AR073007A1 - Derivados de oxazol utiles para tratar trastornos mediados por el receptor mglur5 - Google Patents

Derivados de oxazol utiles para tratar trastornos mediados por el receptor mglur5

Info

Publication number
AR073007A1
AR073007A1 ARP090103083A ARP090103083A AR073007A1 AR 073007 A1 AR073007 A1 AR 073007A1 AR P090103083 A ARP090103083 A AR P090103083A AR P090103083 A ARP090103083 A AR P090103083A AR 073007 A1 AR073007 A1 AR 073007A1
Authority
AR
Argentina
Prior art keywords
mglur5
receiver
useful
treat disorders
disorders mediated
Prior art date
Application number
ARP090103083A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR073007A1 publication Critical patent/AR073007A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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Abstract

La presente se refiere a una forma cristalina nueva de 4-(5-{(1R)-1-[5-(3-clorofenil)isoxazol-3-il]etoxi}-4-metil-4H-1,2,4-triazol-3-il)piridina. Además, la presente también se refiere al uso de la nueva forma cristalina para el tratamiento de trastornos gastrointestinales y a composiciones farmacéuticas que la contienen. Reivindicacion 4: La 4-(5-{(1R)-1-[5-(3-clorofenil)isoxazol-3-il]etoxi}-4-metil-4H-1,2,4-triazol-3-il)piridina en la forma cristalina de acuerdo con la reivindicacion 1, caracterizada por que proporciona un patron de difraccion de rayos X en polvo que presenta sustancialmente el siguiente pico principal con los valores d: Valor del espaciado d (L): 4,0; 5,08; 5,72; 6,21; 6,35; 11,41; 12,63.
ARP090103083A 2008-08-12 2009-08-11 Derivados de oxazol utiles para tratar trastornos mediados por el receptor mglur5 AR073007A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8804908P 2008-08-12 2008-08-12

Publications (1)

Publication Number Publication Date
AR073007A1 true AR073007A1 (es) 2010-10-06

Family

ID=41669085

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103083A AR073007A1 (es) 2008-08-12 2009-08-11 Derivados de oxazol utiles para tratar trastornos mediados por el receptor mglur5

Country Status (15)

Country Link
US (1) US20110224261A1 (es)
EP (1) EP2323658A4 (es)
JP (1) JP2011530589A (es)
KR (1) KR20110044864A (es)
CN (1) CN102176910A (es)
AR (1) AR073007A1 (es)
AU (1) AU2009282522A1 (es)
BR (1) BRPI0917463A2 (es)
CA (1) CA2733920A1 (es)
IL (1) IL210924A0 (es)
MX (1) MX2011001548A (es)
RU (1) RU2011103225A (es)
TW (1) TW201011015A (es)
UY (1) UY32044A (es)
WO (1) WO2010019100A1 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
AR058807A1 (es) * 2005-09-29 2008-02-27 Astrazeneca Ab 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5
TW200821305A (en) * 2006-10-05 2008-05-16 Astrazeneca Ab MGluR5 modulators

Also Published As

Publication number Publication date
IL210924A0 (en) 2011-04-28
JP2011530589A (ja) 2011-12-22
CN102176910A (zh) 2011-09-07
WO2010019100A1 (en) 2010-02-18
EP2323658A4 (en) 2011-10-05
RU2011103225A (ru) 2012-09-20
BRPI0917463A2 (pt) 2015-12-01
TW201011015A (en) 2010-03-16
KR20110044864A (ko) 2011-05-02
MX2011001548A (es) 2011-03-15
US20110224261A1 (en) 2011-09-15
EP2323658A1 (en) 2011-05-25
AU2009282522A1 (en) 2010-02-18
CA2733920A1 (en) 2010-02-18
UY32044A (es) 2010-03-26

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