SG10201609097PA - Nuclear transport modulators and uses thereof - Google Patents

Nuclear transport modulators and uses thereof

Info

Publication number
SG10201609097PA
SG10201609097PA SG10201609097PA SG10201609097PA SG10201609097PA SG 10201609097P A SG10201609097P A SG 10201609097PA SG 10201609097P A SG10201609097P A SG 10201609097PA SG 10201609097P A SG10201609097P A SG 10201609097PA SG 10201609097P A SG10201609097P A SG 10201609097PA
Authority
SG
Singapore
Prior art keywords
nuclear transport
transport modulators
modulators
nuclear
transport
Prior art date
Application number
SG10201609097PA
Inventor
Vincent P Sandanayaka
Sharon Shacham
Michael Kauffman
Sharon Shechter
Dilara Mccauley
Yosef Landesman
William Senapedis
Jean-Rchard Saint-Martin
Original Assignee
Karyopharm Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karyopharm Therapeutics Inc filed Critical Karyopharm Therapeutics Inc
Publication of SG10201609097PA publication Critical patent/SG10201609097PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E10/00—Energy generation through renewable energy sources
    • Y02E10/50—Photovoltaic [PV] energy
    • Y02E10/549—Organic PV cells

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
SG10201609097PA 2011-07-29 2012-07-26 Nuclear transport modulators and uses thereof SG10201609097PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161513432P 2011-07-29 2011-07-29
US201161513428P 2011-07-29 2011-07-29
US201261653588P 2012-05-31 2012-05-31

Publications (1)

Publication Number Publication Date
SG10201609097PA true SG10201609097PA (en) 2016-12-29

Family

ID=46682903

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201609097PA SG10201609097PA (en) 2011-07-29 2012-07-26 Nuclear transport modulators and uses thereof

Country Status (16)

