NO20013072L - Nitrogenholdige heterocykler som faktor Xa-inhibitorer - Google Patents

Nitrogenholdige heterocykler som faktor Xa-inhibitorer

Info

Publication number
NO20013072L
NO20013072L NO20013072A NO20013072A NO20013072L NO 20013072 L NO20013072 L NO 20013072L NO 20013072 A NO20013072 A NO 20013072A NO 20013072 A NO20013072 A NO 20013072A NO 20013072 L NO20013072 L NO 20013072L
Authority
NO
Norway
Prior art keywords
inhibitors
nitrogen
factor
containing heterocycles
heterocycles
Prior art date
Application number
NO20013072A
Other languages
English (en)
Other versions
NO319816B1 (no
NO20013072D0 (no
Inventor
John Matthew Fevig
Joseph Cacciola
Charles G Clark
Patrick Yuk-Sun Lam
Donald J P Pinto
James Russell Pruitt
Karen Anita Rossi
Qui Han
Mimi Lifen Quan
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26811284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20013072(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of NO20013072L publication Critical patent/NO20013072L/no
Publication of NO20013072D0 publication Critical patent/NO20013072D0/no
Publication of NO319816B1 publication Critical patent/NO319816B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20013072A 1998-12-23 2001-06-20 Nitrogenholdige heterocykler,anvendelse av disse for fremstilling av medikamenter samt farmasoytiske preparater. NO319816B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11362898P 1998-12-23 1998-12-23
US12763399P 1999-04-02 1999-04-02
PCT/US1999/030316 WO2000039131A1 (en) 1998-12-23 1999-12-17 Nitrogen containing heterobicycles as factor xa inhibitors

Publications (3)

Publication Number Publication Date
NO20013072L true NO20013072L (no) 2001-06-20
NO20013072D0 NO20013072D0 (no) 2001-06-20
NO319816B1 NO319816B1 (no) 2005-09-19

Family

ID=26811284

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013072A NO319816B1 (no) 1998-12-23 2001-06-20 Nitrogenholdige heterocykler,anvendelse av disse for fremstilling av medikamenter samt farmasoytiske preparater.

Country Status (26)

