PE20001556A1 - Derivados de tetrahidropirano utiles como antagonistas de taquicinina - Google Patents
Derivados de tetrahidropirano utiles como antagonistas de taquicininaInfo
- Publication number
- PE20001556A1 PE20001556A1 PE2000000218A PE0002182000A PE20001556A1 PE 20001556 A1 PE20001556 A1 PE 20001556A1 PE 2000000218 A PE2000000218 A PE 2000000218A PE 0002182000 A PE0002182000 A PE 0002182000A PE 20001556 A1 PE20001556 A1 PE 20001556A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- fluoroalkyl
- taquycinin
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000003527 tetrahydropyrans Chemical class 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- -1 C1-C6 ALKYL Inorganic materials 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE TETRAHIDROPIRANO DE FORMULA I, DONDE: R1 ES H, HALOGENO, ALQUILO C1-C6, NO2, CN, SRa, ENTRE OTROS; R2 ES H, HALOGENO, ALQUILO C1-C6, FLUOROALQUILO C1-C6, ENTRE OTROS; R3 ES H, HALOGENO, FLUOROALQUILO C1-C6; R4 ES H, HALOGENO, ALQUILO C1-C6, ALCOXI C1-C6, NO2, CN, SRa, CONRaRb, ENTRE OTROS; Ra Y Rb SON H, ALQUILO C1-C4; R5 ES H, HALOGENO, ALQUILO C1-C6, FLUOROALQUILO C1-C6, ENTRE OTROS; R6 ES H, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON OH; R7 ES HALOGENO, OH, ALQUENILO C2-C4, N3, NR11R12, NRaCORb, ENTRE OTROS; R8 ES H, ALQUILO C1-C6, FLUOROALQUILO C1-C6, OH, ALCOXI C1-C6, HIDROXIALQUILO C1-C6; R9 Y R10 SON H, HALOGENO, ALQUILO C1-C6, CH2ORc, OXO, CO2Ra, CONRaRb; Rc ES H, ALQUILO C1-C6, FENILO; R11 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C7, ENTRE OTROS; R12 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C7, ALQUILO C1-C4, ENTRE OTROS; n ES 0-2. UN COMPUESTOS PREFERIDO ES (2R,3S,4S,8R)-2-(1-(1-(3,5-BIS(TRIFLUOROMETIL)FENIL)ETIL)OXI)-4-(METANOSULFONILOXI)METIL-3-FENILTETRAHIDROPIRANO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO DE FORMULA I ES UN ANTAGONISTA DEL RECEPTOR DE TAQUICININA DE PREFERENCIA NEUROCININA 1 (NK-1) Y PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, DEPRESION, ANSIEDAD, PREVENCION DEL DOLOR, INFLAMACION
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9906480.0A GB9906480D0 (en) | 1999-03-19 | 1999-03-19 | Therapeutic agents |
| GBGB9924616.7A GB9924616D0 (en) | 1999-10-18 | 1999-10-18 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001556A1 true PE20001556A1 (es) | 2001-01-13 |
Family
ID=26315315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000218A PE20001556A1 (es) | 1999-03-19 | 2000-03-13 | Derivados de tetrahidropirano utiles como antagonistas de taquicinina |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6458830B1 (es) |
| EP (1) | EP1165540B1 (es) |
| JP (1) | JP2002540107A (es) |
| KR (1) | KR20010113773A (es) |
| CN (1) | CN1344264A (es) |
| AT (1) | ATE247096T1 (es) |
| AU (2) | AU746251B2 (es) |
| BG (1) | BG105859A (es) |
| BR (1) | BR0009127A (es) |
| CA (1) | CA2367985A1 (es) |
| CO (1) | CO5150225A1 (es) |
| CZ (1) | CZ20013377A3 (es) |
| DE (1) | DE60004504T2 (es) |
| EA (1) | EA200100902A1 (es) |
| EE (1) | EE200100491A (es) |
| ES (1) | ES2203434T3 (es) |
| HU (1) | HUP0200441A3 (es) |
| IL (1) | IL144236A0 (es) |
| NO (1) | NO20014529L (es) |
| PE (1) | PE20001556A1 (es) |
| PL (1) | PL350123A1 (es) |
| SK (1) | SK13322001A3 (es) |
| WO (2) | WO2000056728A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10001785A1 (de) * | 2000-01-18 | 2001-07-19 | Boehringer Ingelheim Pharma | NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms |
| GB0017256D0 (en) | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| GB0020721D0 (en) | 2000-08-22 | 2000-10-11 | Merck Sharp & Dohme | Therapeutic agents |
| PE20020444A1 (es) | 2000-09-22 | 2002-06-14 | Merck & Co Inc | Antagonistas de receptores de taquiquinina zwitterionica |
| US6906085B2 (en) | 2001-01-17 | 2005-06-14 | Merck Sharp & Dohme Ltd. | Tetrahydropyran derivatives as neurokinin receptor antagonists |
