HK1052508B - 作為凝血因子xa抑制劑的含氮雜雙環 - Google Patents

作為凝血因子xa抑制劑的含氮雜雙環

Info

Publication number
HK1052508B
HK1052508B HK03104763.4A HK03104763A HK1052508B HK 1052508 B HK1052508 B HK 1052508B HK 03104763 A HK03104763 A HK 03104763A HK 1052508 B HK1052508 B HK 1052508B
Authority
HK
Hong Kong
Prior art keywords
inhibitors
factor
nitrogen containing
containing heterobicycles
heterobicycles
Prior art date
Application number
HK03104763.4A
Other languages
English (en)
Other versions
HK1052508A1 (en
Inventor
M Fevig John
Cacciola Joseph
G Clark Charles
Yuk Sun Lam Patrick
J P Pinto Donald
R Pruitt James
A Rossi Karen
Han Qi
L Quan Mimi
Original Assignee
Bristol Myers Squibb Pharma Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26811284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1052508(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Pharma Company filed Critical Bristol Myers Squibb Pharma Company
Publication of HK1052508A1 publication Critical patent/HK1052508A1/xx
Publication of HK1052508B publication Critical patent/HK1052508B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK03104763.4A 1998-12-23 2003-07-04 作為凝血因子xa抑制劑的含氮雜雙環 HK1052508B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11362898P 1998-12-23 1998-12-23
US12763399P 1999-04-02 1999-04-02
PCT/US1999/030316 WO2000039131A1 (en) 1998-12-23 1999-12-17 Nitrogen containing heterobicycles as factor xa inhibitors

Publications (2)

Publication Number Publication Date
HK1052508A1 HK1052508A1 (en) 2003-09-19
HK1052508B true HK1052508B (zh) 2008-08-01

Family

ID=26811284

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03104763.4A HK1052508B (zh) 1998-12-23 2003-07-04 作為凝血因子xa抑制劑的含氮雜雙環

Country Status (26)

Country Link
US (2) US6413980B1 (zh)
EP (1) EP1140941B1 (zh)
JP (1) JP2002533465A (zh)
KR (1) KR100628407B1 (zh)
CN (1) CN100340559C (zh)
AR (1) AR024242A1 (zh)
AT (1) ATE280171T1 (zh)
AU (1) AU759711B2 (zh)
BR (1) BR9917080A (zh)
CA (1) CA2349330C (zh)
DE (1) DE69921358T2 (zh)
DK (1) DK1140941T3 (zh)
EA (1) EA004515B1 (zh)
ES (1) ES2232202T3 (zh)
HK (1) HK1052508B (zh)
HR (1) HRP990396A2 (zh)
IL (2) IL142959A0 (zh)
MX (1) MXPA01006502A (zh)
MY (1) MY138239A (zh)
NO (1) NO319816B1 (zh)
NZ (1) NZ511674A (zh)
PT (1) PT1140941E (zh)
SI (1) SI1140941T1 (zh)
TW (1) TWI225862B (zh)
WO (1) WO2000039131A1 (zh)
ZA (1) ZA200103795B (zh)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000655A1 (en) * 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
WO2002085356A1 (en) * 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]-pyrid in-7-ones as factor xa inhibitors
EP1379244A4 (en) 2001-04-18 2006-03-15 Bristol Myers Squibb Co 1,4,5,6-TETRAHYDROPYRAZOLO-3,4-C] -PYRIDINE-7-ONE AS FACTOR XA HEMMER
US6878710B2 (en) * 2001-05-22 2005-04-12 Bristol-Myers Squibb Pharma Company Bicyclic inhibitors of factor Xa
UA78232C2 (uk) 2001-09-21 2007-03-15 Брістол-Майерс Сквібб Компані Лактамвмісні сполуки та їх похідні як інгібітори фактора ха
TWI320039B (en) 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
AU2002350217A1 (en) * 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
TW200738672A (en) * 2001-12-10 2007-10-16 Bristol Myers Squibb Co Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
ES2310622T3 (es) * 2001-12-19 2009-01-16 Bristol-Myers Squibb Company Compuestos heterociclicos condensados y analogos de los mismos, moduladores de la funcion de los receptores nucleares de hormonas.
DK1482931T3 (da) * 2002-03-05 2011-12-19 Transtech Pharma Inc Mono- og bicycliske azolderivater der inhiberer interaktionen af ligander med RAGE
US7312214B2 (en) 2002-05-10 2007-12-25 Bristol-Myers Squibb Company 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors
CN100513398C (zh) 2002-12-03 2009-07-15 Axys药物公司 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
MXPA05006200A (es) * 2002-12-23 2005-08-19 Aventis Pharma Gmbh Derivados de pirazol como inhibidores del factor xa.
EP1479678A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Pyrazole-derivatives as factor xa inhibitors
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
US7122557B2 (en) * 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
EP1479675A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazole-derivatives as factor Xa inhibitors
ZA200508300B (en) * 2003-05-20 2007-03-28 Transtech Pharma Inc RAGE antagonists as agents to reverse amyloidosis and diseases associated therewith
US7022850B2 (en) 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
US7652135B2 (en) 2003-09-23 2010-01-26 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
MXPA06009301A (es) 2004-02-24 2007-01-26 Sumitomo Chem Takeda Agro Co Composiciones insecticidas.
MX2007001953A (es) 2004-08-18 2007-05-09 Astrazeneca Ab Enantiomeros de pirimidonas fusionadas seleccionadas y usos en el tratamiento y prevencion del cancer.
US20060069085A1 (en) * 2004-09-28 2006-03-30 Rulin Zhao Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US7381732B2 (en) * 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
WO2006083477A2 (en) 2005-01-07 2006-08-10 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
KR20090064478A (ko) * 2006-11-13 2009-06-18 화이자 프로덕츠 인크. 디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도
EP2145889A4 (en) 2007-04-18 2012-04-18 Kissei Pharmaceutical HETEROCYCLIC FUSED CORE DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE DERIVATIVE, AND USE OF THE COMPOSITION FOR MEDICAL PURPOSES
CA2682519A1 (en) 2007-04-18 2008-11-06 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes
WO2011041198A1 (en) 2009-09-30 2011-04-07 Transtech Pharma, Inc. Substituted imidazole derivatives for treatment of alzheimers disease
SG10201501349VA (en) 2010-02-25 2015-04-29 Bristol Myers Squibb Co Apixaban formulations
EP2718262B1 (en) 2011-06-10 2016-08-03 Dipharma Francis S.r.l. Apixaban preparation process
CN104109165A (zh) * 2013-04-19 2014-10-22 四川海思科制药有限公司 4,5-二氢-吡唑并[3,4-c]吡啶-2-酮衍生物、其制备方法以及应用
