MX2015012575A - Novedosos derivados de acrilamida como agentes contra la malaria. - Google Patents

Novedosos derivados de acrilamida como agentes contra la malaria.

Info

Publication number
MX2015012575A
MX2015012575A MX2015012575A MX2015012575A MX2015012575A MX 2015012575 A MX2015012575 A MX 2015012575A MX 2015012575 A MX2015012575 A MX 2015012575A MX 2015012575 A MX2015012575 A MX 2015012575A MX 2015012575 A MX2015012575 A MX 2015012575A
Authority
MX
Mexico
Prior art keywords
acrylamide derivatives
antimalarial agents
novel acrylamide
pharmaceutical compositions
novel
Prior art date
Application number
MX2015012575A
Other languages
English (en)
Inventor
Hamed Aissaoui
Christoph Boss
Romain Siegrist
Thierry Kimmerlin
Claire-Lise Ciana
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2015012575A publication Critical patent/MX2015012575A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a novedosos derivados de acrilamida de la fórmula I: (ver Fórmula) en donde R1, R2, R3, X, y el anillo A son como se definen en la descripción, y a su uso como ingredientes activos en la preparación de composiciones farmacéuticas. La invención también se refiere a los aspectos relacionados, incluyendo composiciones farmacéuticas que contienen estos compuestos, y a su uso como medicamentos para el tratamiento o la prevención de infecciones por protozoarios, tales como en especial malaria.
MX2015012575A 2013-03-15 2014-03-14 Novedosos derivados de acrilamida como agentes contra la malaria. MX2015012575A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13159422 2013-03-15
PCT/IB2014/059801 WO2014141175A1 (en) 2013-03-15 2014-03-14 Novel acrylamide derivatives as antimalarial agents

Publications (1)

Publication Number Publication Date
MX2015012575A true MX2015012575A (es) 2016-01-12

Family

ID=47877928

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012575A MX2015012575A (es) 2013-03-15 2014-03-14 Novedosos derivados de acrilamida como agentes contra la malaria.

Country Status (13)

Country Link
US (1) US9637473B2 (es)
EP (1) EP2970217B1 (es)
JP (1) JP2016516025A (es)
KR (1) KR20150132437A (es)
CN (1) CN105189485B (es)
AU (1) AU2014229221A1 (es)
BR (1) BR112015023560A8 (es)
CA (1) CA2901920A1 (es)
ES (1) ES2646489T3 (es)
MX (1) MX2015012575A (es)
PL (1) PL2970217T3 (es)
RU (1) RU2015144099A (es)
WO (1) WO2014141175A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3036222A2 (en) * 2013-08-23 2016-06-29 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
CN118684882A (zh) * 2024-08-26 2024-09-24 吉林爱惠瞳医用科技有限公司 一种具有抑菌功能的硅水凝胶材料及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2020437A1 (en) 1989-07-05 1991-01-06 Yoshihide Fuse Cinnamamide derivative
JP2769578B2 (ja) 1989-10-13 1998-06-25 大塚製薬株式会社 バソプレシン拮抗剤
GB9819860D0 (en) 1998-09-12 1998-11-04 Zeneca Ltd Chemical compounds
US20040102431A1 (en) * 2000-09-25 2004-05-27 Christoph Boss Substituted amino-aza-cycloalkanes useful against malaria
WO2002038534A2 (en) 2000-11-10 2002-05-16 Actelion Pharmaceuticals Ltd Substituted alkyldiamines as inhibitors of plasmepsin or related proteases
EP1392644A1 (en) * 2001-05-31 2004-03-03 Bristol-Myers Squibb Company Cinnamide derivatives as kcnq potassium channel modulators
US6861424B2 (en) 2001-06-06 2005-03-01 Schering Aktiengesellschaft Platelet adenosine diphosphate receptor antagonists
AU2003238046A1 (en) * 2002-06-27 2004-01-19 Actelion Pharmaceuticals Ltd Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer's disease
RU2005114010A (ru) 2002-10-09 2006-01-20 Сайос Инк. (Us) Производные азаиндола в качестве ингибиторов киназы р38
GB0309781D0 (en) * 2003-04-29 2003-06-04 Glaxo Group Ltd Compounds
WO2005013909A2 (en) 2003-08-07 2005-02-17 Smithkline Beecham Corporation Novel cathepsin k inhibitors
WO2005019176A1 (en) 2003-08-25 2005-03-03 Actelion Pharmaceuticals Ltd Substituted amino-aza-cyclohexanes
WO2005058822A1 (en) 2003-12-17 2005-06-30 Actelion Pharmaceuticals Ltd Substituted amino-cycloalkanes
CA2566094A1 (en) * 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Cinnamide compound
WO2006056930A2 (en) * 2004-11-25 2006-06-01 Actelion Pharmaceuticals Ltd Novel 4 -aminopiperidine derivatives as plasmepsin ii inhibitors
TWI382976B (zh) * 2005-10-21 2013-01-21 Actelion Pharmaceuticals Ltd 作為抗瘧疾劑之新穎哌
DE102006012251A1 (de) * 2006-03-15 2007-11-08 Grünenthal GmbH Substituierte 4-Amino-chinazolin-Derivate und ihre Verwendung zur Herstellung von Arzneimitteln
US20070238718A1 (en) 2006-04-06 2007-10-11 Matthias Grauert Thiazolyl-dihydro-indazole
CA2723612A1 (en) * 2008-05-19 2009-11-26 Actelion Pharmaceuticals Ltd Tetrahydroisoquinolines as antimalarial agents
JP2012509311A (ja) * 2008-11-19 2012-04-19 アクテリオン ファーマシューティカルズ リミテッド 抗マラリア薬としての新規なビス−アミド
US8889688B2 (en) * 2010-01-05 2014-11-18 Actelion Pharmaceuticals Ltd. Piperazines as antimalarial agents
AR079831A1 (es) 2010-01-05 2012-02-22 Actelion Pharmaceuticals Ltd Piperazinas como agentes anti-malaria
WO2013018069A1 (en) * 2011-08-04 2013-02-07 Actelion Pharmaceuticals Ltd Combination of antimalarial agents
WO2015028989A1 (en) 2013-09-02 2015-03-05 Actelion Pharmaceuticals Ltd Novel heterocyclic compounds as antimalarial agents

