BR112014010617A8 - Derivados de 2-(1,2,3-triazol-2-il)benzamida e 3-(1,2,3-triazol-2-il)picolinamida como antagonistas do receptor de orexina - Google Patents

Derivados de 2-(1,2,3-triazol-2-il)benzamida e 3-(1,2,3-triazol-2-il)picolinamida como antagonistas do receptor de orexina

Info

Publication number
BR112014010617A8
BR112014010617A8 BR112014010617A BR112014010617A BR112014010617A8 BR 112014010617 A8 BR112014010617 A8 BR 112014010617A8 BR 112014010617 A BR112014010617 A BR 112014010617A BR 112014010617 A BR112014010617 A BR 112014010617A BR 112014010617 A8 BR112014010617 A8 BR 112014010617A8
Authority
BR
Brazil
Prior art keywords
triazol
benzamide
receptor antagonists
orexin receptor
picolinamide derivatives
Prior art date
Application number
BR112014010617A
Other languages
English (en)
Other versions
BR112014010617A2 (pt
BR112014010617B1 (pt
Inventor
Bolli Martin
Boss Christoph
Brotschi Christine
Heidmann Bibia
Sifferlen Thierry
T Williams Jodi
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BR112014010617A2 publication Critical patent/BR112014010617A2/pt
Publication of BR112014010617A8 publication Critical patent/BR112014010617A8/pt
Publication of BR112014010617B1 publication Critical patent/BR112014010617B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

DERIVADOS DE 2-(1,2,3-TRIAZOL-2-IL)BENZAMIDA E 3-(1,2,3-TRIAZOL-2-IL)PICOLINAMIDA COMO ANTAGONISTAS DO RECEPTOR DE OREXINA. A presente invenção refere-se aos derivados de 2-(1,2,3-triazol-2-il)benzamida e 3-(1,2,3-triazol-2-il)picolinamida da fórmula (I) Fórmula (I) em que Ar1, Q, e R1 até R5 são tais como expostos na descrição, à sua preparação, aos seus sais farmaceuticamente aceitáveis, e ao seu uso como produtos farmacêuticos, às composições farmacêuticas que contêm um ou mais compostos da fórmula (I), e especialmente ao seu uso como antagonistas do receptor de orexina.
BR112014010617-7A 2011-11-08 2012-11-07 Derivados de 2-(1,2,3-triazol-2-il)benzamida e 3-(1,2,3-triazol-2-il)picolinamida como antagonistas do receptor de orexina BR112014010617B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2011/054976 2011-11-08
IB2011054976 2011-11-08
PCT/IB2012/056218 WO2013068935A1 (en) 2011-11-08 2012-11-07 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-yl)picolinamide derivatives as orexin receptor antagonists

Publications (3)

Publication Number Publication Date
BR112014010617A2 BR112014010617A2 (pt) 2017-04-25
BR112014010617A8 true BR112014010617A8 (pt) 2017-12-26
BR112014010617B1 BR112014010617B1 (pt) 2021-12-14

Family

ID=47258050

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014010617-7A BR112014010617B1 (pt) 2011-11-08 2012-11-07 Derivados de 2-(1,2,3-triazol-2-il)benzamida e 3-(1,2,3-triazol-2-il)picolinamida como antagonistas do receptor de orexina

Country Status (28)

