DK1124842T3 - Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer - Google Patents

Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer

Info

Publication number
DK1124842T3
DK1124842T3 DK99955899T DK99955899T DK1124842T3 DK 1124842 T3 DK1124842 T3 DK 1124842T3 DK 99955899 T DK99955899 T DK 99955899T DK 99955899 T DK99955899 T DK 99955899T DK 1124842 T3 DK1124842 T3 DK 1124842T3
Authority
DK
Denmark
Prior art keywords
treatment
neuroectodermal tumors
betulinic acid
acid derivatives
derivatives useful
Prior art date
Application number
DK99955899T
Other languages
English (en)
Inventor
Klaus Michael Debatin
Simone Fulda
Manfred Wiessler
Marek Los
Walter Mier
Original Assignee
Deutsches Krebsforsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch
Application granted granted Critical
Publication of DK1124842T3 publication Critical patent/DK1124842T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK99955899T 1998-10-28 1999-10-28 Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer DK1124842T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/182,588 US6369109B1 (en) 1998-10-28 1998-10-28 Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor
PCT/EP1999/008196 WO2000024762A1 (en) 1998-10-28 1999-10-28 Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumors

Publications (1)

Publication Number Publication Date
DK1124842T3 true DK1124842T3 (da) 2003-09-22

Family

ID=22669114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99955899T DK1124842T3 (da) 1998-10-28 1999-10-28 Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer

Country Status (9)

Country Link
US (1) US6369109B1 (da)
EP (1) EP1124842B1 (da)
AT (1) ATE241641T1 (da)
AU (1) AU1266900A (da)
DE (1) DE69908397T2 (da)
DK (1) DK1124842T3 (da)
ES (1) ES2201800T3 (da)
PT (1) PT1124842E (da)
WO (1) WO2000024762A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0012528D0 (en) 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
AU2001262489A1 (en) * 2000-05-23 2001-12-03 Univerzita Karlova V Praze Triterpenoid derivatives
GB2362649A (en) * 2000-05-25 2001-11-28 Univerzita Palackeho V Olomouc Triterpenoid derivatives
US6951847B2 (en) 2000-09-29 2005-10-04 Regents Of The University Of Minnesota Methods of treating fungal infections using lupeol
AU2001294953A1 (en) * 2000-09-29 2002-04-08 Regents Of The University Of Minnesota Triterpenes having fungicidal activity against yeast
WO2002026762A1 (en) * 2000-09-29 2002-04-04 Regents Of The University Of Minnesota Triterpenes having antibacterial activity
US7488722B2 (en) * 2001-05-11 2009-02-10 University Of Ottawa Anxiolytic Marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods
JPWO2003057224A1 (ja) * 2001-12-28 2005-08-25 日清オイリオグループ株式会社 アポトーシス誘導剤
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
AU2004210714C1 (en) 2003-02-11 2011-01-20 Novelix Pharmaceuticals, Inc. Medicament for inhibiting tumour growth
US7026305B2 (en) * 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
US20060019934A1 (en) * 2004-05-20 2006-01-26 Saxena Brij B Anti-HIV-1 activity of betulinol derivatives
US7282521B2 (en) * 2004-05-24 2007-10-16 University Of North Carolina At Chapel Hill Anti-retroviral moronic acid derivatives
US20090018146A1 (en) * 2005-01-27 2009-01-15 Research Development Corporation Combination Therapy with Triterpenoid Compounds and Proteasome Inhibitors
WO2007112043A2 (en) * 2006-03-23 2007-10-04 Advanced Life Sciences Inc. Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
CA2586614A1 (en) * 2006-10-27 2008-04-27 Universite Du Quebec A Chicoutimi Triterpenes derivatives and uses thereof as antitumor agents or anti-inflammatory agents
RU2317996C1 (ru) * 2006-10-30 2008-02-27 Институт нефтехимии и катализа РАН N'-{n-[3-оксо-лупан-28-оил]-9-аминононаноил}-3-амино-3-фенил-пропионовая кислота и ее соли как противовирусные и иммуностимулирующие агенты
CZ200851A3 (cs) * 2008-01-30 2009-10-21 Institut Of Organic Chemistry, Polish Academy Of Sciences Sacharidové deriváty lupanu, jejich použití a farmaceutické prípravky obsahující tyto deriváty
JOP20190083A1 (ar) 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
EP2340257A4 (en) * 2008-09-10 2012-09-26 Univ Quebec A Chicoutimi BIDESMOSIDIC BETULIN AND BETULINIC ACID DERIVATIVES AND THEIR USE AS ANTITUMOROUS SUBSTANCES
PE20120021A1 (es) 2008-10-10 2012-02-10 Amgen Inc Mutantes fgf21
US8778990B2 (en) * 2008-11-04 2014-07-15 Trustees Of Dartmouth College Betulinic acid derivatives and methods of use thereof
CZ2008723A3 (cs) * 2008-11-13 2010-01-13 Univerzita Palackého v Olomouci 2-Deoxyglykosidy triterpenoidu, zpusob jejich prípravy a jejich použití jako lécivo
EP2517341B1 (en) 2009-12-23 2019-06-26 Marvell World Trade Ltd. Start-up supply for a switch mode power supply
US8742735B2 (en) 2011-05-16 2014-06-03 Marvell World Trade Ltd. High-voltage startup circuit
JP6109817B2 (ja) 2011-05-16 2017-04-05 マーベル ワールド トレード リミテッド 高電圧スタートアップ回路を用いたシステムおよび方法
RU2468031C1 (ru) * 2011-11-02 2012-11-27 Учреждение Российской академии наук Институт химии и химической технологии Сибирского отделения РАН (ИХХТ СО РАН) Способ получения 3,28-дисульфата бетулина
RU2477285C1 (ru) * 2012-03-23 2013-03-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Химии И Химической Технологии Сибирского Отделения Российской Академии Наук (Иххт Со Ран) Способ получения 3-ацетата-28-сульфата бетулина
CN103768078B (zh) 2012-10-22 2019-02-05 北京大学 三萜衍生物及其抗流感用途
CN104910239B (zh) * 2014-03-14 2018-12-07 中国科学院上海药物研究所 五环三萜类化合物及其制备方法、药物组合物和用途
CN114133424B (zh) * 2020-09-03 2023-07-18 沈阳药科大学 三萜类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658947A (en) 1995-03-21 1997-08-19 Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma using betalinic acid
US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) * 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
KR100205045B1 (ko) 1996-12-05 1999-06-15 김송배 신규한 트리테르펜 글리코사이드 화합물, 그의 제조방법 및 그를 함유하는 항암제 조성물

Also Published As

Publication number Publication date
AU1266900A (en) 2000-05-15
EP1124842A1 (en) 2001-08-22
ES2201800T3 (es) 2004-03-16
PT1124842E (pt) 2003-10-31
WO2000024762A1 (en) 2000-05-04
DE69908397D1 (de) 2003-07-03
US6369109B1 (en) 2002-04-09
EP1124842B1 (en) 2003-05-28
DE69908397T2 (de) 2004-04-01
ATE241641T1 (de) 2003-06-15

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