HK1040076A1 - 作為整聯蛋白抑制劑的喹嗪酮 - Google Patents

作為整聯蛋白抑制劑的喹嗪酮

Info

Publication number
HK1040076A1
HK1040076A1 HK02100399.5A HK02100399A HK1040076A1 HK 1040076 A1 HK1040076 A1 HK 1040076A1 HK 02100399 A HK02100399 A HK 02100399A HK 1040076 A1 HK1040076 A1 HK 1040076A1
Authority
HK
Hong Kong
Prior art keywords
quinolizinones
integrin inhibitors
integrin
inhibitors
Prior art date
Application number
HK02100399.5A
Other languages
English (en)
Inventor
S‧拉穆西
B‧扎卡賴
G‧阿塔多
D‧拉布雷克
M‧庫爾切斯尼
G‧法拉杜
R‧雷吉
S‧阿博特
Original Assignee
希雷生物化學有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 希雷生物化學有限公司 filed Critical 希雷生物化學有限公司
Publication of HK1040076A1 publication Critical patent/HK1040076A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
HK02100399.5A 1998-09-21 2002-01-18 作為整聯蛋白抑制劑的喹嗪酮 HK1040076A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10125798P 1998-09-21 1998-09-21
PCT/IB1999/001564 WO2000017197A1 (en) 1998-09-21 1999-09-21 Quinolizinones as integrin inhibitors

Publications (1)

Publication Number Publication Date
HK1040076A1 true HK1040076A1 (zh) 2002-05-24

Family

ID=22283727

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02100399.5A HK1040076A1 (zh) 1998-09-21 2002-01-18 作為整聯蛋白抑制劑的喹嗪酮

Country Status (5)

Country Link
US (1) US6630488B1 (zh)
EP (1) EP1115724A1 (zh)
AU (1) AU5991699A (zh)
HK (1) HK1040076A1 (zh)
WO (1) WO2000017197A1 (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9805655D0 (en) 1998-03-16 1998-05-13 Celltech Therapeutics Ltd Chemical compounds
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
RO122246B1 (ro) * 1999-05-07 2009-03-30 Texas Biotechnology Corporation Derivaţi de acid propionic ce inhibă legarea integrinelor de receptorii acestora, compoziţie farmaceutică ce îi conţine şi utilizare
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
AU2001248553A1 (en) 2000-04-17 2001-10-30 Celltech R And D Limited Enamine derivatives as cell adhesion molecules
FR2808798A1 (fr) * 2000-05-09 2001-11-16 Hoechst Marion Roussel Inc Nouveaux derives antagonistes du recepteur de la vitronectine
US7230133B2 (en) 2003-05-01 2007-06-12 Bristol-Myers Squibb Company Malonamides and malonamide derivatives as modulators of chemokine receptor activity
US7291744B2 (en) 2003-11-13 2007-11-06 Bristol-Myers Squibb Company N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
KR100785088B1 (ko) 2006-05-23 2007-12-12 한국과학기술연구원 두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법
TR201813877T4 (tr) * 2012-02-10 2018-11-21 Hoffmann La Roche Spi̇nal müsküler atrofi̇ni̇n tedavi̇ edi̇lmesi̇ne yöneli̇k bi̇leşi̇kler.
MX352962B (es) 2012-03-01 2017-12-15 Ptc Therapeutics Inc Compuestos para tratar atrofia muscular espinal.
CA2868026C (en) 2012-03-23 2021-02-16 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
JP6081662B2 (ja) 2013-09-27 2017-02-15 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｈｉｖインテグラーゼ阻害薬として有用な置換されたキノリジン誘導体
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
EP3310169B1 (en) 2015-05-30 2023-05-17 PTC Therapeutics, Inc. Methods for modulating rna splicing
CN113750101A (zh) 2015-12-10 2021-12-07 Ptc医疗公司 用于治疗亨廷顿病的方法
US10544155B2 (en) 2015-12-15 2020-01-28 Merck Sharp & Dohme Corp. Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors
CA3043755A1 (en) 2016-11-28 2018-05-31 Ptc Therapeutics, Inc. Methods for modulating rna splicing
SG11201911615WA (en) 2017-06-05 2020-01-30 Ptc Therapeutics Inc Compounds for treating huntington's disease
EP3638318A4 (en) 2017-06-14 2021-03-17 PTC Therapeutics, Inc. METHOD OF MODULATION OF RNA SPLICING
CA3067592A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
MX2019015578A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
US11685746B2 (en) 2018-06-27 2023-06-27 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
PE20211378A1 (es) 2018-06-27 2021-07-27 Ptc Therapeutics Inc Compuestos heterociclicos y de heteroarilo para tratar la enfermedad de huntington

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650804A (en) * 1984-03-30 1987-03-17 Fujisawa Pharmaceutical Co., Ltd. Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents
GB8700016D0 (en) * 1987-01-02 1987-02-11 Fujisawa Pharmaceutical Co Quinolizinone derivatives
JP2514136B2 (ja) * 1990-05-02 1996-07-10 アボツト・ラボラトリーズ キノリジノン型化合物
US5580872A (en) * 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
ATE217309T1 (de) 1993-10-14 2002-05-15 Abbott Lab Verbindungen des chinolizinon-typs
GB9326136D0 (en) * 1993-12-22 1994-02-23 Erba Carlo Spa Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
JPH11510478A (ja) * 1995-06-06 1999-09-14 アボツト・ラボラトリーズ キノリジノン型化合物
AU733551B2 (en) * 1996-09-25 2001-05-17 Astrazeneca Ab Qinoline derivatives inhibiting the effect of growth factors such as VEGF
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
US6630488B1 (en) 2003-10-07
AU5991699A (en) 2000-04-10
WO2000017197A1 (en) 2000-03-30
EP1115724A1 (en) 2001-07-18

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