IL142959A0 - Nitrogen containing heterobicycles as factor xa inhibitors - Google Patents

Nitrogen containing heterobicycles as factor xa inhibitors

Info

Publication number
IL142959A0
IL142959A0 IL14295999A IL14295999A IL142959A0 IL 142959 A0 IL142959 A0 IL 142959A0 IL 14295999 A IL14295999 A IL 14295999A IL 14295999 A IL14295999 A IL 14295999A IL 142959 A0 IL142959 A0 IL 142959A0
Authority
IL
Israel
Prior art keywords
inhibitors
factor
nitrogen containing
containing heterobicycles
heterobicycles
Prior art date
Application number
IL14295999A
Other languages
English (en)
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26811284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL142959(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of IL142959A0 publication Critical patent/IL142959A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL14295999A 1998-12-23 1999-12-17 Nitrogen containing heterobicycles as factor xa inhibitors IL142959A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11362898P 1998-12-23 1998-12-23
US12763399P 1999-04-02 1999-04-02
PCT/US1999/030316 WO2000039131A1 (en) 1998-12-23 1999-12-17 Nitrogen containing heterobicycles as factor xa inhibitors

Publications (1)

Publication Number Publication Date
IL142959A0 true IL142959A0 (en) 2002-04-21

Family

ID=26811284

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14295999A IL142959A0 (en) 1998-12-23 1999-12-17 Nitrogen containing heterobicycles as factor xa inhibitors
IL142959A IL142959A (en) 1998-12-23 2001-05-03 Nitrogen containing heterobicycles and pharmaceutical compositions comprising same

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL142959A IL142959A (en) 1998-12-23 2001-05-03 Nitrogen containing heterobicycles and pharmaceutical compositions comprising same

Country Status (26)

