WO2008133128A1 - 縮合複素環誘導体、それを含有する医薬組成物及びその医薬用途 - Google Patents

縮合複素環誘導体、それを含有する医薬組成物及びその医薬用途 Download PDF

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Publication number
WO2008133128A1
WO2008133128A1 PCT/JP2008/057392 JP2008057392W WO2008133128A1 WO 2008133128 A1 WO2008133128 A1 WO 2008133128A1 JP 2008057392 W JP2008057392 W JP 2008057392W WO 2008133128 A1 WO2008133128 A1 WO 2008133128A1
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WO
WIPO (PCT)
Prior art keywords
derivative
pharmaceutical composition
composition
fused heterocyclic
medical purposes
Prior art date
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PCT/JP2008/057392
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English (en)
French (fr)
Inventor
Takashi Miyagi
Shigeru Yonekubo
Kohsuke Ohno
Mikie Kambara
Nobuhiko Fushimi
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Kissei Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co., Ltd. filed Critical Kissei Pharmaceutical Co., Ltd.
Priority to EP08740473A priority Critical patent/EP2145889A4/en
Priority to JP2009511816A priority patent/JP5352450B2/ja
Priority to US12/596,301 priority patent/US20100130514A1/en
Priority to CA002682400A priority patent/CA2682400A1/en
Publication of WO2008133128A1 publication Critical patent/WO2008133128A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

 本発明は、性ホルモン依存性疾患等の予防又は治療剤として有用な化合物を提供する。すなわち、下記一般式（Ｉ）で表される縮合複素環誘導体、それを含有する医薬組成物及びその医薬用途等を提供する。式（Ｉ）中、環Ａは、５員環不飽和炭化水素又は５員環へテロアリール；ＲＡは、ハロゲン、アルキル、アルケニル、アルキニル、カルボキシ、アルコキシ、カルバモイル、アルキルカルバモイル等；環Ｂはアリール又はヘテロアリール；ＲＢは、ハロゲン、アルキル、カルボキシ、アルコキシ、カルバモイル、アルキルカルバモイル等；Ｅ１、Ｅ２は、酸素原子等；Ｕは、単結合又はアルキレン；Ｘは、Ｙ、－Ｏ－（アルキレン）－Ｙ、－Ｏ－Ｚで表される基（Ｙは、Ｚ又はＺが置換したアミノ等；Ｚは、シクロアルキル、ヘテロシクロアルキル、アリール、ヘテロアリール等）;等である。
PCT/JP2008/057392 2007-04-18 2008-04-16 縮合複素環誘導体、それを含有する医薬組成物及びその医薬用途 WO2008133128A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08740473A EP2145889A4 (en) 2007-04-18 2008-04-16 HETEROCYCLIC FUSED CORE DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE DERIVATIVE, AND USE OF THE COMPOSITION FOR MEDICAL PURPOSES
JP2009511816A JP5352450B2 (ja) 2007-04-18 2008-04-16 縮合複素環誘導体、それを含有する医薬組成物及びその医薬用途
US12/596,301 US20100130514A1 (en) 2007-04-18 2008-04-16 Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes
CA002682400A CA2682400A1 (en) 2007-04-18 2008-04-16 Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-108944 2007-04-18
JP2007108944 2007-04-18

Publications (1)

Publication Number Publication Date
WO2008133128A1 true WO2008133128A1 (ja) 2008-11-06

Family

ID=39925584

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057392 WO2008133128A1 (ja) 2007-04-18 2008-04-16 縮合複素環誘導体、それを含有する医薬組成物及びその医薬用途

Country Status (5)

Country Link
US (1) US20100130514A1 (ja)
EP (1) EP2145889A4 (ja)
JP (1) JP5352450B2 (ja)
CA (1) CA2682400A1 (ja)
WO (1) WO2008133128A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014030743A1 (ja) 2012-08-24 2014-02-27 武田薬品工業株式会社 複素環化合物
WO2014042176A1 (ja) * 2012-09-14 2014-03-20 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
TWI460184B (zh) * 2011-10-25 2014-11-11 Central Glass Co Ltd Siloxanes and their hardened products and their use
WO2017038650A1 (ja) * 2015-08-28 2017-03-09 積水メディカル株式会社 ベンジル化合物
RU2769828C1 (ru) * 2021-12-28 2022-04-06 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Производные урацила, обладающие противовирусной активностью в отношении sars-cov-2

