DK3746446T3 - PRC2-inhibitorer - Google Patents
PRC2-inhibitorer Download PDFInfo
- Publication number
- DK3746446T3 DK3746446T3 DK19710816.0T DK19710816T DK3746446T3 DK 3746446 T3 DK3746446 T3 DK 3746446T3 DK 19710816 T DK19710816 T DK 19710816T DK 3746446 T3 DK3746446 T3 DK 3746446T3
- Authority
- DK
- Denmark
- Prior art keywords
- prc2
- inhibitors
- prc2 inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862624176P | 2018-01-31 | 2018-01-31 | |
| US201862672701P | 2018-05-17 | 2018-05-17 | |
| US201862747736P | 2018-10-19 | 2018-10-19 | |
| PCT/US2019/015677 WO2019152419A1 (en) | 2018-01-31 | 2019-01-29 | Prc2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3746446T3 true DK3746446T3 (da) | 2022-06-27 |
Family
ID=65763738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19710816.0T DK3746446T3 (da) | 2018-01-31 | 2019-01-29 | PRC2-inhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US11485738B2 (da) |
| EP (2) | EP3746446B1 (da) |
| JP (3) | JP7025556B2 (da) |
| KR (2) | KR102451529B1 (da) |
| CN (1) | CN112004816B (da) |
| AU (2) | AU2019214861B2 (da) |
| BR (1) | BR112020015583B1 (da) |
| CA (1) | CA3089639C (da) |
| DK (1) | DK3746446T3 (da) |
| ES (1) | ES2923290T3 (da) |
| HU (1) | HUE059536T2 (da) |
| IL (2) | IL276156B (da) |
| MX (2) | MX2020007974A (da) |
| NZ (1) | NZ766447A (da) |
| PL (1) | PL3746446T3 (da) |
| PT (1) | PT3746446T (da) |
| WO (1) | WO2019152419A1 (da) |
| ZA (2) | ZA202004453B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112004816B (zh) * | 2018-01-31 | 2024-01-05 | 米拉蒂医疗股份有限公司 | Prc2抑制剂 |
| CA3120791A1 (en) * | 2018-11-30 | 2020-06-04 | Tuojie Biotech (Shanghai) Co., Ltd. | Pyrimidine and five-membered nitrogen heterocycle derivative, preparation method therefor, and medical uses thereof |
| EP3980422A1 (en) * | 2019-06-05 | 2022-04-13 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer |
| CN112409385A (zh) * | 2019-08-22 | 2021-02-26 | 上海青煜医药科技有限公司 | 氮杂芳基化合物及其应用 |
| CN113004233B (zh) * | 2019-12-18 | 2022-12-20 | 南京优氟医药科技有限公司 | 一种用于制备prc2抑制剂的化合物、其制备方法和用途 |
| WO2023049724A1 (en) * | 2021-09-24 | 2023-03-30 | Oric Pharmaceuticals, Inc. | Prc2 inhibitors for use in treating blood disorders |
| WO2024059607A1 (en) * | 2022-09-14 | 2024-03-21 | Oric Pharmaceuticals, Inc. | Physical forms of an inhibitor of prc2 |
| GB202216323D0 (en) | 2022-11-02 | 2022-12-14 | Cerevance Ltd | Novel compounds |
| WO2024123669A1 (en) * | 2022-12-05 | 2024-06-13 | Oric Pharmaceuticals, Inc. | Treatment of prostate cancer having androgen receptor variants |
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| SI2566327T1 (sl) | 2010-05-07 | 2017-07-31 | Glaxosmithkline Llc | Indoli |
| WO2011140325A1 (en) | 2010-05-07 | 2011-11-10 | Glaxosmithkline Llc | Indazoles |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| WO2012068589A2 (en) | 2010-11-19 | 2012-05-24 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
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| JP2014511389A (ja) | 2011-02-28 | 2014-05-15 | エピザイム インコーポレイテッド | 置換６，５−縮合二環式ヘテロアリール化合物 |
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
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| WO2012154760A1 (en) | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Fused heterocyclic compounds as sodium channel modulators |
| BR112014007603A2 (pt) | 2011-09-30 | 2017-06-13 | Glaxosmithkline Llc | métodos de tratamento do câncer |
| CA2853501A1 (en) | 2011-10-27 | 2013-05-02 | Memorial Sloan-Kettering Cancer Center | Methyltransferase inhibitors for treating cancer |
