TNSN01034A1 - Sel nouveau et formes polymorphes nouvelles de 4-amino-6, 7- dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydro-isoquinol-2-yl) - 5-(2-pyridyl)quinazoline - Google Patents

Sel nouveau et formes polymorphes nouvelles de 4-amino-6, 7- dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydro-isoquinol-2-yl) - 5-(2-pyridyl)quinazoline

Info

Publication number
TNSN01034A1
TNSN01034A1 TNTNSN01034A TNSN01034A TNSN01034A1 TN SN01034 A1 TNSN01034 A1 TN SN01034A1 TN TNSN01034 A TNTNSN01034 A TN TNSN01034A TN SN01034 A TNSN01034 A TN SN01034A TN SN01034 A1 TNSN01034 A1 TN SN01034A1
Authority
TN
Tunisia
Prior art keywords
new
isoquinol
methanesulfonamido
dimethoxy
tetrahydro
Prior art date
Application number
TNTNSN01034A
Other languages
English (en)
Inventor
Ann Basford Patricia
Blaise Hodgson Paul
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0005200A external-priority patent/GB0005200D0/en
Priority claimed from GB0015900A external-priority patent/GB0015900D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN01034A1 publication Critical patent/TNSN01034A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate

Abstract

LA PRESENTE INVENTION A POUR OBJET LE MESYLATE DE 4 - AMINO-6, 7- DIMETHOXY-2-(5-METHANESULFONAMIDO-1,2,3,4 – TETRAHYDRO-ISOQUINOL-2-YL)-5- (2- PYRIDYL) QUINAZOLINE DE FORMULE ET DES FORMES POLYMORPHES CRISTALLINES ANHYDRES PRATIQUEMENT PURES DE LA BASE LIBRE. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LA PREPARATION DU MESYLATE, AINSI QUE DES COMPOSITIONS LE CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS DANS LE TRAITEMENT DE DIVERSES MALADIES, NOTAMMENT DE L'HYPERPLASIE PROSTATIQUE BENIGNE.
TNTNSN01034A 2000-03-03 2001-03-02 Sel nouveau et formes polymorphes nouvelles de 4-amino-6, 7- dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydro-isoquinol-2-yl) - 5-(2-pyridyl)quinazoline TNSN01034A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0005200A GB0005200D0 (en) 2000-03-03 2000-03-03 New salt form
GB0015900A GB0015900D0 (en) 2000-06-28 2000-06-28 New salt form

Publications (1)

Publication Number Publication Date
TNSN01034A1 true TNSN01034A1 (fr) 2005-11-10

Family

ID=26243792

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN01034A TNSN01034A1 (fr) 2000-03-03 2001-03-02 Sel nouveau et formes polymorphes nouvelles de 4-amino-6, 7- dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydro-isoquinol-2-yl) - 5-(2-pyridyl)quinazoline

Country Status (40)

Country Link
US (1) US6683085B2 (fr)
EP (1) EP1268468B1 (fr)
JP (1) JP3857919B2 (fr)
KR (1) KR100496089B1 (fr)
CN (1) CN1214029C (fr)
AP (1) AP2002002611A0 (fr)
AR (1) AR029482A1 (fr)
AT (1) ATE253570T1 (fr)
AU (1) AU779118B2 (fr)
BG (1) BG106869A (fr)
BR (1) BR0108910A (fr)
CA (1) CA2398963C (fr)
CR (1) CR6731A (fr)
CZ (1) CZ20022858A3 (fr)
DE (1) DE60101157T2 (fr)
DK (1) DK1268468T3 (fr)
EA (1) EA004748B1 (fr)
EE (1) EE200200496A (fr)
ES (1) ES2208565T3 (fr)
GE (1) GEP20043364B (fr)
HK (1) HK1053655A1 (fr)
HN (1) HN2001000036A (fr)
HR (1) HRP20020718A2 (fr)
HU (1) HUP0300006A3 (fr)
IL (1) IL150634A0 (fr)
IS (1) IS6441A (fr)
MA (1) MA26876A1 (fr)
MX (1) MXPA02008665A (fr)
NO (1) NO20024195L (fr)
NZ (1) NZ519672A (fr)
OA (1) OA12186A (fr)
PE (1) PE20011225A1 (fr)
PL (1) PL365070A1 (fr)
PT (1) PT1268468E (fr)
SI (1) SI1268468T1 (fr)
SK (1) SK12282002A3 (fr)
TN (1) TNSN01034A1 (fr)
TR (1) TR200302130T4 (fr)
UA (1) UA72311C2 (fr)
WO (1) WO2001064672A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0124455D0 (en) * 2001-10-11 2001-12-05 Pfizer Ltd Pharmaceutical formulations
US7163696B2 (en) 2001-10-11 2007-01-16 Pfizer Inc. Pharmaceutical formulations
DE10223913A1 (de) * 2002-05-29 2003-12-11 Bayer Cropscience Ag Verfahren zur Herstellung spezifischer Kristallmodifikationen polymorpher Substanzen
GB0221582D0 (en) * 2002-09-17 2002-10-23 Pfizer Ltd Method of treatment
AR043880A1 (es) * 2003-04-22 2005-08-17 Solvay Pharm Gmbh Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas
WO2005089804A2 (fr) * 2004-03-16 2005-09-29 Pfizer Limited Combinaisons d'inhibiteurs de la reductase hmg-coa et d'antagonistes du recepteur adrenergique $g(a)1
CN101584696A (zh) * 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
CN105596301A (zh) * 2016-01-29 2016-05-25 中国药科大学 一种以异喹啉为基本骨架的p2x7受体拮抗剂的纳米混悬剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914114A (en) 1984-05-28 1990-04-03 Merck Patent Gesellschaft Mit Breschrankter Haftung 3-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-5-hydroxy-indole methanesulfonate having sedating and anti-parkinsonism properties
AU594512B2 (en) * 1986-09-16 1990-03-08 Merck Patent Gesellschaft Mit Beschrankter Haftung Hydroxy indole derivatives
GB9700504D0 (en) * 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
SI1268468T1 (en) 2004-04-30
WO2001064672A1 (fr) 2001-09-07
IS6441A (is) 2002-06-25
CR6731A (es) 2004-03-11
TR200302130T4 (tr) 2004-01-21
US6683085B2 (en) 2004-01-27
AU779118B2 (en) 2005-01-06
ES2208565T3 (es) 2004-06-16
NZ519672A (en) 2004-06-25
DE60101157T2 (de) 2004-09-02
EE200200496A (et) 2004-02-16
UA72311C2 (uk) 2005-02-15
EP1268468B1 (fr) 2003-11-05
DK1268468T3 (da) 2004-02-09
AR029482A1 (es) 2003-07-02
CA2398963A1 (fr) 2001-09-07
CN1214029C (zh) 2005-08-10
KR100496089B1 (ko) 2005-06-17
BG106869A (bg) 2002-12-29
AP2002002611A0 (en) 2002-09-30
HUP0300006A2 (en) 2003-05-28
US20020010188A1 (en) 2002-01-24
DE60101157D1 (de) 2003-12-11
NO20024195D0 (no) 2002-09-03
JP2003525289A (ja) 2003-08-26
EP1268468A1 (fr) 2003-01-02
PE20011225A1 (es) 2001-12-08
CN1432010A (zh) 2003-07-23
IL150634A0 (en) 2003-02-12
AU3588801A (en) 2001-09-12
KR20020080463A (ko) 2002-10-23
GEP20043364B (en) 2004-03-10
MA26876A1 (fr) 2004-12-20
BR0108910A (pt) 2002-12-24
CZ20022858A3 (cs) 2003-09-17
EA200200826A1 (ru) 2003-02-27
CA2398963C (fr) 2006-10-24
PL365070A1 (en) 2004-12-27
SK12282002A3 (sk) 2003-10-07
NO20024195L (no) 2002-09-03
ATE253570T1 (de) 2003-11-15
HK1053655A1 (en) 2003-10-31
OA12186A (en) 2006-05-09
JP3857919B2 (ja) 2006-12-13
PT1268468E (pt) 2004-01-30
EA004748B1 (ru) 2004-08-26
HRP20020718A2 (en) 2004-02-29
MXPA02008665A (es) 2003-02-24
HN2001000036A (es) 2001-07-09
HUP0300006A3 (en) 2006-01-30

