MA27190A1 - Derives de tropane servant de modulateurs de ccr5 - Google Patents

Derives de tropane servant de modulateurs de ccr5

Info

Publication number
MA27190A1
MA27190A1 MA27883A MA27883A MA27190A1 MA 27190 A1 MA27190 A1 MA 27190A1 MA 27883 A MA27883 A MA 27883A MA 27883 A MA27883 A MA 27883A MA 27190 A1 MA27190 A1 MA 27190A1
Authority
MA
Morocco
Prior art keywords
modulators
ccr5
treatment
present
tropane derivatives
Prior art date
Application number
MA27883A
Other languages
English (en)
Inventor
Patricia Ann Basford
Stefan Colin John Taylor
Peter Thomas Stephenson
Anthony Wood
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0208071.1A external-priority patent/GB0208071D0/en
Priority claimed from GB0301575A external-priority patent/GB0301575D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of MA27190A1 publication Critical patent/MA27190A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)

Abstract

DEPOSANT Société dite : PFIZER INC. REVENDICATION DE PRIORITES GB 8 Avril 2002 0208071.1 GB 23 Janvier 2003 0301575.7 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés de tropane servant de modulateurs de CCR5 La présente invention propose des composés de formule (I) dans laquelle X, Y, R1, R2 et R3 répondent aux définitions indiquées. Les composés de la présente invention sont des modulateurs, notamment des antagonistes, de l'activité des récepteurs de chimiokines CCR5. Des modulateurs du récepteur CCR5 peuvent être utiles dans le traitement de diverses maladies et affections inflammatoires, et dans le traitement de l'infection par le VIH et par des rétrovirus génétiquement apparentés.
MA27883A 2002-04-08 2004-09-29 Derives de tropane servant de modulateurs de ccr5 MA27190A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0208071.1A GB0208071D0 (en) 2002-04-08 2002-04-08 Tropane derivatives useful in therapy
GB0301575A GB0301575D0 (en) 2003-01-23 2003-01-23 Tropane derivatives useful in therapy

Publications (1)

Publication Number Publication Date
MA27190A1 true MA27190A1 (fr) 2005-01-03

Family

ID=28793308

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27883A MA27190A1 (fr) 2002-04-08 2004-09-29 Derives de tropane servant de modulateurs de ccr5

Country Status (41)

Country Link
EP (1) EP1492789B1 (fr)
JP (2) JP3793200B2 (fr)
KR (1) KR100734685B1 (fr)
CN (1) CN1324025C (fr)
AP (1) AP1789A (fr)
AR (1) AR039383A1 (fr)
AT (1) ATE328882T1 (fr)
AU (1) AU2003214503B2 (fr)
BR (1) BR0309118A (fr)
CA (1) CA2481482C (fr)
CR (1) CR7514A (fr)
CU (1) CU23282A3 (fr)
CY (1) CY1106114T1 (fr)
DE (1) DE60305903T2 (fr)
DK (1) DK1492789T3 (fr)
DO (1) DOP2003000624A (fr)
EA (1) EA007590B1 (fr)
ES (1) ES2263960T3 (fr)
GE (1) GEP20074210B (fr)
HK (1) HK1076102A1 (fr)
HN (1) HN2003000114A (fr)
HR (1) HRP20040940A2 (fr)
IL (1) IL164261A0 (fr)
IS (1) IS2577B (fr)
MA (1) MA27190A1 (fr)
MX (1) MXPA04009220A (fr)
MY (1) MY134223A (fr)
NI (1) NI200300053A (fr)
NO (1) NO329674B1 (fr)
NZ (1) NZ535452A (fr)
OA (1) OA12798A (fr)
PA (1) PA8570801A1 (fr)
PE (1) PE20040082A1 (fr)
PL (1) PL372968A1 (fr)
PT (1) PT1492789E (fr)
RS (1) RS51550B (fr)
SI (1) SI1492789T1 (fr)
TN (1) TNSN04194A1 (fr)
TW (1) TWI280130B (fr)
UY (1) UY27752A1 (fr)
WO (1) WO2003084954A1 (fr)

