MX336247B - Derivados de amida heterociclicos como antagonistas del receptor p2x7. - Google Patents

Derivados de amida heterociclicos como antagonistas del receptor p2x7.

Info

Publication number
MX336247B
MX336247B MX2014008736A MX2014008736A MX336247B MX 336247 B MX336247 B MX 336247B MX 2014008736 A MX2014008736 A MX 2014008736A MX 2014008736 A MX2014008736 A MX 2014008736A MX 336247 B MX336247 B MX 336247B
Authority
MX
Mexico
Prior art keywords
amide derivatives
receptor antagonists
heterocyclic amide
heterocyclic
derivatives
Prior art date
Application number
MX2014008736A
Other languages
English (en)
Other versions
MX2014008736A (es
Inventor
Kurt Hilpert
Francis Hubler
Thierry Kimmerlin
Dorte Renneberg
Simon Stamm
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2014008736A publication Critical patent/MX2014008736A/es
Publication of MX336247B publication Critical patent/MX336247B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a derivados de amida heterocíclicos de la fórmula (I), (ver Fórmula) en donde R1, R2, R3, X y n son como se los define en la especificación, su elaboración y su uso en forma de compuestos farmacéuticamente activos.
MX2014008736A 2012-01-20 2013-01-18 Derivados de amida heterociclicos como antagonistas del receptor p2x7. MX336247B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2012050282 2012-01-20
PCT/IB2013/050479 WO2013108227A1 (en) 2012-01-20 2013-01-18 Heterocyclic amide derivatives as p2x7 receptor antagonists

Publications (2)

Publication Number Publication Date
MX2014008736A MX2014008736A (es) 2014-08-29
MX336247B true MX336247B (es) 2016-01-13

Family

ID=47757670

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008736A MX336247B (es) 2012-01-20 2013-01-18 Derivados de amida heterociclicos como antagonistas del receptor p2x7.

Country Status (23)

Country Link
US (1) US9409917B2 (es)
EP (1) EP2804865B1 (es)
JP (1) JP6111268B2 (es)
KR (1) KR102033190B1 (es)
CN (1) CN104066737B (es)
AR (1) AR089753A1 (es)
AU (1) AU2013210682B2 (es)
BR (1) BR112014017735B1 (es)
CA (1) CA2863228C (es)
CL (1) CL2014001772A1 (es)
EA (1) EA024204B1 (es)
ES (1) ES2563189T3 (es)
HK (1) HK1203932A1 (es)
IL (1) IL233662A0 (es)
MA (1) MA35893B1 (es)
MX (1) MX336247B (es)
NZ (1) NZ628910A (es)
PH (1) PH12014501415A1 (es)
PL (1) PL2804865T3 (es)
SG (1) SG11201403933UA (es)
TW (1) TWI576347B (es)
WO (1) WO2013108227A1 (es)
ZA (1) ZA201406085B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013014587A1 (en) 2011-07-22 2013-01-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
TWI612034B (zh) 2012-12-12 2018-01-21 愛杜西亞製藥有限公司 作爲ｐ２ｘ７受體拮抗劑之吲哚羧醯胺衍生物
US9556117B2 (en) 2012-12-18 2017-01-31 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as P2X7 receptor antagonists
WO2014115078A1 (en) 2013-01-22 2014-07-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
EP2956135B1 (en) 2013-01-22 2016-11-16 Actelion Pharmaceuticals Ltd. Heterocyclic amide derivatives as p2x7 receptor antagonists
JP2017513824A (ja) * 2014-03-26 2017-06-01 ザ チルドレンズ メディカル センター コーポレイション 肥満の処置のためのセラストロールおよび誘導体
PT3609868T (pt) 2017-03-13 2023-12-18 Raqualia Pharma Inc Derivados de tetra-hidroquinolina como antagonistas do recetor p2x7
MA51620A (fr) 2018-01-19 2020-11-25 Cytokinetics Inc Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques
WO2020005887A1 (en) 2018-06-26 2020-01-02 Cytokinetics, Inc. Cardiac sarcomere inhibitors
JP2024508526A (ja) 2021-03-04 2024-02-27 サイトキネティックス， インコーポレイテッド 心筋サルコメア阻害剤

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US9556117B2 (en) 2012-12-18 2017-01-31 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as P2X7 receptor antagonists
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EP2956135B1 (en) 2013-01-22 2016-11-16 Actelion Pharmaceuticals Ltd. Heterocyclic amide derivatives as p2x7 receptor antagonists

Also Published As

Publication number Publication date
US9409917B2 (en) 2016-08-09
BR112014017735B1 (pt) 2022-06-28
BR112014017735A8 (pt) 2017-12-26
MA35893B1 (fr) 2014-12-01
MX2014008736A (es) 2014-08-29
SG11201403933UA (en) 2014-08-28
EP2804865A1 (en) 2014-11-26
TW201333013A (zh) 2013-08-16
KR20140112567A (ko) 2014-09-23
CA2863228A1 (en) 2013-07-25
IL233662A0 (en) 2014-08-31
TWI576347B (zh) 2017-04-01
CN104066737A (zh) 2014-09-24
CL2014001772A1 (es) 2014-10-17
US20150025075A1 (en) 2015-01-22
PH12014501415A1 (en) 2014-09-22
KR102033190B1 (ko) 2019-10-16
BR112014017735A2 (pt) 2017-06-27
CA2863228C (en) 2020-07-21
EA201400822A1 (ru) 2014-12-30
CN104066737B (zh) 2016-06-08
PL2804865T3 (pl) 2016-06-30
EA024204B1 (ru) 2016-08-31
AR089753A1 (es) 2014-09-17
NZ628910A (en) 2016-02-26
JP6111268B2 (ja) 2017-04-05
ES2563189T3 (es) 2016-03-11
EP2804865B1 (en) 2015-12-23
WO2013108227A1 (en) 2013-07-25
HK1203932A1 (en) 2015-11-06
ZA201406085B (en) 2016-05-25
AU2013210682B2 (en) 2017-05-25
JP2015504086A (ja) 2015-02-05
AU2013210682A1 (en) 2014-09-11

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