DK1140941T3 - Nitrogenholdige heterobicykliske forbindelser som faktor Xa-inhibitorer - Google Patents
Nitrogenholdige heterobicykliske forbindelser som faktor Xa-inhibitorerInfo
- Publication number
- DK1140941T3 DK1140941T3 DK99967444T DK99967444T DK1140941T3 DK 1140941 T3 DK1140941 T3 DK 1140941T3 DK 99967444 T DK99967444 T DK 99967444T DK 99967444 T DK99967444 T DK 99967444T DK 1140941 T3 DK1140941 T3 DK 1140941T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- nitrogen
- factor
- heterobicyclic compounds
- containing heterobicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11362898P | 1998-12-23 | 1998-12-23 | |
US12763399P | 1999-04-02 | 1999-04-02 | |
EP99967444A EP1140941B1 (en) | 1998-12-23 | 1999-12-17 | Nitrogen containing heterobicycles as factor xa inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1140941T3 true DK1140941T3 (da) | 2005-02-14 |
Family
ID=26811284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99967444T DK1140941T3 (da) | 1998-12-23 | 1999-12-17 | Nitrogenholdige heterobicykliske forbindelser som faktor Xa-inhibitorer |
Country Status (26)
Country | Link |
---|---|
US (2) | US6413980B1 (da) |
EP (1) | EP1140941B1 (da) |
JP (1) | JP2002533465A (da) |
KR (1) | KR100628407B1 (da) |
CN (1) | CN100340559C (da) |
AR (1) | AR024242A1 (da) |
AT (1) | ATE280171T1 (da) |
AU (1) | AU759711B2 (da) |
BR (1) | BR9917080A (da) |
CA (1) | CA2349330C (da) |
DE (1) | DE69921358T2 (da) |
DK (1) | DK1140941T3 (da) |
EA (1) | EA004515B1 (da) |
ES (1) | ES2232202T3 (da) |
HK (1) | HK1052508B (da) |
HR (1) | HRP990396A2 (da) |
IL (2) | IL142959A0 (da) |
MX (1) | MXPA01006502A (da) |
MY (1) | MY138239A (da) |
NO (1) | NO319816B1 (da) |
NZ (1) | NZ511674A (da) |
PT (1) | PT1140941E (da) |
SI (1) | SI1140941T1 (da) |
TW (1) | TWI225862B (da) |
WO (1) | WO2000039131A1 (da) |
ZA (1) | ZA200103795B (da) |
Families Citing this family (66)
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EP1296982B1 (en) * | 2000-06-23 | 2007-09-19 | Bristol-Myers Squibb Pharma Company | 1-(heteroaryl-phenyl)-condensed pyrazol derivatives as factor xa inhibitors |
US20040077605A1 (en) * | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
EP1854798A3 (en) | 2000-09-19 | 2007-11-28 | Bristol-Myers Squibb Company | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
US20040087548A1 (en) | 2001-02-27 | 2004-05-06 | Salvati Mark E. | Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
US6960595B2 (en) * | 2001-03-23 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | 5-6 to 5-7 Heterobicycles as factor Xa inhibitors |
WO2002085356A1 (en) * | 2001-04-18 | 2002-10-31 | Bristol-Myers Squibb Company | 1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]-pyrid in-7-ones as factor xa inhibitors |
EP1379244A4 (en) | 2001-04-18 | 2006-03-15 | Bristol Myers Squibb Co | 1,4,5,6-TETRAHYDROPYRAZOLO-3,4-C] -PYRIDINE-7-ONE AS FACTOR XA HEMMER |
US6878710B2 (en) * | 2001-05-22 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Bicyclic inhibitors of factor Xa |
MXPA04002526A (es) | 2001-09-21 | 2004-05-31 | Bristol Myers Squibb Co | Compuestos que contienen lactama y sus derivados como inhibidores del factor xa. |
TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
WO2003048081A2 (en) * | 2001-12-04 | 2003-06-12 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
TW200738672A (en) | 2001-12-10 | 2007-10-16 | Bristol Myers Squibb Co | Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
DE60228330D1 (de) * | 2001-12-19 | 2008-09-25 | Bristol Myers Squibb Co | Kondensierte heterocyclische verbindungen und deren analoga; modulatoren der funktion von nukleären hormonrezeptoren |
CN101597262A (zh) * | 2002-03-05 | 2009-12-09 | 特兰斯泰克制药公司 | 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物 |
AU2003273179A1 (en) | 2002-05-10 | 2003-12-12 | Bristol-Myers Squibb Company | 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors |
PT1569912E (pt) | 2002-12-03 | 2015-09-15 | Pharmacyclics Llc | Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia |
CA2511321A1 (en) * | 2002-12-23 | 2004-07-08 | Aventis Pharma Deutschland Gmbh | Pyrazole-derivatives as factor xa inhibitors |
US7429581B2 (en) | 2002-12-23 | 2008-09-30 | Sanofi-Aventis Deutschland Gmbh | Pyrazole-derivatives as factor Xa inhibitors |
EP1479678A1 (en) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Pyrazole-derivatives as factor xa inhibitors |
US7135469B2 (en) * | 2003-03-18 | 2006-11-14 | Bristol Myers Squibb, Co. | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors |
US7122557B2 (en) * | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
EP1479675A1 (en) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Indazole-derivatives as factor Xa inhibitors |
EP1635823A1 (en) * | 2003-05-20 | 2006-03-22 | TransTech Pharma Inc. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
US7022850B2 (en) | 2003-05-22 | 2006-04-04 | Bristol-Myers Squibb Co. | Bicyclicpyrimidones and their use to treat diseases |
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US20080293744A1 (en) | 2004-08-18 | 2008-11-27 | Astrazeneca Ab | Enantiomers of Selected Fused Pyrimidones and Uses in the Treatment and Prevention of Cancer |
US20060069085A1 (en) * | 2004-09-28 | 2006-03-30 | Rulin Zhao | Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
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US8202999B2 (en) | 2005-01-07 | 2012-06-19 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
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US20100130514A1 (en) | 2007-04-18 | 2010-05-27 | Kissei Pharmaceutical Co., Ltd. | Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes |
US8426427B2 (en) | 2007-04-18 | 2013-04-23 | Kissei Pharmaceutical Co., Ltd. | Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes |
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CN109602713A (zh) | 2010-02-25 | 2019-04-12 | 百时美-施贵宝爱尔兰控股公司 | 包含药物组合物的片剂或胶囊剂 |
US8884016B2 (en) | 2011-06-10 | 2014-11-11 | Dipharma Francis S.R.L. | Apixaban preparation process |
CN104109165A (zh) * | 2013-04-19 | 2014-10-22 | 四川海思科制药有限公司 | 4,5-二氢-吡唑并[3,4-c]吡啶-2-酮衍生物、其制备方法以及应用 |
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AR096816A1 (es) | 2013-07-08 | 2016-02-03 | Bayer Cropscience Ag | Derivados de arilsulfuro y arilsulfóxido de seis miembros enlazados con c-n como agentes para combatir parásitos |
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WO2015162551A1 (en) | 2014-04-21 | 2015-10-29 | Mylan Laboratories Ltd | Process for the preparation of apixaban |
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ES2881373T3 (es) | 2014-09-05 | 2021-11-29 | Unichem Lab Ltd | Un procedimiento mejorado para la preparación de apixabán e intermedios del mismo |
CN104311556B (zh) * | 2014-09-19 | 2016-06-01 | 广东东阳光药业有限公司 | 含有环氧烷基取代基的吡唑并哌啶酮类化合物及其组合物及用途 |
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CN104513239B (zh) * | 2014-12-10 | 2017-08-22 | 沈阳药科大学 | 吡唑并[3,4‑c]吡啶‑7‑酮类化合物及其应用 |
US10077263B2 (en) | 2016-04-29 | 2018-09-18 | Optimus Drugs Private Limited | Process for the preparation of Apixaban |
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JP7273951B2 (ja) | 2018-09-12 | 2023-05-15 | ノバルティス アーゲー | 抗ウイルス性ピリドピラジンジオン化合物 |
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KR20220070005A (ko) | 2019-09-26 | 2022-05-27 | 노파르티스 아게 | 항바이러스성 피라졸로피리디논 화합물 |
GB202107722D0 (en) | 2021-05-28 | 2021-07-14 | Lunac Therapeutics Ltd | Factor XIIA Inhibitors |
WO2023083286A1 (en) * | 2021-11-12 | 2023-05-19 | Insilico Medicine Ip Limited | Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof |
CN113956248B (zh) * | 2021-11-12 | 2023-07-04 | 贵州中医药大学 | 一种具有抗炎作用的化合物衍生物及其制备方法和应用 |
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US3340269A (en) * | 1964-09-08 | 1967-09-05 | Ciba Geigy Corp | 1-substituted 4-acyl-2, 3-dioxo-piperidine |
US3365459A (en) * | 1964-09-08 | 1968-01-23 | Ciba Geigy Corp | Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives |
US3423414A (en) * | 1966-01-13 | 1969-01-21 | Ciba Geigy Corp | Pyrazolopyridines |
