BR112017026272A2 - ?composto, composição farmacêutica, método para o tratamento de uma desordem relacionada a receptor m1 muscarínico e uso do composto? - Google Patents
?composto, composição farmacêutica, método para o tratamento de uma desordem relacionada a receptor m1 muscarínico e uso do composto?Info
- Publication number
- BR112017026272A2 BR112017026272A2 BR112017026272A BR112017026272A BR112017026272A2 BR 112017026272 A2 BR112017026272 A2 BR 112017026272A2 BR 112017026272 A BR112017026272 A BR 112017026272A BR 112017026272 A BR112017026272 A BR 112017026272A BR 112017026272 A2 BR112017026272 A2 BR 112017026272A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- muscarinic
- receptor
- treating
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Liquid Crystal Display Device Control (AREA)
- Arrangement And Driving Of Transmission Devices (AREA)
- Electrophonic Musical Instruments (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
a presente invenção se refere a um composto tendo a fórmula (i), ou estereoisômeros e sais farmaceuticamente aceitáveis como moduladores alostéricos positivos de receptor m1 muscarínico. a presente invenção também se refere a métodos de preparar os referidos compostos e composições farmacêuticas que compreendem os referidos compostos. os compostos da presente invenção são úteis no tratamento de várias desordens que são relacionadas a receptor m1 muscarínico.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2851/CHE/2015 | 2015-06-08 | ||
IN2851CH2015 | 2015-06-08 | ||
PCT/IB2016/000771 WO2016198937A1 (en) | 2015-06-08 | 2016-06-08 | Muscarinic m1 receptor positive allosteric modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017026272A2 true BR112017026272A2 (pt) | 2018-09-11 |
BR112017026272B1 BR112017026272B1 (pt) | 2023-04-11 |
Family
ID=56411822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017026272-0A BR112017026272B1 (pt) | 2015-06-08 | 2016-06-08 | Composto e composição farmacêutica |
Country Status (29)
Country | Link |
---|---|
US (1) | US10308620B2 (pt) |
EP (1) | EP3303331B1 (pt) |
JP (1) | JP6466602B2 (pt) |
KR (1) | KR102052058B1 (pt) |
CN (1) | CN107922400B (pt) |
AU (1) | AU2016276139B2 (pt) |
BR (1) | BR112017026272B1 (pt) |
CA (1) | CA2987843C (pt) |
CY (1) | CY1121693T1 (pt) |
DK (1) | DK3303331T3 (pt) |
EA (1) | EA032602B1 (pt) |
ES (1) | ES2719626T3 (pt) |
HK (1) | HK1247919A1 (pt) |
HR (1) | HRP20190624T1 (pt) |
HU (1) | HUE044902T2 (pt) |
IL (1) | IL255994B (pt) |
LT (1) | LT3303331T (pt) |
MA (1) | MA43913B1 (pt) |
MD (1) | MD3303331T2 (pt) |
ME (1) | ME03379B (pt) |
MX (1) | MX2017015961A (pt) |
NZ (1) | NZ737892A (pt) |
PL (1) | PL3303331T3 (pt) |
PT (1) | PT3303331T (pt) |
RS (1) | RS58665B1 (pt) |
SI (1) | SI3303331T1 (pt) |
TR (1) | TR201904639T4 (pt) |
WO (1) | WO2016198937A1 (pt) |
ZA (1) | ZA201708108B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3076757C (en) * | 2017-10-18 | 2022-10-11 | Suven Life Sciences Limited | Heteroaryl compounds as muscarinic m1 receptor positive allosteric modulators |
JP7110338B2 (ja) * | 2017-10-27 | 2022-08-01 | スヴェン・ライフ・サイエンシーズ・リミテッド | ムスカリンm1受容体陽性アロステリックモジュレーターである多環式アミド類 |
WO2020206410A1 (en) * | 2019-04-04 | 2020-10-08 | University Of Maryland, Baltimore | Methods of using muscarinic antagonists in the treatment of depression |
