EA200100902A1 - Производные тетрагидропирана и их использование в качестве терапевтических агентов - Google Patents

Производные тетрагидропирана и их использование в качестве терапевтических агентов

Info

Publication number
EA200100902A1
EA200100902A1 EA200100902A EA200100902A EA200100902A1 EA 200100902 A1 EA200100902 A1 EA 200100902A1 EA 200100902 A EA200100902 A EA 200100902A EA 200100902 A EA200100902 A EA 200100902A EA 200100902 A1 EA200100902 A1 EA 200100902A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydroxy
alkoxy
cor
coor
Prior art date
Application number
EA200100902A
Other languages
English (en)
Inventor
Саймон Нейл Оуэн
Эйлин Мэри Сьюард
Кристофер Джон Свэйн
Брайан Джон Уилльямс
Original Assignee
Мерк Шарп Энд Домэ Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9906480.0A external-priority patent/GB9906480D0/en
Priority claimed from GBGB9924616.7A external-priority patent/GB9924616D0/en
Application filed by Мерк Шарп Энд Домэ Лимитед filed Critical Мерк Шарп Энд Домэ Лимитед
Publication of EA200100902A1 publication Critical patent/EA200100902A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I), в которых R, R, R, R, R, Rи Rпредставляют различные заместители; Rпредставляет водород или Cалкильную группу, необязательно замещенную гидроксигруппой; Rпредставляет галоген, гидрокси, Cалкенил, N, -NRR, -NRCOR, -OSOR, -(CH)NRCH)COOR, COR, COORили пятичленное или шестичленное азотсодержащее гетероароматическое кольцо, необязательно содержащее 1, 2 или 3 дополнительных гетероатома, выбранных из N, О и S, причем указанное гетероароматическое кольцо необязательно замещено в любом возможном для замещения положении заместителем, выбранным из =O, =S, галогена, гидрокси, -SH, COR, COR, -ZNRR, Cалкила, гидрокси Cалкила, фтор Cалкила, Cалкокси, фтор Cалкокси или Cалкокси, замещенной Cалкокси или гидроксильной группой; Rпредставляет водород, Cалкил, фтор Cалкил, гидрокси, Cалкокси или гидрокси Cалкил; и n равно нулю, 1 или 2; или к его фармацевтически приемлемой соли. Данные соединения представляют особый интерес для использования при лечении или для профилактики депрессии, беспокойства, боли, воспалений, мигрени, рвоты или постгерпетической невралгии.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100902A 1999-03-19 2000-03-16 Производные тетрагидропирана и их использование в качестве терапевтических агентов EA200100902A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9906480.0A GB9906480D0 (en) 1999-03-19 1999-03-19 Therapeutic agents
GBGB9924616.7A GB9924616D0 (en) 1999-10-18 1999-10-18 Therapeutic agents
PCT/GB2000/000977 WO2000056728A1 (en) 1999-03-19 2000-03-16 Tetrahydropyran derivatives and their use as therapeutic agents

Publications (1)

Publication Number Publication Date
EA200100902A1 true EA200100902A1 (ru) 2002-02-28

Family

ID=26315315

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100902A EA200100902A1 (ru) 1999-03-19 2000-03-16 Производные тетрагидропирана и их использование в качестве терапевтических агентов

Country Status (23)

Country Link
US (1) US6458830B1 (ru)
EP (1) EP1165540B1 (ru)
JP (1) JP2002540107A (ru)
KR (1) KR20010113773A (ru)
CN (1) CN1344264A (ru)
AT (1) ATE247096T1 (ru)
AU (2) AU746251B2 (ru)
BG (1) BG105859A (ru)
BR (1) BR0009127A (ru)
CA (1) CA2367985A1 (ru)
CO (1) CO5150225A1 (ru)
CZ (1) CZ20013377A3 (ru)
DE (1) DE60004504T2 (ru)
EA (1) EA200100902A1 (ru)
EE (1) EE200100491A (ru)
ES (1) ES2203434T3 (ru)
HU (1) HUP0200441A3 (ru)
IL (1) IL144236A0 (ru)
NO (1) NO20014529L (ru)
PE (1) PE20001556A1 (ru)
PL (1) PL350123A1 (ru)
SK (1) SK13322001A3 (ru)
WO (2) WO2000056727A1 (ru)

