CY1121693T1 - Θετικοι αλλοστερικοι διαμορφωτες μουσκαρινικου υποδοχεα μ1 - Google Patents
Θετικοι αλλοστερικοι διαμορφωτες μουσκαρινικου υποδοχεα μ1Info
- Publication number
- CY1121693T1 CY1121693T1 CY20191100379T CY191100379T CY1121693T1 CY 1121693 T1 CY1121693 T1 CY 1121693T1 CY 20191100379 T CY20191100379 T CY 20191100379T CY 191100379 T CY191100379 T CY 191100379T CY 1121693 T1 CY1121693 T1 CY 1121693T1
- Authority
- CY
- Cyprus
- Prior art keywords
- muscarinic receptor
- receptor modulators
- compounds
- positive exterior
- muscarinic
- Prior art date
Links
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 title abstract 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102000007207 Muscarinic M1 Receptor Human genes 0.000 abstract 1
- 108010008406 Muscarinic M1 Receptor Proteins 0.000 abstract 1
- 230000003281 allosteric effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Arrangement And Driving Of Transmission Devices (AREA)
- Electrophonic Musical Instruments (AREA)
- Liquid Crystal Display Device Control (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μια ένωση του Χημικού Τύπου (I), ή σε στερεοϊσομερή και σε φαρμακευτικά αποδεκτά άλατα ως θετικούς αλλοστερικούς διαμορφωτές μουσκαρινικού υποδοχέα Μ1. Αυτή η εφεύρεση αναφέρεται επίσης σε μεθόδους παρασκευής τέτοιων ενώσεων και φαρμακευτικών συνθέσεων που περιλαμβάνουν τέτοιες ενώσεις. Οι ενώσεις αυτής της εφεύρεσης είναι χρήσιμες στη θεραπεία διαφόρων διαταραχών που σχετίζονται με τον μουσκαρινικό υποδοχέα Μ1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2851CH2015 | 2015-06-08 | ||
| PCT/IB2016/000771 WO2016198937A1 (en) | 2015-06-08 | 2016-06-08 | Muscarinic m1 receptor positive allosteric modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121693T1 true CY1121693T1 (el) | 2020-07-31 |
Family
ID=56411822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100379T CY1121693T1 (el) | 2015-06-08 | 2019-04-05 | Θετικοι αλλοστερικοι διαμορφωτες μουσκαρινικου υποδοχεα μ1 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US10308620B2 (el) |
| EP (1) | EP3303331B1 (el) |
| JP (1) | JP6466602B2 (el) |
| KR (1) | KR102052058B1 (el) |
| CN (1) | CN107922400B (el) |
| AU (1) | AU2016276139B2 (el) |
| BR (1) | BR112017026272B1 (el) |
| CA (1) | CA2987843C (el) |
| CY (1) | CY1121693T1 (el) |
| DK (1) | DK3303331T3 (el) |
| EA (1) | EA032602B1 (el) |
| ES (1) | ES2719626T3 (el) |
| HK (1) | HK1247919A1 (el) |
| HR (1) | HRP20190624T1 (el) |
| HU (1) | HUE044902T2 (el) |
| IL (1) | IL255994B (el) |
| LT (1) | LT3303331T (el) |
| MA (1) | MA43913B1 (el) |
| MD (1) | MD3303331T2 (el) |
| ME (1) | ME03379B (el) |
| MX (1) | MX2017015961A (el) |
| NZ (1) | NZ737892A (el) |
| PL (1) | PL3303331T3 (el) |
| PT (1) | PT3303331T (el) |
| RS (1) | RS58665B1 (el) |