Country Link
US (1) US9150566B2 (pt)
EP (1) EP2776430B1 (pt)
JP (1) JP5718535B2 (pt)
KR (1) KR101676930B1 (pt)
CN (1) CN103917538B (pt)
AR (1) AR088692A1 (pt)
AU (1) AU2012335194B2 (pt)
BR (1) BR112014010617B1 (pt)
CA (1) CA2846568C (pt)
CL (1) CL2014000659A1 (pt)
CY (1) CY1117638T1 (pt)
DK (1) DK2776430T3 (pt)
EA (1) EA024106B1 (pt)
ES (1) ES2572703T3 (pt)
HK (1) HK1199022A1 (pt)
HR (1) HRP20160678T1 (pt)
HU (1) HUE029239T2 (pt)
IL (1) IL232462A (pt)
IN (1) IN2014CN04127A (pt)
MX (1) MX343837B (pt)
MY (1) MY167791A (pt)
PL (1) PL2776430T3 (pt)
SG (1) SG11201401665WA (pt)
SI (1) SI2776430T1 (pt)
TW (2) TWI555747B (pt)
UA (1) UA112317C2 (pt)
WO (1) WO2013068935A1 (pt)
ZA (1) ZA201404189B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
EP2811997B1 (en) 2012-02-07 2018-04-11 Eolas Therapeutics Inc. Substituted prolines/piperidines as orexin receptor antagonists
DK2855453T3 (en) 2012-06-04 2017-02-06 Actelion Pharmaceuticals Ltd Benzimidazol-proline derivatives
JP2016510810A (ja) 2013-03-12 2016-04-11 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ オレキシン受容体アンタゴニストとしてのアゼチジンアミド誘導体
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
EA030137B1 (ru) 2013-12-03 2018-06-29 Идорсиа Фармасьютиклз Лтд Кристаллическая форма (s)-(2-(6-хлор-7-метил-1н-бензо[d]имидазол-2-ил)-2-метилпирролидин-1-ил)(5-метокси-2-(2h-1,2,3-триазол-2-ил)фенил)метанона и ее применение в качестве антагонистов орексинового рецептора
MX366642B (es) 2013-12-04 2019-07-17 Idorsia Pharmaceuticals Ltd Uso de derivados de bencimidazol-prolina.
JP2017024990A (ja) * 2013-12-13 2017-02-02 大正製薬株式会社 オキサゾリジン及びオキサジナン誘導体
CN105814042B (zh) * 2013-12-13 2018-09-28 大正制药株式会社 噁嗪烷化合物的晶形及其制造方法
US9968624B2 (en) 2014-05-16 2018-05-15 The University Of Tokyo Depression treatment agent
EP3180332B1 (en) 2014-08-13 2021-10-27 Eolas Therapeutics Inc. Difluoropyrrolidines as orexin receptor modulators
WO2016095205A1 (en) 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. Heteroaryl orexin receptor antagonists
CN104557744B (zh) * 2014-12-23 2017-04-12 广东东阳光药业有限公司 一种三氮唑化合物的制备方法
SG11201804223TA (en) 2015-11-23 2018-06-28 Sunshine Lake Pharma Co Ltd OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF
KR20180107232A (ko) 2016-02-12 2018-10-01 아스트라제네카 아베 오렉신 수용체 조정제로서의 할로-치환된 피페리딘
CN110612291B (zh) 2017-05-03 2024-02-13 爱杜西亚药品有限公司 2-([1,2,3]三唑-2-基)-苯甲酸衍生物的制备
WO2020099511A1 (en) * 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
GB201901142D0 (en) * 2019-01-28 2019-03-20 Heptares Therapeutics Ltd OX1 Antagonists
JP2024505967A (ja) 2021-02-02 2024-02-08 イドーシア ファーマシューティカルズ リミテッド （４－メチル－２－［１，２，３］トリアゾール－２－イル－フェニル）－［（ｒ）－３－（３－［１，２，３］トリアゾール－２－イル－ベンジル）－モルホリン－４－イル］－メタノンの結晶形
WO2023218023A1 (en) * 2022-05-13 2023-11-16 Idorsia Pharmaceuticals Ltd Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives
CN115947697A (zh) * 2022-12-28 2023-04-11 苏州汉德创宏生化科技有限公司 一种3-氧代吗啉-4-羧酸叔丁酯的合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130432A (en) 1990-12-21 1992-07-14 Syntex (U.S.A.) Inc. Process for preparing cyclic amines and intermediate products thereof
CA2111957A1 (en) 1991-06-27 1993-01-07 Richard A. Glennon Sigma receptor ligands and the use thereof
EP1435955A2 (en) * 2001-05-05 2004-07-14 SmithKline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
HUP0400326A2 (hu) * 2001-06-28 2004-09-28 Smithkline Beecham P.L.C. Orexin receptor antagonistákként alkalmazható ciklikus N-(aril-karbonil)-amin-származékok és ezeket tartalmazó gyógyszerkészítmények
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
GB0124463D0 (en) * 2001-10-11 2001-12-05 Smithkline Beecham Plc Compounds
GB0130335D0 (en) * 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
EP1751111B1 (en) 2004-03-01 2014-12-31 Actelion Pharmaceuticals Ltd. Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
MX2008011647A (es) 2006-03-15 2008-09-22 Actelion Pharmaceuticals Ltd Derivados de tetrahidroisoquinolina para mejorar la funcion de la memoria.
JP2009543785A (ja) 2006-07-14 2009-12-10 メルク エンド カムパニー インコーポレーテッド 架橋ジアゼパンオレキシン受容体アンタゴニスト
GB0620818D0 (en) 2006-10-19 2006-11-29 Ucb Sa Therapeutic agents
PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
JP2010540429A (ja) 2007-09-24 2010-12-24 アクテリオン ファーマシューティカルズ リミテッド オレキシン受容体拮抗薬としてのピロリジン類及びピペリジン類
PE20091010A1 (es) 2007-10-10 2009-08-08 Actelion Pharmaceuticals Ltd Derivados de tetrahidroquinolina
US8669272B2 (en) * 2008-10-21 2014-03-11 Merck Sharp & Dohme Corp. 2,5-disubstituted piperidine orexin receptor antagonists
JP2012506375A (ja) 2008-10-21 2012-03-15 メルク・シャープ・エンド・ドーム・コーポレイション ２，５−二置換ピペリジンオレキシン受容体アンタゴニスト
WO2010048013A1 (en) * 2008-10-21 2010-04-29 Merck Sharp & Dohme Corp. 2,5-disubstituted morpholine orexin receptor antagonists
EP2370426A1 (en) 2008-12-02 2011-10-05 Glaxo Group Limited N-{[(ir,4s,6r-3-(2-pyridinylcarbonyl)-3-azabicyclo [4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives and uses thereof
JP2012510493A (ja) 2008-12-02 2012-05-10 グラクソ グループ リミテッド Ｎ−｛［（ｉｒ、４ｓ、６ｒ）−３−（２−ピリジニルカルボニル）−３−アザビシクロ［４．１．０］ヘプタ−４−イル］メチル｝−２−ヘテロアリールアミン誘導体およびその使用
EP2491034B1 (en) 2009-10-23 2013-12-18 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds as orexin receptor modulators
EP2491038B1 (en) 2009-10-23 2016-04-06 Janssen Pharmaceutica N.V. Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators
WO2011050202A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators

Also Published As

Publication number Publication date
ZA201404189B (en) 2017-08-30
SG11201401665WA (en) 2014-09-26
MX2014005635A (es) 2014-06-23
CN103917538B (zh) 2016-08-24
TWI565703B (zh) 2017-01-11
KR20140096338A (ko) 2014-08-05
TW201323421A (zh) 2013-06-16
AR088692A1 (es) 2014-06-25
CL2014000659A1 (es) 2014-08-18
CY1117638T1 (el) 2017-04-26
CN103917538A (zh) 2014-07-09
AU2012335194A1 (en) 2014-07-03
MX343837B (es) 2016-11-24
BR112014010617A2 (pt) 2017-04-25
EA024106B1 (ru) 2016-08-31
BR112014010617B1 (pt) 2021-12-14
NZ625896A (en) 2016-04-29
MY167791A (en) 2018-09-26
CA2846568A1 (en) 2013-05-16
EP2776430A1 (en) 2014-09-17
ES2572703T3 (es) 2016-06-01
TWI555747B (zh) 2016-11-01
JP2014532753A (ja) 2014-12-08
HK1199022A1 (zh) 2015-06-19
IL232462A (en) 2016-11-30
PL2776430T3 (pl) 2016-09-30
KR101676930B1 (ko) 2016-11-16
AU2012335194B2 (en) 2017-05-25
TW201632517A (zh) 2016-09-16
UA112317C2 (uk) 2016-08-25
US9150566B2 (en) 2015-10-06
JP5718535B2 (ja) 2015-05-13
US20150158855A1 (en) 2015-06-11
IL232462A0 (en) 2014-06-30
HRP20160678T1 (hr) 2016-07-15
HUE029239T2 (en) 2017-02-28
SI2776430T1 (sl) 2016-06-30
IN2014CN04127A (pt) 2015-07-10
EA201400553A1 (ru) 2014-10-30
WO2013068935A1 (en) 2013-05-16
CA2846568C (en) 2020-01-14
DK2776430T3 (en) 2016-05-09
EP2776430B1 (en) 2016-03-16

Similar Documents

Publication Publication Date Title
BR112014010617A8 (pt) Derivados de 2-(1,2,3-triazol-2-il)benzamida e 3-(1,2,3-triazol-2-il)picolinamida como antagonistas do receptor de orexina
BR112014030173A2 (pt) derivados de benzimidazol-prolina
BR112019001551A2 (pt) moduladores do receptor de piperidina cxcr7
BR112015007516A2 (pt) antagonistas do receptor de orexina que são derivados de [orto bi-(hetero-)aril]-[2-(meta bi-(hetero-)aril)- pirrolidin-1-il]-metanona
BR112012031561A2 (pt) morfolino pirimidinas e seu uso em terapia.
BR112015013463A2 (pt) derivados de carboxamida indol como antagonistas do receptor de p2x7
BR112014017735A8 (pt) Compostos derivados de amida heterocíclicos como antagonistas do receptor de p2x7, composição farmacêutica, e, uso de um composto
BR112014031755A8 (pt) Derivados de 1-[m-carboxamido (hetero) aril-metil]-heterociclil-carboxamida
BR112015023161A2 (pt) derivados de piridin-4-ila
BR112017015093A2 (pt) derivados de hidroxialquil-piperazina como moduladores do receptor cxcr3
PH12015502632A1 (en) Cxcr7 receptor modulators
BR112017015116A2 (pt) derivados de (r)-2-metil-piperazina como moduladores do receptor cxcr3
BR112016001238A8 (pt) Derivados de 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona, seus usos e composição farmacêutica os compreendendo
BR112015023560A8 (pt) Novos derivados de acrilamida como agentes antimaláricos
BR112018070214A2 (pt) antagonistas c5ar solúveis
UA112586C2 (uk) Похідні бензімідазолпроліну
BR112014016896A2 (pt) derivados de heteroarilamida tendo propriedades antiandrogênicas
BR112015031827A2 (pt) composto, processo para preparação de um composto, composição farmacêutica

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B25C Requirement related to requested transfer of rights

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/11/2012, OBSERVADAS AS CONDICOES LEGAIS.