KR102285472B1 (ko) | 2019-06-14 | 2021-08-03 | 엘지전자 주식회사 | 음향의 이퀄라이징 방법과, 이를 구현하는 로봇 및 ai 서버 |
CN110606827B (zh) * | 2019-09-26 | 2023-03-14 | 西安凯立新材料股份有限公司 | 一步法合成甲氨基吡啶类化合物的方法 |
WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1183847A (en) | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
AU2006322045A1 (en) | 2005-12-05 | 2007-06-14 | Merck & Co., Inc. | Quinolone M1 receptor positive allosteric modulators |
US8883850B2 (en) | 2010-05-28 | 2014-11-11 | Merck Sharp & Dohme Corp. | Naphthalene carboxamide M1 receptor positive allosteric modulators |
JP2014076948A (ja) | 2011-02-09 | 2014-05-01 | Astellas Pharma Inc | イソキノリンアミド誘導体 |
US9403802B2 (en) * | 2012-03-02 | 2016-08-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use therefor |
TW201512197A (zh) | 2013-08-30 | 2015-04-01 | Hoffmann La Roche | 吡咯并吡啶或吡唑并吡啶衍生物 |
GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
US9708278B2 (en) * | 2013-11-27 | 2017-07-18 | Vanderbilt University | Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1 |
GB201409044D0 (en) * | 2014-05-21 | 2014-07-02 | Ucl Business Plc | New compounds |
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2016
- 2016-06-08 WO PCT/IB2016/000771 patent/WO2016198937A1/en active Application Filing
- 2016-06-08 CA CA2987843A patent/CA2987843C/en active Active
- 2016-06-08 RS RS20190440A patent/RS58665B1/sr unknown
- 2016-06-08 US US15/580,632 patent/US10308620B2/en active Active
- 2016-06-08 MD MDE20180352T patent/MD3303331T2/ro unknown
- 2016-06-08 PT PT16738860T patent/PT3303331T/pt unknown
- 2016-06-08 EP EP16738860.2A patent/EP3303331B1/en active Active
- 2016-06-08 TR TR2019/04639T patent/TR201904639T4/tr unknown
- 2016-06-08 MX MX2017015961A patent/MX2017015961A/es active IP Right Grant
- 2016-06-08 ME MEP-2019-99A patent/ME03379B/me unknown
- 2016-06-08 BR BR112017026272-0A patent/BR112017026272B1/pt active IP Right Grant
- 2016-06-08 PL PL16738860T patent/PL3303331T3/pl unknown
- 2016-06-08 HU HUE16738860 patent/HUE044902T2/hu unknown
- 2016-06-08 AU AU2016276139A patent/AU2016276139B2/en active Active
- 2016-06-08 ES ES16738860T patent/ES2719626T3/es active Active
- 2016-06-08 DK DK16738860.2T patent/DK3303331T3/en active
- 2016-06-08 CN CN201680040849.9A patent/CN107922400B/zh active Active
- 2016-06-08 JP JP2017563539A patent/JP6466602B2/ja active Active
- 2016-06-08 LT LTEP16738860.2T patent/LT3303331T/lt unknown
- 2016-06-08 EA EA201792594A patent/EA032602B1/ru unknown
- 2016-06-08 NZ NZ737892A patent/NZ737892A/en unknown
- 2016-06-08 KR KR1020187000574A patent/KR102052058B1/ko active IP Right Grant
- 2016-06-08 MA MA43913A patent/MA43913B1/fr unknown
- 2016-06-08 SI SI201630220T patent/SI3303331T1/sl unknown
-
2017
- 2017-11-29 IL IL255994A patent/IL255994B/en active IP Right Grant
- 2017-11-29 ZA ZA2017/08108A patent/ZA201708108B/en unknown
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2018
- 2018-06-05 HK HK18107344.8A patent/HK1247919A1/zh unknown
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2019
- 2019-04-01 HR HRP20190624TT patent/HRP20190624T1/hr unknown
- 2019-04-05 CY CY20191100379T patent/CY1121693T1/el unknown
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/06/2016, OBSERVADAS AS CONDICOES LEGAIS |