Country Link
US (2) US6413980B1 (no)
EP (1) EP1140941B1 (no)
JP (1) JP2002533465A (no)
KR (1) KR100628407B1 (no)
CN (1) CN100340559C (no)
AR (1) AR024242A1 (no)
AT (1) ATE280171T1 (no)
AU (1) AU759711B2 (no)
BR (1) BR9917080A (no)
CA (1) CA2349330C (no)
DE (1) DE69921358T2 (no)
DK (1) DK1140941T3 (no)
EA (1) EA004515B1 (no)
ES (1) ES2232202T3 (no)
HK (1) HK1052508B (no)
HR (1) HRP990396A2 (no)
IL (2) IL142959A0 (no)
MX (1) MXPA01006502A (no)
MY (1) MY138239A (no)
NO (1) NO319816B1 (no)
NZ (1) NZ511674A (no)
PT (1) PT1140941E (no)
SI (1) SI1140941T1 (no)
TW (1) TWI225862B (no)
WO (1) WO2000039131A1 (no)
ZA (1) ZA200103795B (no)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60130555T2 (de) * 2000-06-23 2008-06-19 Bristol-Myers Squibb Pharma Co. 1-(heteroaryl-phenyl)-kondensierte pyrazol-derivate als factor xa inhibitoren
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
US6750225B2 (en) 2001-04-18 2004-06-15 Bristol-Myers Squibb Pharms Company 1,4,5,6-tetrahydropyrazolo-[3,4,-c]-pyridin-7-ones useful as factor Xa inhibitors
US6706730B2 (en) 2001-04-18 2004-03-16 Bristol-Myers Squibb Pharma Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors
EP1414449A4 (en) * 2001-05-22 2005-04-06 Bristol Myers Squibb Co FACTOR XA BICYCLIC INHIBITORS
TWI320039B (en) 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
BRPI0212726B8 (pt) * 2001-09-21 2021-05-25 Bristol Myers Squibb Co compostos contendo lactamas, e derivados dos mesmos, composição farmacêutica que os compreende e seus usos
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
WO2003048081A2 (en) * 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
TW200738672A (en) 2001-12-10 2007-10-16 Bristol Myers Squibb Co Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
ATE404544T1 (de) * 2001-12-19 2008-08-15 Bristol Myers Squibb Co Kondensierte heterocyclische verbindungen und deren analoga; modulatoren der funktion von nukleären hormonrezeptoren
CN100525763C (zh) * 2002-03-05 2009-08-12 特兰斯泰克制药公司 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物
US7312214B2 (en) 2002-05-10 2007-12-25 Bristol-Myers Squibb Company 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
AU2003292218A1 (en) * 2002-12-23 2004-07-14 Sanofi-Aventis Deutschland Gmbh PYRAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS
EP1479678A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Pyrazole-derivatives as factor xa inhibitors
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
US7122557B2 (en) * 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
EP1479675A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazole-derivatives as factor Xa inhibitors
CA2522275A1 (en) * 2003-05-20 2005-01-06 Transtech Pharma, Inc. Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
US7022850B2 (en) 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
ATE546452T1 (de) 2003-09-23 2012-03-15 Vertex Pharma Pyrazolopyrrolderivate als proteinkinaseinhibitoren
WO2005079575A1 (ja) 2004-02-24 2005-09-01 Sumitomo Chemical Takeda Agro Company, Limited 殺虫剤組成物
MX2007001953A (es) 2004-08-18 2007-05-09 Astrazeneca Ab Enantiomeros de pirimidonas fusionadas seleccionadas y usos en el tratamiento y prevencion del cancer.
US20060069085A1 (en) * 2004-09-28 2006-03-30 Rulin Zhao Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US7381732B2 (en) 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
KR20140018997A (ko) 2005-01-07 2014-02-13 신타 파마슈티칼스 코프. 염증 및 면역 관련 용도를 위한 화합물
CA2669311C (en) * 2006-11-13 2011-09-20 Pfizer Products Inc. Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
CA2682400A1 (en) 2007-04-18 2008-11-06 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes
JP5352449B2 (ja) 2007-04-18 2013-11-27 キッセイ薬品工業株式会社 縮合へテロ環誘導体、それを含有する医薬組成物及びその医薬用途
JP5805646B2 (ja) 2009-09-30 2015-11-04 ブイティーブイ・セラピューティクス・エルエルシー アルツハイマー病の治療のための置換イミダゾール誘導体
KR20170126016A (ko) 2010-02-25 2017-11-15 브리스톨-마이어스 스퀴브 홀딩스 아일랜드 아픽사반 제제
US8884016B2 (en) 2011-06-10 2014-11-11 Dipharma Francis S.R.L. Apixaban preparation process
CN104109165A (zh) * 2013-04-19 2014-10-22 四川海思科制药有限公司 4,5-二氢-吡唑并[3,4-c]吡啶-2-酮衍生物、其制备方法以及应用
CN103992310B (zh) * 2013-05-14 2016-07-06 中国医学科学院医药生物技术研究所 一组取代苯并杂环胺衍生物及其制备方法和作为impdh抑制剂的相关应用
WO2014202027A1 (zh) * 2013-06-21 2014-12-24 四川海思科制药有限公司 4,5-二氢吡唑并[3,4-c]吡啶-2-酮的螺环衍生物、其制备方法以及应用
