CO5601019A2 - Polimorfo del clohidrato de la [6,7-bis(2-metoxi-etoxi)-quinazolin-4-il]-(3-etinil-fenil) amina - Google Patents

Polimorfo del clohidrato de la [6,7-bis(2-metoxi-etoxi)-quinazolin-4-il]-(3-etinil-fenil) amina

Info

Publication number
CO5601019A2
CO5601019A2 CO05082094A CO05082094A CO5601019A2 CO 5601019 A2 CO5601019 A2 CO 5601019A2 CO 05082094 A CO05082094 A CO 05082094A CO 05082094 A CO05082094 A CO 05082094A CO 5601019 A2 CO5601019 A2 CO 5601019A2
Authority
CO
Colombia
Prior art keywords
quinazolin
bis
phenyl
polymorph
clohydrate
Prior art date
Application number
CO05082094A
Other languages
English (en)
Inventor
Andre Gerard Bubendorf
Michael Hening
Pirmin Hidber
Goesta Rimmler
Franziska Rohrer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32842701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5601019(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5601019A2 publication Critical patent/CO5601019A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1.- Un polimorfo cristalino del clorhidrato de la [6,7-bis(2-metoxi-etoxi)-quinazolin-4-il]-(3-etinil-fenil)amina que se caracteriza por un diagrama de difracción de polvo de rayos X que tiene picos característicos que se expresan engrados 2-theta situados aproximadamente en: 7.- Un proceso para la obtención de un polimorfo cristalinoya definido en una cualquiera de las reivindicaciones de 1 a5, dicho proceso consiste en hacer reaccionar un compuesto de la fórmula (II) ...
CO05082094A 2003-02-17 2005-08-18 Polimorfo del clohidrato de la [6,7-bis(2-metoxi-etoxi)-quinazolin-4-il]-(3-etinil-fenil) amina CO5601019A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03003587 2003-02-17

Publications (1)

Publication Number Publication Date
CO5601019A2 true CO5601019A2 (es) 2006-01-31

Family

ID=32842701

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05082094A CO5601019A2 (es) 2003-02-17 2005-08-18 Polimorfo del clohidrato de la [6,7-bis(2-metoxi-etoxi)-quinazolin-4-il]-(3-etinil-fenil) amina

Country Status (24)

Country Link
US (1) US7148231B2 (es)
EP (1) EP1597239B2 (es)
JP (1) JP4456079B2 (es)
KR (1) KR100797430B1 (es)
CN (1) CN100506803C (es)
AT (1) ATE408605T1 (es)
AU (1) AU2004212067C1 (es)
BR (1) BRPI0407520A (es)
CA (1) CA2514977C (es)
CO (1) CO5601019A2 (es)
DE (1) DE602004016628D1 (es)
DK (1) DK1597239T4 (es)
ES (1) ES2314373T5 (es)
HR (1) HRP20050707B1 (es)
IL (1) IL169975A (es)
MX (1) MXPA05008598A (es)
NO (1) NO330781B1 (es)
NZ (1) NZ541500A (es)
PL (1) PL225428B1 (es)
PT (1) PT1597239E (es)
RU (1) RU2376294C2 (es)
SI (1) SI1597239T2 (es)
WO (1) WO2004072049A1 (es)
ZA (1) ZA200506339B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US7625911B2 (en) * 2005-01-12 2009-12-01 Mai De Ltd. Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
US20100204470A1 (en) * 2006-06-27 2010-08-12 Sandoz Ag method for salt preparation
WO2008012105A1 (en) 2006-07-28 2008-01-31 Synthon B.V. Crystalline erlotinib
US8372856B2 (en) 2006-10-27 2013-02-12 Synthon Bv Hydrates of erlotinib hydrochloride
EP2170844B1 (en) * 2007-02-21 2016-05-04 Natco Pharma Limited Novel polymorphs of erlotinib hydrochloride and method of preparation
EP2139868B1 (en) * 2007-04-04 2015-07-29 Cipla Limited Process for preparation of erlotinib and its pharmaceutically acceptable salts
WO2009024989A2 (en) * 2007-08-17 2009-02-26 Hetero Drugs Limited A novel hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form b
WO2009025875A1 (en) * 2007-08-23 2009-02-26 Plus Chemicals Sa Stable formulations of crystalline erlotinib hcl
US20090124642A1 (en) * 2007-08-23 2009-05-14 Augusto Canavesi Crystalline forms of Erlotinib HCI and formulations thereof
US20100004449A1 (en) * 2008-07-07 2010-01-07 Plus Chemicals Sa Crystalline forms of erlotinib base and erlotinib hcl
WO2010040212A1 (en) * 2008-10-08 2010-04-15 Apotex Pharmachem Inc. Processes for the preparation of erlotinib hydrochloride
EP2213281A1 (en) 2009-02-02 2010-08-04 Ratiopharm GmbH Pharmaceutical composition comprising N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
US8440823B2 (en) 2009-03-26 2013-05-14 Ranbaxy Laboratories Limited Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
WO2011058525A2 (en) 2009-11-12 2011-05-19 Ranbaxy Laboratories Limited Processes for the preparation of erlotinib hydrochloride form a and erlotinib hydrochloride form b
CN101987834B (zh) * 2010-06-13 2012-07-18 信泰制药（苏州）有限公司 一种结晶形态的盐酸埃罗替尼及其制备方法
US8952022B2 (en) 2010-07-23 2015-02-10 Generics [Uk] Limited Pure erlotinib
US20140121373A1 (en) 2011-05-03 2014-05-01 Cadila Healthcare Limited Process for preparing stable polymorphic form of erlotinib hydrochloride
NZ630289A (en) 2012-09-04 2016-08-26 Shilpa Medicare Ltd Crystalline erlotinib hydrochloride process
WO2014118737A1 (en) 2013-01-31 2014-08-07 Ranbaxy Laboratories Limited Erlotinib salts
CN103333124B (zh) * 2013-05-28 2015-03-25 埃斯特维华义制药有限公司 一种制备盐酸厄洛替尼晶型f的方法
WO2016082879A1 (en) * 2014-11-27 2016-06-02 Synthon B.V. Pharmaceutical composition comprising erlotinib hydrochloride
RU2610337C1 (ru) * 2015-12-10 2017-02-09 Индивидуальный предприниматель Михайлов Олег Ростиславович Кристаллическая β-модификация N-(3-этинилфенил)-6,7-бис(2 метоксиэтокси)хиназолин-4-амин гидрохлорида, способ её получения и фармацевтическая композиция на её основе
JP2019059685A (ja) * 2017-09-26 2019-04-18 日本化薬株式会社 エルロチニブを有効成分とする医薬錠剤
JP2020090456A (ja) * 2018-12-05 2020-06-11 日本化薬株式会社 エルロチニブを有効成分とする医薬錠剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6434574A (en) * 1987-07-30 1989-02-06 Mazda Motor Full mold casting device
EP0817775B1 (en) 1995-03-30 2001-09-12 Pfizer Inc. Quinazoline derivatives
US5747498A (en) † 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
CZ298230B6 (cs) 1998-04-29 2007-08-01 Osi Pharmaceuticals, Inc. Anhydrát a monohydrát N-(3-ethinylfenyl)-6,7-bis(2-methoxyethoxy)-4-chinazolinamin mesylátu
YU13200A (sh) 1999-03-31 2002-10-18 Pfizer Products Inc. Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування

Also Published As

Publication number Publication date
AU2004212067C1 (en) 2009-09-24
SI1597239T2 (sl) 2022-10-28
EP1597239B2 (en) 2022-07-20
KR20050095898A (ko) 2005-10-04
PT1597239E (pt) 2008-10-10
US20040162300A1 (en) 2004-08-19
ZA200506339B (en) 2006-05-31
RU2005128774A (ru) 2006-05-10
HRP20050707B1 (hr) 2013-10-25
CN100506803C (zh) 2009-07-01
HRP20050707A2 (en) 2006-07-31
ES2314373T5 (es) 2022-10-11
CA2514977A1 (en) 2004-08-26
EP1597239B1 (en) 2008-09-17
NO20053953L (no) 2005-08-31
DK1597239T4 (da) 2022-09-26
EP1597239A1 (en) 2005-11-23
PL225428B1 (pl) 2017-04-28
NZ541500A (en) 2008-03-28
KR100797430B1 (ko) 2008-01-23
DE602004016628D1 (de) 2008-10-30
DK1597239T3 (da) 2008-12-08
NO330781B1 (no) 2011-07-18
MXPA05008598A (es) 2005-11-04
ES2314373T3 (es) 2009-03-16
IL169975A (en) 2011-06-30
SI1597239T1 (sl) 2009-02-28
AU2004212067B2 (en) 2009-03-19
JP4456079B2 (ja) 2010-04-28
JP2006521288A (ja) 2006-09-21
AU2004212067A1 (en) 2004-08-26
RU2376294C2 (ru) 2009-12-20
CN1751032A (zh) 2006-03-22
PL378561A1 (pl) 2006-05-02
US7148231B2 (en) 2006-12-12
CA2514977C (en) 2010-06-22
WO2004072049A1 (en) 2004-08-26
BRPI0407520A (pt) 2006-02-14
ATE408605T1 (de) 2008-10-15

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