CY1120273T1 - Συνθεσεις και μεθοδοι για την τροποποιηση φαρνεσοειδων υποδοχεων χ - Google Patents

Συνθεσεις και μεθοδοι για την τροποποιηση φαρνεσοειδων υποδοχεων χ

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Publication number
CY1120273T1
CY1120273T1 CY20181100557T CY181100557T CY1120273T1 CY 1120273 T1 CY1120273 T1 CY 1120273T1 CY 20181100557 T CY20181100557 T CY 20181100557T CY 181100557 T CY181100557 T CY 181100557T CY 1120273 T1 CY1120273 T1 CY 1120273T1
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CY
Cyprus
Prior art keywords
compositions
holdings
modifying
methods
stereoisomer
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Application number
CY20181100557T
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English (en)
Inventor
David Tully
Donatella Chianelli
Xiaodong Liu
Valentina Molteni
John Nelson
Jason ROLAND
Paul Rucker
Original Assignee
Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51982773&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120273(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1120273T1 publication Critical patent/CY1120273T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με ενώσεις του Τύπου I, ένα στερεοϊσομερές, ένα εναντιομερές, ένα φαρμακευτικώς αποδεκτό άλας ή ένα συζυγές αμινοξύ αυτών, όπου οι μεταβλητές είναι όπως ορίζονται στο παρόν, και οι φαρμακευτικές συνθέσεις αυτών, οι οποίες είναι χρήσιμες ως διαμορφωτές της δραστικότητας των φαρνεσοειδών υποδοχέων Χ (FXR).
CY20181100557T 2013-11-05 2018-05-24 Συνθεσεις και μεθοδοι για την τροποποιηση φαρνεσοειδων υποδοχεων χ CY1120273T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361900013P 2013-11-05 2013-11-05
PCT/US2014/063948 WO2015069666A1 (en) 2013-11-05 2014-11-04 Compositions and methods for modulating farnesoid x receptors

Publications (1)

Publication Number Publication Date
CY1120273T1 true CY1120273T1 (el) 2019-07-10

Family

ID=51982773

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Country Status (42)

Country Link
US (5) US9682939B2 (el)
EP (1) EP3065738B1 (el)
JP (1) JP6424231B2 (el)
KR (1) KR102350357B1 (el)
CN (1) CN105682656B (el)
AP (1) AP2016009165A0 (el)
AR (1) AR098316A1 (el)
AU (1) AU2014346919B2 (el)
BR (1) BR112016009630B1 (el)
CA (1) CA2927705C (el)
CL (1) CL2016000982A1 (el)
CR (1) CR20160212A (el)
CU (1) CU24375B1 (el)
CY (1) CY1120273T1 (el)
DK (1) DK3065738T3 (el)
EA (1) EA030430B1 (el)
ES (1) ES2670984T3 (el)
GT (1) GT201600085A (el)
HR (1) HRP20180817T1 (el)
HU (1) HUE039155T2 (el)
IL (1) IL245242B (el)
JO (1) JO3454B1 (el)
LT (1) LT3065738T (el)
MA (1) MA39088B1 (el)
MX (1) MX364834B (el)
MY (1) MY175903A (el)
NO (1) NO3105103T3 (el)
NZ (1) NZ719078A (el)
PE (1) PE20160682A1 (el)
PH (1) PH12016500777A1 (el)
PL (1) PL3065738T3 (el)
PT (1) PT3065738T (el)
RS (1) RS57179B1 (el)
SG (1) SG11201603026PA (el)
SI (1) SI3065738T1 (el)
SV (1) SV2016005192A (el)
TN (1) TN2016000143A1 (el)
TR (1) TR201807321T4 (el)
TW (1) TWI662027B (el)
UY (1) UY35818A (el)
WO (1) WO2015069666A1 (el)
ZA (1) ZA201602555B (el)

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HRP20180817T1 (hr) 2018-06-29
JP2016535784A (ja) 2016-11-17
ZA201602555B (en) 2017-06-28
US20190062283A1 (en) 2019-02-28
IL245242B (en) 2019-03-31
LT3065738T (lt) 2018-05-10
CA2927705C (en) 2021-09-21
CN105682656A (zh) 2016-06-15
US20210253534A1 (en) 2021-08-19
KR20160079091A (ko) 2016-07-05
ES2670984T3 (es) 2018-06-04
UY35818A (es) 2015-05-29
PL3065738T3 (pl) 2018-07-31
PE20160682A1 (es) 2016-07-23
BR112016009630B1 (pt) 2021-02-09
CU20160063A7 (es) 2016-09-30
TR201807321T4 (tr) 2018-06-21
EP3065738A1 (en) 2016-09-14
US20160340317A1 (en) 2016-11-24
TW201612163A (en) 2016-04-01
AU2014346919B2 (en) 2017-02-02
US10683271B2 (en) 2020-06-16
PH12016500777B1 (en) 2016-05-30
MX2016005865A (es) 2016-07-13
KR102350357B1 (ko) 2022-01-14
JO3454B1 (ar) 2020-07-05
IL245242A0 (en) 2016-06-30
WO2015069666A1 (en) 2015-05-14
AP2016009165A0 (en) 2016-04-30
MA39088B1 (fr) 2018-06-29
MY175903A (en) 2020-07-15
TWI662027B (zh) 2019-06-11
HUE039155T2 (hu) 2018-12-28
EP3065738B1 (en) 2018-02-28
NZ719078A (en) 2018-07-27
DK3065738T3 (en) 2018-06-06
PH12016500777A1 (en) 2016-05-30
JP6424231B2 (ja) 2018-11-14
US9682939B2 (en) 2017-06-20
CU24375B1 (es) 2018-12-05
PT3065738T (pt) 2018-06-04
US20200247757A1 (en) 2020-08-06
BR112016009630A8 (pt) 2020-04-07
RS57179B1 (sr) 2018-07-31
MX364834B (es) 2019-05-08
NO3105103T3 (el) 2018-05-12
AU2014346919A1 (en) 2016-05-12
EA030430B1 (ru) 2018-08-31
CN105682656B (zh) 2019-11-05
AR098316A1 (es) 2016-05-26
EA201690930A1 (ru) 2016-08-31
MA39088A1 (fr) 2017-07-31
US10077240B2 (en) 2018-09-18
CL2016000982A1 (es) 2016-10-07
SV2016005192A (es) 2016-11-21
US20170275256A1 (en) 2017-09-28
SI3065738T1 (en) 2018-06-29
CA2927705A1 (en) 2015-05-14
SG11201603026PA (en) 2016-05-30
US11021446B2 (en) 2021-06-01
GT201600085A (es) 2019-07-19
CR20160212A (es) 2016-07-22
TN2016000143A1 (en) 2017-10-06

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