DE69908397D1 - Betulinsäure derivate zur behandlung von neuroektodermalen tumoren - Google Patents
Betulinsäure derivate zur behandlung von neuroektodermalen tumorenInfo
- Publication number
- DE69908397D1 DE69908397D1 DE69908397T DE69908397T DE69908397D1 DE 69908397 D1 DE69908397 D1 DE 69908397D1 DE 69908397 T DE69908397 T DE 69908397T DE 69908397 T DE69908397 T DE 69908397T DE 69908397 D1 DE69908397 D1 DE 69908397D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- betulinic acid
- tumors
- neuroektodermal
- acid derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title 1
- 208000009277 Neuroectodermal Tumors Diseases 0.000 abstract 4
- QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 abstract 3
- CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 abstract 3
- DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 abstract 3
- PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 abstract 3
- MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/182,588 US6369109B1 (en) | 1998-10-28 | 1998-10-28 | Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor |
| US182588 | 1998-10-28 | ||
| PCT/EP1999/008196 WO2000024762A1 (en) | 1998-10-28 | 1999-10-28 | Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69908397D1 true DE69908397D1 (de) | 2003-07-03 |
| DE69908397T2 DE69908397T2 (de) | 2004-04-01 |
Family
ID=22669114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69908397T Expired - Lifetime DE69908397T2 (de) | 1998-10-28 | 1999-10-28 | Betulinsäure derivate zur behandlung von neuroektodermalen tumoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6369109B1 (de) |
| EP (1) | EP1124842B1 (de) |
| AT (1) | ATE241641T1 (de) |
| AU (1) | AU1266900A (de) |
| DE (1) | DE69908397T2 (de) |
| DK (1) | DK1124842T3 (de) |
| ES (1) | ES2201800T3 (de) |
| PT (1) | PT1124842E (de) |
| WO (1) | WO2000024762A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1292562A1 (de) * | 2000-05-23 | 2003-03-19 | Univerzita palackeho V Olomouci | Triterpenen derivaten |
| GB2362649A (en) * | 2000-05-25 | 2001-11-28 | Univerzita Palackeho V Olomouc | Triterpenoid derivatives |
| GB0012528D0 (en) | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
| US6642217B2 (en) | 2000-09-29 | 2003-11-04 | Naturtek, Llc | Triterpenes having human antifungal and antiyeast activity |
| AU2001294959A1 (en) | 2000-09-29 | 2002-04-08 | Robert M. Carlson | Triterpenes having antibacterial activity |
| US6951847B2 (en) | 2000-09-29 | 2005-10-04 | Regents Of The University Of Minnesota | Methods of treating fungal infections using lupeol |
| WO2002091858A1 (en) * | 2001-05-11 | 2002-11-21 | University Of Ottawa | Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods |
| JPWO2003057224A1 (ja) * | 2001-12-28 | 2005-08-25 | 日清オイリオグループ株式会社 | アポトーシス誘導剤 |
| US7041309B2 (en) * | 2002-06-13 | 2006-05-09 | Neuropro Technologies, Inc. | Spinal fusion using an HMG-CoA reductase inhibitor |
| SI1594885T1 (sl) | 2003-02-11 | 2009-06-30 | Novelix Pharmaceuticals Inc | Zdravilo za inhibiranje rasti tumorjev |
| US7026305B2 (en) * | 2003-04-14 | 2006-04-11 | Meharry Medical College | Anti-HIV agents with dual sites of action |
| US20060019934A1 (en) * | 2004-05-20 | 2006-01-26 | Saxena Brij B | Anti-HIV-1 activity of betulinol derivatives |
| US7282521B2 (en) * | 2004-05-24 | 2007-10-16 | University Of North Carolina At Chapel Hill | Anti-retroviral moronic acid derivatives |
| US20090018146A1 (en) * | 2005-01-27 | 2009-01-15 | Research Development Corporation | Combination Therapy with Triterpenoid Compounds and Proteasome Inhibitors |
| EP1996205A2 (de) * | 2006-03-23 | 2008-12-03 | Advanced Life Sciences Inc. | Synthetische pentacyclische triterpenoide und derivate von betulinsäure und betulin |