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US6855724B2 (en) 2002-04-08 2005-02-15 Agouron Pharmaceuticals, Inc. Tropane derivatives useful in therapy
BR0309118A (pt) * 2002-04-08 2005-02-01 Pfizer Derivados de tropano úteis em terapêutica
EP1786816A4 (fr) 2003-09-10 2009-11-04 Virochem Pharma Inc Composes de spirohydantoine et procedes de modulation de l'activite des recepteurs de chimiokine
AU2004278158B2 (en) * 2003-10-03 2009-08-13 Pfizer Inc. Imidazopyridine substituted tropane derivatives with CCR5 receptor antagonist activity for the treatment of HIV and inflammation
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8131026B2 (en) 2004-04-16 2012-03-06 Validity Sensors, Inc. Method and apparatus for fingerprint image reconstruction
DE602005022900D1 (de) 2004-10-04 2010-09-23 Validity Sensors Inc Fingerabdruckerfassende konstruktionen mit einem substrat
WO2006064340A2 (fr) * 2004-12-13 2006-06-22 Pfizer Limited Elaboration de n-acyl beta-aminoaldehydes
US7932235B2 (en) 2006-11-17 2011-04-26 Concert Pharmaceuticals, Inc. Triazolyl tropane derivatives
BRPI0810192C1 (pt) 2007-04-13 2021-05-25 Dong Wha Pharm Co Ltd aspartato do ácido 1-ciclopropil-6-fluoro-7-(8-metoxiimino-2,6-diaza-espiro [3,4] oct-6-il)-4-oxo-1,4-diidro- [1,8] naftiridina-3-carboxílico, método para preparação do mesmo e composição farmacêutica antimicrobiana compreendendo o mesmo.
WO2009029257A1 (fr) * 2007-08-27 2009-03-05 Theravance, Inc. Composes d'alkyl-8-azabicyclo[3.2.1.]octane disubstitutes utilises en tant qu'antagonistes du recepteur opioide mu
CN101712679B (zh) 2008-10-08 2013-04-10 中国科学院上海药物研究所 一种酰胺类化合物、其药物组合物及其制备方法和用途
JP2013511489A (ja) * 2009-11-21 2013-04-04 エフ．ホフマン−ラ ロシュ アーゲー 複素環式抗ウイルス化合物
AR079492A1 (es) 2009-12-23 2012-02-01 Ironwood Pharmaceuticals Inc Moduladores de crth2
PE20130529A1 (es) 2010-04-02 2013-05-14 Phivco 1 Llc Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico
US20130216552A1 (en) 2010-07-12 2013-08-22 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012009134A1 (fr) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Modulateurs de crth2
HUE047354T2 (hu) 2011-05-18 2020-04-28 Vertex Pharmaceuticals Europe Ltd Ivacaftor deuterizált származékai
WO2013024022A1 (fr) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour traiter l'hypertension pulmonaire
CN106977511B (zh) * 2011-12-19 2019-04-12 中国科学院上海药物研究所 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途
JP6146990B2 (ja) * 2012-11-16 2017-06-14 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
GB201321749D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321748D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2016160945A1 (fr) 2015-03-31 2016-10-06 Concert Pharmaceuticals, Inc. Vx-661 deutéré
US10759721B2 (en) 2015-09-25 2020-09-01 Vertex Pharmaceuticals (Europe) Limited Deuterated CFTR potentiators
JP2017105824A (ja) * 2017-02-10 2017-06-15 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
IL274763B2 (en) 2017-12-01 2024-01-01 Vertex Pharma Methods for making cystic fibrosis transmembrane conductance modulator modulators
EP3768256A4 (fr) 2018-03-19 2021-11-24 Emory University Inhibiteurs d'entrée pantropique
JP6654223B2 (ja) * 2018-08-13 2020-02-26 バーテックス ファーマシューティカルズ （ヨーロッパ） リミテッド 重水素化されたｃｆｔｒ増強物質
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

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PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
WO2001080106A1 (fr) * 2000-04-19 2001-10-25 Satoshi Yamazaki Procede de diffusion d'outil publicitaire et support magnetique pour le logiciel
SK286129B6 (sk) * 2000-05-26 2008-04-07 Pfizer Inc. Tropánové deriváty, ich použitie, spôsob a medziprodukt na ich výrobu, kombinácia a farmaceutická kompozícia s ich obsahom
BR0309118A (pt) * 2002-04-08 2005-02-01 Pfizer Derivados de tropano úteis em terapêutica

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Publication number Publication date
EP1492789A1 (fr) 2005-01-05
AU2003214503A1 (en) 2003-10-20
JP2006182784A (ja) 2006-07-13
UY27752A1 (es) 2003-11-28
ATE328882T1 (de) 2006-06-15
JP3793200B2 (ja) 2006-07-05
NZ535452A (en) 2006-11-30
OA12798A (en) 2006-07-10
GEP20074210B (en) 2007-10-10
BR0309118A (pt) 2005-02-01
CY1106114T1 (el) 2011-06-08
NO329674B1 (no) 2010-11-29
TNSN04194A1 (fr) 2007-03-12
IS2577B (is) 2010-02-15
WO2003084954A1 (fr) 2003-10-16
MY134223A (en) 2007-11-30
PL372968A1 (en) 2005-08-08
RS51550B (en) 2011-06-30
AR039383A1 (es) 2005-02-16
KR20040099420A (ko) 2004-11-26
MXPA04009220A (es) 2005-09-30
AP1789A (en) 2007-10-05
RS88804A (en) 2006-12-15
IL164261A0 (en) 2005-12-18
NI200300053A (es) 2005-11-01
DK1492789T3 (da) 2006-09-11
CR7514A (es) 2004-11-08
DE60305903T2 (de) 2007-03-08
ES2263960T3 (es) 2006-12-16
EA200401167A1 (ru) 2005-04-28
CN1324025C (zh) 2007-07-04
NO20044615L (no) 2004-10-26
PA8570801A1 (es) 2004-11-26
AU2003214503B2 (en) 2008-08-07
AP2004003147A0 (en) 2004-09-30
HRP20040940A2 (en) 2005-04-30
IS7453A (is) 2004-09-16
EP1492789B1 (fr) 2006-06-07
JP4571078B2 (ja) 2010-10-27
DOP2003000624A (es) 2003-10-15
HK1076102A1 (en) 2006-01-06
CA2481482C (fr) 2009-11-10
PT1492789E (pt) 2006-09-29
TW200403242A (en) 2004-03-01
EA007590B1 (ru) 2006-12-29
CU23282A3 (es) 2008-06-30
CA2481482A1 (fr) 2003-10-16
SI1492789T1 (sl) 2006-10-31
HN2003000114A (es) 2004-05-05
PE20040082A1 (es) 2004-03-20
DE60305903D1 (de) 2006-07-20
TWI280130B (en) 2007-05-01
JP2005532285A (ja) 2005-10-27
KR100734685B1 (ko) 2007-07-02
CN1646526A (zh) 2005-07-27

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