US3939161A (en) * | 1973-10-29 | 1976-02-17 | Abbott Laboratories | 1,3-Dimethyl- 1H-pyrazolo(4,3-D) pyrimidine-7 (6H)-ones |
JPS5721388A (en) * | 1980-07-11 | 1982-02-04 | Nippon Nohyaku Co Ltd | Condensed pyrazole derivative |
JPS63145282A (ja) * | 1986-12-08 | 1988-06-17 | Taiyo Yakuhin Kogyo Kk | ピリダジン誘導体 |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
ATE236163T1 (de) * | 1991-08-07 | 2003-04-15 | Suntory Ltd | Pyrroloazepinverbindungen |
WO1994020460A1 (en) | 1993-03-11 | 1994-09-15 | Smithkline Beecham Corporation | Chemical compounds |
CA2166721C (en) * | 1993-07-06 | 1999-07-27 | Allen Jacob Duplantier | Bicyclic tetrahydro pyrazolopyridines |
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US6323201B1 (en) * | 1994-12-29 | 2001-11-27 | The Regents Of The University Of California | Compounds for inhibition of ceramide-mediated signal transduction |
EP0939757A1 (en) * | 1995-12-22 | 1999-09-08 | Dupont Pharmaceuticals Company | Novel integrin receptor antagonists |
DE69716810T2 (de) * | 1996-05-15 | 2003-02-27 | Pfizer | 2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one |
FR2750862B1 (fr) * | 1996-07-12 | 1998-10-16 | Dupin Jean Pierre | Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques |
TW589309B (en) * | 1997-07-03 | 2004-06-01 | Bristol Myers Squibb Pharma Co | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders |
ES2230841T3 (es) * | 1998-03-27 | 2005-05-01 | Bristol-Myers Squibb Pharma Company | Pirazolinas y triazolinas disustituidas como inhibidores del factor xa. |
DE19845153A1 (de) | 1998-10-01 | 2000-04-06 | Merck Patent Gmbh | Imidazo[4,5]-pyridin-4-on-derivate |
DE19900471A1 (de) | 1999-01-08 | 2000-07-13 | Merck Patent Gmbh | Imidazo[4,5c]-pyridin-4-on-derivate |
MX228790B (es) | 1999-09-17 | 2005-06-30 | Millennium Pharm Inc | Inhibidores del factor xa. |
-
1999
- 1999-12-17 PT PT99967444T patent/PT1140941E/pt unknown
- 1999-12-17 SI SI9930721T patent/SI1140941T1/xx unknown
- 1999-12-17 DK DK99967444T patent/DK1140941T3/da active
- 1999-12-17 KR KR1020017007991A patent/KR100628407B1/ko not_active IP Right Cessation
- 1999-12-17 MX MXPA01006502A patent/MXPA01006502A/es active IP Right Grant
- 1999-12-17 EP EP99967444A patent/EP1140941B1/en not_active Expired - Lifetime
- 1999-12-17 AT AT99967444T patent/ATE280171T1/de active
- 1999-12-17 NZ NZ511674A patent/NZ511674A/en not_active IP Right Cessation
- 1999-12-17 WO PCT/US1999/030316 patent/WO2000039131A1/en active IP Right Grant
- 1999-12-17 CN CNB998147710A patent/CN100340559C/zh not_active Expired - Fee Related
- 1999-12-17 EA EA200100688A patent/EA004515B1/ru not_active IP Right Cessation
- 1999-12-17 DE DE69921358T patent/DE69921358T2/de not_active Expired - Lifetime
- 1999-12-17 JP JP2000591042A patent/JP2002533465A/ja active Pending
- 1999-12-17 ES ES99967444T patent/ES2232202T3/es not_active Expired - Lifetime
- 1999-12-17 IL IL14295999A patent/IL142959A0/xx unknown
- 1999-12-17 AU AU23717/00A patent/AU759711B2/en active Active
- 1999-12-17 BR BR9917080-9A patent/BR9917080A/pt not_active Application Discontinuation
- 1999-12-17 CA CA002349330A patent/CA2349330C/en not_active Expired - Lifetime
- 1999-12-21 HR HR990396A patent/HRP990396A2/hr not_active Application Discontinuation
- 1999-12-22 US US09/470,326 patent/US6413980B1/en not_active Expired - Lifetime
- 1999-12-22 MY MYPI99005666A patent/MY138239A/en unknown
- 1999-12-23 AR ARP990106759A patent/AR024242A1/es active IP Right Grant
-
2000
- 2000-01-15 TW TW088122748A patent/TWI225862B/zh not_active IP Right Cessation
-
2001
- 2001-05-03 IL IL142959A patent/IL142959A/en not_active IP Right Cessation
- 2001-05-10 ZA ZA200103795A patent/ZA200103795B/en unknown
- 2001-06-20 NO NO20013072A patent/NO319816B1/no not_active IP Right Cessation
- 2001-07-03 US US09/898,279 patent/US6673810B2/en not_active Expired - Lifetime
-
2003
- 2003-07-04 HK HK03104763.4A patent/HK1052508B/zh not_active IP Right Cessation
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