| SI (1) | SI3303331T1 (el) |
| TR (1) | TR201904639T4 (el) |
| WO (1) | WO2016198937A1 (el) |
| ZA (1) | ZA201708108B (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102438588B1 (ko) * | 2017-10-18 | 2022-08-31 | 수벤 라이프 사이언시스 리미티드 | 무스카린 m1 수용체 양성 알로스테릭 조절제로서 헤테로아릴 화합물 |
| KR102406885B1 (ko) | 2017-10-27 | 2022-06-08 | 수벤 라이프 사이언시스 리미티드 | 무스카린 m1 수용체 양성 알로스테릭 조절제로서 다환형 아미드 |
| US20220152005A1 (en) * | 2019-04-04 | 2022-05-19 | Andrew Coop | Methods of using muscarinic antagonists in the treatment of depression |
| KR102285472B1 (ko) | 2019-06-14 | 2021-08-03 | 엘지전자 주식회사 | 음향의 이퀄라이징 방법과, 이를 구현하는 로봇 및 ai 서버 |
| CN110606827B (zh) * | 2019-09-26 | 2023-03-14 | 西安凯立新材料股份有限公司 | 一步法合成甲氨基吡啶类化合物的方法 |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1183847A (en) | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| WO2007100366A2 (en) | 2005-12-05 | 2007-09-07 | Merck & Co., Inc. | Quinolone m1 receptor positive allosteric modulators |
| EP2575454B1 (en) | 2010-05-28 | 2018-08-29 | Merck Sharp & Dohme Corp. | Naphthalene carboxamide m1 receptor positive allosteric modulators |
| JP2014076948A (ja) | 2011-02-09 | 2014-05-01 | Astellas Pharma Inc | イソキノリンアミド誘導体 |
| US9403802B2 (en) * | 2012-03-02 | 2016-08-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use therefor |
| TW201512197A (zh) * | 2013-08-30 | 2015-04-01 | Hoffmann La Roche | 吡咯并吡啶或吡唑并吡啶衍生物 |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| US9708278B2 (en) | 2013-11-27 | 2017-07-18 | Vanderbilt University | Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1 |
| GB201409044D0 (en) * | 2014-05-21 | 2014-07-02 | Ucl Business Plc | New compounds |
-
2016
- 2016-06-08 NZ NZ737892A patent/NZ737892A/en unknown
- 2016-06-08 EA EA201792594A patent/EA032602B1/ru unknown
- 2016-06-08 LT LTEP16738860.2T patent/LT3303331T/lt unknown
- 2016-06-08 PL PL16738860T patent/PL3303331T3/pl unknown
- 2016-06-08 KR KR1020187000574A patent/KR102052058B1/ko active IP Right Grant
- 2016-06-08 AU AU2016276139A patent/AU2016276139B2/en active Active
- 2016-06-08 RS RS20190440A patent/RS58665B1/sr unknown
- 2016-06-08 MD MDE20180352T patent/MD3303331T2/ro unknown
- 2016-06-08 MX MX2017015961A patent/MX2017015961A/es active IP Right Grant
- 2016-06-08 SI SI201630220T patent/SI3303331T1/sl unknown
- 2016-06-08 TR TR2019/04639T patent/TR201904639T4/tr unknown
- 2016-06-08 MA MA43913A patent/MA43913B1/fr unknown
- 2016-06-08 EP EP16738860.2A patent/EP3303331B1/en active Active
- 2016-06-08 ES ES16738860T patent/ES2719626T3/es active Active
- 2016-06-08 WO PCT/IB2016/000771 patent/WO2016198937A1/en active Application Filing
- 2016-06-08 CA CA2987843A patent/CA2987843C/en active Active
- 2016-06-08 PT PT16738860T patent/PT3303331T/pt unknown
- 2016-06-08 DK DK16738860.2T patent/DK3303331T3/en active
