BR112022025612A2 - Derivados de di-hidro-oxazol e tioureia modulando a via do inflamassoma nlrp3 - Google Patents

Derivados de di-hidro-oxazol e tioureia modulando a via do inflamassoma nlrp3

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Publication number
BR112022025612A2
BR112022025612A2 BR112022025612A BR112022025612A BR112022025612A2 BR 112022025612 A2 BR112022025612 A2 BR 112022025612A2 BR 112022025612 A BR112022025612 A BR 112022025612A BR 112022025612 A BR112022025612 A BR 112022025612A BR 112022025612 A2 BR112022025612 A2 BR 112022025612A2
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BR
Brazil
Prior art keywords
nlrp3
pathway
inflamasoma
oxazole
dihydro
Prior art date
Application number
BR112022025612A
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English (en)
Inventor
Gabellieri Emanuele
Molette Jérôme
Dehlinger Véronique
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Ac Immune Sa
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Filing date
Publication date
Application filed by Ac Immune Sa filed Critical Ac Immune Sa
Publication of BR112022025612A2 publication Critical patent/BR112022025612A2/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

DERIVADOS DE DI-HIDRO-OXAZOL E TIOUREIA MODULANDO A VIA DO INFLAMASSOMA NLRP3. A presente invenção se refere a compostos da fórmula (I') e (II') para o tratamento, alívio ou prevenção de doenças, distúrbios e anormalidades que respondem à modulação ou inibição da ativação de um componente da via do inflamassoma NLRP3. Em particular, o componente da via do inflamassoma é uma família de receptores semelhantes a NOD (NLR), o inflamassoma da proteína 3 contendo domínio de pirina (NLRP3). Mais particularmente, os compostos da presente invenção têm a capacidade de modular a via do inflamassoma NLRP3. Além disso, os compostos da presente invenção são adequados para o tratamento, alívio ou prevenção de doenças, distúrbios e anormalidades que respondem à modulação, em particular diminuição, dos níveis de IL-1 beta e/ou IL-18.
BR112022025612A 2020-06-19 2021-06-18 Derivados de di-hidro-oxazol e tioureia modulando a via do inflamassoma nlrp3 BR112022025612A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20181221 2020-06-19
EP21164097 2021-03-22
PCT/EP2021/066695 WO2021255279A1 (en) 2020-06-19 2021-06-18 D i h yd rooxazo le and thiourea derivatives modulating the nlrp3 inflammasome pathway

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BR112022025612A2 true BR112022025612A2 (pt) 2023-01-17

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US (1) US20230250070A1 (pt)
EP (1) EP4168395A1 (pt)
JP (1) JP2023531008A (pt)
KR (1) KR20230028425A (pt)
CN (1) CN115768754A (pt)
AU (1) AU2021291065A1 (pt)
BR (1) BR112022025612A2 (pt)
CA (1) CA3178361A1 (pt)
IL (1) IL299084A (pt)
MX (1) MX2022014709A (pt)
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MX2020001777A (es) 2017-08-15 2020-03-24 Inflazome Ltd Compuestos novedosos.
WO2019034688A1 (en) 2017-08-15 2019-02-21 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
EP3668840A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
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EP3692020A1 (en) 2017-10-03 2020-08-12 Inflazome Limited Novel compounds
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EP3707137A1 (en) 2017-11-09 2020-09-16 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019092172A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
MA50567A (fr) 2017-11-09 2020-09-16 Inflazome Ltd Nouveaux composés de sulfonamide carboxamide
CR20200588A (es) 2018-05-04 2021-06-24 Inflazome Ltd Compuestos novedosos
MA53170A (fr) 2018-07-20 2021-05-26 F Hoffmann La Roche Sa Composés de sulfonylurée en tant qu'inhibiteurs de l'activité de l'interleukine 1
BR112021001044A2 (pt) 2018-07-20 2021-04-13 F. Hoffmann-La Roche Ag Compostos de sulfonimidamida como inibidores da atividade de interleucina-1
EP3827008A1 (en) 2018-07-25 2021-06-02 Novartis AG Nlrp3 inflammasome inhibitors
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CN114302876A (zh) 2019-09-06 2022-04-08 英夫拉索姆有限公司 Nlrp3抑制剂

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MX2022014709A (es) 2022-12-16
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IL299084A (en) 2023-02-01
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