DK3681884T3 - Rad51-inhibitorer - Google Patents
Rad51-inhibitorer Download PDFInfo
- Publication number
- DK3681884T3 DK3681884T3 DK18782257.2T DK18782257T DK3681884T3 DK 3681884 T3 DK3681884 T3 DK 3681884T3 DK 18782257 T DK18782257 T DK 18782257T DK 3681884 T3 DK3681884 T3 DK 3681884T3
- Authority
- DK
- Denmark
- Prior art keywords
- rad51 inhibitors
- rad51
- inhibitors
- Prior art date
Links
- 102000001195 RAD51 Human genes 0.000 title 1
- 108010068097 Rad51 Recombinase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762556763P | 2017-09-11 | 2017-09-11 | |
| US201862711959P | 2018-07-30 | 2018-07-30 | |
| PCT/US2018/050391 WO2019051465A1 (en) | 2017-09-11 | 2018-09-11 | RAD51 INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3681884T3 true DK3681884T3 (da) | 2022-08-22 |
Family
ID=63722779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18782257.2T DK3681884T3 (da) | 2017-09-11 | 2018-09-11 | Rad51-inhibitorer |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10590122B2 (da) |
| EP (2) | EP3681884B1 (da) |
| JP (1) | JP7265537B2 (da) |
| KR (1) | KR20200105808A (da) |
| CN (1) | CN111542521B (da) |
| AU (1) | AU2018328818C1 (da) |
| BR (1) | BR112020004828A2 (da) |
| CA (1) | CA3075062A1 (da) |
| DK (1) | DK3681884T3 (da) |
| ES (1) | ES2925218T3 (da) |
| HU (1) | HUE059969T2 (da) |
| IL (2) | IL273156B (da) |
| MX (2) | MX2020002745A (da) |
| PH (1) | PH12020550079A1 (da) |
| PL (1) | PL3681884T3 (da) |
| PT (1) | PT3681884T (da) |
| SG (2) | SG10202107087YA (da) |
| SI (1) | SI3681884T1 (da) |
| TW (1) | TWI791608B (da) |
| WO (1) | WO2019051465A1 (da) |
| ZA (1) | ZA202104029B (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111263756B (zh) | 2017-07-11 | 2023-05-16 | 赛泰尔治疗公司 | Rad51抑制剂 |
| SG10202107087YA (en) | 2017-09-11 | 2021-07-29 | Cyteir Therapeutics Inc | Rad51 inhibitors |
| CN114072390A (zh) | 2019-03-12 | 2022-02-18 | 赛泰尔治疗公司 | Rad51 抑制剂 |
| WO2020198298A1 (en) | 2019-03-25 | 2020-10-01 | Cyteir Therapeutics, Inc. | Combinations of rad51 and parp inhibitors |
| CA3143716A1 (en) * | 2019-06-21 | 2020-12-24 | Cyteir Therapeutics, Inc. | Methods of using rad51 inhibitors for treatment of pancreatic cancer |
| EP4108663A1 (en) | 2020-02-19 | 2022-12-28 | Simcere Pharmaceutical Co., Ltd. | Substituted aryl compound |
| JP2023517884A (ja) * | 2020-03-03 | 2023-04-27 | サイティアー セラピューティクス，インコーポレイティド | 癌を治療するための特定の投薬量でのｒａｄ５１阻害剤化合物６７ａ（２３０１０８５－０６－１） |
| JP2022151436A (ja) * | 2021-03-26 | 2022-10-07 | 均 石井 | 髄膜炎と脳炎の治療薬。 |
| WO2023078271A1 (zh) * | 2021-11-02 | 2023-05-11 | 上海旭成医药科技有限公司 | 芳香化合物、其制备方法、中间体、药物组合物和应用 |
| CN116196314B (zh) * | 2023-05-04 | 2023-08-15 | 广州市妇女儿童医疗中心 | Ri-1或其盐在制备防治胃肠道疾病的药物中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| DK0834576T3 (da) | 1990-12-06 | 2002-04-22 | Affymetrix Inc A Delaware Corp | Påvisning af nukleinsyresekvenser |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US6309823B1 (en) | 1993-10-26 | 2001-10-30 | Affymetrix, Inc. | Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same |
| GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
| JP2010514777A (ja) | 2006-12-26 | 2010-05-06 | ファーマサイクリックス，インク． | 併用療法においてヒストンデアセチラーゼ阻害剤を使用し、バイオマーカーをモニタする方法 |
| SG181803A1 (en) | 2009-12-17 | 2012-07-30 | Merck Sharp & Dohme | Aminopyrimidines as syk inhibitors |
| US10912761B2 (en) * | 2012-11-30 | 2021-02-09 | The University Of Chicago | Methods and compositions involving RAD51 inhibitors |
| TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
| WO2016140971A1 (en) * | 2015-03-02 | 2016-09-09 | The Regents Of The University Of California | Novel rad51 inhibitors and uses thereof |
| WO2016196955A1 (en) | 2015-06-04 | 2016-12-08 | Drexel University | Inhibitors of RAD52 Recombination Protein and Methods Using Same |
| CN111263756B (zh) | 2017-07-11 | 2023-05-16 | 赛泰尔治疗公司 | Rad51抑制剂 |
| SG10202107087YA (en) * | 2017-09-11 | 2021-07-29 | Cyteir Therapeutics Inc | Rad51 inhibitors |
| CN114072390A (zh) | 2019-03-12 | 2022-02-18 | 赛泰尔治疗公司 | Rad51 抑制剂 |
| WO2020198298A1 (en) * | 2019-03-25 | 2020-10-01 | Cyteir Therapeutics, Inc. | Combinations of rad51 and parp inhibitors |
-
2018
- 2018-09-11 SG SG10202107087YA patent/SG10202107087YA/en unknown
- 2018-09-11 MX MX2020002745A patent/MX2020002745A/es unknown
- 2018-09-11 CN CN201880072664.5A patent/CN111542521B/zh active Active
- 2018-09-11 JP JP2020514206A patent/JP7265537B2/ja active Active
- 2018-09-11 ES ES18782257T patent/ES2925218T3/es active Active
- 2018-09-11 TW TW107131953A patent/TWI791608B/zh active
- 2018-09-11 KR KR1020207010585A patent/KR20200105808A/ko not_active Application Discontinuation
- 2018-09-11 SI SI201830740T patent/SI3681884T1/sl unknown
- 2018-09-11 WO PCT/US2018/050391 patent/WO2019051465A1/en active Application Filing
- 2018-09-11 DK DK18782257.2T patent/DK3681884T3/da active
- 2018-09-11 SG SG11202002069WA patent/SG11202002069WA/en unknown
- 2018-09-11 BR BR112020004828-3A patent/BR112020004828A2/pt unknown
- 2018-09-11 US US16/127,229 patent/US10590122B2/en active Active
- 2018-09-11 CA CA3075062A patent/CA3075062A1/en active Pending
- 2018-09-11 PT PT187822572T patent/PT3681884T/pt unknown
- 2018-09-11 IL IL273156A patent/IL273156B/en unknown
- 2018-09-11 HU HUE18782257A patent/HUE059969T2/hu unknown
- 2018-09-11 EP EP18782257.2A patent/EP3681884B1/en active Active
- 2018-09-11 AU AU2018328818A patent/AU2018328818C1/en active Active
- 2018-09-11 PL PL18782257.2T patent/PL3681884T3/pl unknown
- 2018-09-11 IL IL293332A patent/IL293332B2/en unknown
- 2018-09-11 EP EP22175891.5A patent/EP4112616A1/en active Pending
- 2018-12-31 US US16/236,894 patent/US10336746B1/en active Active
-
2020
- 2020-01-06 US US16/734,566 patent/US11084812B2/en active Active
- 2020-03-06 PH PH12020550079A patent/PH12020550079A1/en unknown
- 2020-03-11 MX MX2023004221A patent/MX2023004221A/es unknown
-
2021
- 2021-06-11 ZA ZA2021/04029A patent/ZA202104029B/en unknown
- 2021-06-30 US US17/363,099 patent/US20220056022A1/en active Pending
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