Country Link
US (2) US6413980B1 (xx)
EP (1) EP1140941B1 (xx)
JP (1) JP2002533465A (xx)
KR (1) KR100628407B1 (xx)
CN (1) CN100340559C (xx)
AR (1) AR024242A1 (xx)
AT (1) ATE280171T1 (xx)
AU (1) AU759711B2 (xx)
BR (1) BR9917080A (xx)
CA (1) CA2349330C (xx)
DE (1) DE69921358T2 (xx)
DK (1) DK1140941T3 (xx)
EA (1) EA004515B1 (xx)
ES (1) ES2232202T3 (xx)
HK (1) HK1052508B (xx)
HR (1) HRP990396A2 (xx)
IL (2) IL142959A0 (xx)
MX (1) MXPA01006502A (xx)
MY (1) MY138239A (xx)
NO (1) NO319816B1 (xx)
NZ (1) NZ511674A (xx)
PT (1) PT1140941E (xx)
SI (1) SI1140941T1 (xx)
TW (1) TWI225862B (xx)
WO (1) WO2000039131A1 (xx)
ZA (1) ZA200103795B (xx)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001268712A1 (en) 2000-06-23 2002-01-08 Bristol-Myers Squibb Company 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor Xa inhibitors
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
EP1379245A4 (en) 2001-04-18 2006-07-26 Bristol Myers Squibb Co 1, 4, 5, 6-TETRAHYDROPYRAZOLO- 3, 4-C-PYRIDINE-7-ONE AS FACTOR XA HEMMER
US6706730B2 (en) 2001-04-18 2004-03-16 Bristol-Myers Squibb Pharma Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors
EP1414449A4 (en) * 2001-05-22 2005-04-06 Bristol Myers Squibb Co FACTOR XA BICYCLIC INHIBITORS
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
JP4249621B2 (ja) 2001-09-21 2009-04-02 ブリストル−マイヤーズ スクイブ カンパニー 第Ｘａ因子阻害剤としてのラクタム含有化合物およびその誘導体
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
AU2002350217A1 (en) * 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
TW200303201A (en) * 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
ES2310622T3 (es) * 2001-12-19 2009-01-16 Bristol-Myers Squibb Company Compuestos heterociclicos condensados y analogos de los mismos, moduladores de la funcion de los receptores nucleares de hormonas.
CN101613321A (zh) 2002-03-05 2009-12-30 特兰斯泰克制药公司 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物
WO2003099276A1 (en) 2002-05-10 2003-12-04 Bristol-Myers Squibb Company 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors
ES2543588T3 (es) 2002-12-03 2015-08-20 Pharmacyclics Llc Derivados de 2-(2-hidroxibifenil-3-il)-1H-benzoimidazol-5-carboxamidina como inhibidores del factor VIIa
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
BR0317659A (pt) * 2002-12-23 2005-12-06 Aventis Pharma Gmbh Derivados de pirazol como inibidores de fator xa
EP1479678A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Pyrazole-derivatives as factor xa inhibitors
US7122557B2 (en) * 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
EP1479675A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazole-derivatives as factor Xa inhibitors
BRPI0410436A (pt) * 2003-05-20 2006-05-30 Transtech Pharma Inc antagonistas de rage como agentes para amiloidose reversa e doenças associadas com a mesma
US7022850B2 (en) 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
JP2007506787A (ja) 2003-09-23 2007-03-22 バーテックス　ファーマシューティカルズ　インコーポレイテッド プロテインキナーゼインヒビターとしてのピラゾロピロール誘導体
MXPA06009301A (es) 2004-02-24 2007-01-26 Sumitomo Chem Takeda Agro Co Composiciones insecticidas.
CA2575188A1 (en) 2004-08-18 2006-02-23 Astrazeneca Ab Enantiomers of selected fused pyrimidones and uses in the treatment and preventi on of cancer
US20060069085A1 (en) * 2004-09-28 2006-03-30 Rulin Zhao Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US7381732B2 (en) * 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
MX2007008290A (es) 2005-01-07 2008-02-15 Synta Pharmaceuticals Corp Compuestos para inflamacion y usos inmuno-relacionados.
JP2010509392A (ja) * 2006-11-13 2010-03-25 ファイザー・プロダクツ・インク ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用
JP5352450B2 (ja) 2007-04-18 2013-11-27 キッセイ薬品工業株式会社 縮合複素環誘導体、それを含有する医薬組成物及びその医薬用途
EP2147922B1 (en) 2007-04-18 2017-08-02 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes
WO2011041198A1 (en) 2009-09-30 2011-04-07 Transtech Pharma, Inc. Substituted imidazole derivatives for treatment of alzheimers disease
CN102770126A (zh) 2010-02-25 2012-11-07 百时美施贵宝公司 阿哌沙班制剂
WO2012168364A1 (en) 2011-06-10 2012-12-13 Dipharma Francis S.R.L. Apixaban preparation process
CN104109165A (zh) * 2013-04-19 2014-10-22 四川海思科制药有限公司 4,5-二氢-吡唑并[3,4-c]吡啶-2-酮衍生物、其制备方法以及应用
CN103992310B (zh) * 2013-05-14 2016-07-06 中国医学科学院医药生物技术研究所 一组取代苯并杂环胺衍生物及其制备方法和作为impdh抑制剂的相关应用
WO2014202027A1 (zh) * 2013-06-21 2014-12-24 四川海思科制药有限公司 4,5-二氢吡唑并[3,4-c]吡啶-2-酮的螺环衍生物、其制备方法以及应用
AR096816A1 (es) 2013-07-08 2016-02-03 Bayer Cropscience Ag Derivados de arilsulfuro y arilsulfóxido de seis miembros enlazados con c-n como agentes para combatir parásitos
CN105745212B (zh) * 2013-12-06 2017-09-12 四川海思科制药有限公司 取代的4,5‑二氢吡唑并[3,4‑c]吡啶‑2‑酮的螺环衍生物及应用
WO2015162551A1 (en) 2014-04-21 2015-10-29 Mylan Laboratories Ltd Process for the preparation of apixaban
EP3147283B1 (en) * 2014-05-22 2022-08-17 North China Pharmaceutical Company., Ltd. Hydrazine compound as blood coagulation factor xa inhibitor
CN105085515B (zh) * 2014-05-22 2019-02-01 华北制药股份有限公司 作为凝血因子Xa抑制剂的酰肼类化合物
EP3190111B1 (en) 2014-09-02 2020-05-06 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Pyrazolo[3,4-c]pyridine derivatives
WO2016035007A2 (en) 2014-09-05 2016-03-10 Unichem Laboratories Limited An improved process for the preparation of apixaban and intermediates thereof
CN104277037B (zh) * 2014-09-19 2015-12-09 广东东阳光药业有限公司 含有螺环的吡唑并哌啶酮类化合物及其组合物及用途
CN104311574B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 含有噻唑的吡唑并哌啶酮类化合物及其组合物及用途
CN104311557B (zh) * 2014-09-19 2016-01-06 广东东阳光药业有限公司 含有二酮取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN104311575B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 含有稠环的吡唑并哌啶酮类化合物及其组合物及用途
CN104277039B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有取代丁炔基的吡唑并哌啶酮类化合物及其组合物及用途
CN104311555B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 吡唑并哌啶酮类化合物及其组合物及用途
CN104311556B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有环氧烷基取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途
CN104513239B (zh) * 2014-12-10 2017-08-22 沈阳药科大学 吡唑并[3,4‑c]吡啶‑7‑酮类化合物及其应用
US10077263B2 (en) 2016-04-29 2018-09-18 Optimus Drugs Private Limited Process for the preparation of Apixaban
US11510909B2 (en) 2017-02-17 2022-11-29 Unichem Laboratories Ltd. Pharmaceutical composition of apixaban
CN107235986B (zh) * 2017-05-27 2019-04-12 华南师范大学 一种合成氮氧杂桥联唑啉化合物的方法
GB201807014D0 (en) 2018-04-30 2018-06-13 Univ Leeds Innovations Ltd Factor xlla inhibitors
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
KR102128509B1 (ko) * 2018-12-19 2020-07-01 한국과학기술연구원 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
KR20220070005A (ko) 2019-09-26 2022-05-27 노파르티스 아게 항바이러스성 피라졸로피리디논 화합물
GB202107722D0 (en) 2021-05-28 2021-07-14 Lunac Therapeutics Ltd Factor XIIA Inhibitors
TW202334142A (zh) 2021-11-12 2023-09-01 香港商英矽智能科技知識產權有限公司 泛素特異性蛋白酶１（ｕｓｐ１）之小分子抑制劑及其用途
CN113956248B (zh) * 2021-11-12 2023-07-04 贵州中医药大学 一种具有抗炎作用的化合物衍生物及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
US3423414A (en) * 1966-01-13 1969-01-21 Ciba Geigy Corp Pyrazolopyridines
US3939161A (en) * 1973-10-29 1976-02-17 Abbott Laboratories 1,3-Dimethyl- 1H-pyrazolo(4,3-D) pyrimidine-7 (6H)-ones
JPS5721388A (en) * 1980-07-11 1982-02-04 Nippon Nohyaku Co Ltd Condensed pyrazole derivative
JPS63145282A (ja) * 1986-12-08 1988-06-17 Taiyo Yakuhin Kogyo Kk ピリダジン誘導体
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
JP3242653B2 (ja) * 1991-08-07 2001-12-25 サントリー株式会社 ピロロアゼピン化合物
WO1994020460A1 (en) 1993-03-11 1994-09-15 Smithkline Beecham Corporation Chemical compounds
JP2944048B2 (ja) * 1993-07-06 1999-08-30 フアイザー・インコーポレイテツド 二環式テトラヒドロピラゾロピリジン
KR970707124A (ko) * 1994-10-20 1997-12-01 스피겔 알렌 제이 비사이클릭 테트라하이드로 피라졸로피리딘 및 약제로서 이의 용도(bicyclic tetrahydro pyrazolopyridines and their use as medicaments)
US6323201B1 (en) * 1994-12-29 2001-11-27 The Regents Of The University Of California Compounds for inhibition of ceramide-mediated signal transduction
AU1345697A (en) * 1995-12-22 1997-07-17 Du Pont Merck Pharmaceutical Company, The Novel integrin receptor antagonists
EP0807633B1 (en) * 1996-05-15 2002-11-06 Pfizer Inc. Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones
FR2750862B1 (fr) * 1996-07-12 1998-10-16 Dupin Jean Pierre Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques
HUP0100179A3 (en) * 1997-07-03 2002-12-28 Bristol Myers Squibb Pharma Co Imidazopyrimidine and imidazopyridine derivatives and pharmaceutical compositions thereof
WO1999050255A2 (en) * 1998-03-27 1999-10-07 Du Pont Pharmaceuticals Company Disubstituted pyrazolines and triazolines as factor xa inhibitors
DE19845153A1 (de) 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
DE19900471A1 (de) 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
HUP0203954A2 (hu) 1999-09-17 2003-03-28 Millennium Pharmaceuticals, Inc. Xa faktor inhibitorok

Also Published As

Publication number Publication date
ZA200103795B (en) 2002-08-12
AU2371700A (en) 2000-07-31
ATE280171T1 (de) 2004-11-15
HRP990396A2 (en) 2000-08-31
NO20013072L (no) 2001-06-20
US6673810B2 (en) 2004-01-06
NO319816B1 (no) 2005-09-19
MY138239A (en) 2009-05-29
IL142959A (en) 2010-05-31
WO2000039131A1 (en) 2000-07-06
DE69921358T2 (de) 2006-03-09
JP2002533465A (ja) 2002-10-08
SI1140941T1 (en) 2005-04-30
US20030004167A1 (en) 2003-01-02
ES2232202T3 (es) 2005-05-16
US6413980B1 (en) 2002-07-02
KR100628407B1 (ko) 2006-09-26
AR024242A1 (es) 2002-09-25
EP1140941B1 (en) 2004-10-20
EA004515B1 (ru) 2004-04-29
AU759711B2 (en) 2003-04-17
DK1140941T3 (da) 2005-02-14
NZ511674A (en) 2003-11-28
CN100340559C (zh) 2007-10-03
CN1391575A (zh) 2003-01-15
KR20010092754A (ko) 2001-10-26
CA2349330C (en) 2009-09-29
BR9917080A (pt) 2002-03-12
MXPA01006502A (es) 2002-04-08
PT1140941E (pt) 2005-02-28
NO20013072D0 (no) 2001-06-20
TWI225862B (en) 2005-01-01
CA2349330A1 (en) 2000-07-06
EP1140941A1 (en) 2001-10-10
HK1052508A1 (en) 2003-09-19
EA200100688A1 (ru) 2001-12-24
DE69921358D1 (de) 2004-11-25
HK1052508B (zh) 2008-08-01

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