- 2016-06-08 US US15/580,632 patent/US10308620B2/en active Active
- 2016-06-08 JP JP2017563539A patent/JP6466602B2/ja active Active
- 2016-06-08 BR BR112017026272-0A patent/BR112017026272B1/pt active IP Right Grant
- 2016-06-08 ME MEP-2019-99A patent/ME03379B/me unknown
- 2016-06-08 HU HUE16738860 patent/HUE044902T2/hu unknown
- 2016-06-08 CN CN201680040849.9A patent/CN107922400B/zh active Active
-
2017
- 2017-11-29 ZA ZA2017/08108A patent/ZA201708108B/en unknown
- 2017-11-29 IL IL255994A patent/IL255994B/en active IP Right Grant
-
2018
- 2018-06-05 HK HK18107344.8A patent/HK1247919A1/zh unknown
-
2019
- 2019-04-01 HR HRP20190624TT patent/HRP20190624T1/hr unknown
- 2019-04-05 CY CY20191100379T patent/CY1121693T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1124496T1 (el) | Οξυστερολες και μεθοδοι χρησης αυτων | |
| CY1121693T1 (el) | Θετικοι αλλοστερικοι διαμορφωτες μουσκαρινικου υποδοχεα μ1 | |
| CY1121413T1 (el) | Διυδροπυρρολοπυριδινης αναστολεις ror-γαμμα | |
| CY1123417T1 (el) | Παραγωγα τετρα�δροϊσοκινολινης | |
| CY1122730T1 (el) | 1,2,4-τριαζολες ως διαμορφωτες πυρηνικης μεταφορας και χρησεις αυτων | |
| CY1122046T1 (el) | Δικυκλικα ετεροκυκλικα παραγωγα ως αναστολεις βρομοτομεων | |
| CY1122534T1 (el) | Νεες ενωσεις μεθυλο-πιπεριδινης χρησιμες για την αναστολη της μ1κροσωμικης συνθετασης-1 της προσταγλανδινης ε2 | |
| CY1121706T1 (el) | Ενωσεις υποκατασταθεισες διυδροϊσοκινολινονης | |
| CY1124620T1 (el) | Οξυστερολες και μεθοδοι χρησης αυτων | |
| CY1120273T1 (el) | Συνθεσεις και μεθοδοι για την τροποποιηση φαρνεσοειδων υποδοχεων χ | |
| CY1123059T1 (el) | Αναστολη του διαυλου ιοντων παροδικου δυναμικου του υποδοχεα α1 | |
| CY1123479T1 (el) | Θετικοι αλλοστερικοι διαμορφωτες μουσκαρινικου υποδοχεα μ1 | |
| CY1122321T1 (el) | Παραγωγα φθοροϊνδολιου ως θετικοι αλλοστερικοι διαμορφωτες του μουσκαρινικου υποδοχεα μ1 | |
| CY1120881T1 (el) | Ανταγωνιστες υποδοχεα 5-ητ3 | |
| CY1121972T1 (el) | Mono- ή διυποκατεστημενα ινδολια ως αναστολεις του αναδιπλασιασμου του ιου του δαγκειου πυρετου | |
| EA201791256A1 (ru) | Производные хиназолина, применяемые для лечения вич | |
| CY1118365T1 (el) | Διαμορφωτες διυδροπυραζολης του gpr40 | |
| CY1117105T1 (el) | Ενωσεις πυριδαζινονης και χρηση τους ως αναστολεις του daao | |
| EA201791304A1 (ru) | Производные изохинолина для лечения вич | |
| CY1121898T1 (el) | Ενωσεις αμιδιου ως αγωνιστες tου υποδοχεα 5-ht4 | |
| CY1122077T1 (el) | Νεα δακτυλιωμενα φαινοξυακεταμιδια | |
| EA201691600A1 (ru) | Дигидропиридиноновые ингибиторы mgat2 для применения в лечении метаболических нарушений | |
| CY1122439T1 (el) | Κυκλοαλκυλ-συνδεδεμενα παραγωγα δι-ετεροκυκλων | |
| CY1121650T1 (el) | Αναστολεις συνθασης αλδοστερονης | |
| EA201791600A1 (ru) | Производные гидроксиалкилпиперазина в качестве модуляторов cxcr3 рецептора |