| CA2586614A1 (en) * | 2006-10-27 | 2008-04-27 | Universite Du Quebec A Chicoutimi | Triterpenes derivatives and uses thereof as antitumor agents or anti-inflammatory agents |
| RU2317996C1 (ru) * | 2006-10-30 | 2008-02-27 | Институт нефтехимии и катализа РАН | N'-{n-[3-оксо-лупан-28-оил]-9-аминононаноил}-3-амино-3-фенил-пропионовая кислота и ее соли как противовирусные и иммуностимулирующие агенты |
| CZ200851A3 (cs) * | 2008-01-30 | 2009-10-21 | Institut Of Organic Chemistry, Polish Academy Of Sciences | Sacharidové deriváty lupanu, jejich použití a farmaceutické prípravky obsahující tyto deriváty |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| CA2736568A1 (en) * | 2008-09-10 | 2010-03-18 | Universite Du Quebec A Chicoutimi | Bidesmosidic betulin and betulinic acid derivatives and uses thereof as antitumor agents |
| MX341149B (es) | 2008-10-10 | 2016-08-09 | Amgen Inc | Mutantes fgf21 y uso de los mismos. |
| WO2010053817A1 (en) * | 2008-11-04 | 2010-05-14 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
| CZ301318B6 (cs) * | 2008-11-13 | 2010-01-13 | Univerzita Palackého v Olomouci | 2-Deoxyglykosidy triterpenoidu, zpusob jejich prípravy a jejich použití jako lécivo |
| CN102668347B (zh) | 2009-12-23 | 2015-12-02 | 马维尔国际贸易有限公司 | 启动电源 |
| WO2012158496A2 (en) | 2011-05-16 | 2012-11-22 | Marvell World Trade Ltd. | High-voltage startup circuit |
| US8742735B2 (en) | 2011-05-16 | 2014-06-03 | Marvell World Trade Ltd. | High-voltage startup circuit |
| RU2468031C1 (ru) * | 2011-11-02 | 2012-11-27 | Учреждение Российской академии наук Институт химии и химической технологии Сибирского отделения РАН (ИХХТ СО РАН) | Способ получения 3,28-дисульфата бетулина |
| RU2477285C1 (ru) * | 2012-03-23 | 2013-03-10 | Федеральное Государственное Бюджетное Учреждение Науки Институт Химии И Химической Технологии Сибирского Отделения Российской Академии Наук (Иххт Со Ран) | Способ получения 3-ацетата-28-сульфата бетулина |
| CN103768078B (zh) | 2012-10-22 | 2019-02-05 | 北京大学 | 三萜衍生物及其抗流感用途 |
| CN104910239B (zh) * | 2014-03-14 | 2018-12-07 | 中国科学院上海药物研究所 | 五环三萜类化合物及其制备方法、药物组合物和用途 |
| CN114133424B (zh) * | 2020-09-03 | 2023-07-18 | 沈阳药科大学 | 三萜类化合物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869535A (en) | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
| US5962527A (en) * | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
| US5658947A (en) | 1995-03-21 | 1997-08-19 | Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma using betalinic acid |
| KR100205045B1 (ko) | 1996-12-05 | 1999-06-15 | 김송배 | 신규한 트리테르펜 글리코사이드 화합물, 그의 제조방법 및 그를 함유하는 항암제 조성물 |
-
1998
- 1998-10-28 US US09/182,588 patent/US6369109B1/en not_active Expired - Lifetime
-
1999
- 1999-10-28 AT AT99955899T patent/ATE241641T1/de not_active IP Right Cessation
- 1999-10-28 ES ES99955899T patent/ES2201800T3/es not_active Expired - Lifetime
- 1999-10-28 WO PCT/EP1999/008196 patent/WO2000024762A1/en active IP Right Grant
- 1999-10-28 DE DE69908397T patent/DE69908397T2/de not_active Expired - Lifetime
- 1999-10-28 EP EP99955899A patent/EP1124842B1/de not_active Expired - Lifetime
- 1999-10-28 AU AU12669/00A patent/AU1266900A/en not_active Abandoned
- 1999-10-28 DK DK99955899T patent/DK1124842T3/da active
- 1999-10-28 PT PT99955899T patent/PT1124842E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000024762A1 (en) | 2000-05-04 |
| ATE241641T1 (de) | 2003-06-15 |
| US6369109B1 (en) | 2002-04-09 |
| ES2201800T3 (es) | 2004-03-16 |
| AU1266900A (en) | 2000-05-15 |
| PT1124842E (pt) | 2003-10-31 |
| DE69908397T2 (de) | 2004-04-01 |
| EP1124842B1 (de) | 2003-05-28 |
| EP1124842A1 (de) | 2001-08-22 |
| DK1124842T3 (da) | 2003-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |