MA26876A1 - Mesylate et formes polymorphes de 4-amino-6, 7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydro-isoquinol-2-yl)-5-(2-pyridyl)quinazoline - Google Patents
Mesylate et formes polymorphes de 4-amino-6, 7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydro-isoquinol-2-yl)-5-(2-pyridyl)quinazolineInfo
- Publication number
- MA26876A1 MA26876A1 MA26776A MA26776A MA26876A1 MA 26876 A1 MA26876 A1 MA 26876A1 MA 26776 A MA26776 A MA 26776A MA 26776 A MA26776 A MA 26776A MA 26876 A1 MA26876 A1 MA 26876A1
- Authority
- MA
- Morocco
- Prior art keywords
- isoquinol
- quinazoline
- mesylate
- dimethoxy
- tetrahydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
Abstract
DEPOSANT Société dite : PFIZER INC. REVENDICATION DE PRIORITES GB 3 Mars 2000 0005200.1 GB 28 Juin 2000 0015900.4 Voir en annexe le titre de l'invention et le texte de l'abrégé Mésylate et formes polymorphes de 4-amino-6,7-diméthoxy-2-(5-méthanesulfonamido-1,2,3,4-tétrahydro-isoquinol-2-yl)-5-(2-pyridyl)quinazoline La présente invention propose le mésylate de 4-amino-6,7-diméthoxy-2-(5-méthanesuifonamido-1,2,3,4-tétrahydro-isoquinol-2-yl)-5-(2-pyridyl)quinazoline de formule (1), conjointement avec des procédés de préparation, et des compositions le contenant. L'invention concerne également des formes polymorphes cristallines anhydres substantiellement pures de la base libre. Les composés sont particulièrement utiles dans le traitement de l'hyperplasie prostatique bénigne.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0005200A GB0005200D0 (en) | 2000-03-03 | 2000-03-03 | New salt form |
GB0015900A GB0015900D0 (en) | 2000-06-28 | 2000-06-28 | New salt form |
Publications (1)
Publication Number | Publication Date |
---|---|
MA26876A1 true MA26876A1 (fr) | 2004-12-20 |
Family
ID=26243792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA26776A MA26876A1 (fr) | 2000-03-03 | 2002-08-15 | Mesylate et formes polymorphes de 4-amino-6, 7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydro-isoquinol-2-yl)-5-(2-pyridyl)quinazoline |
Country Status (40)
Country | Link |
---|---|
US (1) | US6683085B2 (fr) |
EP (1) | EP1268468B1 (fr) |
JP (1) | JP3857919B2 (fr) |
KR (1) | KR100496089B1 (fr) |
CN (1) | CN1214029C (fr) |
AP (1) | AP2002002611A0 (fr) |
AR (1) | AR029482A1 (fr) |
AT (1) | ATE253570T1 (fr) |
AU (1) | AU779118B2 (fr) |
BG (1) | BG106869A (fr) |
BR (1) | BR0108910A (fr) |
CA (1) | CA2398963C (fr) |
CR (1) | CR6731A (fr) |
CZ (1) | CZ20022858A3 (fr) |
DE (1) | DE60101157T2 (fr) |
DK (1) | DK1268468T3 (fr) |
EA (1) | EA004748B1 (fr) |
EE (1) | EE200200496A (fr) |
ES (1) | ES2208565T3 (fr) |
GE (1) | GEP20043364B (fr) |
HK (1) | HK1053655A1 (fr) |
HN (1) | HN2001000036A (fr) |
HR (1) | HRP20020718A2 (fr) |
HU (1) | HUP0300006A3 (fr) |
IL (1) | IL150634A0 (fr) |
IS (1) | IS6441A (fr) |
MA (1) | MA26876A1 (fr) |
MX (1) | MXPA02008665A (fr) |
NO (1) | NO20024195L (fr) |
NZ (1) | NZ519672A (fr) |
OA (1) | OA12186A (fr) |
PE (1) | PE20011225A1 (fr) |
PL (1) | PL365070A1 (fr) |
PT (1) | PT1268468E (fr) |
SI (1) | SI1268468T1 (fr) |
SK (1) | SK12282002A3 (fr) |
TN (1) | TNSN01034A1 (fr) |
TR (1) | TR200302130T4 (fr) |
UA (1) | UA72311C2 (fr) |
WO (1) | WO2001064672A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0124455D0 (en) * | 2001-10-11 | 2001-12-05 | Pfizer Ltd | Pharmaceutical formulations |
US7163696B2 (en) | 2001-10-11 | 2007-01-16 | Pfizer Inc. | Pharmaceutical formulations |
DE10223913A1 (de) * | 2002-05-29 | 2003-12-11 | Bayer Cropscience Ag | Verfahren zur Herstellung spezifischer Kristallmodifikationen polymorpher Substanzen |
GB0221582D0 (en) * | 2002-09-17 | 2002-10-23 | Pfizer Ltd | Method of treatment |
AR043880A1 (es) * | 2003-04-22 | 2005-08-17 | Solvay Pharm Gmbh | Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas |
