MA53388A - Inhibiteurs d'inflammasome nlrp3 - Google Patents

Inhibiteurs d'inflammasome nlrp3

Info

Publication number
MA53388A
MA53388A MA053388A MA53388A MA53388A MA 53388 A MA53388 A MA 53388A MA 053388 A MA053388 A MA 053388A MA 53388 A MA53388 A MA 53388A MA 53388 A MA53388 A MA 53388A
Authority
MA
Morocco
Prior art keywords
inflammasome
nlrp3 inhibitors
nlrp3
inhibitors
Prior art date
Application number
MA053388A
Other languages
English (en)
Inventor
Christopher Farady
Nina Gommermann
Philipp Janser
Angela Mackay
Henri Mattes
Nikolaus Johannes Stiefl
Juraj Velcicky
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA53388A publication Critical patent/MA53388A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/612Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA053388A 2018-07-25 2019-07-23 Inhibiteurs d'inflammasome nlrp3 MA53388A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18185580 2018-07-25
EP19175246 2019-05-17

Publications (1)

Publication Number Publication Date
MA53388A true MA53388A (fr) 2021-06-02

Family

ID=67989037

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053388A MA53388A (fr) 2018-07-25 2019-07-23 Inhibiteurs d'inflammasome nlrp3

Country Status (21)

Country Link
US (1) US20210308140A1 (fr)
EP (1) EP3827008B1 (fr)
KR (1) KR20210038877A (fr)
CN (1) CN112424207B (fr)
AU (1) AU2019309727B2 (fr)
BR (1) BR112021000964A2 (fr)
CA (1) CA3103943A1 (fr)
CL (1) CL2021000191A1 (fr)
CO (1) CO2021000537A2 (fr)
CR (1) CR20210045A (fr)
CU (1) CU20210009A7 (fr)
DO (1) DOP2021000019A (fr)
EC (1) ECSP21004787A (fr)
IL (1) IL280336A (fr)
JO (1) JOP20210017A1 (fr)
MA (1) MA53388A (fr)
MX (1) MX2021000925A (fr)
PE (1) PE20210406A1 (fr)
PH (1) PH12021550166A1 (fr)
SG (1) SG11202012321PA (fr)
WO (1) WO2020021447A1 (fr)

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WO2021209539A1 (fr) 2020-04-15 2021-10-21 Janssen Pharmaceutica Nv Pyrrolo[1,2-d][1,2,4]triazine-2-yl-acétamides utilisés en tant qu'inhibiteurs de la voie de l'inflammasome nlrp3
EP4139312A1 (fr) 2020-04-23 2023-03-01 JANSSEN Pharmaceutica NV Composés tricycliques en tant qu'inhibiteurs de nlrp3
CN115485280A (zh) 2020-04-30 2022-12-16 詹森药业有限公司 新三嗪并吲哚化合物
US20230202989A1 (en) 2020-05-28 2023-06-29 Janssen Pharmaceutica Nv Compounds
BR112022025612A2 (pt) 2020-06-19 2023-01-17 Ac Immune Sa Derivados de di-hidro-oxazol e tioureia modulando a via do inflamassoma nlrp3
IL300289A (en) * 2020-08-14 2023-04-01 Denali Therapeutics Inc Compounds, preparations and methods
EP3974415A1 (fr) 2020-09-24 2022-03-30 Janssen Pharmaceutica NV Nouveaux composés
WO2022063896A1 (fr) 2020-09-24 2022-03-31 Janssen Pharmaceutica Nv Nouveaux composés
CN114478537B (zh) * 2020-11-13 2024-02-02 上海拓界生物医药科技有限公司 环酰胺并环化合物及其医药用途
US20240174670A1 (en) 2021-03-04 2024-05-30 Janssen Pharmaceutica Nv 4-amino-6-oxo-pyridazine derivatives modulating nlrp3
MX2023010310A (es) 2021-03-04 2023-09-12 Janssen Pharmaceutica Nv Derivados de 4-alcoxi-6-oxo-piridazina que modulan nlrp3.
CN113230240B (zh) * 2021-03-22 2022-12-27 广州医科大学 1,3-二苯基丙-2-烯-1-酮衍生物及其应用
AU2022258327A1 (en) * 2021-04-13 2023-11-23 Unity Biotechnology, Inc. Methods of treating retinal vasculopathies
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
WO2022229315A1 (fr) * 2021-04-29 2022-11-03 Janssen Pharmaceutica Nv Dérivés de phtalazinone en tant qu'inhibiteurs d'inflammation de nlrp3
IL294231A (en) 2021-06-23 2023-01-01 Yoda Pharmaceuticals Inc History of benzimidazole for the treatment and/or prevention of nlrp3-mediated diseases and disorders
KR20240029027A (ko) 2021-07-01 2024-03-05 얀센 파마슈티카 엔브이 5-옥소-피리도[2,3-d]피리다진-6(5H)-일 아세트아미드
WO2023028536A1 (fr) * 2021-08-25 2023-03-02 Ptc Therapeutics, Inc. Dérivés de 1, 2, 4-triazine utiles en tant qu'inhibiteurs de nlrp3
EP4401739A1 (fr) * 2021-09-17 2024-07-24 Nico Therapeutics, Inc. Composés, compositions et procédés
KR20230066899A (ko) 2021-11-08 2023-05-16 제일약품주식회사 Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물
WO2023118521A1 (fr) 2021-12-22 2023-06-29 Ac Immune Sa Composés dérivés de dihydro-oxazol
WO2023156643A1 (fr) * 2022-02-21 2023-08-24 Sanofi Composés thiénopyrrolotriazine, leur préparation et leur utilisation thérapeutique
US20240034735A1 (en) 2022-07-14 2024-02-01 Ac Immune Sa Novel compounds
US20240101563A1 (en) 2022-07-28 2024-03-28 Ac Immune Sa Novel compounds
TW202417456A (zh) * 2022-08-10 2024-05-01 日商武田藥品工業股份有限公司 雜環化合物
KR20240022938A (ko) 2022-08-12 2024-02-20 제일약품주식회사 Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물
TW202421626A (zh) 2022-09-23 2024-06-01 美商默沙東有限責任公司 衍生物

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Also Published As

Publication number Publication date
SG11202012321PA (en) 2021-02-25
MX2021000925A (es) 2021-03-31
CL2021000191A1 (es) 2021-08-20
JP2021532124A (ja) 2021-11-25
CO2021000537A2 (es) 2021-01-29
EP3827008B1 (fr) 2024-07-31
ECSP21004787A (es) 2021-03-31
CA3103943A1 (fr) 2020-01-30
IL280336A (en) 2021-03-01
DOP2021000019A (es) 2021-02-15
PE20210406A1 (es) 2021-03-02
AU2019309727A1 (en) 2021-01-07
AU2019309727B2 (en) 2021-12-23
WO2020021447A1 (fr) 2020-01-30
JOP20210017A1 (ar) 2021-01-21
CU20210009A7 (es) 2021-08-06
EP3827008A1 (fr) 2021-06-02
CN112424207B (zh) 2024-03-19
CN112424207A (zh) 2021-02-26
PH12021550166A1 (en) 2021-09-13
US20210308140A1 (en) 2021-10-07
BR112021000964A2 (pt) 2021-04-20
CR20210045A (es) 2021-06-18
KR20210038877A (ko) 2021-04-08

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