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DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
GB0017256D0 (en) 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0020721D0 (en) 2000-08-22 2000-10-11 Merck Sharp & Dohme Therapeutic agents
PE20020444A1 (es) 2000-09-22 2002-06-14 Merck & Co Inc Antagonistas de receptores de taquiquinina zwitterionica
JP2004518671A (ja) * 2001-01-17 2004-06-24 メルク シャープ エンド ドーム リミテッド ニューロキニン受容体アンタゴニストとしてのテトラヒドロピラン誘導体
GB0121874D0 (en) * 2001-09-10 2001-10-31 Merck Sharp & Dohme Therapeutic agents
GB0217068D0 (en) * 2002-07-23 2002-08-28 Merck Sharp & Dohme Therapeutic agents
WO2004037843A2 (en) * 2002-10-25 2004-05-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
WO2004050084A2 (en) * 2002-11-29 2004-06-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ace-inhibitors having antioxidant and nitricoxid-donor activity
WO2004078750A1 (en) * 2003-03-07 2004-09-16 Merck Sharp & Dohme Limited Tetrahydropyran compounds as tachykinin antagonists
US7589205B2 (en) 2004-09-08 2009-09-15 Nycomed Gmbh 3-thia-10-aza-phenanthrene derivatives
EP1819661B1 (en) * 2004-11-30 2009-04-22 Mallinckrodt, Inc. Crystallization method for benzphetamine
WO2006115188A1 (ja) 2005-04-22 2006-11-02 Daiichi Sankyo Company, Limited ヘテロ環化合物
CN100395242C (zh) * 2006-06-08 2008-06-18 华东理工大学 烷氧基萘和萘醌类吡喃碳糖苷化合物及其制备方法
DE102007010077B4 (de) * 2007-02-28 2010-04-08 RUHR-UNIVERSITäT BOCHUM [1,3]-Dioxane zur Modulation von GABAa-Rezeptoren
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
EP2892509A4 (en) * 2012-09-04 2016-05-18 Lauren Sciences Llc BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
US10987322B2 (en) 2014-06-06 2021-04-27 Flexus Biosciences, Inc. Immunoregulatory agents
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
CN107205970A (zh) 2014-11-05 2017-09-26 弗莱塞斯生物科学公司 免疫调节剂
HU231150B1 (hu) 2017-03-13 2021-03-29 Richter Gedeon Nyrt Eljárás racém 3-alkilpiperidin-3-karbonsav-etil-észterek optikai izomerjeinek elválasztására
KR20200118022A (ko) * 2018-02-06 2020-10-14 다이이찌 산쿄 가부시키가이샤 아미노알킬 화합물
AU2019223237A1 (en) 2018-02-26 2020-09-03 Ospedale San Raffaele S.R.L. NK-1 antagonists for use in the treatment of ocular pain
WO2021180885A1 (en) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

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GB9301920D0 (en) * 1993-02-01 1993-03-17 Foundation For Ethnobiology Th Polycetylenes

Also Published As

Publication number Publication date
EP1165540B1 (en) 2003-08-13
EE200100491A (et) 2002-12-16
NO20014529D0 (no) 2001-09-18
BG105859A (bg) 2002-04-30
HUP0200441A2 (hu) 2002-07-29
DE60004504D1 (de) 2003-09-18
DE60004504T2 (de) 2004-06-24
CA2367985A1 (en) 2000-09-28
SK13322001A3 (sk) 2002-02-05
CZ20013377A3 (cs) 2002-02-13
CO5150225A1 (es) 2002-04-29
EP1165540A1 (en) 2002-01-02
US6458830B1 (en) 2002-10-01
AU3304400A (en) 2000-10-09
ATE247096T1 (de) 2003-08-15
PE20001556A1 (es) 2001-01-13
ES2203434T3 (es) 2004-04-16
CN1344264A (zh) 2002-04-10
BR0009127A (pt) 2001-12-26
PL350123A1 (en) 2002-11-04
KR20010113773A (ko) 2001-12-28
IL144236A0 (en) 2002-05-23
AU3304200A (en) 2000-10-09
WO2000056727A1 (en) 2000-09-28
HUP0200441A3 (en) 2002-09-30
AU746251B2 (en) 2002-04-18
JP2002540107A (ja) 2002-11-26
NO20014529L (no) 2001-11-13
WO2000056728A1 (en) 2000-09-28

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