CL2008003266A1 - Compuestos derivados de pirimidindiona y triazindiona sustituidas con cicloguanidina, utiles como antagonista del receptor de procineticina; composicion farmaceutica que comprende dichos compuestos; y uso en el tratamiento de enfermedades gastrointestinales. - Google Patents
Compuestos derivados de pirimidindiona y triazindiona sustituidas con cicloguanidina, utiles como antagonista del receptor de procineticina; composicion farmaceutica que comprende dichos compuestos; y uso en el tratamiento de enfermedades gastrointestinales.Info
- Publication number
- CL2008003266A1 CL2008003266A1 CL2008003266A CL2008003266A CL2008003266A1 CL 2008003266 A1 CL2008003266 A1 CL 2008003266A1 CL 2008003266 A CL2008003266 A CL 2008003266A CL 2008003266 A CL2008003266 A CL 2008003266A CL 2008003266 A1 CL2008003266 A1 CL 2008003266A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- treatment
- pharmaceutical composition
- useful
- cycloguanidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/38—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de amino-heteroarilo, útiles como antagonistas del receptor de procineticina; composición farmacéutica que comprende dichos compuestos; y uso en el tratamiento de enfermedades gastrointestinales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98363807P | 2007-10-30 | 2007-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008003266A1 true CL2008003266A1 (es) | 2009-10-16 |
Family
ID=40206493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008003266A CL2008003266A1 (es) | 2007-10-30 | 2008-10-30 | Compuestos derivados de pirimidindiona y triazindiona sustituidas con cicloguanidina, utiles como antagonista del receptor de procineticina; composicion farmaceutica que comprende dichos compuestos; y uso en el tratamiento de enfermedades gastrointestinales. |
Country Status (8)
Country | Link |
---|---|
US (2) | US8324380B2 (es) |
EP (1) | EP2215067A1 (es) |
JP (1) | JP2011502154A (es) |
AR (1) | AR069127A1 (es) |
CA (1) | CA2704185C (es) |
CL (1) | CL2008003266A1 (es) |
TW (1) | TWI448456B (es) |
WO (1) | WO2009058653A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9150546B2 (en) | 2009-02-13 | 2015-10-06 | Shionogi & Co., Ltd. | Triazine derivative and pharmaceutical composition comprising the same |
CA2803539A1 (en) * | 2010-06-28 | 2012-01-12 | Janssen Pharmaceutica Nv | Prokineticin 1 receptor antagonists for the treatment of pain |
EP2585069A1 (en) * | 2010-06-28 | 2013-05-01 | Janssen Pharmaceutica, N.V. | Prokineticin 1 receptor antagonists for the treatment of pain |
CN103153968B (zh) * | 2010-08-10 | 2016-02-03 | 盐野义制药株式会社 | 三唑衍生物及含有其的具有镇痛作用的药物组合物 |
JP6075621B2 (ja) | 2010-08-10 | 2017-02-08 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
US9988373B2 (en) | 2013-12-26 | 2018-06-05 | Shionogi & Co., Ltd. | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same |
RU2683245C1 (ru) | 2015-04-24 | 2019-03-27 | Сионоги Энд Ко., Лтд. | 6-членные гетероциклические производные и содержащая их фармацевтическая композиция |
RU2753524C2 (ru) | 2016-10-17 | 2021-08-17 | Сионоги Энд Ко., Лтд. | Бициклические азотсодержащие гетероциклические производные и включающие их фармацевтические композиции |
CN116650498A (zh) * | 2021-04-14 | 2023-08-29 | 盐野义制药株式会社 | 具有病毒增殖抑制作用的三嗪衍生物及含有其的药物组合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7115560B2 (en) | 2003-03-25 | 2006-10-03 | The Regents Of The University Of California | Methods for modulating gastric secretion using prokineticin receptor antagonists |
US7968710B2 (en) * | 2005-03-24 | 2011-06-28 | Janssen Pharmaceutica Nv | Prokineticin 1 receptor antagonists |
WO2006102112A2 (en) * | 2005-03-24 | 2006-09-28 | Janssen Pharmaceutica N.V. | Prokineticin 1 receptor |
BRPI0609317A2 (pt) * | 2005-03-24 | 2010-03-16 | Janssen Pharmaceutica Nv | derivados de pirimidindiona como antagonistas de receptores de procineticina 2 |
US7855201B2 (en) * | 2005-12-06 | 2010-12-21 | Merck Sharp & Dohme. Corp. | Morpholine carboxamide prokineticin receptor antagonists |
CA2635845A1 (en) * | 2005-12-29 | 2007-07-12 | Janssen Pharmaceutica N.V. | Prokineticin 2 receptor antagonists |
JP5452934B2 (ja) * | 2005-12-29 | 2014-03-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | プロキネチシン1受容体アンタゴニスト |
-
2008
- 2008-10-23 WO PCT/US2008/080915 patent/WO2009058653A1/en active Application Filing
- 2008-10-23 CA CA2704185A patent/CA2704185C/en not_active Expired - Fee Related
- 2008-10-23 US US12/256,891 patent/US8324380B2/en active Active
- 2008-10-23 JP JP2010532152A patent/JP2011502154A/ja active Pending
- 2008-10-23 EP EP08844522A patent/EP2215067A1/en not_active Withdrawn
- 2008-10-29 TW TW097141565A patent/TWI448456B/zh not_active IP Right Cessation
- 2008-10-30 AR ARP080104760A patent/AR069127A1/es not_active Application Discontinuation
- 2008-10-30 CL CL2008003266A patent/CL2008003266A1/es unknown
-
2012
- 2012-10-17 US US13/653,452 patent/US20140038968A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8324380B2 (en) | 2012-12-04 |
AR069127A1 (es) | 2009-12-30 |
US20090163505A1 (en) | 2009-06-25 |
JP2011502154A (ja) | 2011-01-20 |
TWI448456B (zh) | 2014-08-11 |
EP2215067A1 (en) | 2010-08-11 |
WO2009058653A1 (en) | 2009-05-07 |
US20140038968A1 (en) | 2014-02-06 |
CA2704185A1 (en) | 2009-05-07 |
CA2704185C (en) | 2016-02-16 |
TW200934765A (en) | 2009-08-16 |
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