BR0108910A - Mesilato de 4-amino-6,7-dimetóxi-2-(5-metanossulfonamido-1,2,3,4- tetrahidroisoquinol-2-il)-5-(2-piridil)-quinazolina e polimorfos - Google Patents

Mesilato de 4-amino-6,7-dimetóxi-2-(5-metanossulfonamido-1,2,3,4- tetrahidroisoquinol-2-il)-5-(2-piridil)-quinazolina e polimorfos

Info

Publication number
BR0108910A
BR0108910A BR0108910-2A BR0108910A BR0108910A BR 0108910 A BR0108910 A BR 0108910A BR 0108910 A BR0108910 A BR 0108910A BR 0108910 A BR0108910 A BR 0108910A
Authority
BR
Brazil
Prior art keywords
dimethoxy
pyridyl
amino
tetrahydroisoquinol
methanesulfonamido
Prior art date
Application number
BR0108910-2A
Other languages
English (en)
Inventor
Patricia Ann Basford
Paul Blaise Hodgson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0005200A external-priority patent/GB0005200D0/en
Priority claimed from GB0015900A external-priority patent/GB0015900D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of BR0108910A publication Critical patent/BR0108910A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

"MESILATO DE 4-AMINO-6,7-DIMETóXI-2-(5-METANOSSULFONAMIDO-1,2,3,4- TETRAHIDROISOQUINOL-2-IL)-5-(2-PIRIDIL)-QUINAZOLINA E POLIMORFOS". A presente invenção refere-se ao mesilato de 4-amino-6,7-dimetóxi-2-(5-metanossulfonamido-1,2,3,4-tetrahidroiso quinol-2-il)-5-(2-piridil)-quinazolina da fórmula (1) juntamente com processos da sua preparação e com as composições que o contém. A invenção refere-se também com formas puras, anidras e cristalinas da base livre. Os compostos são especialmente úteis no tratamento da hiperplasia benigna da próstata.
BR0108910-2A 2000-03-03 2001-02-23 Mesilato de 4-amino-6,7-dimetóxi-2-(5-metanossulfonamido-1,2,3,4- tetrahidroisoquinol-2-il)-5-(2-piridil)-quinazolina e polimorfos BR0108910A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0005200A GB0005200D0 (en) 2000-03-03 2000-03-03 New salt form
GB0015900A GB0015900D0 (en) 2000-06-28 2000-06-28 New salt form
PCT/IB2001/000244 WO2001064672A1 (en) 2000-03-03 2001-02-23 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylat and polymorphs

Publications (1)

Publication Number Publication Date
BR0108910A true BR0108910A (pt) 2002-12-24

Family

ID=26243792

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108910-2A BR0108910A (pt) 2000-03-03 2001-02-23 Mesilato de 4-amino-6,7-dimetóxi-2-(5-metanossulfonamido-1,2,3,4- tetrahidroisoquinol-2-il)-5-(2-piridil)-quinazolina e polimorfos

Country Status (40)