Similar Documents

Publication Publication Date Title
TNSN02009A1 (fr) Pyrimidinones bicycliques condensees nouvelles, inhibitrices de mmp, et compositions les contenant.
MA27883A1 (fr) Derives de pyrido [2,1-a] isoquinoline utilises comme inhibiteurs de dpp-iv
MXPA04004464A (es) Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades.
TNSN00231A1 (fr) Forme cristalline de 4-carboxyamino-2-substitue-1,2,3,4- tetrahydroquinoleine, et compositions la contenant
TNSN02032A1 (fr) Derives de glutaramide a substituant n-phenpropylcyclopentyle nouveaux, et compositions les contenant.
TNSN01095A1 (fr) DERIVES DE PYRROLO [2,3-d] PYRIMIDINE NOUVEAUX ET COMPOSITIONS LES CONTENANT
TNSN02010A1 (fr) Derives de pyrimidine nouveaux inhibiteurs de mmp, et compositions les contenant
TNSN02014A1 (fr) Composes nouveaux agonistes de ppar et compositions les contenant
TNSN02008A1 (fr) Derives d'acides isophtalique nouveaux inhibiteurs de mmp, et compositions les contenant
TNSN00121A1 (fr) Composes nouveaux inhibiteurs de metalloproteases, procede pour leur preparation et compositions pharmaceutiques les contenant
MY138252A (en) Azabicyclic-substitud fused-heteroaryl compounds for the treatment of disease
MXPA05008172A (es) Derivados de malonamida como inhibidores gamma-secretasa.
HK1055721A1 (en) Compounds to treat alzheimer's disease.
TNSN02012A1 (fr) Derives de pyrimidine nouveaux inhibiteurs de mmp, et compositions les contenant
HK1033907A1 (en) Metal chelators for use in the treatment of alzheimer's disease.
TNSN98238A1 (fr) Macrolides nouveaux
DE60112055D1 (de) Inhibitoren von gamma-secretase
TNSN01126A1 (fr) Imidazoles substitues nouveaux, procede pour leur preparation et compositions les contenant
TNSN01034A1 (fr) Sel nouveau et formes polymorphes nouvelles de 4-amino-6, 7- dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydro-isoquinol-2-yl) - 5-(2-pyridyl)quinazoline
TNSN02015A1 (fr) Composes nouveaux antagonistes de ppar, et compositions les contenant
TNSN98127A1 (fr) Derives d'azetidinylpropylpiperidine , procede pour leur preparation et compositions pharmaceutiques les contenant.
TNSN01046A1 (fr) Ethers de diphenyle utiles en therapeutique
TNSN99198A1 (fr) PYRAZOLOPYRIMIDINONES NOUVELLES INHIBITRICES DE PDE-5 GMPc, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
TNSN03112A1 (fr) Sel consistant en citrate de 5, 8, 14 - triazatetracyclo (10.3.1.02,11.04,9) - hexadeca-2(11),3,5,7,9-pentaene- et compositions pharmaceutiques le contenant.
TNSN01175A1 (fr) Derives de piperidines antagonistes selectives de sous- types de recepteurs de nmda, et compositions les contenant.