US9783509B2 (en) 2013-07-08 2017-10-10 Bayer Cropscience Aktiengesellschaft Six-membered C-N-linked aryl sulfide derivatives and aryl sulfoxide derivatives as pest conrol agents
CN105745212B (zh) * 2013-12-06 2017-09-12 四川海思科制药有限公司 取代的4,5‑二氢吡唑并[3,4‑c]吡啶‑2‑酮的螺环衍生物及应用
WO2015162551A1 (en) 2014-04-21 2015-10-29 Mylan Laboratories Ltd Process for the preparation of apixaban
EP3147283B1 (en) * 2014-05-22 2022-08-17 North China Pharmaceutical Company., Ltd. Hydrazine compound as blood coagulation factor xa inhibitor
CN105085515B (zh) * 2014-05-22 2019-02-01 华北制药股份有限公司 作为凝血因子Xa抑制剂的酰肼类化合物
CA2959987C (en) * 2014-09-02 2023-05-09 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Pyrazolo[3,4-c]pyridine compounds and their anti-thrombosis effect
ES2881373T3 (es) 2014-09-05 2021-11-29 Unichem Lab Ltd Un procedimiento mejorado para la preparación de apixabán e intermedios del mismo
CN104311575B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 含有稠环的吡唑并哌啶酮类化合物及其组合物及用途
CN104277039B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有取代丁炔基的吡唑并哌啶酮类化合物及其组合物及用途
CN104311574B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 含有噻唑的吡唑并哌啶酮类化合物及其组合物及用途
CN104311556B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有环氧烷基取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN104311557B (zh) * 2014-09-19 2016-01-06 广东东阳光药业有限公司 含有二酮取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN104311555B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 吡唑并哌啶酮类化合物及其组合物及用途
CN104277037B (zh) * 2014-09-19 2015-12-09 广东东阳光药业有限公司 含有螺环的吡唑并哌啶酮类化合物及其组合物及用途
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途
CN104513239B (zh) * 2014-12-10 2017-08-22 沈阳药科大学 吡唑并[3,4‑c]吡啶‑7‑酮类化合物及其应用
US10077263B2 (en) 2016-04-29 2018-09-18 Optimus Drugs Private Limited Process for the preparation of Apixaban
US11510909B2 (en) 2017-02-17 2022-11-29 Unichem Laboratories Ltd. Pharmaceutical composition of apixaban
CN107235986B (zh) * 2017-05-27 2019-04-12 华南师范大学 一种合成氮氧杂桥联唑啉化合物的方法
GB201807014D0 (en) 2018-04-30 2018-06-13 Univ Leeds Innovations Ltd Factor xlla inhibitors
KR20230170813A (ko) 2018-09-12 2023-12-19 노파르티스 아게 항바이러스 피리도피라진디온 화합물
KR102128509B1 (ko) * 2018-12-19 2020-07-01 한국과학기술연구원 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
KR20220070005A (ko) 2019-09-26 2022-05-27 노파르티스 아게 항바이러스성 피라졸로피리디논 화합물
GB202107722D0 (en) 2021-05-28 2021-07-14 Lunac Therapeutics Ltd Factor XIIA Inhibitors
WO2023083286A1 (en) * 2021-11-12 2023-05-19 Insilico Medicine Ip Limited Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof
CN113956248B (zh) * 2021-11-12 2023-07-04 贵州中医药大学 一种具有抗炎作用的化合物衍生物及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
US3423414A (en) * 1966-01-13 1969-01-21 Ciba Geigy Corp Pyrazolopyridines
US3939161A (en) * 1973-10-29 1976-02-17 Abbott Laboratories 1,3-Dimethyl- 1H-pyrazolo(4,3-D) pyrimidine-7 (6H)-ones
JPS5721388A (en) * 1980-07-11 1982-02-04 Nippon Nohyaku Co Ltd Condensed pyrazole derivative
JPS63145282A (ja) * 1986-12-08 1988-06-17 Taiyo Yakuhin Kogyo Kk ピリダジン誘導体
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
US5399557A (en) * 1991-08-07 1995-03-21 Suntory Limited Pyrroloazepine compound
WO1994020460A1 (en) 1993-03-11 1994-09-15 Smithkline Beecham Corporation Chemical compounds
HUT74170A (en) * 1993-07-06 1996-11-28 Pfizer Bicyclic tetrahydro pyrazolopyridines
JPH09511758A (ja) * 1994-10-20 1997-11-25 フアイザー・インコーポレイテツド 二環式テトラヒドロピラゾロピリジンおよび医薬としてのその使用
US6323201B1 (en) * 1994-12-29 2001-11-27 The Regents Of The University Of California Compounds for inhibition of ceramide-mediated signal transduction
CA2240439A1 (en) * 1995-12-22 1997-07-03 The Dupont Merck Pharmaceutical Company Novel integrin receptor antagonists
ATE227293T1 (de) * 1996-05-15 2002-11-15 Pfizer 2,3-disubstituierte-(5,6)-heteroarylkondensiert - pyrimidin-4-one
FR2750862B1 (fr) * 1996-07-12 1998-10-16 Dupin Jean Pierre Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques
TW589309B (en) * 1997-07-03 2004-06-01 Bristol Myers Squibb Pharma Co Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
ATE278673T1 (de) * 1998-03-27 2004-10-15 Bristol Myers Squibb Pharma Co Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren
DE19845153A1 (de) 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
DE19900471A1 (de) 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
RU2002110295A (ru) 1999-09-17 2003-12-10 Милленниум Фармасьютикалс, Инк. (Us) Ингибиторы фактора Ха

