AR057810A1 - Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo y composicion farmaceutica - Google Patents

Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo y composicion farmaceutica

Info

Publication number
AR057810A1
AR057810A1 ARP060103981A ARP060103981A AR057810A1 AR 057810 A1 AR057810 A1 AR 057810A1 AR P060103981 A ARP060103981 A AR P060103981A AR P060103981 A ARP060103981 A AR P060103981A AR 057810 A1 AR057810 A1 AR 057810A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
hydrogen
alkoxy
piperazinyl
Prior art date
Application number
ARP060103981A
Other languages
English (en)
Inventor
Nicholas A Meanwell
Robert G Gentles
Min Ding
John A Bender
John F Kadow
Piyasena Hewawasam
Thomas W Hudyma
Xiaofan Zheng
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR057810A1 publication Critical patent/AR057810A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Los compuestos de la formula (1), sales farmacéuticamente aceptables del mismo y composiciones. Los compuestos tienen actividad contra el virus de hepatitis C (VHC) y son utiles en el tratamiento de aquellos infectados con VHC. Reivindicacion 1: Un compuesto de la formula (1), en donde: R1 es CO2R5 o CONR6R7; R2 es hidroxi, alcoxi C1-6, NR8R9, o R3 es hidrogeno, halo, alquilo C1-6, o alcoxi C1-6; R4 es cicloalquilo C5-7; R5 es hidrogeno o alquilo; R6 es hidrogeno, alquilo C1-6, cicloalquilo C3- 7, alcoxi C1-6, o SO2R10; R7 es hidrogeno, alquilo C1-6, o cicloalquilo C3-7; R8 es hidrogeno, alquilo C1-6, cicloalquilo C3-7, hidroxialquilo C1-6, alcoxiC1-6-alquiloC1-6, aminoalquilo C1-6, alquilaminoC1-6-alquiloC1-6, diquilaminoC1-6-alquilo C1- 6, R9 es hidrogeno, alquilo C1-6, cicloalquilo C3-7, hidroxialquilo C1-6, alcoxiC1-6-alquiloC1-6, aminoalquilo C1-6, alquilaminoC1-6-alquiloC1-6, dialquilaminoC1-6-alquiloC1-6; o NR8 R9 al tomarse junto es pirrolidinilo, piperidinilo, piperazinilo, homomorfolinilo, homopiperidinilo, morfolinilo, o tiomorfolinilo, y es sustituid o con 0-2 sustituyentes seleccionados de halo, hidroxi, alquilo C1-6, amino, alquilamino C1-6, dialquilamino C1-6, pirrolidinilo, piperidinilo, piperazinilo, N- (alquiloC1-6)piperazinilo, morfolinilo y tiomorfolinilo; y R10 es alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-7, amino, alquilamino C1-6, dialquilamino C1-6, o R10 es pirrolidinilo, piperidinilo, piperazinilo, homomorfolinilo, homopiperidinilo, morfolinilo, o tiomorfolinilo, y es sustituido con 0-2 sustituyentes seleccionados de halo y alquilo c1-6; o una sal o solvato farmacéuticamente aceptable del mismo.
ARP060103981A 2005-09-12 2006-09-12 Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo y composicion farmaceutica AR057810A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71618705P 2005-09-12 2005-09-12
US80997906P 2006-06-01 2006-06-01
US11/507,731 US7399758B2 (en) 2005-09-12 2006-08-22 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors

Publications (1)

Publication Number Publication Date
AR057810A1 true AR057810A1 (es) 2007-12-19

Family

ID=37603284

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103981A AR057810A1 (es) 2005-09-12 2006-09-12 Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo y composicion farmaceutica

Country Status (5)

Country Link
US (2) US7399758B2 (es)
AR (1) AR057810A1 (es)
PE (1) PE20070676A1 (es)
TW (1) TW200745035A (es)
WO (1) WO2007033032A1 (es)

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Also Published As

Publication number Publication date
US20070184024A1 (en) 2007-08-09
US7485633B2 (en) 2009-02-03
PE20070676A1 (es) 2007-08-10
WO2007033032A1 (en) 2007-03-22
US20070060565A1 (en) 2007-03-15
TW200745035A (en) 2007-12-16
US7399758B2 (en) 2008-07-15

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