PE20080704A1 - Inhibidores ns5b del virus hepatitis c de indolobenzazepina fusionados a ciclopropilo - Google Patents
Inhibidores ns5b del virus hepatitis c de indolobenzazepina fusionados a ciclopropiloInfo
- Publication number
- PE20080704A1 PE20080704A1 PE2007000614A PE2007000614A PE20080704A1 PE 20080704 A1 PE20080704 A1 PE 20080704A1 PE 2007000614 A PE2007000614 A PE 2007000614A PE 2007000614 A PE2007000614 A PE 2007000614A PE 20080704 A1 PE20080704 A1 PE 20080704A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cyclopropyl
- indolobenzazepine
- fused
- hepatitis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Abstract
SE REFIERE A COMPUESTOS INDOLOBENZAZEPINA FUSIONADOS A CICLOPROPILO DE FORMULA (I), EN DONDE R1 ES CO2R5 O CONR6R7; R2 ES PIPERIDINILO O PIPERAZINILO SUSTITUIDO CON 3 SUSTUSTITUYENTES SELECCIONADOS DE ALQUILO, ALCOXIALQUILO, ENTRE OTROS; R3 ES H, HALO, ALQUILO, ALQUENILO, ALCOXI, ENTRE OTROS; R4 ES CICLOALQUILO; R5 ES H O ALQUILO; R6 ES H, ALQUILO, ALQUILO-SO2; CICLOALQUILO-SO2, (R7)(R8)NSO2 O (R9)SO2; R7 Y R8 SON INDEPENDIENTEMENTE H O ALQUILO. SON SELECCIONADOS: CICLOPROPIL[d]INDOLO[2,1-a][2]BENZAZEPINA-5-CARBOXAMIDA,1a-[[(3a,5a)-4-ACETIL-3,5-DIMETIL-1-PIPERAZINIL]CARBONIL]-8-CICLOHEXIL-N-[(DIMETILAMINO)SULFONIL]-1,1a,2,12b-TETRAHIDRO-11-METOXI, CICLOPROPIL[d]INDOLO[2,1-a][2]BENZAZEPINA-5-CARBOXAMIDA, 8-CICLOHEXIL-1,1a,2,12b-TETRAHIDRO-11-METOXI-N-(2-PROPILSULFONIL}-1a-[[(3R,5S)-3,4,5-TRIMETIL-1-PIPERAZINIL]CARBONIL], ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ADEMAS PUEDE COMPRENDER OTRO AGENTE ANTI VHC. ESTOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE NS5B DEL VHC SIENDO UTILES EN EL TRATAMIENTO DE INFECCION DEL VHC
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80236806P | 2006-05-22 | 2006-05-22 | |
US89425307P | 2007-03-12 | 2007-03-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080704A1 true PE20080704A1 (es) | 2008-06-13 |
Family
ID=38514150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000614A PE20080704A1 (es) | 2006-05-22 | 2007-05-18 | Inhibidores ns5b del virus hepatitis c de indolobenzazepina fusionados a ciclopropilo |
Country Status (5)
Country | Link |
---|---|
US (1) | US7521441B2 (es) |
AR (1) | AR061053A1 (es) |
PE (1) | PE20080704A1 (es) |
TW (1) | TW200817403A (es) |
WO (1) | WO2007140109A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1688420A4 (en) * | 2003-11-19 | 2008-10-22 | Japan Tobacco Inc | 5-5 LOW-CONDENSED HETEROCYCLIC COMPOUND AND THEIR USE AS HCV POLYMERASE INHIBITOR |
US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
US7521443B2 (en) * | 2006-05-17 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7541351B2 (en) * | 2007-01-11 | 2009-06-02 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7541352B2 (en) * | 2007-02-02 | 2009-06-02 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7517872B2 (en) * | 2007-02-22 | 2009-04-14 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7998951B2 (en) * | 2007-03-05 | 2011-08-16 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
US7538102B2 (en) * | 2007-03-14 | 2009-05-26 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
US7521444B2 (en) * | 2007-03-14 | 2009-04-21 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7541353B2 (en) * | 2007-03-14 | 2009-06-02 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7547690B2 (en) * | 2007-03-14 | 2009-06-16 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
US7538103B2 (en) * | 2007-03-15 | 2009-05-26 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
CN102872461A (zh) | 2007-05-04 | 2013-01-16 | 弗特克斯药品有限公司 | 用于治疗hcv感染的组合治疗 |