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113666943A (zh) * 2020-05-15 2021-11-19 苏州泽璟生物制药股份有限公司 氘代四氢噻吩并[3,4-d]嘧啶二酮化合物以及包含该化合物的药物组合物
CN115260211B (zh) * 2021-04-29 2024-02-06 长春金赛药业有限责任公司 含噻吩稠环类衍生物、药物组合物及其制备方法和应用

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JPH06510992A (ja) 1991-09-20 1994-12-08 ビーエーエスエフ　アクチェンゲゼルシャフト 置換３−フェニルウラシル
WO1995028405A1 (en) * 1994-04-19 1995-10-26 Takeda Chemical Industries, Ltd. Bicyclic thiophene derivatives and use as gonadotropin releasing hormone antagonists
WO1996024597A1 (en) 1995-02-08 1996-08-15 Takeda Chemical Industries, Ltd. Thienopyrimidine derivatives, their production and use
WO2000039131A1 (en) 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company Nitrogen containing heterobicycles as factor xa inhibitors
WO2001055119A2 (en) * 2000-01-25 2001-08-02 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
WO2005019188A1 (ja) 2003-08-22 2005-03-03 Takeda Pharmaceutical Company Limited 縮合ピリミジン誘導体およびその用途
WO2006083005A1 (ja) 2005-02-03 2006-08-10 Takeda Pharmaceutical Company Limited 縮合ピリミジン誘導体およびその用途
WO2007046392A1 (ja) * 2005-10-19 2007-04-26 Kissei Pharmaceutical Co., Ltd. 縮合複素環誘導体、それを含有する医薬組成物及びその医薬用途

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JP2007513504A (ja) * 2003-11-29 2007-05-24 クロス マッチ テクノロジーズ， インコーポレイテッド 圧電デバイスおよびそれを製造する方法
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI460184B (zh) * 2011-10-25 2014-11-11 Central Glass Co Ltd Siloxanes and their hardened products and their use
WO2014030743A1 (ja) 2012-08-24 2014-02-27 武田薬品工業株式会社 複素環化合物
CN104755465A (zh) * 2012-08-24 2015-07-01 武田药品工业株式会社 杂环化合物
WO2014042176A1 (ja) * 2012-09-14 2014-03-20 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
JPWO2014042176A1 (ja) * 2012-09-14 2016-08-18 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
JP6201076B1 (ja) * 2015-08-28 2017-09-20 積水メディカル株式会社 ベンジル化合物
WO2017038650A1 (ja) * 2015-08-28 2017-03-09 積水メディカル株式会社 ベンジル化合物
JP2018002700A (ja) * 2015-08-28 2018-01-11 積水メディカル株式会社 ベンジル化合物
KR20180044305A (ko) * 2015-08-28 2018-05-02 세키스이 메디칼 가부시키가이샤 벤질 화합물
CN108026116A (zh) * 2015-08-28 2018-05-11 积水医疗株式会社 苄基化合物
US10822357B2 (en) 2015-08-28 2020-11-03 Sekisui Medical Co., Ltd. Benzyl compound
US11591351B2 (en) 2015-08-28 2023-02-28 Sekisui Medical Co., Ltd. Benzyl compound
KR102630720B1 (ko) 2015-08-28 2024-01-29 세키스이 메디칼 가부시키가이샤 벤질 화합물
RU2769828C1 (ru) * 2021-12-28 2022-04-06 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Производные урацила, обладающие противовирусной активностью в отношении sars-cov-2

Also Published As

Publication number Publication date
JPWO2008133128A1 (ja) 2010-07-22
CA2682400A1 (en) 2008-11-06
EP2145889A4 (en) 2012-04-18
EP2145889A1 (en) 2010-01-20
US20100130514A1 (en) 2010-05-27
JP5352450B2 (ja) 2013-11-27

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