Also Published As

Publication number Publication date
CA2349330C (en) 2009-09-29
TWI225862B (en) 2005-01-01
ES2232202T3 (es) 2005-05-16
ATE280171T1 (de) 2004-11-15
CA2349330A1 (en) 2000-07-06
JP2002533465A (ja) 2002-10-08
WO2000039131A1 (en) 2000-07-06
DE69921358D1 (de) 2004-11-25
KR100628407B1 (ko) 2006-09-26
MY138239A (en) 2009-05-29
PT1140941E (pt) 2005-02-28
DK1140941T3 (da) 2005-02-14
US6413980B1 (en) 2002-07-02
AU2371700A (en) 2000-07-31
NZ511674A (en) 2003-11-28
MXPA01006502A (es) 2002-04-08
NO319816B1 (no) 2005-09-19
US6673810B2 (en) 2004-01-06
CN1391575A (zh) 2003-01-15
IL142959A0 (en) 2002-04-21
NO20013072D0 (no) 2001-06-20
KR20010092754A (ko) 2001-10-26
EP1140941B1 (en) 2004-10-20
ZA200103795B (en) 2002-08-12
SI1140941T1 (en) 2005-04-30
HK1052508A1 (en) 2003-09-19
HK1052508B (zh) 2008-08-01
EP1140941A1 (en) 2001-10-10
HRP990396A2 (en) 2000-08-31
AU759711B2 (en) 2003-04-17
EA200100688A1 (ru) 2001-12-24
BR9917080A (pt) 2002-03-12
AR024242A1 (es) 2002-09-25
DE69921358T2 (de) 2006-03-09
EA004515B1 (ru) 2004-04-29
US20030004167A1 (en) 2003-01-02
CN100340559C (zh) 2007-10-03
IL142959A (en) 2010-05-31

Similar Documents

Publication Publication Date Title
NO20013072L (no) Nitrogenholdige heterocykler som faktor Xa-inhibitorer
NO992633D0 (no) Nitrogenholdige heteroaromatiske forbindelser som faktor Xa-inhibitorer
NO20021230D0 (no) Inhibitorer for faktor Xa
NO20001687D0 (no) Benzamidinderivater som faktor Xa-inhibitorer
NO20003808D0 (no) Substituerte oksoazaheterosyklylfaktor Xa inhibitorer
NO20042592L (no) Indol-2-karboksamider som faktor XA inhibitorer
NO20011293D0 (no) Faktor VIIa-inhibitorer
DK1427415T3 (da) Forbindelser indeholdende lactam og derivater heraf som faktor Xa-hæmmere
DK0991638T3 (da) Hidtil ukendte guanidinmimetika som faktor Xa-inhibitorer
DK2253620T3 (da) Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
PT1181017E (pt) Inibidores de metaloproteases
AU2002350217A8 (en) Glycinamides as factor xa inhibitors
AU2002365896A8 (en) Substituted amino methyl factor xa inhibitors
PT1194404E (pt) Inibidores de aspartil-protease
DK1395553T3 (da) Pyrrolidinderivater som faktor Xa-inhibitorer
NO20042990L (no) Pyrrolidin-2-oner som faktor XA inhibitorer
DK1189929T3 (da) Faktor VIIa-inhibitorer
ATE252547T1 (de) Matrixmetalloproteinaseinhibitoren
NO20014234D0 (no) Pyrazol-3-on-derivater som faktor-Xa-inhibitorer
ATE305452T1 (de) Faktor xa inhibitor
DK1082321T3 (da) Heterocykliske derivater, som inhiberer faktor Xa

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees