MX2009003227A - Moduladores de los receptores de glutamato metabotropicos 5(mglur5). - Google Patents

Moduladores de los receptores de glutamato metabotropicos 5(mglur5).

Info

Publication number
MX2009003227A
MX2009003227A MX2009003227A MX2009003227A MX2009003227A MX 2009003227 A MX2009003227 A MX 2009003227A MX 2009003227 A MX2009003227 A MX 2009003227A MX 2009003227 A MX2009003227 A MX 2009003227A MX 2009003227 A MX2009003227 A MX 2009003227A
Authority
MX
Mexico
Prior art keywords
compounds
mglur5 modulators
preparation
mglur5
modulators
Prior art date
Application number
MX2009003227A
Other languages
English (en)
Inventor
Abdelmalik Slassi
Tao Xin
Methvin Isaac
Louise Edwards
Tomislav Stefanac
Peter Dove
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39032082&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009003227(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2009003227A publication Critical patent/MX2009003227A/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I), en donde R1 a R5, X y Z además son definidos en la descripción. La invención también se refiere a procesos para la preparación de los compuestos e intermedios usados en la preparación, composiciones farmacéuticas que contienen los compuestos, y para usar los compuestos en terapia.
MX2009003227A 2006-10-05 2007-09-25 Moduladores de los receptores de glutamato metabotropicos 5(mglur5). MX2009003227A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82832506P 2006-10-05 2006-10-05
PCT/IB2007/002784 WO2008041075A1 (en) 2006-10-05 2007-09-25 Mglur5 modulators

Publications (1)

Publication Number Publication Date
MX2009003227A true MX2009003227A (es) 2009-04-06

Family

ID=39032082

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003227A MX2009003227A (es) 2006-10-05 2007-09-25 Moduladores de los receptores de glutamato metabotropicos 5(mglur5).

Country Status (21)

Country Link
US (1) US7772235B2 (es)
EP (1) EP2079730A1 (es)
JP (1) JP2010505809A (es)
KR (1) KR20090060328A (es)
CN (1) CN101547916A (es)
AR (1) AR062965A1 (es)
AU (1) AU2007303889B2 (es)
BR (1) BRPI0719155A2 (es)
CA (1) CA2665083A1 (es)
CL (1) CL2007002757A1 (es)
CO (1) CO6220935A2 (es)
IL (1) IL197722A0 (es)
MX (1) MX2009003227A (es)
NO (1) NO20091626L (es)
NZ (1) NZ575657A (es)
PE (1) PE20081378A1 (es)
RU (1) RU2439068C2 (es)
SA (1) SA07280518B1 (es)
TW (1) TW200821305A (es)
UY (1) UY30610A1 (es)
WO (1) WO2008041075A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009054786A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole aryl n-oxides derivatives as modulators of mglur5
WO2009054787A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole carboxylic acid derivatives as modulators of mglur5
WO2009054793A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Thiophene 1,2,4-triazole derivatives as modulators of mglur5
WO2009054785A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole ether derivatives as modulators of mglur5
WO2009054790A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Amide linked heteroaromatic derivatives as modulators of mglur5
EA201000656A1 (ru) * 2007-10-26 2010-12-30 Астразенека Аб Аминопроизводные 1,2,4-триазола в качестве модуляторов mglur5
AR073268A1 (es) * 2008-08-12 2010-10-28 Astrazeneca Ab Forma cristalina de 4-(5-[(1r)-1-[5-(3-clorofenil)isoxazol-3-il] etoxi]-4-metil-4h-1,2,4-triazol-3-il)piridina.
AR073007A1 (es) * 2008-08-12 2010-10-06 Astrazeneca Ab Derivados de oxazol utiles para tratar trastornos mediados por el receptor mglur5
BRPI0923053A2 (pt) * 2008-12-18 2017-06-06 Astrazeneca Ab processo para preparar um composto
US20100273805A1 (en) * 2009-04-23 2010-10-28 Astrazeneca Ab Sulphide bridged derivatives as modulators of mglur5 733
IN2012DN03322A (es) * 2009-09-21 2015-10-23 Univ Vanderbilt
US20130203735A1 (en) * 2010-10-28 2013-08-08 John T. Sisko Caprolactam mglur5 receptor modulators
JP2013544891A (ja) 2010-12-08 2013-12-19 ヴァンダービルト ユニバーシティー ｍＧＬＵＲ５受容体のアロステリック調節剤としての二環式ピラゾール化合物
US8592422B2 (en) * 2010-12-17 2013-11-26 Vanderbilt University Bicyclic triazole and pyrazole lactams as allosteric modulators of mGluR5 receptors
US8471027B2 (en) 2011-04-06 2013-06-25 Hoffmann-La Roche Inc. Adamantyl compounds
EP2857387A1 (en) 2013-10-07 2015-04-08 Boehringer Ingelheim International Gmbh Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid
WO2018010163A1 (zh) * 2016-07-15 2018-01-18 泸州东方农化有限公司 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4637578B2 (ja) * 2002-08-09 2011-02-23 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体−５の調節因子としての１，２，４−オキサジアゾール類
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
GB0514296D0 (en) 2005-07-12 2005-08-17 Novartis Ag Organic compounds
UY29796A1 (es) * 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor
TW200808800A (en) * 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V

Also Published As

Publication number Publication date
BRPI0719155A2 (pt) 2014-02-04
NZ575657A (en) 2011-03-31
UY30610A1 (es) 2008-05-02
CL2007002757A1 (es) 2008-06-20
US7772235B2 (en) 2010-08-10
RU2439068C2 (ru) 2012-01-10
SA07280518B1 (ar) 2011-01-15
CO6220935A2 (es) 2010-11-19
PE20081378A1 (es) 2008-11-12
RU2009111113A (ru) 2010-11-10
EP2079730A1 (en) 2009-07-22
AU2007303889A2 (en) 2010-07-15
AR062965A1 (es) 2008-12-17
IL197722A0 (en) 2009-12-24
CA2665083A1 (en) 2008-04-10
AU2007303889A1 (en) 2008-04-10
NO20091626L (no) 2009-05-04
KR20090060328A (ko) 2009-06-11
AU2007303889B2 (en) 2011-02-24
US20080125436A1 (en) 2008-05-29
CN101547916A (zh) 2009-09-30
TW200821305A (en) 2008-05-16
WO2008041075A1 (en) 2008-04-10
JP2010505809A (ja) 2010-02-25

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