EA201590205A1 - N-алкил 2-(дизамещенные)алкиниладенозин-5-уронамиды в качестве а-агонистов - Google Patents
N-алкил 2-(дизамещенные)алкиниладенозин-5-уронамиды в качестве а-агонистовInfo
- Publication number
- EA201590205A1 EA201590205A1 EA201590205A EA201590205A EA201590205A1 EA 201590205 A1 EA201590205 A1 EA 201590205A1 EA 201590205 A EA201590205 A EA 201590205A EA 201590205 A EA201590205 A EA 201590205A EA 201590205 A1 EA201590205 A1 EA 201590205A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- uronamides
- alkyl
- agonists
- alkyniladaenosine
- dislocated
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Настоящее изобретение предлагает алкил-2-(дизамещенные)алкиниладенозин-5'-уронамиды и их производные и фармацевтические композиции, содержащие их, которые являются селективными агонистами A-аденозиновых рецепторов (AR). Эти соединения и композиции применимы в качестве фармацевтических средств.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261678605P | 2012-08-01 | 2012-08-01 | |
US201361787188P | 2013-03-15 | 2013-03-15 | |
PCT/US2013/053053 WO2014022577A1 (en) | 2012-08-01 | 2013-07-31 | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as a2a agonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201590205A1 true EA201590205A1 (ru) | 2015-06-30 |
EA027174B1 EA027174B1 (ru) | 2017-06-30 |
Family
ID=50025663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590205A EA027174B1 (ru) | 2012-08-01 | 2013-07-31 | N-алкил 2-(дизамещенные)алкиниладенозин-5-уронамиды в качестве a-агонистов |
Country Status (15)
Country | Link |
---|---|
US (1) | US9067963B2 (ru) |
EP (1) | EP2879683B1 (ru) |
JP (1) | JP6545618B2 (ru) |
KR (1) | KR20150036767A (ru) |
CN (1) | CN104582709A (ru) |
AU (1) | AU2013296420B2 (ru) |
BR (1) | BR112015002249A2 (ru) |
CA (1) | CA2880040A1 (ru) |
EA (1) | EA027174B1 (ru) |
IL (1) | IL236986A (ru) |
IN (1) | IN2015DN00538A (ru) |
MX (1) | MX367879B (ru) |
NZ (1) | NZ703992A (ru) |
WO (1) | WO2014022577A1 (ru) |
ZA (1) | ZA201501350B (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5042215B2 (ja) | 2005-05-26 | 2012-10-03 | ニューロン システムズ, インコーポレイテッド | 網膜疾患を処置するための組成物および方法 |
US9822141B2 (en) * | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
KR102243169B1 (ko) | 2013-01-23 | 2021-04-22 | 알데이라 테라퓨틱스, 아이엔씨. | 독성 알데히드 관련된 질병 및 치료 |
EP3337486B1 (en) | 2015-08-21 | 2024-04-03 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
AU2017264697A1 (en) | 2016-05-09 | 2018-11-22 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
WO2018170476A1 (en) | 2017-03-16 | 2018-09-20 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
EP3694500A4 (en) | 2017-10-10 | 2021-06-30 | Aldeyra Therapeutics, Inc. | TREATMENT OF INFLAMMATORY DISORDERS |
WO2020223685A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
EP3988100A4 (en) * | 2019-06-21 | 2023-07-26 | Academy of Military Medical Sciences | ADENOSINE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT OR ASSOCIATED STEREOISOMER, AND USE |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
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US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
JPS6299395A (ja) | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
JPH02104783A (ja) * | 1988-10-11 | 1990-04-17 | Kanai Hiroyuki | スチールコードおよびタイヤ |
KR0137786B1 (ko) | 1988-11-15 | 1998-05-15 | 하마구찌 미찌오 | 심장 또는 뇌의 허혈성 질환의 치료, 예방제 |
US5283327A (en) | 1989-06-20 | 1994-02-01 | Yamasa Shoyu Kabushiki Kaisha | Tri-O-acetyl-2-alkynyladenosines |
US5189027A (en) | 1990-11-30 | 1993-02-23 | Yamasa Shoyu Kabushiki Kaisha | 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases |
JP3025557B2 (ja) * | 1991-06-28 | 2000-03-27 | ヤマサ醤油株式会社 | 2‐アルキニルアデノシン誘導体 |
IT1254915B (it) | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
JP2002173427A (ja) * | 1998-09-01 | 2002-06-21 | Yamasa Shoyu Co Ltd | 眼疾患治療用医薬組成物 |