| GB0121874D0 (en) | 2001-09-10 | 2001-10-31 | Merck Sharp & Dohme | Therapeutic agents |
| GB0217068D0 (en) * | 2002-07-23 | 2002-08-28 | Merck Sharp & Dohme | Therapeutic agents |
| WO2004037843A2 (en) * | 2002-10-25 | 2004-05-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
| WO2004050084A2 (en) * | 2002-11-29 | 2004-06-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Ace-inhibitors having antioxidant and nitricoxid-donor activity |
| WO2004078750A1 (en) * | 2003-03-07 | 2004-09-16 | Merck Sharp & Dohme Limited | Tetrahydropyran compounds as tachykinin antagonists |
| AU2005281703B2 (en) | 2004-09-08 | 2011-11-17 | Takeda Gmbh | Novel 3-thia-10-aza-phenanthrene derivatives |
| DE602005014138D1 (de) * | 2004-11-30 | 2009-06-04 | Mallinckrodt Inc | Verfahren zur kristallisierung von benzphetamin |
| CN101203512A (zh) * | 2005-04-22 | 2008-06-18 | 第一三共株式会社 | 杂环化合物 |
| CN100395242C (zh) * | 2006-06-08 | 2008-06-18 | 华东理工大学 | 烷氧基萘和萘醌类吡喃碳糖苷化合物及其制备方法 |
| DE102007010077B4 (de) * | 2007-02-28 | 2010-04-08 | RUHR-UNIVERSITäT BOCHUM | [1,3]-Dioxane zur Modulation von GABAa-Rezeptoren |
| US9782397B2 (en) | 2011-07-04 | 2017-10-10 | Irbm Science Park S.P.A. | Treatment of corneal neovascularization |
| WO2014039504A1 (en) * | 2012-09-04 | 2014-03-13 | Lauren Sciences Llc | Bolaamphiphilic compounds, compositions and uses thereof |
| WO2015188085A1 (en) | 2014-06-06 | 2015-12-10 | Flexus Biosciences, Inc. | Immunoregulatory agents |
| UY36391A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| EA201790806A1 (ru) * | 2014-11-05 | 2017-11-30 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
| UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| HU231150B1 (hu) | 2017-03-13 | 2021-03-29 | Richter Gedeon Nyrt | Eljárás racém 3-alkilpiperidin-3-karbonsav-etil-észterek optikai izomerjeinek elválasztására |
| JP7183196B2 (ja) * | 2018-02-06 | 2022-12-05 | 第一三共株式会社 | アミノアルキル化合物 |
| RU2020131446A (ru) | 2018-02-26 | 2022-03-28 | Оспедале Сан Раффаэле С.Р.Л. | Антагонисты nk-1 для применения в лечении глазной боли |
| WO2021180885A1 (en) | 2020-03-11 | 2021-09-16 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9301920D0 (en) * | 1993-02-01 | 1993-03-17 | Foundation For Ethnobiology Th | Polycetylenes |
-
2000
- 2000-03-10 CO CO00017612A patent/CO5150225A1/es unknown
- 2000-03-13 PE PE2000000218A patent/PE20001556A1/es not_active Application Discontinuation
- 2000-03-16 EE EEP200100491A patent/EE200100491A/xx unknown
- 2000-03-16 BR BR0009127-8A patent/BR0009127A/pt not_active Application Discontinuation
- 2000-03-16 KR KR1020017011885A patent/KR20010113773A/ko not_active Application Discontinuation
- 2000-03-16 PL PL00350123A patent/PL350123A1/xx not_active Application Discontinuation
- 2000-03-16 AU AU33042/00A patent/AU746251B2/en not_active Ceased
- 2000-03-16 WO PCT/GB2000/000977 patent/WO2000056728A1/en not_active Application Discontinuation
- 2000-03-16 ES ES00911045T patent/ES2203434T3/es not_active Expired - Lifetime
- 2000-03-16 WO PCT/GB2000/000974 patent/WO2000056727A1/en active IP Right Grant
- 2000-03-16 EP EP00911045A patent/EP1165540B1/en not_active Expired - Lifetime
- 2000-03-16 CZ CZ20013377A patent/CZ20013377A3/cs unknown
- 2000-03-16 CN CN00805114A patent/CN1344264A/zh active Pending
- 2000-03-16 DE DE60004504T patent/DE60004504T2/de not_active Expired - Fee Related
- 2000-03-16 JP JP2000606588A patent/JP2002540107A/ja not_active Withdrawn
- 2000-03-16 AU AU33044/00A patent/AU3304400A/en not_active Abandoned
- 2000-03-16 US US09/936,343 patent/US6458830B1/en not_active Expired - Fee Related
- 2000-03-16 EA EA200100902A patent/EA200100902A1/ru unknown
- 2000-03-16 AT AT00911045T patent/ATE247096T1/de not_active IP Right Cessation
- 2000-03-16 HU HU0200441A patent/HUP0200441A3/hu unknown
- 2000-03-16 IL IL14423600A patent/IL144236A0/xx unknown