Country Link
US (4) US9428490B2 (en)
EP (1) EP2736883B1 (en)
JP (3) JP6006794B2 (en)
KR (1) KR102022715B1 (en)
CN (1) CN103842340B (en)
AU (2) AU2016213805A1 (en)
BR (1) BR112014001933A2 (en)
CA (1) CA2842364A1 (en)
CL (2) CL2014000224A1 (en)
EA (1) EA201490406A1 (en)
HK (1) HK1198478A1 (en)
MX (1) MX350442B (en)
PE (1) PE20141003A1 (en)
SG (1) SG10201609097PA (en)
UA (1) UA117902C2 (en)
WO (1) WO2013019561A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2542089B1 (en) 2010-03-05 2017-01-18 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
AU2012207565B2 (en) 2011-01-17 2016-04-07 Karyopharm Therapeutics Inc. Olefin containing nuclear transport modulators and uses thereof
EA201490406A1 (en) * 2011-07-29 2014-07-30 Кариофарм Терапевтикс, Инк. NUCLEAR TRANSPORT MODULATORS AND THEIR APPLICATION
CN110372673B (en) 2011-07-29 2023-10-03 卡尔约药物治疗公司 Hydrazide-containing nuclear transport modulators and uses thereof
ES2702279T3 (en) 2012-05-09 2019-02-28 Biogen Ma Inc Modulators of nuclear transport and uses thereof
JO3407B1 (en) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd Tetrahydropyrazolopyrimidine Compounds
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
US10202366B2 (en) 2013-03-15 2019-02-12 Karyopharm Therapeutics Inc. Methods of promoting wound healing using CRM1 inhibitors
ME03421B (en) * 2013-06-21 2020-01-20 Karyopharm Therapeutics Inc 1,2,4-triazoles as nuclear transport modulators and uses thereof
WO2014205393A1 (en) * 2013-06-21 2014-12-24 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
BR112016000779A8 (en) 2013-07-18 2020-01-07 Novartis Ag autotaxin inhibitors that comprise heteroaromatic ring benzylamide cycle nucleus, their uses, pharmaceutical composition and combination
US9487536B2 (en) 2013-11-08 2016-11-08 Board Of Trustees Of The University Of Arkansas Melampomagnolide B derivatives
US9469650B2 (en) 2013-11-08 2016-10-18 Board Of Trustees Of The University Of Arkansas Melampomagnolide B derivatives
ES2739637T3 (en) * 2013-11-28 2020-02-03 Inst Nat Sante Rech Med Pharmaceutical methods and compositions for the treatment of beta-thalassemias
EP3116501A1 (en) 2014-03-13 2017-01-18 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
US9745292B2 (en) 2014-03-13 2017-08-29 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing CFTR activity
WO2015196071A1 (en) 2014-06-19 2015-12-23 Proteostasis Therapeutics, Inc. Compounds, compositions and methods of increasing cftr activity
EP4112615A1 (en) 2014-08-15 2023-01-04 Karyopharm Therapeutics Inc. Compositions comprising one crystalline form of selinexor
WO2016090166A1 (en) 2014-12-03 2016-06-09 Board Of Trustees Of The University Of Arkansas Melampomagnolide b dimers
US10392378B2 (en) 2014-12-23 2019-08-27 Proteostasis Therapeutics, Inc. Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis
MA41253A (en) 2014-12-23 2017-10-31 Proteostasis Therapeutics Inc COMPOUNDS, COMPOSITIONS AND PROCESSES TO INCREASE THE ACTIVITY OF CFTR
WO2016105468A1 (en) 2014-12-23 2016-06-30 Proteostasis Therapeutics, Inc. Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis
WO2016105484A1 (en) 2014-12-23 2016-06-30 Proteostasis Therapeutics, Inc. Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis
WO2017019589A1 (en) 2015-07-24 2017-02-02 Proteostasis Therapeutics, Inc. Compounds, compositions and methods of increasing cftr activity
KR102279993B1 (en) 2015-09-23 2021-07-21 엑스더블유파마 리미티드 Precursors of gamma-hydroxybutyric acid and compositions and uses thereof
KR20180093882A (en) 2015-10-06 2018-08-22 프로테오스타시스 테라퓨틱스, 인크. Compounds, compositions, and methods for CFTR regulation
CN105384673B (en) * 2015-11-09 2017-11-14 南京富润凯德生物医药有限公司 The synthetic method of 3 fluoro azetidine derivatives
EP3397634A1 (en) 2015-12-31 2018-11-07 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
MA43529A (en) 2015-12-31 2018-11-07 Karyopharm Therapeutics Inc NUCLEAR TRANSPORT MODULATORS AND THEIR USES
EP3407885A4 (en) * 2016-01-29 2019-06-19 BioVentures, LLC Triazole derivatives of melampomagnolide b and methods of use thereof
MX2018012331A (en) 2016-04-07 2019-05-23 Proteostasis Therapeutics Inc Silicone atoms containing ivacaftor analogues.
RU2018146946A (en) * 2016-06-08 2020-07-10 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед CHEMICAL COMPOUNDS
WO2017223188A1 (en) 2016-06-21 2017-12-28 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
US11065230B2 (en) 2016-09-16 2021-07-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of systemic mastocytosis
WO2018098472A1 (en) 2016-11-28 2018-05-31 Karyopharm Therapeutics Inc. Crm1 inhibitors for treating epilepsy
CN106831731B (en) * 2017-01-17 2019-11-08 广州市闻皓生物科技有限公司 A kind of synthetic method of Selinexor bulk pharmaceutical chemicals
JP6991239B2 (en) 2017-03-30 2022-01-12 エックスダブリューファルマ リミテッド Bicyclic heteroaryl derivatives and their preparation and use
BR112020014189B1 (en) 2018-01-10 2022-07-12 XWPharma Ltd. COMPOUND, PHARMACEUTICAL COMPOSITION AND USE OF COMPOUND
WO2019232724A1 (en) * 2018-06-06 2019-12-12 Xw Laboratories, Inc. Compounds as nuclear transport modulators and uses thereof
WO2020062251A1 (en) 2018-09-30 2020-04-02 Xw Laboratories, Inc. Compounds as neuronal histamine receptor-3 antagonists and uses thereof
CN111606890A (en) 2019-02-26 2020-09-01 微境生物医药科技(上海)有限公司 Acryloyl group-containing nuclear transport modulators and uses thereof
JP2020141256A (en) 2019-02-28 2020-09-03 ソニーセミコンダクタソリューションズ株式会社 Demodulation circuit, demodulation method, transmission device
CA3162919A1 (en) 2019-12-20 2021-06-24 XWPharma Ltd. Methods of synthesizing 4-valyloxybutyric acid
CN115038432B (en) 2020-06-18 2023-12-26 凯瑞康宁生物工程（武汉）有限公司 Controlled release granulation of water-soluble active pharmaceutical ingredient
JP2023537192A (en) 2020-06-18 2023-08-31 エックスダブリューファーマ リミテッド Pharmaceutical Granules of Water-Soluble Pharmaceutical Active Ingredients
US11896573B2 (en) 2020-07-24 2024-02-13 XWPharma Ltd. Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative
WO2022076466A1 (en) 2020-10-05 2022-04-14 XWPharma Ltd. Modified release compositions of a gamma-hydroxybutyric acid derivative
WO2022143779A1 (en) * 2020-12-29 2022-07-07 南京明德新药研发有限公司 Alkenyl-containing compound and application thereof
US11510892B2 (en) 2021-03-19 2022-11-29 XWPharma Ltd. Pharmacokinetics of combined release formulations of a γ-hydroxybutyric acid derivative
WO2023018966A1 (en) 2021-08-13 2023-02-16 XWPharma Ltd. Pharmaceutical compositions and oral dosage forms of ketamine derivatives
CN116514773A (en) * 2023-04-24 2023-08-01 重庆汉佩生物科技有限公司 Verdinexor (KPT-335) and synthesis method of hydrochloride thereof

