MX2015012575A - Novedosos derivados de acrilamida como agentes contra la malaria. - Google Patents
Novedosos derivados de acrilamida como agentes contra la malaria.Info
- Publication number
- MX2015012575A MX2015012575A MX2015012575A MX2015012575A MX2015012575A MX 2015012575 A MX2015012575 A MX 2015012575A MX 2015012575 A MX2015012575 A MX 2015012575A MX 2015012575 A MX2015012575 A MX 2015012575A MX 2015012575 A MX2015012575 A MX 2015012575A
- Authority
- MX
- Mexico
- Prior art keywords
- acrylamide derivatives
- antimalarial agents
- novel acrylamide
- pharmaceutical compositions
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La invención se refiere a novedosos derivados de acrilamida de la fórmula I: (ver Fórmula) en donde R1, R2, R3, X, y el anillo A son como se definen en la descripción, y a su uso como ingredientes activos en la preparación de composiciones farmacéuticas. La invención también se refiere a los aspectos relacionados, incluyendo composiciones farmacéuticas que contienen estos compuestos, y a su uso como medicamentos para el tratamiento o la prevención de infecciones por protozoarios, tales como en especial malaria.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13159422 | 2013-03-15 | ||
PCT/IB2014/059801 WO2014141175A1 (en) | 2013-03-15 | 2014-03-14 | Novel acrylamide derivatives as antimalarial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015012575A true MX2015012575A (es) | 2016-01-12 |
Family
ID=47877928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015012575A MX2015012575A (es) | 2013-03-15 | 2014-03-14 | Novedosos derivados de acrilamida como agentes contra la malaria. |
Country Status (13)
Country | Link |
---|---|
US (1) | US9637473B2 (es) |
EP (1) | EP2970217B1 (es) |
JP (1) | JP2016516025A (es) |
KR (1) | KR20150132437A (es) |
CN (1) | CN105189485B (es) |
AU (1) | AU2014229221A1 (es) |
BR (1) | BR112015023560A8 (es) |
CA (1) | CA2901920A1 (es) |
ES (1) | ES2646489T3 (es) |
MX (1) | MX2015012575A (es) |
PL (1) | PL2970217T3 (es) |
RU (1) | RU2015144099A (es) |
WO (1) | WO2014141175A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3816155A1 (en) * | 2013-08-23 | 2021-05-05 | Virginia Commonwealth University | Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2020437A1 (en) | 1989-07-05 | 1991-01-06 | Yoshihide Fuse | Cinnamamide derivative |
JP2769578B2 (ja) | 1989-10-13 | 1998-06-25 | 大塚製薬株式会社 | バソプレシン拮抗剤 |
GB9819860D0 (en) | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
CN1458923A (zh) * | 2000-09-25 | 2003-11-26 | 埃科特莱茵药品有限公司 | 抗疟用取代氨基-氮杂-环烷类化合物 |
HUP0301443A2 (hu) | 2000-11-10 | 2003-12-29 | Actelion Pharmaceuticals Ltd. | Szubsztituált alkil-diaminok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
JP2004535413A (ja) * | 2001-05-31 | 2004-11-25 | ブリストル−マイヤーズ スクイブ カンパニー | Kcnqカリウムチャンネルモジュレーターとしてのシンナミド誘導体 |
US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
AU2003238046A1 (en) * | 2002-06-27 | 2004-01-19 | Actelion Pharmaceuticals Ltd | Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer's disease |
EP1560582A4 (en) | 2002-10-09 | 2008-03-12 | Scios Inc | AZAINDOL DERIVATIVES AS INHIBITORS OF THE p38 KINASE |
GB0309781D0 (en) * | 2003-04-29 | 2003-06-04 | Glaxo Group Ltd | Compounds |
WO2005013909A2 (en) | 2003-08-07 | 2005-02-17 | Smithkline Beecham Corporation | Novel cathepsin k inhibitors |
WO2005019176A1 (en) | 2003-08-25 | 2005-03-03 | Actelion Pharmaceuticals Ltd | Substituted amino-aza-cyclohexanes |
WO2005058822A1 (en) | 2003-12-17 | 2005-06-30 | Actelion Pharmaceuticals Ltd | Substituted amino-cycloalkanes |
KR101128065B1 (ko) * | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
CA2587888A1 (en) | 2004-11-25 | 2006-06-01 | Actelion Pharmaceuticals Ltd | Novel 4-aminopiperidine derivatives as plasmepsin ii inhibitors |
AR057836A1 (es) * | 2005-10-21 | 2007-12-19 | Actelion Pharmaceuticals Ltd | Piperizinas como agentes contra la malaria |
DE102006012251A1 (de) * | 2006-03-15 | 2007-11-08 | Grünenthal GmbH | Substituierte 4-Amino-chinazolin-Derivate und ihre Verwendung zur Herstellung von Arzneimitteln |
US20070238718A1 (en) | 2006-04-06 | 2007-10-11 | Matthias Grauert | Thiazolyl-dihydro-indazole |
EP2282996A1 (en) * | 2008-05-19 | 2011-02-16 | Actelion Pharmaceuticals Ltd. | Tetrahydroisoquinolines as antimalarial agents |
EP2358673A1 (en) * | 2008-11-19 | 2011-08-24 | Actelion Pharmaceuticals Ltd. | Novel bis-amides as antimalarial agents |
WO2011083413A1 (en) * | 2010-01-05 | 2011-07-14 | Actelion Pharmaceuticals Ltd | Piperazines as antimalarial agents |
US8889688B2 (en) * | 2010-01-05 | 2014-11-18 | Actelion Pharmaceuticals Ltd. | Piperazines as antimalarial agents |
WO2013018069A1 (en) * | 2011-08-04 | 2013-02-07 | Actelion Pharmaceuticals Ltd | Combination of antimalarial agents |
WO2015028989A1 (en) | 2013-09-02 | 2015-03-05 | Actelion Pharmaceuticals Ltd | Novel heterocyclic compounds as antimalarial agents |
-
2014
- 2014-03-14 BR BR112015023560A patent/BR112015023560A8/pt not_active Application Discontinuation
- 2014-03-14 RU RU2015144099A patent/RU2015144099A/ru not_active Application Discontinuation
- 2014-03-14 KR KR1020157029371A patent/KR20150132437A/ko not_active Application Discontinuation
- 2014-03-14 EP EP14715428.0A patent/EP2970217B1/en not_active Not-in-force
- 2014-03-14 MX MX2015012575A patent/MX2015012575A/es unknown
- 2014-03-14 CA CA2901920A patent/CA2901920A1/en not_active Abandoned
- 2014-03-14 US US14/777,459 patent/US9637473B2/en not_active Expired - Fee Related
- 2014-03-14 CN CN201480016180.0A patent/CN105189485B/zh not_active Expired - Fee Related
- 2014-03-14 AU AU2014229221A patent/AU2014229221A1/en not_active Abandoned
- 2014-03-14 WO PCT/IB2014/059801 patent/WO2014141175A1/en active Application Filing
- 2014-03-14 JP JP2015562527A patent/JP2016516025A/ja active Pending
- 2014-03-14 ES ES14715428.0T patent/ES2646489T3/es active Active
- 2014-03-14 PL PL14715428T patent/PL2970217T3/pl unknown
Also Published As
Publication number | Publication date |
---|---|
WO2014141175A1 (en) | 2014-09-18 |
KR20150132437A (ko) | 2015-11-25 |
BR112015023560A8 (pt) | 2017-12-26 |
US20160024050A1 (en) | 2016-01-28 |
CA2901920A1 (en) | 2014-09-18 |
PL2970217T3 (pl) | 2018-01-31 |
ES2646489T3 (es) | 2017-12-14 |
AU2014229221A1 (en) | 2015-11-05 |
CN105189485A (zh) | 2015-12-23 |
JP2016516025A (ja) | 2016-06-02 |
EP2970217B1 (en) | 2017-08-09 |
CN105189485B (zh) | 2017-10-24 |
RU2015144099A (ru) | 2017-04-21 |
BR112015023560A2 (pt) | 2017-07-18 |
US9637473B2 (en) | 2017-05-02 |
EP2970217A1 (en) | 2016-01-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12020551089A1 (en) | Pyrrolopyrimidine compounds used as tlr7 agonist | |
PH12018502747A1 (en) | Boronic acid derivatives and therapeutic uses thereof | |
CR20200312A (es) | Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1 | |
MX2022013612A (es) | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas. | |
TN2017000524A1 (en) | New bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them | |
TN2017000511A1 (en) | New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them. | |
TN2017000521A1 (en) | New aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them | |
NZ733174A (en) | Quinazoline derivatives used to treat hiv | |
PH12015501385A1 (en) | Autotaxin inhibitors | |
MX2020011449A (es) | Oxiesteroles y metodos de uso de los mismos. | |
MX2018015709A (es) | Derivados de azabencimidazol como inhibidores de pi3k beta. | |
NZ710854A (en) | Quinolines derivatives as novel anticancer agents | |
NZ733125A (en) | Isoquinoline compounds for the treatment of hiv | |
MX2018005041A (es) | Compuestos para tratar la esclerosis lateral amiotrofica. | |
MX2017014035A (es) | Formas solidas novedosas. | |
TN2019000204A1 (en) | Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same | |
GEP20227353B (en) | Tetracyclic heterocycle compounds useful as hiv integrase inhibitors | |
PH12017500810A1 (en) | Substituted 2,4 diamino-quinoline as new anticancer agents | |
PH12018500378B1 (en) | Novel annelated phenoxyacetamides | |
TW201613864A (en) | Novel compounds | |
MX2015014083A (es) | Inhibidores de enzima de escision de proteina precursora beta-amiloide (app) en el sitio beta 1 (bace1). | |
PH12018500377A1 (en) | Novel annelated benzamides | |
PH12015502632A1 (en) | Cxcr7 receptor modulators | |
MX2018004304A (es) | DERIVADOS DE QUINOXALINA Y PIRIDOPRAZINA COMO INHIBIDORES DE PI3Kß. | |
CY1115600T1 (el) | Πιπεραζινες ως ανθελονοσιακοι παραγοντες |