR086290 A1 AR 086290A1
Authority
AR
Argentina
Prior art keywords
phenyl
alkoxy
haloxy
alkyl
independently selected
Prior art date
Application number
Other languages
English (en)
Inventor
Sheldon Hiebert
Ramkumar Rajamani
Li Sun
Eric Qiang-Mull
P V K Suresh Babu
Michael S Bowsher
Qian Zhao
Nicholas A Meanwell
Kishore V Renduchintala
Kandhasamy Sarkunam
Pulicharla Nagalakshmi
Paul Michael Scola
Eric P Gillis
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46172898&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR086290(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR086290A1 publication Critical patent/AR086290A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2053—IL-8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Inhibidores del virus de la Hepatitis C que presentan la fórmula general (1). También, composiciones que comprenden los compuestos y métodos para la utilización de los compuestos para inhibir el VHC.Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1) o una sal farmacéuticamente aceptable del mismo, donde p es 1 ó 2; - - - - - es un enlace simple o doble; R1 se selecciona a partir de los compuestos de formula (2) ó (3), donde R1 se une al resto molecular principal a través de cualquier átomo de carbono sustituible del grupo; m es 0, 1, ó 2; n es 0, 1, 2, 3, 4, 5 ó 6; X0 se selecciona a partir de CH y N; X1 se selecciona a partir de CH y N; X2 y X3 se seleccionan en forma independiente a partir de CH, C(Ra) y N; siempre que al menos uno entre X1, X2, y X3 sea diferente de N; cada Ra se selecciona independientemente a partir de alqueniloxilo, alcoxilo, alcoxialcoxilo, alquilo, benzodioxanilo carboxamida, carboxilo, carboxialcoxilo, ciano, cicloalquilalcoxilo cicloalquiloxilo, deuteroalcoxilo, dialquilamina, halo, haloalquilo, haloalcoxilo haloalcoxicarbonilo, hidroxilo, morfolinilo, fenilo, piperazinilo, pirazolilo, y piridinilo, pirrolidinilo, donde el morfolinilo, el fenilo, el piperazinilo, el piridinilo, y el pirrolidinilo se sustituyen opcionalmente por uno o dos grupos seleccionados independientemente a partir de alcoxilo, alquilo, alquilsulfonilo, halo, haloalcoxilo, haloalquilo, y morfolinilo; y donde dos grupos Ra adyacentes, junto con los átomos de carbono a los que están unidos, pueden opcionalmente formar un anillo seleccionado a partir de dioxanilo, dioxolanilo, morfolinilo, piranilo, y fenilo, donde el anillo se sustituye opcionalmente por uno o dos grupos seleccionados independientemente a partir de alquilo y halo; Rb es alquilo; Rx se selecciona a partir de metilo y etilo; Ry y Rz se seleccionan independientemente a partir de hidrógeno y hidroxilo; siempre que cuando - - - - - es un doble enlace, Ry y Rz son cada uno hidrógeno; R2 se selecciona a partir de hidrógeno, alquilo, halo, haloalcoxilo, haloalquilo, y hidroxialquilo; y R3 se selecciona a partir de hidrógeno, alcoxialcoxicarbonilo, alcoxicarbonilo, alquilaminocarbonilo alquilcarbonilo, cicloalquilalcoxicarbonilo cicloalquilcarbonilo, cicloalquiloxicarbonilo deuteroalcoxicarbonilo, deuterohaloalcoxicarbonilo, dialquilaminocarbonilo, dialquilaminocarbonilocarbonilo, haloalcoxicarbonilo haloalquilaminocarbonilo, haloalquilcarbonilo, heterociclilcarbonilo heterocicliloxicarbonilo fenilcarbonilo, y feniloxicarbonilo donde el cicloalquilo parte del cicloalquilalcoxicarbonilo el cicloalquilcarbonilo y el cicloalquiloxicarbonilo el heterociclilo parte del heterociclilcarbonilo y el heterocicliloxicarbonilo, y el fenilo parte del fenilcarbonilo y el feniloxicarbonilo se sustituyen opcionalmente por uno, dos o tres grupos seleccionados independientemente a partir de alquilo, alquilamino, alquilcarbonilo, cicloalquilo, dialquilamino, halo, haloalcoxilo, y haloalquilo.
ARP120101594 2011-05-05 2012-05-04 Inhibidores del virus de la hepatitis c AR086290A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161482658P 2011-05-05 2011-05-05
US201261611171P 2012-03-15 2012-03-15
US13/459,403 US8957203B2 (en) 2011-05-05 2012-04-30 Hepatitis C virus inhibitors

Publications (1)

Publication Number Publication Date
AR086290A1 true AR086290A1 (es) 2013-12-04

Family

ID=46172898

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120101594 AR086290A1 (es) 2011-05-05 2012-05-04 Inhibidores del virus de la hepatitis c

Country Status (30)

Country Link
US (2) US8957203B2 (es)
EP (1) EP2705049B1 (es)
JP (1) JP6023178B2 (es)
KR (1) KR20140035383A (es)
CN (1) CN103797024B (es)
AR (1) AR086290A1 (es)
AU (1) AU2012250920B2 (es)
BR (1) BR112013028487A2 (es)
CA (1) CA2835105A1 (es)
CL (1) CL2013003171A1 (es)
CO (1) CO6821947A2 (es)
CY (1) CY1118567T1 (es)
DK (1) DK2705049T3 (es)
EA (1) EA022624B1 (es)
ES (1) ES2610967T3 (es)
HR (1) HRP20161632T1 (es)
HU (1) HUE033001T2 (es)
IL (1) IL229270B (es)
LT (1) LT2705049T (es)
MX (1) MX2013012749A (es)
PE (1) PE20141032A1 (es)
PL (1) PL2705049T3 (es)
PT (1) PT2705049T (es)
RS (1) RS55563B1 (es)
SG (1) SG194749A1 (es)
SI (1) SI2705049T1 (es)
SM (1) SMT201700029B (es)
TW (1) TWI542589B (es)
UY (1) UY34057A (es)
WO (1) WO2012151195A1 (es)

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AU2012250920A1 (en) 2014-01-09
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