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| EP2780013A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| US9085583B2 (en) | 2012-02-10 | 2015-07-21 | Constellation—Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
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| US9562041B2 (en) | 2012-05-16 | 2017-02-07 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
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| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
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| JP2016523955A (ja) | 2013-07-10 | 2016-08-12 | グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｎｏ．２ Ｌｉｍｉｔｅｄ | Ｚｅｓｔｅホモログ２エンハンサー阻害剤 |
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| WO2015077193A1 (en) | 2013-11-19 | 2015-05-28 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
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| BR112016020621B1 (pt) | 2014-03-17 | 2022-06-07 | Daiichi Sankyo Company, Limited | Composto, composição farmacêutica, inibidor de atividade da enzima ezh1 e/ou ezh2, agente terapêutico para tumores, e, agente antitumor |
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| CN109942556A (zh) | 2017-12-21 | 2019-06-28 | 上海青煜医药科技有限公司 | 嘧啶酮化合物及其应用 |
| CN112004816B (zh) | 2018-01-31 | 2024-01-05 | 米拉蒂医疗股份有限公司 | Prc2抑制剂 |
| CN110156787B (zh) | 2018-02-13 | 2021-11-02 | 中国科学院上海药物研究所 | 一种三氮唑并嘧啶衍生化合物、包含其的药物组合物及其用途 |
| CN110563722A (zh) | 2018-06-06 | 2019-12-13 | 上海青煜医药科技有限公司 | 吡啶或哒嗪并环化合物及其应用 |
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| EP3980422A1 (en) | 2019-06-05 | 2022-04-13 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer |
-
2019
- 2019-01-29 CN CN201980011176.8A patent/CN112004816B/zh active Active
- 2019-01-29 PL PL19710816.0T patent/PL3746446T3/pl unknown
- 2019-01-29 MX MX2020007974A patent/MX2020007974A/es unknown
- 2019-01-29 US US16/966,708 patent/US11485738B2/en active Active
- 2019-01-29 DK DK19710816.0T patent/DK3746446T3/da active
- 2019-01-29 WO PCT/US2019/015677 patent/WO2019152419A1/en active Application Filing
- 2019-01-29 BR BR112020015583-7A patent/BR112020015583B1/pt active IP Right Grant
- 2019-01-29 EP EP19710816.0A patent/EP3746446B1/en active Active
- 2019-01-29 CA CA3089639A patent/CA3089639C/en active Active
- 2019-01-29 EP EP22165237.3A patent/EP4043466A1/en active Pending
- 2019-01-29 KR KR1020207024436A patent/KR102451529B1/ko active IP Right Grant
- 2019-01-29 HU HUE19710816A patent/HUE059536T2/hu unknown
- 2019-01-29 AU AU2019214861A patent/AU2019214861B2/en active Active
- 2019-01-29 ES ES19710816T patent/ES2923290T3/es active Active
- 2019-01-29 PT PT197108160T patent/PT3746446T/pt unknown
- 2019-01-29 NZ NZ766447A patent/NZ766447A/en unknown
- 2019-01-29 KR KR1020227034197A patent/KR20220139439A/ko not_active Application Discontinuation
- 2019-01-29 JP JP2020541557A patent/JP7025556B2/ja active Active
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2020
- 2020-07-20 ZA ZA2020/04453A patent/ZA202004453B/en unknown
- 2020-07-20 IL IL276156A patent/IL276156B/en unknown
- 2020-07-29 MX MX2021012501A patent/MX2021012501A/es unknown
- 2020-12-09 US US17/116,270 patent/US11091495B2/en active Active
-
2021
- 2021-03-31 US US17/219,379 patent/US11220509B2/en active Active
- 2021-08-04 IL IL285354A patent/IL285354B/en unknown
- 2021-10-13 ZA ZA2021/07835A patent/ZA202107835B/en unknown
- 2021-11-12 AU AU2021266351A patent/AU2021266351B2/en active Active
-
2022
- 2022-02-10 JP JP2022019319A patent/JP7288527B2/ja active Active
- 2022-08-26 US US17/822,667 patent/US20230137025A1/en active Pending
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2023
- 2023-05-26 JP JP2023086866A patent/JP7495555B2/ja active Active
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