Country Link
US (1) US6683085B2 (pt)
EP (1) EP1268468B1 (pt)
JP (1) JP3857919B2 (pt)
KR (1) KR100496089B1 (pt)
CN (1) CN1214029C (pt)
AP (1) AP2002002611A0 (pt)
AR (1) AR029482A1 (pt)
AT (1) ATE253570T1 (pt)
AU (1) AU779118B2 (pt)
BG (1) BG106869A (pt)
BR (1) BR0108910A (pt)
CA (1) CA2398963C (pt)
CR (1) CR6731A (pt)
CZ (1) CZ20022858A3 (pt)
DE (1) DE60101157T2 (pt)
DK (1) DK1268468T3 (pt)
EA (1) EA004748B1 (pt)
EE (1) EE200200496A (pt)
ES (1) ES2208565T3 (pt)
GE (1) GEP20043364B (pt)
HK (1) HK1053655A1 (pt)
HN (1) HN2001000036A (pt)
HR (1) HRP20020718A2 (pt)
HU (1) HUP0300006A3 (pt)
IL (1) IL150634A0 (pt)
IS (1) IS6441A (pt)
MA (1) MA26876A1 (pt)
MX (1) MXPA02008665A (pt)
NO (1) NO20024195L (pt)
NZ (1) NZ519672A (pt)
OA (1) OA12186A (pt)
PE (1) PE20011225A1 (pt)
PL (1) PL365070A1 (pt)
PT (1) PT1268468E (pt)
SI (1) SI1268468T1 (pt)
SK (1) SK12282002A3 (pt)
TN (1) TNSN01034A1 (pt)
TR (1) TR200302130T4 (pt)
UA (1) UA72311C2 (pt)
WO (1) WO2001064672A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0124455D0 (en) * 2001-10-11 2001-12-05 Pfizer Ltd Pharmaceutical formulations
US7163696B2 (en) 2001-10-11 2007-01-16 Pfizer Inc. Pharmaceutical formulations
DE10223913A1 (de) * 2002-05-29 2003-12-11 Bayer Cropscience Ag Verfahren zur Herstellung spezifischer Kristallmodifikationen polymorpher Substanzen
GB0221582D0 (en) * 2002-09-17 2002-10-23 Pfizer Ltd Method of treatment
AR043880A1 (es) * 2003-04-22 2005-08-17 Solvay Pharm Gmbh Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas
WO2005089804A2 (en) * 2004-03-16 2005-09-29 Pfizer Limited Combinations of hmg-coa reductase inhibitors and alpha1 adrenergic receptor antagonists
CN101584696A (zh) * 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
CN105596301A (zh) * 2016-01-29 2016-05-25 中国药科大学 一种以异喹啉为基本骨架的p2x7受体拮抗剂的纳米混悬剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914114A (en) 1984-05-28 1990-04-03 Merck Patent Gesellschaft Mit Breschrankter Haftung 3-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-5-hydroxy-indole methanesulfonate having sedating and anti-parkinsonism properties
AU594512B2 (en) * 1986-09-16 1990-03-08 Merck Patent Gesellschaft Mit Beschrankter Haftung Hydroxy indole derivatives
GB9700504D0 (en) * 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
SI1268468T1 (en) 2004-04-30
WO2001064672A1 (en) 2001-09-07
IS6441A (is) 2002-06-25
CR6731A (es) 2004-03-11
TR200302130T4 (tr) 2004-01-21
US6683085B2 (en) 2004-01-27
AU779118B2 (en) 2005-01-06
ES2208565T3 (es) 2004-06-16
NZ519672A (en) 2004-06-25
DE60101157T2 (de) 2004-09-02
TNSN01034A1 (fr) 2005-11-10
EE200200496A (et) 2004-02-16
UA72311C2 (uk) 2005-02-15
EP1268468B1 (en) 2003-11-05
DK1268468T3 (da) 2004-02-09
AR029482A1 (es) 2003-07-02
CA2398963A1 (en) 2001-09-07
CN1214029C (zh) 2005-08-10
KR100496089B1 (ko) 2005-06-17
BG106869A (bg) 2002-12-29
AP2002002611A0 (en) 2002-09-30
HUP0300006A2 (en) 2003-05-28
US20020010188A1 (en) 2002-01-24
DE60101157D1 (de) 2003-12-11
NO20024195D0 (no) 2002-09-03
JP2003525289A (ja) 2003-08-26
EP1268468A1 (en) 2003-01-02
PE20011225A1 (es) 2001-12-08
CN1432010A (zh) 2003-07-23
IL150634A0 (en) 2003-02-12
AU3588801A (en) 2001-09-12
KR20020080463A (ko) 2002-10-23
GEP20043364B (en) 2004-03-10
MA26876A1 (fr) 2004-12-20
CZ20022858A3 (cs) 2003-09-17
EA200200826A1 (ru) 2003-02-27
CA2398963C (en) 2006-10-24
PL365070A1 (en) 2004-12-27
SK12282002A3 (sk) 2003-10-07
NO20024195L (no) 2002-09-03
ATE253570T1 (de) 2003-11-15
HK1053655A1 (en) 2003-10-31
OA12186A (en) 2006-05-09
JP3857919B2 (ja) 2006-12-13
PT1268468E (pt) 2004-01-30
EA004748B1 (ru) 2004-08-26
HRP20020718A2 (en) 2004-02-29
MXPA02008665A (es) 2003-02-24
HN2001000036A (es) 2001-07-09
HUP0300006A3 (en) 2006-01-30

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.