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR840000529A (en) * 1981-07-07 1984-02-25 콘스탄틴 루이스 클레멘트 Method for preparing indole derivative
US4778796A (en) * 1985-07-19 1988-10-18 Dainippon Pharmaceutical Co., Ltd. ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
IL97249A (en) 1990-02-23 1995-01-24 Takeda Chemical Industries Ltd 4,5,6,7- Tetrahydrothiazolo (5,4-b) pyridine and 5,6-dihydro-4h pyrrolo (3,2-d) thiazolo compounds, their production and pharmaceutical compositions containing them
JP3111321B2 (en) * 1990-02-23 2000-11-20 武田薬品工業株式会社 Condensed thiazole compound
US5541213A (en) * 1993-06-24 1996-07-30 Eisai Co., Ltd. Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility
US5468353A (en) * 1994-05-05 1995-11-21 Minnesota Mining And Manufacturing Company Mist suppressant for solvent extraction metal electrowinning
WO1996016040A1 (en) * 1994-11-23 1996-05-30 Neurogen Corporation Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
US20030018025A1 (en) * 1995-06-07 2003-01-23 Neurogen Corporation, Corporation Of The State Of Delaware Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives: new classes of dopamine receptor subtype specific ligands
EP0858457A1 (en) * 1995-10-20 1998-08-19 Dr. Karl Thomae GmbH 5-membered heterocycles, pharmaceutical agents containing said compounds and the use thereof and methods of producing them
EP0893446B1 (en) * 1996-04-04 2006-10-04 Shionogi & Co., Ltd. Cephem compounds and drugs containing the compounds
DE69723267T2 (en) 1996-04-25 2004-04-22 Nissan Chemical Industries, Ltd. ETHYLENE DERIVATIVES AND PESTICIDES
US5994398A (en) * 1996-12-11 1999-11-30 Elan Pharmaceuticals, Inc. Arylsulfonamides as phospholipase A2 inhibitors
JP4416198B2 (en) * 1997-12-19 2010-02-17 武田薬品工業株式会社 Anilide derivatives, their production and use
WO1999050264A1 (en) * 1998-03-30 1999-10-07 Kyowa Hakko Kogyo Co., Ltd. Quinazoline derivatives
CO5271680A1 (en) * 2000-02-21 2003-04-30 Smithkline Beecham Corp COMPOUNDS
EP2083005A1 (en) * 2000-09-29 2009-07-29 TopoTarget UK Limited Carbamic acid compounds comprising an amide linkage as HDAC inhibitors
EP1429765A2 (en) * 2001-09-14 2004-06-23 Methylgene, Inc. Inhibitors of histone deacetylase
AU2003287965A1 (en) * 2002-10-24 2004-05-13 Carex Sa Modulation of peroxisome proliferator activated receptors activity
DE10250743A1 (en) * 2002-10-31 2004-05-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg New amide compounds having MCH antagonist activity and medicaments containing these compounds
JP4145230B2 (en) * 2002-11-01 2008-09-03 武田薬品工業株式会社 Preventive and therapeutic agents for neurological disorders
TW200416029A (en) * 2002-11-01 2004-09-01 Takeda Chemical Industries Ltd Agent for preventing or treating neuropathy
US7342115B2 (en) * 2002-11-08 2008-03-11 Neurogen Corporation 3-substituted-6-aryl pyridines
WO2004076418A1 (en) * 2003-02-28 2004-09-10 Galderma Research & Development, S.N.C. Ligands that modulate lxr-type receptors
EP1757591A4 (en) * 2004-05-26 2010-05-05 Eisai R&D Man Co Ltd Cinnamide compound
BRPI0515015A (en) * 2004-08-11 2008-07-01 Kyorin Seiyaku Kk cyclic aminobenzoic acid derivative; medicine; ppar (alpha) agonist; ppar (alpha) double agonist, y; ppar double agonist (alpha), (delta); par modulator; lipid agent; prophylactic or therapeutic agent comprising at least one of the pharmaceutically acceptable cyclic derivatives of aminobenzoic acid or salt thereof
WO2006088246A1 (en) * 2005-02-18 2006-08-24 Takeda Pharmaceutical Company Limited Agent for controlling function of gpr34 receptor
USRE46792E1 (en) 2005-11-15 2018-04-17 Otsuka Pharmaceutical Co., Ltd. Oxazole compound and pharmaceutical composition
WO2007102580A1 (en) 2006-03-09 2007-09-13 Eisai R & D Management Co., Ltd. Polycyclic cinnamide derivative
JP5554988B2 (en) * 2006-04-07 2014-07-23 メチルジーン インコーポレイテッド Inhibitors of histone deacetylase
BRPI0710266B8 (en) 2006-04-18 2021-05-25 Nippon Chemiphar Co compound, medicine, and use of a compound
US8653115B2 (en) 2006-06-13 2014-02-18 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Heterocyclic non-nucleoside compounds, their preparation, pharmaceutical composition and their use as antiviral agents
KR101410318B1 (en) * 2006-07-27 2014-06-27 (주)아모레퍼시픽 Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist； and pharmaceutical compositions containing the same
ATE532770T1 (en) * 2006-09-05 2011-11-15 Kyowa Hakko Kirin Co Ltd IMIDAZOLE DERIVATIVE
EP1942104A1 (en) * 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
EP1939180A1 (en) * 2006-12-20 2008-07-02 sanofi-aventis Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase
EP2542089B1 (en) * 2010-03-05 2017-01-18 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
AU2012207565B2 (en) 2011-01-17 2016-04-07 Karyopharm Therapeutics Inc. Olefin containing nuclear transport modulators and uses thereof
US9152882B2 (en) * 2011-06-17 2015-10-06 Microsoft Technology Licensing, Llc. Location-aided recognition
CN110372673B (en) * 2011-07-29 2023-10-03 卡尔约药物治疗公司 Hydrazide-containing nuclear transport modulators and uses thereof
EA201490406A1 (en) * 2011-07-29 2014-07-30 Кариофарм Терапевтикс, Инк. NUCLEAR TRANSPORT MODULATORS AND THEIR APPLICATION
ES2702279T3 (en) 2012-05-09 2019-02-28 Biogen Ma Inc Modulators of nuclear transport and uses thereof
US20160016916A1 (en) 2013-03-15 2016-01-21 Karyopharm Therapeutics Inc. Exo Olefin-Containing Nuclear Transport Modulators and Uses Thereof
US10202366B2 (en) * 2013-03-15 2019-02-12 Karyopharm Therapeutics Inc. Methods of promoting wound healing using CRM1 inhibitors
ME03421B (en) 2013-06-21 2020-01-20 Karyopharm Therapeutics Inc 1,2,4-triazoles as nuclear transport modulators and uses thereof
WO2014205393A1 (en) 2013-06-21 2014-12-24 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof

Also Published As

Publication number Publication date
CN103842340B (en) 2017-09-22
US20200087313A1 (en) 2020-03-19
MX350442B (en) 2017-09-06
CL2015001259A1 (en) 2015-07-24
JP2014521653A (en) 2014-08-28
US20170137430A1 (en) 2017-05-18
NZ621520A (en) 2016-05-27
US9428490B2 (en) 2016-08-30
AU2012290467A1 (en) 2014-03-13
MX2014001180A (en) 2015-01-27
HK1198478A1 (en) 2015-05-08
JP2016199604A (en) 2016-12-01
PE20141003A1 (en) 2014-09-02
US20220056038A1 (en) 2022-02-24
CN103842340A (en) 2014-06-04
JP6752235B2 (en) 2020-09-09
WO2013019561A1 (en) 2013-02-07
UA117902C2 (en) 2018-10-25
CL2014000224A1 (en) 2014-12-05
EP2736883A1 (en) 2014-06-04
AU2016213805A1 (en) 2016-09-01
KR102022715B1 (en) 2019-09-18
KR20140062480A (en) 2014-05-23
EP2736883B1 (en) 2019-09-04
CA2842364A1 (en) 2013-02-07
BR112014001933A2 (en) 2017-02-21
EA201490406A1 (en) 2014-07-30
JP2018083832A (en) 2018-05-31
US20150018332A1 (en) 2015-01-15
WO2013019561A8 (en) 2013-07-04
JP6006794B2 (en) 2016-10-12
AU2018204256A1 (en) 2018-07-05

Similar Documents

Publication Publication Date Title
ZA202004892B (en) Nuclear transport modulators and uses thereof
HUS2100030I1 (en) Hydrazide containing nuclear transport modulators and uses thereof
HK1198478A1 (en) Nuclear transport modulators and uses thereof
HRP20190524T1 (en) Nuclear transport modulators and uses thereof
HK1191512A1 (en) Olefin containing nuclear transport modulators and uses thereof
EP2542089A4 (en) Nuclear transport modulatiors and uses thereof
EP2668084A4 (en) Handling and transport system
SG10201602149XA (en) SALL4 And Uses Thereof
EP2737394A4 (en) Incident handling
GB2485537B8 (en) Integral - surface and air - personal transport
GB201118798D0 (en) Interthermic and intrathermic anionic radioactivity