WO2005089804A2 (fr) * | 2004-03-16 | 2005-09-29 | Pfizer Limited | Combinaisons d'inhibiteurs de la reductase hmg-coa et d'antagonistes du recepteur adrenergique $g(a)1 |
CN101584696A (zh) * | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
CN105596301A (zh) * | 2016-01-29 | 2016-05-25 | 中国药科大学 | 一种以异喹啉为基本骨架的p2x7受体拮抗剂的纳米混悬剂及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4914114A (en) | 1984-05-28 | 1990-04-03 | Merck Patent Gesellschaft Mit Breschrankter Haftung | 3-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-5-hydroxy-indole methanesulfonate having sedating and anti-parkinsonism properties |
AU594512B2 (en) * | 1986-09-16 | 1990-03-08 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Hydroxy indole derivatives |
GB9700504D0 (en) * | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
-
2001
- 2001-02-23 SK SK1228-2002A patent/SK12282002A3/sk unknown
- 2001-02-23 CN CNB018052304A patent/CN1214029C/zh not_active Expired - Fee Related
- 2001-02-23 HU HU0300006A patent/HUP0300006A3/hu unknown
- 2001-02-23 MX MXPA02008665A patent/MXPA02008665A/es active IP Right Grant
- 2001-02-23 AP APAP/P/2002/002611A patent/AP2002002611A0/en unknown
- 2001-02-23 AT AT01908029T patent/ATE253570T1/de not_active IP Right Cessation
- 2001-02-23 GE GE4907A patent/GEP20043364B/en unknown
- 2001-02-23 EE EEP200200496A patent/EE200200496A/xx unknown
- 2001-02-23 KR KR10-2002-7011506A patent/KR100496089B1/ko not_active IP Right Cessation
- 2001-02-23 ES ES01908029T patent/ES2208565T3/es not_active Expired - Lifetime
- 2001-02-23 BR BR0108910-2A patent/BR0108910A/pt not_active Application Discontinuation
- 2001-02-23 IL IL15063401A patent/IL150634A0/xx unknown
- 2001-02-23 OA OA1200200266A patent/OA12186A/fr unknown
- 2001-02-23 EA EA200200826A patent/EA004748B1/ru not_active IP Right Cessation
- 2001-02-23 AU AU35888/01A patent/AU779118B2/en not_active Ceased
- 2001-02-23 PT PT01908029T patent/PT1268468E/pt unknown
- 2001-02-23 EP EP01908029A patent/EP1268468B1/fr not_active Expired - Lifetime
- 2001-02-23 CA CA002398963A patent/CA2398963C/fr not_active Expired - Fee Related
- 2001-02-23 DK DK01908029T patent/DK1268468T3/da active
- 2001-02-23 WO PCT/IB2001/000244 patent/WO2001064672A1/fr active IP Right Grant
- 2001-02-23 TR TR2003/02130T patent/TR200302130T4/xx unknown
- 2001-02-23 UA UA2002097181A patent/UA72311C2/uk unknown
- 2001-02-23 PL PL01365070A patent/PL365070A1/xx unknown
- 2001-02-23 CZ CZ20022858A patent/CZ20022858A3/cs unknown
- 2001-02-23 SI SI200130064T patent/SI1268468T1/xx unknown
- 2001-02-23 NZ NZ519672A patent/NZ519672A/en unknown
- 2001-02-23 JP JP2001563512A patent/JP3857919B2/ja not_active Expired - Fee Related
- 2001-02-23 DE DE60101157T patent/DE60101157T2/de not_active Expired - Lifetime
- 2001-02-28 PE PE2001000202A patent/PE20011225A1/es not_active Application Discontinuation
- 2001-02-28 HN HN2001000036A patent/HN2001000036A/es unknown
- 2001-03-01 US US09/797,112 patent/US6683085B2/en not_active Expired - Fee Related
- 2001-03-01 AR ARP010100977A patent/AR029482A1/es unknown
- 2001-03-02 TN TNTNSN01034A patent/TNSN01034A1/fr unknown
-
2002
- 2002-06-24 BG BG106869A patent/BG106869A/bg unknown
- 2002-06-25 IS IS6441A patent/IS6441A/is unknown
- 2002-08-15 MA MA26776A patent/MA26876A1/fr unknown
- 2002-08-19 CR CR6731A patent/CR6731A/es not_active Application Discontinuation
- 2002-08-30 HR HR20020718A patent/HRP20020718A2/xx not_active Application Discontinuation
- 2002-09-03 NO NO20024195A patent/NO20024195L/no not_active Application Discontinuation
-
2003
- 2003-08-22 HK HK03106016A patent/HK1053655A1/xx not_active IP Right Cessation
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