PE20070676A1 - Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo - Google Patents

Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo

Info

Publication number
PE20070676A1
PE20070676A1 PE2006001104A PE2006001104A PE20070676A1 PE 20070676 A1 PE20070676 A1 PE 20070676A1 PE 2006001104 A PE2006001104 A PE 2006001104A PE 2006001104 A PE2006001104 A PE 2006001104A PE 20070676 A1 PE20070676 A1 PE 20070676A1
Authority
PE
Peru
Prior art keywords
alkyl
cyclopropyl
fused
cycloalkyl
hcv inhibitors
Prior art date
Application number
PE2006001104A
Other languages
English (en)
Inventor
Nicholas A Meanwell
Robert G Gentles
John A Bender
Piyasena Hewawasam
Xiaofan Zheng
Thomas W Hudyma
John F Kadow
Min Ding
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20070676A1 publication Critical patent/PE20070676A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES CO2R5, CONR6R7; R2 ES HIDROXI, ALCOXI, BENCILOXI, ENTRE OTROS; R3 ES H, HALOGENO, HALO, ALQUILO; R4 ES CICLOALQUILO C5-C7; R5 ES H, ALQUILO; R6 ES H, ALQUILO, CICLOALQUILO, ALQUILO; R7 ES H, ALQUILO, CICLOALQUILO. SON COMPUESTOS PREFERIDOS: ACIDO (+/-)-8-CICLOHEXIL-1,1a,2,12b-TETRAHIDRO-1a-(4-MORFOLINILCARBONIL)-CICLOPROP[d]INDOLO[2,1-a][2]BENZAZEPIN-5-CARBOXILICO, ESTER DE METILO; ACIDO (+/-)CICLOPROP[d]INDOLO[2,1-a][2]BENZAZEPIN-5-CARBOXILICO, ESTER DE 8-CICLOHEXIL-1,1a,2,12b-TETRAHIDRO-11-METOXI-1a-[(4-MORFOLINILCARBONIL)AMINO]-METILO; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA POLIMERASA NS5B UTILES EN EL TRATAMIENTO DEL VIRUS DE LA HEPATITIS C
PE2006001104A 2005-09-12 2006-09-12 Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo PE20070676A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71618705P 2005-09-12 2005-09-12
US80997906P 2006-06-01 2006-06-01
US11/507,731 US7399758B2 (en) 2005-09-12 2006-08-22 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors

Publications (1)

Publication Number Publication Date
PE20070676A1 true PE20070676A1 (es) 2007-08-10

Family

ID=37603284

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001104A PE20070676A1 (es) 2005-09-12 2006-09-12 Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo

Country Status (5)

Country Link
US (2) US7399758B2 (es)
AR (1) AR057810A1 (es)
PE (1) PE20070676A1 (es)
TW (1) TW200745035A (es)
WO (1) WO2007033032A1 (es)

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US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor
US7399758B2 (en) * 2005-09-12 2008-07-15 Meanwell Nicholas A Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7456165B2 (en) * 2006-02-08 2008-11-25 Bristol-Myers Squibb Company HCV NS5B inhibitors
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US7456166B2 (en) * 2006-05-17 2008-11-25 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7521443B2 (en) * 2006-05-17 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7521441B2 (en) * 2006-05-22 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7521442B2 (en) * 2006-05-25 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
WO2007140254A2 (en) * 2006-05-25 2007-12-06 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
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US7541353B2 (en) * 2007-03-14 2009-06-02 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7538102B2 (en) * 2007-03-14 2009-05-26 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US7538103B2 (en) * 2007-03-15 2009-05-26 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
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US8129367B2 (en) * 2007-11-21 2012-03-06 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
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KR20100126560A (ko) * 2008-03-27 2010-12-01 브리스톨-마이어스 스큅 컴퍼니 피롤리딘 융합된 인돌로벤자디아제핀 ｈｃｖ ｎｓ5ｂ 억제제
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US8133884B2 (en) * 2008-05-06 2012-03-13 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
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JP6306002B2 (ja) * 2012-07-18 2018-04-04 ブリストル−マイヤーズ・スクイブ・ホールディングス・アイルランドＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｈｏｌｄｉｎｇｓ Ｉｒｅｌａｎｄ （４ｂＳ，５ａＲ）−１２−シクロヘキシル−Ｎ−（Ｎ，Ｎ−ジメチルスルファモイル）−３−メトキシ−５ａ−（（１Ｒ，５Ｓ）−３−メチル−３，８−ジアザビシクロ［３．２．１］オクタン−８−カルボニル）−４ｂ，５，５ａ，６−テトラヒドロベンゾ［３，４］シクロプロパ［５，６］アゼピノ［１，２−Ａ］インドール−９−カルボキサミドを製造するための新規な方法および中間体
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US7456165B2 (en) 2006-02-08 2008-11-25 Bristol-Myers Squibb Company HCV NS5B inhibitors

Also Published As

Publication number Publication date
US20070184024A1 (en) 2007-08-09
US7399758B2 (en) 2008-07-15
WO2007033032A1 (en) 2007-03-22
US20070060565A1 (en) 2007-03-15
US7485633B2 (en) 2009-02-03
TW200745035A (en) 2007-12-16
AR057810A1 (es) 2007-12-19

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