US8143243B2 (en) * | 2007-08-09 | 2012-03-27 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7652004B2 (en) * | 2007-08-09 | 2010-01-26 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7642251B2 (en) * | 2007-08-09 | 2010-01-05 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US8129367B2 (en) * | 2007-11-21 | 2012-03-06 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
US8124601B2 (en) * | 2007-11-21 | 2012-02-28 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
CA2710644C (en) | 2007-12-24 | 2016-03-29 | Tibotec Pharmaceuticals | Macrocyclic indoles as hepatitis c virus inhibitors |
EP2268643B1 (en) * | 2008-03-27 | 2014-08-06 | Bristol-Myers Squibb Company | Dioxolane and dioxolanone fused indolobenzadiazepine hcv ns5b inhibitors |
EP2280978B1 (en) * | 2008-03-27 | 2013-04-24 | Bristol-Myers Squibb Company | Pyrrolidine fused indolobenzadiazepine hcv ns5b inhibitors |
MX2010010061A (es) * | 2008-03-27 | 2010-09-30 | Bristol Myers Squibb Co | Compuestos para el tratamiento de hepatitis c. |
US8133884B2 (en) * | 2008-05-06 | 2012-03-13 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
TWI454476B (zh) | 2008-07-08 | 2014-10-01 | Tibotec Pharm Ltd | 用作c型肝炎病毒抑制劑之巨環吲哚衍生物 |
UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
US8143244B2 (en) * | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
AU2011268922B2 (en) | 2010-06-24 | 2014-06-12 | Janssen Sciences Ireland Uc | Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid |
WO2012087833A1 (en) | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Hepatitis c inhibitors and uses thereof |
AU2011352145A1 (en) | 2010-12-30 | 2013-07-18 | Abbvie Inc. | Phenanthridine macrocyclic hepatitis C serine protease inhibitors |
MX2013007677A (es) | 2010-12-30 | 2013-07-30 | Abbvie Inc | Inhibidores macrociclicos de serina proteasa de hepatitis. |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
WO2018009811A1 (en) | 2016-07-08 | 2018-01-11 | Genentech, Inc. | Use of human epididymis protein 4 (he4) for assessing responsiveness of muc 16-positive cancer treatment |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1719773E (pt) | 2004-02-24 | 2009-06-03 | Japan Tobacco Inc | Compostos heterotetracíclicos fundidos e a sua utilização como inibidores da polimerase do hcv |
US7348425B2 (en) * | 2004-08-09 | 2008-03-25 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
US7153848B2 (en) * | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
WO2006040039A1 (de) | 2004-10-13 | 2006-04-20 | Merck Patent Gmbh | Als kinaseinhibitoren geeignete derivate des n, n ´ -diphenylharnstoffs |
CA2585113A1 (en) | 2004-10-26 | 2006-05-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
GB0518390D0 (en) | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US7399758B2 (en) * | 2005-09-12 | 2008-07-15 | Meanwell Nicholas A | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7473688B2 (en) * | 2005-09-13 | 2009-01-06 | Bristol-Myers Squibb Company | Indolobenzazepine HCV NS5B inhibitors |
US7456165B2 (en) * | 2006-02-08 | 2008-11-25 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
-
2007
- 2007-05-07 US US11/745,090 patent/US7521441B2/en active Active
- 2007-05-14 WO PCT/US2007/068861 patent/WO2007140109A1/en active Application Filing
- 2007-05-18 PE PE2007000614A patent/PE20080704A1/es not_active Application Discontinuation
- 2007-05-21 AR ARP070102188A patent/AR061053A1/es not_active Application Discontinuation
- 2007-05-22 TW TW096118101A patent/TW200817403A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW200817403A (en) | 2008-04-16 |
AR061053A1 (es) | 2008-07-30 |
WO2007140109A1 (en) | 2007-12-06 |
US7521441B2 (en) | 2009-04-21 |
US20070270406A1 (en) | 2007-11-22 |
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