DK3720840T3 - Cathepsinhæmmere - Google Patents

Cathepsinhæmmere Download PDF

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Publication number
DK3720840T3
DK3720840T3 DK18839759.0T DK18839759T DK3720840T3 DK 3720840 T3 DK3720840 T3 DK 3720840T3 DK 18839759 T DK18839759 T DK 18839759T DK 3720840 T3 DK3720840 T3 DK 3720840T3
Authority
DK
Denmark
Prior art keywords
catheps
inhibitors
catheps inhibitors
Prior art date
Application number
DK18839759.0T
Other languages
English (en)
Inventor
Huib Ovaa
Maria Wilhelmina Elisabeth Mons
Boeckel Stan Van
Original Assignee
Academisch Ziekenhuis Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL2020021A external-priority patent/NL2020021B1/en
Application filed by Academisch Ziekenhuis Leiden filed Critical Academisch Ziekenhuis Leiden
Application granted granted Critical
Publication of DK3720840T3 publication Critical patent/DK3720840T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/14Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK18839759.0T 2017-12-05 2018-12-05 Cathepsinhæmmere DK3720840T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2020021A NL2020021B1 (en) 2017-12-05 2017-12-05 Cathepsin inhibitors
NL2021544 2018-09-03
PCT/NL2018/050810 WO2019112426A1 (en) 2017-12-05 2018-12-05 Cathepsin inhibitors

Publications (1)

Publication Number Publication Date
DK3720840T3 true DK3720840T3 (da) 2022-03-21

Family

ID=65228614

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18839759.0T DK3720840T3 (da) 2017-12-05 2018-12-05 Cathepsinhæmmere

Country Status (5)

Country Link
US (3) US11174224B2 (da)
EP (2) EP4046987A1 (da)
DK (1) DK3720840T3 (da)
ES (1) ES2908999T3 (da)
WO (1) WO2019112426A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4046987A1 (en) * 2017-12-05 2022-08-24 Academisch Ziekenhuis Leiden (h.o.d.n. LUMC) Cathepsin inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002145849A (ja) * 2000-11-10 2002-05-22 Kyorin Pharmaceut Co Ltd アルキニルアミノ酸誘導体及びその製造法
PT1482924E (pt) 2002-03-05 2008-08-27 Axys Pharm Inc Inibidores de proteases da cisteína catepsina
EP4046987A1 (en) * 2017-12-05 2022-08-24 Academisch Ziekenhuis Leiden (h.o.d.n. LUMC) Cathepsin inhibitors

Also Published As

Publication number Publication date
EP3720840A1 (en) 2020-10-14
US20240182409A1 (en) 2024-06-06
ES2908999T3 (es) 2022-05-04
EP3720840B1 (en) 2022-01-19
EP4046987A1 (en) 2022-08-24
US11820734B2 (en) 2023-11-21
WO2019112426A1 (en) 2019-06-13
US11174224B2 (en) 2021-11-16
US20220227705A1 (en) 2022-07-21
US20200385341A1 (en) 2020-12-10

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