CN103992310B (zh) * 2013-05-14 2016-07-06 中国医学科学院医药生物技术研究所 一组取代苯并杂环胺衍生物及其制备方法和作为impdh抑制剂的相关应用
WO2014202027A1 (zh) * 2013-06-21 2014-12-24 四川海思科制药有限公司 4,5-二氢吡唑并[3,4-c]吡啶-2-酮的螺环衍生物、其制备方法以及应用
TW201542532A (zh) 2013-07-08 2015-11-16 Bayer Cropscience Ag 作為殺蟲劑的六員ｃ－ｎ－鍵結之芳基硫化物及芳基亞碸衍生物
CN105745212B (zh) * 2013-12-06 2017-09-12 四川海思科制药有限公司 取代的4,5‑二氢吡唑并[3,4‑c]吡啶‑2‑酮的螺环衍生物及应用
WO2015162551A1 (en) 2014-04-21 2015-10-29 Mylan Laboratories Ltd Process for the preparation of apixaban
WO2015176625A1 (zh) * 2014-05-22 2015-11-26 南京明德新药研发股份有限公司 作为凝血因子Xa抑制剂的酰肼类化合物
CN105085515B (zh) * 2014-05-22 2019-02-01 华北制药股份有限公司 作为凝血因子Xa抑制剂的酰肼类化合物
CN105384739B (zh) * 2014-09-02 2020-03-20 石药集团中奇制药技术（石家庄）有限公司 吡唑并[3,4-c]吡啶类衍生物
EP3189053B1 (en) 2014-09-05 2021-05-05 Unichem Laboratories Limited An improved process for the preparation of apixaban and intermediates thereof
CN104311557B (zh) * 2014-09-19 2016-01-06 广东东阳光药业有限公司 含有二酮取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN104277039B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有取代丁炔基的吡唑并哌啶酮类化合物及其组合物及用途
CN104277037B (zh) * 2014-09-19 2015-12-09 广东东阳光药业有限公司 含有螺环的吡唑并哌啶酮类化合物及其组合物及用途
CN104311575B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 含有稠环的吡唑并哌啶酮类化合物及其组合物及用途
CN104311555B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 吡唑并哌啶酮类化合物及其组合物及用途
CN104311574B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 含有噻唑的吡唑并哌啶酮类化合物及其组合物及用途
CN104311556B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有环氧烷基取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途
CN104513239B (zh) * 2014-12-10 2017-08-22 沈阳药科大学 吡唑并[3,4‑c]吡啶‑7‑酮类化合物及其应用
US10077263B2 (en) 2016-04-29 2018-09-18 Optimus Drugs Private Limited Process for the preparation of Apixaban
US11510909B2 (en) 2017-02-17 2022-11-29 Unichem Laboratories Ltd. Pharmaceutical composition of apixaban
CN107235986B (zh) * 2017-05-27 2019-04-12 华南师范大学 一种合成氮氧杂桥联唑啉化合物的方法
GB201807014D0 (en) 2018-04-30 2018-06-13 Univ Leeds Innovations Ltd Factor xlla inhibitors
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
KR102128509B1 (ko) * 2018-12-19 2020-07-01 한국과학기술연구원 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
KR20220070005A (ko) 2019-09-26 2022-05-27 노파르티스 아게 항바이러스성 피라졸로피리디논 화합물
GB202107722D0 (en) 2021-05-28 2021-07-14 Lunac Therapeutics Ltd Factor XIIA Inhibitors
CA3235765A1 (en) * 2021-11-12 2023-05-19 Jianping Wu Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof
CN113956248B (zh) * 2021-11-12 2023-07-04 贵州中医药大学 一种具有抗炎作用的化合物衍生物及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
US3423414A (en) * 1966-01-13 1969-01-21 Ciba Geigy Corp Pyrazolopyridines
US3939161A (en) * 1973-10-29 1976-02-17 Abbott Laboratories 1,3-Dimethyl- 1H-pyrazolo(4,3-D) pyrimidine-7 (6H)-ones
JPS5721388A (en) * 1980-07-11 1982-02-04 Nippon Nohyaku Co Ltd Condensed pyrazole derivative
JPS63145282A (ja) * 1986-12-08 1988-06-17 Taiyo Yakuhin Kogyo Kk ピリダジン誘導体
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
WO1993003032A1 (en) * 1991-08-07 1993-02-18 Suntory Limited Pyrroloazepine compound
WO1994020460A1 (en) 1993-03-11 1994-09-15 Smithkline Beecham Corporation Chemical compounds
HUT74170A (en) * 1993-07-06 1996-11-28 Pfizer Bicyclic tetrahydro pyrazolopyridines
CN1050129C (zh) * 1994-10-20 2000-03-08 美国辉瑞有限公司 二环四氢吡唑并吡啶和其作为药物的应用
US6323201B1 (en) * 1994-12-29 2001-11-27 The Regents Of The University Of California Compounds for inhibition of ceramide-mediated signal transduction
WO1997023480A1 (en) * 1995-12-22 1997-07-03 The Du Pont Merck Pharmaceutical Company Novel integrin receptor antagonists
PT807633E (pt) * 1996-05-15 2003-02-28 Pfizer Novas pirimidin-4-onas substituidas em 2,3, e fundidas com heteroarilo em (5,6)
FR2750862B1 (fr) * 1996-07-12 1998-10-16 Dupin Jean Pierre Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques
EP0994877A1 (en) * 1997-07-03 2000-04-26 Du Pont Pharmaceuticals Company Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
EP1064270B1 (en) * 1998-03-27 2004-10-06 Bristol-Myers Squibb Pharma Company Disubstituted pyrazolines and triazolines as factor xa inhibitors
DE19845153A1 (de) 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
DE19900471A1 (de) 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
TR200201413T2 (tr) 1999-09-17 2003-02-21 Millennium Pharmaceuticals, Inc. Faktör Xa' nın inhibitörleri.

