ATE280171T1 - Stickstoffhaltige heterobicyclen als faktor-xa- hemmer - Google Patents

Stickstoffhaltige heterobicyclen als faktor-xa- hemmer

Info

Publication number
ATE280171T1
ATE280171T1 AT99967444T AT99967444T ATE280171T1 AT E280171 T1 ATE280171 T1 AT E280171T1 AT 99967444 T AT99967444 T AT 99967444T AT 99967444 T AT99967444 T AT 99967444T AT E280171 T1 ATE280171 T1 AT E280171T1
Authority
AT
Austria
Prior art keywords
inhibitors
nitrogen
factor
containing heterobicycles
heterobicycles
Prior art date
Application number
AT99967444T
Other languages
English (en)
Inventor
John M Fevig
Joseph Cacciola
Charles G Clark
Patrick Yuk Sun Lam
Donald J P Pinto
James R Pruitt
Karen A Rossi
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26811284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE280171(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of ATE280171T1 publication Critical patent/ATE280171T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT99967444T 1998-12-23 1999-12-17 Stickstoffhaltige heterobicyclen als faktor-xa- hemmer ATE280171T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11362898P 1998-12-23 1998-12-23
US12763399P 1999-04-02 1999-04-02
PCT/US1999/030316 WO2000039131A1 (en) 1998-12-23 1999-12-17 Nitrogen containing heterobicycles as factor xa inhibitors

Publications (1)

Publication Number Publication Date
ATE280171T1 true ATE280171T1 (de) 2004-11-15

Family

ID=26811284

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99967444T ATE280171T1 (de) 1998-12-23 1999-12-17 Stickstoffhaltige heterobicyclen als faktor-xa- hemmer

Country Status (26)

Country Link
US (2) US6413980B1 (de)
EP (1) EP1140941B1 (de)
JP (1) JP2002533465A (de)
KR (1) KR100628407B1 (de)
CN (1) CN100340559C (de)
AR (1) AR024242A1 (de)
AT (1) ATE280171T1 (de)
AU (1) AU759711B2 (de)
BR (1) BR9917080A (de)
CA (1) CA2349330C (de)
DE (1) DE69921358T2 (de)
DK (1) DK1140941T3 (de)
EA (1) EA004515B1 (de)
ES (1) ES2232202T3 (de)
HK (1) HK1052508B (de)
HR (1) HRP990396A2 (de)
IL (2) IL142959A0 (de)
MX (1) MXPA01006502A (de)
MY (1) MY138239A (de)
NO (1) NO319816B1 (de)
NZ (1) NZ511674A (de)
PT (1) PT1140941E (de)
SI (1) SI1140941T1 (de)
TW (1) TWI225862B (de)
WO (1) WO2000039131A1 (de)
ZA (1) ZA200103795B (de)

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US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1854798A3 (de) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
EP1379245A4 (de) 2001-04-18 2006-07-26 Bristol Myers Squibb Co 1, 4, 5, 6-tetrahydropyrazolo- 3, 4-c|-pyridin-7-one als faktor xa hemmer
WO2002085353A1 (en) * 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor xa inhibitors
US6878710B2 (en) * 2001-05-22 2005-04-12 Bristol-Myers Squibb Pharma Company Bicyclic inhibitors of factor Xa
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
CH1427415H1 (de) 2001-09-21 2023-12-21 Bristol Myers Squibb Holdings Ireland Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer
AU2002350217A1 (en) * 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
TW200738672A (en) * 2001-12-10 2007-10-16 Bristol Myers Squibb Co Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
AU2002364082A1 (en) * 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function
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AU2003273179A1 (en) 2002-05-10 2003-12-12 Bristol-Myers Squibb Company 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
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EP1479675A1 (de) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazolderivate als Faktor Xa-Inhibitoren
US7022850B2 (en) 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
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CN103992310B (zh) * 2013-05-14 2016-07-06 中国医学科学院医药生物技术研究所 一组取代苯并杂环胺衍生物及其制备方法和作为impdh抑制剂的相关应用
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CN105085515B (zh) * 2014-05-22 2019-02-01 华北制药股份有限公司 作为凝血因子Xa抑制剂的酰肼类化合物
WO2015176625A1 (zh) * 2014-05-22 2015-11-26 南京明德新药研发股份有限公司 作为凝血因子Xa抑制剂的酰肼类化合物
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CN104277037B (zh) * 2014-09-19 2015-12-09 广东东阳光药业有限公司 含有螺环的吡唑并哌啶酮类化合物及其组合物及用途
CN104311556B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有环氧烷基取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN104277039B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有取代丁炔基的吡唑并哌啶酮类化合物及其组合物及用途
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途
CN104513239B (zh) * 2014-12-10 2017-08-22 沈阳药科大学 吡唑并[3,4‑c]吡啶‑7‑酮类化合物及其应用
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CN107235986B (zh) * 2017-05-27 2019-04-12 华南师范大学 一种合成氮氧杂桥联唑啉化合物的方法
GB201807014D0 (en) 2018-04-30 2018-06-13 Univ Leeds Innovations Ltd Factor xlla inhibitors
US11072610B2 (en) 2018-09-12 2021-07-27 Novartis Ag Antiviral pyridopyrazinedione compounds
KR102128509B1 (ko) * 2018-12-19 2020-07-01 한국과학기술연구원 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
TW202126649A (zh) 2019-09-26 2021-07-16 瑞士商諾華公司 抗病毒吡唑并吡啶酮化合物
GB202107722D0 (en) 2021-05-28 2021-07-14 Lunac Therapeutics Ltd Factor XIIA Inhibitors
CN113956248B (zh) * 2021-11-12 2023-07-04 贵州中医药大学 一种具有抗炎作用的化合物衍生物及其制备方法和应用
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Also Published As

Publication number Publication date
AU759711B2 (en) 2003-04-17
NO319816B1 (no) 2005-09-19
ZA200103795B (en) 2002-08-12
NO20013072L (no) 2001-06-20
IL142959A0 (en) 2002-04-21
DK1140941T3 (da) 2005-02-14
EA200100688A1 (ru) 2001-12-24
NZ511674A (en) 2003-11-28
WO2000039131A1 (en) 2000-07-06
MY138239A (en) 2009-05-29
AU2371700A (en) 2000-07-31
SI1140941T1 (en) 2005-04-30
MXPA01006502A (es) 2002-04-08
TWI225862B (en) 2005-01-01
US20030004167A1 (en) 2003-01-02
DE69921358T2 (de) 2006-03-09
HRP990396A2 (en) 2000-08-31
IL142959A (en) 2010-05-31
HK1052508B (zh) 2008-08-01
DE69921358D1 (de) 2004-11-25
US6673810B2 (en) 2004-01-06
ES2232202T3 (es) 2005-05-16
PT1140941E (pt) 2005-02-28
KR20010092754A (ko) 2001-10-26
CA2349330C (en) 2009-09-29
AR024242A1 (es) 2002-09-25
CA2349330A1 (en) 2000-07-06
NO20013072D0 (no) 2001-06-20
EP1140941A1 (de) 2001-10-10
KR100628407B1 (ko) 2006-09-26
CN1391575A (zh) 2003-01-15
CN100340559C (zh) 2007-10-03
BR9917080A (pt) 2002-03-12
HK1052508A1 (en) 2003-09-19
US6413980B1 (en) 2002-07-02
EP1140941B1 (de) 2004-10-20
EA004515B1 (ru) 2004-04-29
JP2002533465A (ja) 2002-10-08

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