DK1597239T3 - Polymorf af {6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl}-(3E) - Google Patents

Polymorf af {6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl}-(3E)

Info

Publication number
DK1597239T3
DK1597239T3 DK04710031T DK04710031T DK1597239T3 DK 1597239 T3 DK1597239 T3 DK 1597239T3 DK 04710031 T DK04710031 T DK 04710031T DK 04710031 T DK04710031 T DK 04710031T DK 1597239 T3 DK1597239 T3 DK 1597239T3
Authority
DK
Denmark
Prior art keywords
quinazolin
ethoxy
methoxy
bis
polymorph
Prior art date
Application number
DK04710031T
Other languages
English (en)
Other versions
DK1597239T4 (da
Inventor
Andre Gerard Bubendorf
Michael Hennig
Pirmin Hidber
Goesta Rimmler
Franziska Rohrer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32842701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1597239(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK1597239T3 publication Critical patent/DK1597239T3/da
Application granted granted Critical
Publication of DK1597239T4 publication Critical patent/DK1597239T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
DK04710031.8T 2003-02-17 2004-02-11 Polymorf af {6,7-bis(2-methoxy-ethoxy)-quinazolin-4-yl}-(3e) DK1597239T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03003587 2003-02-17
PCT/EP2004/001244 WO2004072049A1 (en) 2003-02-17 2004-02-11 Polymorph of {6,7-bis(2-methoxy-ethoxy)-quinazolin-4-yl}-(3e)

Publications (2)

Publication Number Publication Date
DK1597239T3 true DK1597239T3 (da) 2008-12-08
DK1597239T4 DK1597239T4 (da) 2022-09-26

Family

ID=32842701

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04710031.8T DK1597239T4 (da) 2003-02-17 2004-02-11 Polymorf af {6,7-bis(2-methoxy-ethoxy)-quinazolin-4-yl}-(3e)

Country Status (24)

Country Link
US (1) US7148231B2 (da)
EP (1) EP1597239B2 (da)
JP (1) JP4456079B2 (da)
KR (1) KR100797430B1 (da)
CN (1) CN100506803C (da)
AT (1) ATE408605T1 (da)
AU (1) AU2004212067C1 (da)
BR (1) BRPI0407520A (da)
CA (1) CA2514977C (da)
CO (1) CO5601019A2 (da)
DE (1) DE602004016628D1 (da)
DK (1) DK1597239T4 (da)
ES (1) ES2314373T5 (da)
HR (1) HRP20050707B1 (da)
IL (1) IL169975A (da)
MX (1) MXPA05008598A (da)
NO (1) NO330781B1 (da)
NZ (1) NZ541500A (da)
PL (1) PL225428B1 (da)
PT (1) PT1597239E (da)
RU (1) RU2376294C2 (da)
SI (1) SI1597239T2 (da)
WO (1) WO2004072049A1 (da)
ZA (1) ZA200506339B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US7625911B2 (en) * 2005-01-12 2009-12-01 Mai De Ltd. Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
SI2032521T1 (sl) 2006-06-27 2010-02-26 Sandoz Ag Nov postopek za pripravo soli
CN101547910A (zh) 2006-07-28 2009-09-30 合成纤维有限公司 结晶埃罗替尼
US8372856B2 (en) 2006-10-27 2013-02-12 Synthon Bv Hydrates of erlotinib hydrochloride
PT2170844T (pt) 2007-02-21 2016-08-05 Natco Pharma Ltd Novos polimorfos de cloridrato de erlotinib e método de preparação
KR101441930B1 (ko) * 2007-04-04 2014-09-19 시플라 리미티드 에르로티닙 및 그의 약학적으로 허용가능한 염의 제조방법
EP2218713A1 (en) 2007-08-17 2010-08-18 Hetero Drugs Limited Erlotinib hydrochloride polymorph Form A substantially free of polymorph Form B
US20090124642A1 (en) * 2007-08-23 2009-05-14 Augusto Canavesi Crystalline forms of Erlotinib HCI and formulations thereof
US20090131665A1 (en) * 2007-08-23 2009-05-21 Ales Gavenda Process for the preparation of crystalline forms A, B and pure crystalline form a of erlotinib HCI
WO2010005924A1 (en) * 2008-07-07 2010-01-14 Plus Chemicals Sa Crystalline forms of erlotinib base and erlotinib hcl
WO2010040212A1 (en) * 2008-10-08 2010-04-15 Apotex Pharmachem Inc. Processes for the preparation of erlotinib hydrochloride
EP2213281A1 (en) 2009-02-02 2010-08-04 Ratiopharm GmbH Pharmaceutical composition comprising N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
US8440823B2 (en) 2009-03-26 2013-05-14 Ranbaxy Laboratories Limited Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
WO2011058525A2 (en) 2009-11-12 2011-05-19 Ranbaxy Laboratories Limited Processes for the preparation of erlotinib hydrochloride form a and erlotinib hydrochloride form b
CN101987834B (zh) * 2010-06-13 2012-07-18 信泰制药（苏州）有限公司 一种结晶形态的盐酸埃罗替尼及其制备方法
US8952022B2 (en) 2010-07-23 2015-02-10 Generics [Uk] Limited Pure erlotinib
US20140121373A1 (en) 2011-05-03 2014-05-01 Cadila Healthcare Limited Process for preparing stable polymorphic form of erlotinib hydrochloride
WO2014037961A1 (en) 2012-09-04 2014-03-13 Shilpa Medicare Limited Crystalline erlotinib hydrochloride process
WO2014118737A1 (en) 2013-01-31 2014-08-07 Ranbaxy Laboratories Limited Erlotinib salts
CN103333124B (zh) * 2013-05-28 2015-03-25 埃斯特维华义制药有限公司 一种制备盐酸厄洛替尼晶型f的方法
WO2016082879A1 (en) * 2014-11-27 2016-06-02 Synthon B.V. Pharmaceutical composition comprising erlotinib hydrochloride
RU2610337C1 (ru) * 2015-12-10 2017-02-09 Индивидуальный предприниматель Михайлов Олег Ростиславович Кристаллическая β-модификация N-(3-этинилфенил)-6,7-бис(2 метоксиэтокси)хиназолин-4-амин гидрохлорида, способ её получения и фармацевтическая композиция на её основе
JP2019059685A (ja) * 2017-09-26 2019-04-18 日本化薬株式会社 エルロチニブを有効成分とする医薬錠剤
JP2020090456A (ja) * 2018-12-05 2020-06-11 日本化薬株式会社 エルロチニブを有効成分とする医薬錠剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6434574A (en) * 1987-07-30 1989-02-06 Mazda Motor Full mold casting device
EP0817775B1 (en) 1995-03-30 2001-09-12 Pfizer Inc. Quinazoline derivatives
US5747498A (en) † 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
TR200003166T2 (tr) 1998-04-29 2001-02-21 Osi Pharmaceuticals, Inc. N-(3-etinilfenilamino)-6, 7-bis(2-metoksietoksi)-4-kuinozolamin mesilat anhidrat ve monohidrat.
RS49836B (sr) 1999-03-31 2008-08-07 Pfizer Products Inc., Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування

Also Published As

Publication number Publication date
DE602004016628D1 (de) 2008-10-30
PT1597239E (pt) 2008-10-10
AU2004212067B2 (en) 2009-03-19
AU2004212067C1 (en) 2009-09-24
ES2314373T5 (es) 2022-10-11
EP1597239B1 (en) 2008-09-17
BRPI0407520A (pt) 2006-02-14
CN1751032A (zh) 2006-03-22
NO330781B1 (no) 2011-07-18
IL169975A (en) 2011-06-30
JP2006521288A (ja) 2006-09-21
EP1597239A1 (en) 2005-11-23
US20040162300A1 (en) 2004-08-19
ZA200506339B (en) 2006-05-31
WO2004072049A1 (en) 2004-08-26
PL225428B1 (pl) 2017-04-28
AU2004212067A1 (en) 2004-08-26
CN100506803C (zh) 2009-07-01
DK1597239T4 (da) 2022-09-26
US7148231B2 (en) 2006-12-12
RU2376294C2 (ru) 2009-12-20
ATE408605T1 (de) 2008-10-15
PL378561A1 (pl) 2006-05-02
ES2314373T3 (es) 2009-03-16
SI1597239T2 (sl) 2022-10-28
HRP20050707B1 (hr) 2013-10-25
CA2514977A1 (en) 2004-08-26
NZ541500A (en) 2008-03-28
KR100797430B1 (ko) 2008-01-23
CO5601019A2 (es) 2006-01-31
RU2005128774A (ru) 2006-05-10
EP1597239B2 (en) 2022-07-20
NO20053953L (no) 2005-08-31
MXPA05008598A (es) 2005-11-04
CA2514977C (en) 2010-06-22
SI1597239T1 (sl) 2009-02-28
JP4456079B2 (ja) 2010-04-28
HRP20050707A2 (en) 2006-07-31
KR20050095898A (ko) 2005-10-04

Similar Documents

Publication Publication Date Title
HRP20050707B1 (hr) Polimorf od {6,7-bis(2-metoksi-etoksi)-kinazolin-4-il}-(3e)
ATE419253T1 (de) Inhibitoren von thienopyridin- und furopyridinkinase
AP1434A (en) Stable polymorph of N-(3-Ethynylphenylamino) -6, 7-bis (2-methoxyethoxy) -4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof.
ATE554087T1 (de) Neue kinaseinhibitoren
DE60316013D1 (de) Heteroaryl-pyrimidinderivate als jak-inhibitoren
PL406680A1 (pl) Inhibitory kinaz tyrozynowych
DK1347971T3 (da) Thiazolylinhibitorer af tyrosinkinaser fra Tec-familien
EA200501333A1 (ru) 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
UA84167C2 (ru) Производные хиназолина как ингибиторы тирозинкиназы, способ их получения (варианты), фармацевтическая композиция на их основе
BR0316350A (pt) Diaminotriazóis úteis como inibidores de proteìna cinases
TW200634012A (en) 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents
UA85593C2 (uk) Похідні хіназолінону як інгібітори parp
UA88012C2 (uk) Похідні хіназоліндіону як інгібітори parp
HK1087613A1 (en) Quinazoline derivatives and their use in the treatment of cancer
WO2004063151A3 (en) Novel tyrosine kinase inhibitors
UA85394C2 (ru) Замещенные хинолины в качестве ингибиторов ферментов протеинтирозиновых киназ
BRPI0615272A2 (pt) inibidores de p38 map kinase e métodos para uso dos mesmos
WO2004030620A3 (en) Novel tyrosine kinase inhibitors
BRPI0416030A (pt) pirido-7-pirimidin-7-onas substituìdas com hidroxialquila
WO2004092144A3 (en) Quinazoline compounds useful as p38 kinase inhibitors
BRPI0407841A (pt) inibidores heterocìclicos de quinase
ATE507218T1 (de) Benzodiazepin-derivate als rock-kinasen hemmer
WO2005097755A3 (de) Imidazolderivate als hemmer von tyrosinkinase
BR0214611A (pt) Antagonistas vii de receptor ccr-3
ATE540951T1 (de) Substituierte 7,8-dihydro-1h-pyrimidoä4,5- büdiazepin-4-amine als kinase inhibitoren