US6322771B1 (en) * | 1999-06-18 | 2001-11-27 | University Of Virginia Patent Foundation | Induction of pharmacological stress with adenosine receptor agonists |
UA74367C2 (ru) | 2000-03-23 | 2005-12-15 | Сольве Фармас'Ютікалз Б.В. | ПРОИЗВОДНЫЕ 4,5-ДИГИДРО-1Н-ПИРАЗОЛА, КОТОРЫЕ ПРОЯВЛЯЮТ АНТАГОНИСТИЧЕСКУЮ АКТИВНОСТЬ ОТНОСИТЕЛЬНО СВ<sub>1, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЕЕ ИЗГОТОВЛЕНИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ (ВАРИАНТЫ) |
JP4514452B2 (ja) | 2001-10-01 | 2010-07-28 | ユニバーシティ オブ バージニア パテント ファウンデーション | A2aアゴニスト活性を有する2−プロピルアデノシン・アナログおよびその組成物 |
ES2333651T3 (es) | 2002-09-09 | 2010-02-25 | Cv Therapeutics, Inc. | Agonistas del receptor de adenosina a3. |
CN101068825B (zh) | 2004-08-02 | 2013-05-08 | 弗吉尼亚大学专利基金会 | 具有a2a激动剂活性的具有修饰的5'-核糖基团的2-丙炔基腺苷类似物 |
WO2006091896A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Pyridyl substituted xanthines |
WO2007120972A2 (en) * | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
WO2008000743A2 (en) * | 2006-06-27 | 2008-01-03 | Biovitrum Ab (Publ) | Novel 2',3'-methylidene acetyl adenosine prodrugs for use as prodrugs for adenosine receptor agonists |
WO2008124150A1 (en) * | 2007-04-09 | 2008-10-16 | University Of Virginia Patent Foundation | Method of treating enteritis, intestinal damage, and diarrhea from c. difficile with an a2a adenosine receptor agonist |
CN101668768B (zh) | 2007-05-17 | 2012-08-29 | 吉利德帕洛阿尔托股份有限公司 | 制备a2a-腺苷受体激动剂及其多晶型物的方法 |
US8058259B2 (en) | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
US8293720B2 (en) | 2007-12-20 | 2012-10-23 | Dogwood Pharmaceuticals, Inc. | Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
CA2766073A1 (en) | 2009-06-30 | 2011-01-06 | Forest Laboratories Holdings Limited | Alkoxy-carbonyl-amino-alkynyl-adenosine compounds and derivatives thereof as a2ar agonists |
-
2013
- 2013-07-31 AU AU2013296420A patent/AU2013296420B2/en not_active Ceased
- 2013-07-31 CN CN201380043401.9A patent/CN104582709A/zh active Pending
- 2013-07-31 NZ NZ703992A patent/NZ703992A/en not_active IP Right Cessation
- 2013-07-31 EA EA201590205A patent/EA027174B1/ru not_active IP Right Cessation
- 2013-07-31 US US13/956,111 patent/US9067963B2/en not_active Expired - Fee Related
- 2013-07-31 KR KR20157004901A patent/KR20150036767A/ko not_active Application Discontinuation
- 2013-07-31 IN IN538DEN2015 patent/IN2015DN00538A/en unknown
- 2013-07-31 JP JP2015525562A patent/JP6545618B2/ja not_active Expired - Fee Related
- 2013-07-31 MX MX2015001370A patent/MX367879B/es active IP Right Grant
- 2013-07-31 CA CA2880040A patent/CA2880040A1/en not_active Abandoned
- 2013-07-31 BR BR112015002249A patent/BR112015002249A2/pt not_active Application Discontinuation
- 2013-07-31 EP EP13825985.8A patent/EP2879683B1/en active Active
- 2013-07-31 WO PCT/US2013/053053 patent/WO2014022577A1/en active Application Filing
-
2015
- 2015-01-29 IL IL236986A patent/IL236986A/en active IP Right Grant
- 2015-02-27 ZA ZA2015/01350A patent/ZA201501350B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201501350B (en) | 2016-12-21 |
EP2879683A4 (en) | 2016-04-20 |
JP2015524440A (ja) | 2015-08-24 |
WO2014022577A1 (en) | 2014-02-06 |
US20140037538A1 (en) | 2014-02-06 |
EP2879683A1 (en) | 2015-06-10 |
US9067963B2 (en) | 2015-06-30 |
JP6545618B2 (ja) | 2019-07-17 |
NZ703992A (en) | 2018-04-27 |
CN104582709A (zh) | 2015-04-29 |
EP2879683B1 (en) | 2020-01-22 |
IN2015DN00538A (ru) | 2015-06-26 |
MX367879B (es) | 2019-09-10 |
CA2880040A1 (en) | 2014-02-06 |
MX2015001370A (es) | 2016-04-26 |
BR112015002249A2 (pt) | 2017-07-04 |
AU2013296420B2 (en) | 2017-12-07 |
IL236986A (en) | 2017-06-29 |
AU2013296420A1 (en) | 2015-02-12 |
KR20150036767A (ko) | 2015-04-07 |
EA027174B1 (ru) | 2017-06-30 |
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