MA53287A - Inhibiteurs de prmt5 - Google Patents

Inhibiteurs de prmt5

Info

Publication number
MA53287A
MA53287A MA053287A MA53287A MA53287A MA 53287 A MA53287 A MA 53287A MA 053287 A MA053287 A MA 053287A MA 53287 A MA53287 A MA 53287A MA 53287 A MA53287 A MA 53287A
Authority
MA
Morocco
Prior art keywords
prmt5 inhibitors
prmt5
inhibitors
Prior art date
Application number
MA053287A
Other languages
English (en)
Inventor
David A Candito
Patrick S Fier
Craig Gibeau
Timothy J Henderson
Chunhui Huang
Jonathan M E Hughes
Shuhei Kawamura
Michelle Machacek
Jean-Laurent Paparin
Ryan Quiroz
Houcine Rahali
Michael H Reutershan
Sulagna Sanyal
Sebastian Schneider
Phieng Siliphaivanh
Steven M Silverman
David L Sloman
Murray Wan
David Witter
Yingchun Ye
Charles S Yeung
Original Assignee
Merck Sharp & Dohme
Msd Int Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Msd Int Gmbh filed Critical Merck Sharp & Dohme
Publication of MA53287A publication Critical patent/MA53287A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA053287A 2018-08-07 2019-08-05 Inhibiteurs de prmt5 MA53287A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862715446P 2018-08-07 2018-08-07
US201962792623P 2019-01-15 2019-01-15
US201962859490P 2019-06-10 2019-06-10

Publications (1)

Publication Number Publication Date
MA53287A true MA53287A (fr) 2022-05-11

Family

ID=69414248

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053287A MA53287A (fr) 2018-08-07 2019-08-05 Inhibiteurs de prmt5

Country Status (11)

Country Link
US (1) US20220363707A1 (fr)
EP (1) EP3833355A4 (fr)
JP (1) JP7446282B2 (fr)
KR (1) KR20210046009A (fr)
CN (1) CN112805006A (fr)
AU (1) AU2019317549A1 (fr)
BR (1) BR112021002267A8 (fr)
CA (1) CA3108388A1 (fr)
MA (1) MA53287A (fr)
MX (1) MX2021001486A (fr)
WO (1) WO2020033288A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020081257A1 (fr) 2018-10-05 2020-04-23 Vertex Pharmaceuticals Incorporated Modulateurs de l'alpha -1 antitrypsine
US11198699B2 (en) 2019-04-02 2021-12-14 Aligos Therapeutics, Inc. Compounds targeting PRMT5
UY38696A (es) 2019-05-14 2020-11-30 Vertex Pharma Moduladores de alfa-1 antitripsina
CN114126614A (zh) * 2019-05-30 2022-03-01 安杰斯制药公司 作为prmt5抑制剂的杂环化合物
EP4069698A1 (fr) 2019-12-03 2022-10-12 Lupin Limited Analogues nucléosidiques substitués en tant qu'inhibiteurs de prmt5
US20220112194A1 (en) * 2020-04-01 2022-04-14 Aligos Therapeutics, Inc. Compounds targeting prmt5
CN115697969A (zh) * 2020-04-03 2023-02-03 弗特克斯药品有限公司 作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1抗胰蛋白酶调节剂的7-或8-羟基-异喹啉和7-或8-羟基-喹啉衍生物
WO2023001133A1 (fr) * 2021-07-20 2023-01-26 上海齐鲁制药研究中心有限公司 Inhibiteur de prmt5
WO2023017152A1 (fr) 2021-08-13 2023-02-16 Albert-Ludwigs-Universität Freiburg Inhibiteurs à petites molécules spécifiques qui bloquent l'activité et la fonction de la méthyltransférase kmt9
CN116655638B (zh) * 2022-05-12 2024-01-26 上海齐鲁制药研究中心有限公司 氘代prmt5抑制剂
TW202406908A (zh) * 2022-08-09 2024-02-16 大陸商上海湃隆生物科技有限公司 新型prmt5抑制劑及其應用
WO2024101965A1 (fr) * 2022-11-10 2024-05-16 에스케이바이오팜 주식회사 Combinaison pharmaceutique d'inhibiteur de prmt5 et de substance induisant des dommages à l'adn

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5721275B2 (ja) * 2009-04-22 2015-05-20 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエス シーアール， ブイ．ブイ．アイ． 治療的使用のための新規７−デアザプリンヌクレオシド
WO2012170347A1 (fr) * 2011-06-09 2012-12-13 Isis Pharmaceuticals, Inc. Nucléosides bicycliques et composés oligomères préparés à partir de ceux-ci
US20170198006A1 (en) * 2014-06-25 2017-07-13 Epizyme, Inc. Prmt5 inhibitors and uses thereof
TW202321249A (zh) * 2015-08-26 2023-06-01 比利時商健生藥品公司 使用作為ｐｒｍｔ５抑制劑之新穎經６－６雙環芳香環取代之核苷類似物
CN105837573B (zh) * 2016-03-28 2018-07-27 江西青峰药业有限公司 一种9-[3a,6-二羟基六氢-1H-环戊二烯并[c]呋喃-4-基]鸟嘌呤的制备方法
WO2018065365A1 (fr) 2016-10-03 2018-04-12 Janssen Pharmaceutica Nv Nouveaux analogues de carbanucléoside substitués par un système cyclique, monocyclique et bicyclique destinés à être utilisés en tant qu'inhibiteurs de prmt5
MX2020001598A (es) 2017-08-09 2020-10-28 Prelude Therapeutics Inc Inhibidores selectivos de proteína arginina metiltransferasa 5 (prmt5).

Also Published As

Publication number Publication date
WO2020033288A1 (fr) 2020-02-13
CA3108388A1 (fr) 2020-02-13
JP2022501316A (ja) 2022-01-06
US20220363707A1 (en) 2022-11-17
EP3833355A4 (fr) 2022-05-11
CN112805006A (zh) 2021-05-14
JP7446282B2 (ja) 2024-03-08
AU2019317549A1 (en) 2021-02-25
EP3833355A1 (fr) 2021-06-16
BR112021002267A8 (pt) 2023-02-07
MX2021001486A (es) 2021-07-15
KR20210046009A (ko) 2021-04-27
BR112021002267A2 (pt) 2021-05-04

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