Also Published As

Publication number Publication date
US20160024050A1 (en) 2016-01-28
AU2014229221A1 (en) 2015-11-05
KR20150132437A (ko) 2015-11-25
PL2970217T3 (pl) 2018-01-31
CN105189485B (zh) 2017-10-24
EP2970217B1 (en) 2017-08-09
ES2646489T3 (es) 2017-12-14
BR112015023560A2 (pt) 2017-07-18
EP2970217A1 (en) 2016-01-20
US9637473B2 (en) 2017-05-02
RU2015144099A (ru) 2017-04-21
WO2014141175A1 (en) 2014-09-18
JP2016516025A (ja) 2016-06-02
CA2901920A1 (en) 2014-09-18
CN105189485A (zh) 2015-12-23
BR112015023560A8 (pt) 2017-12-26

Similar Documents

Publication Publication Date Title
PH12020551089A1 (en) Pyrrolopyrimidine compounds used as tlr7 agonist
PH12018502747A1 (en) Boronic acid derivatives and therapeutic uses thereof
MX2022013612A (es) Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas.
TN2017000524A1 (en) New bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them
TN2017000521A1 (en) New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
TN2017000511A1 (en) New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them.
NZ733125A (en) Isoquinoline compounds for the treatment of hiv
NZ710854A (en) Quinolines derivatives as novel anticancer agents
MX390302B (es) Oxiesteroles y metodos de uso de los mismos
NZ733174A (en) Quinazoline derivatives used to treat hiv
PH12015501385A1 (en) Autotaxin inhibitors
MX2018005041A (es) Compuestos para tratar la esclerosis lateral amiotrofica.
GEAP202115121A (en) Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
MX378732B (es) Formas solidas novedosas
TW201613864A (en) Novel compounds
TN2019000204A1 (en) Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
MY193740A (en) "substituted 2,4 diamino-quinoline as new anticancer agents"
PH12015502365A1 (en) Bace1 inhibitors
PH12018500378B1 (en) Novel annelated phenoxyacetamides
PH12018500377A1 (en) Novel annelated benzamides
EA201890906A1 (ru) ПРОИЗВОДНЫЕ ХИНОКСАЛИНА И ПИРИДОПИРАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ
PH12015502632A1 (en) Cxcr7 receptor modulators
PH12012501261A1 (en) Piperazines as antimalarial agents
MX2015012575A (es) Novedosos derivados de acrilamida como agentes contra la malaria.
MX2017002544A (es) Derivados de isoquinolinona utiles en el tratamiento contra el cancer.