KR840000529A - Method for preparing indole derivative - Google Patents

Method for preparing indole derivative Download PDF

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Publication number
KR840000529A
KR840000529A KR1019820002992A KR820002992A KR840000529A KR 840000529 A KR840000529 A KR 840000529A KR 1019820002992 A KR1019820002992 A KR 1019820002992A KR 820002992 A KR820002992 A KR 820002992A KR 840000529 A KR840000529 A KR 840000529A
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KR
South Korea
Prior art keywords
compound
formula
cooh
alkyl
conh
Prior art date
Application number
KR1019820002992A
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Korean (ko)
Inventor
에드워드 크로스(외 1) 피터
Original Assignee
콘스탄틴 루이스 클레멘트
화이자 코포레이숀
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Application filed by 콘스탄틴 루이스 클레멘트, 화이자 코포레이숀 filed Critical 콘스탄틴 루이스 클레멘트
Publication of KR840000529A publication Critical patent/KR840000529A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00

Abstract

내용 없음No content

Description

인돌 유도체의 제조방법Method for preparing indole derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (13)

하기 일반식 (Ⅱ)의 화합물을 하기 일반식 (Ⅲ)의 화합물과 반응시키고 임의로 하기 (a), (b) 중의 하나 이상의 반응을 실시함을 포함하여 하기 일반식 (Ⅰ)의 화합물 또는 그 약제학적으로 허용되는 염을 제조하는 방법.A compound of formula (I) or a medicament thereof, comprising reacting a compound of formula (II) with a compound of formula (III) and optionally reacting one or more of the following (a), (b): Method for preparing a scientifically acceptable salt. (a) 일반식 (Ⅰ)의 생성물을 그 약제학적으로 허용되는 염으로 전환시킨다.(a) The product of general formula (I) is converted into its pharmaceutically acceptable salt. (b) Y가 -COOH인 일반식 (Ⅰ)의 생성물을 산클로라이드 또는 산브로마이드 또는 이미다졸리드로 형성시킨 후, 암모니아와 반응시켜 Y가 -CONH2인 화합물로 전환시킨다.(b) The product of formula (I), wherein Y is -COOH, is formed with acid chloride or acid bromide or imidazolide, and then reacted with ammonia to convert to a compound with Y -CONH 2 . (상기식에서 R1은 H 또는 C1-C4알킬이고 ; R2는 H, C1-C4알킬, C1-C4알콕시Wherein R 1 is H or C 1 -C 4 alkyl; R 2 is H, C 1 -C 4 alkyl, C 1 -C 4 alkoxy 또는 할로이고 ; R3는 H 또는 메틸이고 ; Y는 -COOH, -COO(C1-C4알킬) 또는 -Or halo; R 3 is H or methyl; Y is -COOH, -COO (C 1 -C 4 alkyl) or- CONH2이고 ; Z는 1-이미다졸릴 또는 3-피리딜이다.)CONH 2 ; Z is 1-imidazolyl or 3-pyridyl.) 제 1 항에 있어서, 반응이 염기 존재하에 수행하는 방법.The method of claim 1 wherein the reaction is carried out in the presence of a base. 제 2 항에 있어서, 상기 염기는 벤질트리메틸 암모늄 하이드록사이드 또는 테트라부틸 암모늄 플루오라이드인 방법.The method of claim 2, wherein the base is benzyltrimethyl ammonium hydroxide or tetrabutyl ammonium fluoride. 제 1 항 내지 3항 중의 어느 하나에 있어서, R3가 H인 방법.The method according to any one of claims 1 to 3, wherein R 3 is H. 제 1 항 내지 4항 중의 어느 하나에 있어서, R1이 메틸이고, Y가 -COOH인 방법.The method according to any one of claims 1 to 4, wherein R 1 is methyl and Y is -COOH. 제 1 항 내지 5항 중의 어느 하나에 있어서, 화합물이 Y가 인돌환에 대해 트랜스인 E형 화합물인 방법.The method according to any one of claims 1 to 5, wherein the compound is an E-type compound wherein Y is trans with respect to the indole ring. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820002992A 1981-07-07 1982-07-05 Method for preparing indole derivative KR840000529A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8120878 1981-07-07
GB8120878 1981-07-07

Publications (1)

Publication Number Publication Date
KR840000529A true KR840000529A (en) 1984-02-25

Family

ID=10523060

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820002992A KR840000529A (en) 1981-07-07 1982-07-05 Method for preparing indole derivative

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JP (1) JPS5841875A (en)
KR (1) KR840000529A (en)
ZA (1) ZA824789B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4561147A (en) * 1982-12-27 1985-12-31 Miwa Lock Co. Ltd. Hinge which facilitates opening door after the gate frame is distorted
WO1993020065A1 (en) * 1992-03-27 1993-10-14 Kyoto Pharmaceutical Industries, Ltd. Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor
WO2013019561A1 (en) * 2011-07-29 2013-02-07 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
PT2736887T (en) 2011-07-29 2018-01-15 Karyopharm Therapeutics Inc Hydrazide containing nuclear transport modulators and uses thereof
KR20200115688A (en) 2012-05-09 2020-10-07 바이오젠 엠에이 인코포레이티드 Nuclear transport modulators and uses thereof
EP2968278B8 (en) 2013-03-15 2019-05-22 Karyopharm Therapeutics Inc. Methods of promoting wound healing using crm1 inhibitors
ME03421B (en) 2013-06-21 2020-01-20 Karyopharm Therapeutics Inc 1,2,4-triazoles as nuclear transport modulators and uses thereof
EA201790384A1 (en) 2014-08-15 2017-08-31 Кариофарм Терапевтикс, Инк. POLYMORPHES OF SILINEXOR
WO2017117529A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
US10709706B2 (en) 2015-12-31 2020-07-14 Karopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
US11602530B2 (en) 2016-11-28 2023-03-14 Biogen Ma Inc. CRM1 inhibitors for treating epilepsy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003901B1 (en) * 1978-02-24 1981-08-05 Pfizer Limited 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them
DK151884C (en) * 1979-03-07 1988-06-13 Pfizer METHOD OF ANALOGUE FOR THE PREPARATION OF 3- (1-IMIDAZOLYLALKYL) INCIDENTAL OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF

Also Published As

Publication number Publication date
JPS5841875A (en) 1983-03-11
ZA824789B (en) 1983-04-27

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