Also Published As

Publication number Publication date
MXPA01006502A (es) 2002-04-08
IL142959A0 (en) 2002-04-21
AU2371700A (en) 2000-07-31
US6413980B1 (en) 2002-07-02
PT1140941E (pt) 2005-02-28
CN1391575A (zh) 2003-01-15
US6673810B2 (en) 2004-01-06
EP1140941B1 (en) 2004-10-20
DE69921358D1 (de) 2004-11-25
AU759711B2 (en) 2003-04-17
EA004515B1 (ru) 2004-04-29
US20030004167A1 (en) 2003-01-02
CA2349330A1 (en) 2000-07-06
ZA200103795B (en) 2002-08-12
HRP990396A2 (en) 2000-08-31
CN100340559C (zh) 2007-10-03
SI1140941T1 (en) 2005-04-30
NZ511674A (en) 2003-11-28
EA200100688A1 (ru) 2001-12-24
JP2002533465A (ja) 2002-10-08
WO2000039131A1 (en) 2000-07-06
IL142959A (en) 2010-05-31
NO20013072D0 (no) 2001-06-20
NO20013072L (no) 2001-06-20
EP1140941A1 (en) 2001-10-10
HK1052508A1 (en) 2003-09-19
CA2349330C (en) 2009-09-29
MY138239A (en) 2009-05-29
TWI225862B (en) 2005-01-01
ES2232202T3 (es) 2005-05-16
DK1140941T3 (da) 2005-02-14
KR20010092754A (ko) 2001-10-26
AR024242A1 (es) 2002-09-25
BR9917080A (pt) 2002-03-12
NO319816B1 (no) 2005-09-19
ATE280171T1 (de) 2004-11-15
KR100628407B1 (ko) 2006-09-26
DE69921358T2 (de) 2006-03-09

Similar Documents

Publication Publication Date Title
HK1052508A1 (en) Nitrogen containing heterobicycles as factor xa inhibitors
IL137517A0 (en) Substituted oxoazaheterocyclyl factor xa inhibitors
EP1140871A4 (en) THROMBIN OR FACTOR XA INHIBITORS
IL130286A0 (en) Nitrogen containing heteroaromatics as factor Xa inhibitors
IL148698A0 (en) INHIBITORS OF FACTOR Xa
EP1124822A4 (en) THROMBIN INHIBITORS
IL141415A0 (en) Factor viia inhibitors
EP1082324A4 (en) IMIDAZOPYRIDINE COMPOUNDS AS THROMBINE INHIBITORS
HK1040076A1 (zh) 作為整聯蛋白抑制劑的喹嗪酮
EP1117660A4 (en) THROMBIN INHIBITORS
IL136139A0 (en) Thrombin inhibitors
HK1047289A1 (en) Factor viia inhibitors
PL350941A1 (en) Pyrazole-3-on-derivative as factor xa inhibitors
EP1153022A4 (en) PROTEASE INHIBITORS
IL140243A0 (en) Fkbp inhibitors
EP1017383A4 (en) THROMBIN INHIBITORS
EP1189618A4 (en) thrombin
EP1039907A4 (en) THROMBIN INHIBITORS
LT99076A (en) Nitrogen containing heteroaromatics as factor xa inhibitors
GB9806034D0 (en) Thrombin inhibitors
GB9807941D0 (en) Thrombin inhibitors
GB9809784D0 (en) Thrombin Inhibitors
SI1109560T1 (en) Compounds useful as aicarft inhibitors
GB9803416D0 (en) Inhibitors
AU1923300A (en) Substituted oxoazaheterocyclyl factor xa inhibitors

Legal Events

Date Code Title Description
AS Change of ownership

Owner name: BRISTOL-MYERS SQUIBB PHARMA COMPANY

Free format text: FORMER OWNER(S): DU PONT PHARMACEUTICALS COMPANY

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20111217