- 2000-03-16 SK SK1332-2001A patent/SK13322001A3/sk unknown
- 2000-03-16 CA CA002367985A patent/CA2367985A1/en not_active Abandoned
-
2001
- 2001-08-30 BG BG105859A patent/BG105859A/bg unknown
- 2001-09-18 NO NO20014529A patent/NO20014529L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1344264A (zh) | 2002-04-10 |
| US6458830B1 (en) | 2002-10-01 |
| CO5150225A1 (es) | 2002-04-29 |
| DE60004504D1 (de) | 2003-09-18 |
| JP2002540107A (ja) | 2002-11-26 |
| PL350123A1 (en) | 2002-11-04 |
| EE200100491A (et) | 2002-12-16 |
| BG105859A (bg) | 2002-04-30 |
| CZ20013377A3 (cs) | 2002-02-13 |
| WO2000056728A1 (en) | 2000-09-28 |
| BR0009127A (pt) | 2001-12-26 |
| EP1165540A1 (en) | 2002-01-02 |
| SK13322001A3 (sk) | 2002-02-05 |
| EP1165540B1 (en) | 2003-08-13 |
| WO2000056727A1 (en) | 2000-09-28 |
| HUP0200441A3 (en) | 2002-09-30 |
| HUP0200441A2 (hu) | 2002-07-29 |
| IL144236A0 (en) | 2002-05-23 |
| AU3304200A (en) | 2000-10-09 |
| ES2203434T3 (es) | 2004-04-16 |
| NO20014529L (no) | 2001-11-13 |
| EA200100902A1 (ru) | 2002-02-28 |
| AU3304400A (en) | 2000-10-09 |
| DE60004504T2 (de) | 2004-06-24 |
| NO20014529D0 (no) | 2001-09-18 |
| AU746251B2 (en) | 2002-04-18 |
| CA2367985A1 (en) | 2000-09-28 |
| ATE247096T1 (de) | 2003-08-15 |
| KR20010113773A (ko) | 2001-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20001556A1 (es) | Derivados de tetrahidropirano utiles como antagonistas de taquicinina | |
| MA27190A1 (fr) | Derives de tropane servant de modulateurs de ccr5 | |
| DE60025189D1 (de) | Cyanopyrrole als progesteronrezeptoragonisten | |
| PE20010854A1 (es) | USO DE DERIVADOS DE PIRIMIDINA 4 SUSTITUIDOS COMO ANTAGONISTAS DE LOS RECEPTORES DE GLUTAMATO mGluR1 | |
| RU98123001A (ru) | Арилпиримидиновые производные | |
| ATE161821T1 (de) | Azyklische ethylendiaminderivate als 'substance p rezeptor' antagonisten | |
| PE20000166A1 (es) | Compuestos 4-(2-ceto-1-benzilimidazolinil)piperidina como agonistas del receptor orl1 | |
| PE20010930A1 (es) | Bifenil sulfonamidas como antagonistas de receptores de angiotensina endotelina duales | |
| PE20011119A1 (es) | Composiciones farmaceuticas de agonista/antagonista de estrogenos para el tratamiento de afecciones que responden a un aumento de testosterona | |
| PE20010741A1 (es) | Derivados de piperazina como antagonistas de taquicininas | |
| PE20020858A1 (es) | Indanil aminas aciladas | |
| PE20030238A1 (es) | Uso de los antagonistas del receptor nk-1 para el tratamiento de lesiones cerebrales, espinales y neuronales | |
| RU98108027A (ru) | Производные имидазола, обладающие аффинностью в отношении активности альфа2- рецепторов | |
| PE20011068A1 (es) | 1,3-pirrolidinas disustituidas | |
| YU60696A (sh) | Dihidropirimidini i njihova primena | |
| PE20060632A1 (es) | Derivados de arilsulfonilestilbeno como antagonistas de los receptores 5-ht2a | |
| PE20081315A1 (es) | Derivados de benzimidazol como antagonistas de vr-1 | |
| PE20021067A1 (es) | Empleo de antagonistas del receptor nk3 | |
| DE59707062D1 (de) | 2,3-benzodiazepinderivate und deren verwendung als ampa-rezeptoren-hemmer | |
| DK1189900T3 (da) | Heterocykliske aminopyrrolidinderivater som melatonerge lægemidler | |
| AR005916A1 (es) | Compuestos de oxadiazol, y de tiadiazol, su uso, procedimientos para prepararlos, composiciones farmaceuticas que los contienen y un compuesto util como intermedio | |
| PE20020436A1 (es) | Derivados de tetrahidropirano como antagonistas del receptor de neuroquinina 1 (nk-1) | |
| ATE369348T1 (de) | Zyklisierte benzamid-neurokinin-antagonisten zur verwendung in therapie | |
| PE20050587A1 (es) | Derivados de diazindol-dicarbonilo-piperazinilo como agentes antivirales | |
| PE20030539A1 (es) | Derivados de piperazina antagonistas de los receptores de somatostatina sst1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |