DE602004025302D1 - Aryloxy- und Arylthioxyacetophenon-Verbindungen zur Behandlung von Krebs - Google Patents
Aryloxy- und Arylthioxyacetophenon-Verbindungen zur Behandlung von KrebsInfo
- Publication number
- DE602004025302D1 DE602004025302D1 DE602004025302T DE602004025302T DE602004025302D1 DE 602004025302 D1 DE602004025302 D1 DE 602004025302D1 DE 602004025302 T DE602004025302 T DE 602004025302T DE 602004025302 T DE602004025302 T DE 602004025302T DE 602004025302 D1 DE602004025302 D1 DE 602004025302D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- treatment
- formula
- arylthioxyacetophenone
- aryloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03405912 | 2003-12-22 | ||
EP03405911 | 2003-12-22 | ||
EP04405517 | 2004-08-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004025302D1 true DE602004025302D1 (de) | 2010-03-11 |
Family
ID=34714028
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004010845T Active DE602004010845T2 (de) | 2003-12-22 | 2004-12-21 | Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen |
DE602004025302T Active DE602004025302D1 (de) | 2003-12-22 | 2004-12-21 | Aryloxy- und Arylthioxyacetophenon-Verbindungen zur Behandlung von Krebs |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004010845T Active DE602004010845T2 (de) | 2003-12-22 | 2004-12-21 | Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen |
Country Status (9)
Country | Link |
---|---|
US (1) | US8486996B2 (de) |
EP (2) | EP1894917B1 (de) |
JP (1) | JP4805166B2 (de) |
CN (1) | CN101061101B (de) |
AT (2) | ATE381554T1 (de) |
CA (1) | CA2545821C (de) |
DE (2) | DE602004010845T2 (de) |
ES (2) | ES2338060T3 (de) |
WO (1) | WO2005061476A2 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007019417A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Oxazolopyridine derivatives as sirtuin modulators |
EP2001880A2 (de) | 2006-03-07 | 2008-12-17 | Array Biopharma, Inc. | Heterobicyclische pyrazolverbindungen und verfahren zu ihrer verwendung |
RU2448111C2 (ru) * | 2006-08-21 | 2012-04-20 | Дженентек, Инк. | Соединения азабензофуранила и способ их применения |
ES2528797T3 (es) | 2006-08-21 | 2015-02-12 | Genentech, Inc. | Compuestos de aza-benzotiofenilo y métodos de uso |
ATE531720T1 (de) * | 2006-08-21 | 2011-11-15 | Genentech Inc | Aza-benzofuranylverbindungen und anwendungsverfahren dafür |
ZA200900896B (en) * | 2006-08-21 | 2010-06-30 | Genentech Inc | Aza-benzofuranyl compounds and methods of use |
NZ578744A (en) | 2007-01-31 | 2012-02-24 | Vertex Pharma | 2-aminopyridine derivatives useful as kinase inhibitors |
ES2389992T3 (es) * | 2007-11-02 | 2012-11-05 | Vertex Pharmaceuticals Incorporated | Derivados de [1H-pirazolo[3,4-b]piridin-4-il]-fenilo o -piridin-2-ilo como proteína cinasa c-theta |
PE20110570A1 (es) | 2008-07-01 | 2011-08-26 | Genentech Inc | Heterociclos biciclicos sustituidos |
US8492427B2 (en) | 2008-07-01 | 2013-07-23 | Genentech, Inc. | Isoindolones derivatives as MEK kinase inhibitors and methods of use |
US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
WO2010011768A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
CA2731451A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
MX2011001319A (es) | 2008-08-06 | 2011-04-05 | Vertex Pharma | Inhibidores de aminopiridina cinasa. |
CN102459259A (zh) | 2009-05-06 | 2012-05-16 | 沃泰克斯药物股份有限公司 | 吡唑并吡啶类 |
WO2011094290A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
US9067932B2 (en) | 2010-01-27 | 2015-06-30 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
AU2011209649A1 (en) | 2010-01-27 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
BR112021005274A2 (pt) | 2018-09-22 | 2021-06-15 | Torrent Pharmaceuticals Limited | métodos para produção de compostos de pirazol |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2350109A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofuranyl sulfonates |
WO2001007031A1 (fr) | 1999-07-26 | 2001-02-01 | Shionogi & Co., Ltd. | Derives de benzene, compositions immunostimulantes ou agents de retablissement de la pharmacosensibilite les contenant |
GB9920872D0 (en) * | 1999-09-04 | 1999-11-10 | Glaxo Group Ltd | Benzophenones as inhibitors of reverse transcriptase |
DE19947154A1 (de) * | 1999-10-01 | 2001-10-04 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
US6982274B2 (en) * | 2001-04-16 | 2006-01-03 | Eisai Co., Ltd. | 1H-indazole compound |
US7144885B2 (en) | 2002-02-22 | 2006-12-05 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
DE60307998T2 (de) * | 2002-02-22 | 2007-04-05 | Bayer Pharmaceuticals Corp., West Haven | Zur behandlung hyperproliferativer erkrankungen geeignete benzofuran- und benzothiophenderivate |
DE60315666T2 (de) * | 2002-07-11 | 2008-05-08 | Bayer Pharmaceuticals Corp., West Haven | Furopyridin- und furopyrimidinderivate zur behandlung von hyperproliferativen erkrankungen |
-
2004
- 2004-12-21 ES ES07118973T patent/ES2338060T3/es active Active
- 2004-12-21 AT AT04804957T patent/ATE381554T1/de active
- 2004-12-21 CA CA2545821A patent/CA2545821C/en not_active Expired - Fee Related
- 2004-12-21 CN CN2004800386105A patent/CN101061101B/zh not_active Expired - Fee Related
- 2004-12-21 DE DE602004010845T patent/DE602004010845T2/de active Active
- 2004-12-21 DE DE602004025302T patent/DE602004025302D1/de active Active
- 2004-12-21 JP JP2006546171A patent/JP4805166B2/ja not_active Expired - Fee Related
- 2004-12-21 EP EP07118973A patent/EP1894917B1/de not_active Not-in-force
- 2004-12-21 EP EP04804957A patent/EP1697336B1/de not_active Not-in-force
- 2004-12-21 WO PCT/EP2004/053622 patent/WO2005061476A2/en active IP Right Grant
- 2004-12-21 ES ES04804957T patent/ES2298853T3/es active Active
- 2004-12-21 AT AT07118973T patent/ATE455765T1/de active
-
2006
- 2006-05-12 US US11/433,511 patent/US8486996B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN101061101A (zh) | 2007-10-24 |
ES2338060T3 (es) | 2010-05-03 |
EP1894917B1 (de) | 2010-01-20 |
EP1894917A1 (de) | 2008-03-05 |
JP4805166B2 (ja) | 2011-11-02 |
WO2005061476A3 (en) | 2006-01-26 |
EP1697336A2 (de) | 2006-09-06 |
JP2007517787A (ja) | 2007-07-05 |
DE602004010845D1 (de) | 2008-01-31 |
US8486996B2 (en) | 2013-07-16 |
ATE381554T1 (de) | 2008-01-15 |
ES2298853T3 (es) | 2008-05-16 |
ATE455765T1 (de) | 2010-02-15 |
WO2005061476A2 (en) | 2005-07-07 |
DE602004010845T2 (de) | 2008-12-04 |
EP1697336B1 (de) | 2007-12-19 |
CN101061101B (zh) | 2011-09-07 |
CA2545821C (en) | 2010-09-21 |
US20060205739A1 (en) | 2006-09-14 |
CA2545821A1 (en) | 2005-07-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602004025302D1 (de) | Aryloxy- und Arylthioxyacetophenon-Verbindungen zur Behandlung von Krebs | |
CY1107422T1 (el) | Φουραζανοβενζιμιδαζoλες | |
AP1635A (en) | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease. | |
SE0300119D0 (sv) | Novel compounds | |
MXPA04000677A (es) | Tienopirimidindionas y su uso en modulacion de enfermedades autoinmunes. | |
DK1506203T3 (da) | Syntese af epothiloner, mellemprodukter deraf, analoger deraf og anvendelser deraf | |
TW200519088A (en) | Aryl or heteroaryl amide compounds | |
NO20054185D0 (no) | Methods of radiofluorination of biologically active vectors | |
SE0202133D0 (sv) | Novel compounds | |
SE0104140D0 (sv) | Novel Compounds | |
SE0200920D0 (sv) | Novel compounds | |
NO20054361D0 (no) | Benzensylfonamidderivater, fremgangsmate for fremstilling og anvendelse derav for behandlig av smerte | |
DE602005022284D1 (de) | Substituierte benzimidazole und deren verwendung zur induktion von apoptose | |
TW200833670A (en) | Novel compounds 569 | |
MY141233A (en) | Enantiomers of selected fused heterocyclics and uses thereof | |
TW200740781A (en) | Novel compounds | |
DE602004029355D1 (de) | Sulfopyrrolderivate | |
SE0300456D0 (sv) | Novel compounds | |
SE0101038D0 (sv) | Novel compounds | |
EA200600992A1 (ru) | Амиды тиазолидинона, амиды тиазолидинкарбоновой кислоты, способы их получения и их применение | |
SE0303280D0 (sv) | Novel compounds | |
MXPA05014068A (es) | Dicetopiperazinas sustituidas y su uso como antagonistas de oxitocina. | |
SE0302755D0 (sv) | Novel compounds | |
MXPA06000892A (es) | Compuestos azapoliciclicos arilo fusionados. | |
DE60213541D1 (de) | Discodermolid-Analoga und ihre pharmazeutische Verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |