ATE337780T1 - Indoly-lsulphonyl-verbindungen zur behandlung von störungen des zns - Google Patents
Indoly-lsulphonyl-verbindungen zur behandlung von störungen des znsInfo
- Publication number
- ATE337780T1 ATE337780T1 AT01997304T AT01997304T ATE337780T1 AT E337780 T1 ATE337780 T1 AT E337780T1 AT 01997304 T AT01997304 T AT 01997304T AT 01997304 T AT01997304 T AT 01997304T AT E337780 T1 ATE337780 T1 AT E337780T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- compounds
- lsulphonyl
- indoly
- cns disorders
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0028708A GB0028708D0 (en) | 2000-11-24 | 2000-11-24 | Novel compounds |
GB0113517A GB0113517D0 (en) | 2001-06-04 | 2001-06-04 | Novel Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE337780T1 true ATE337780T1 (de) | 2006-09-15 |
Family
ID=26245327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01997304T ATE337780T1 (de) | 2000-11-24 | 2001-11-16 | Indoly-lsulphonyl-verbindungen zur behandlung von störungen des zns |
Country Status (8)
Country | Link |
---|---|
US (1) | US20050176705A1 (de) |
EP (1) | EP1335722B1 (de) |
JP (1) | JP2004517072A (de) |
AT (1) | ATE337780T1 (de) |
AU (1) | AU2002220715A1 (de) |
DE (1) | DE60122767T2 (de) |
ES (1) | ES2271124T3 (de) |
WO (1) | WO2002041889A2 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002032863A1 (en) | 2000-10-20 | 2002-04-25 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
KR20040010709A (ko) | 2001-06-15 | 2004-01-31 | 에프. 호프만-라 로슈 아게 | 5-ht6 수용체 친화력을 갖는 4-피페라지닐인돌 유도체 |
AU2003208711A1 (en) * | 2002-02-12 | 2003-09-04 | Akzo Nobel N.V. | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders |
IL164108A0 (en) * | 2002-03-27 | 2005-12-18 | Glaxo Group Ltd | Quinoline derivatives and their useas 5-ht6 ligands |
RU2323927C2 (ru) * | 2002-06-05 | 2008-05-10 | Ф.Хоффманн-Ля Рош Аг | Производные 1-сульфонил-4-аминоалкоксииндола и фармацевтическая композиция, обладающая активностью модулятора 5-нт6 рецептора |
AU2003267063B2 (en) | 2002-09-17 | 2009-08-06 | F. Hoffman-La Roche Ag | 2,4-substituted indoles and their use as 5-HT6 modulators |
KR20050073560A (ko) * | 2002-10-18 | 2005-07-14 | 에프. 호프만-라 로슈 아게 | 5-ht6 수용체 친화성을 갖는 4-피페라진일 벤젠설폰일인돌 |
PT1581492E (pt) * | 2002-11-28 | 2008-09-19 | Suven Life Sciences Ltd | Indoles n-arilsulfonil-3-substituídos possuindo afinidade de receptor de serotonina, processo para a sua preparação e composição farmacêutica contendo os mesmos |
TWI289141B (en) * | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
RS20060035A (en) | 2003-07-22 | 2008-08-07 | Arena Pharmaceuticals Inc., | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
SE0302760D0 (sv) * | 2003-10-20 | 2003-10-20 | Biovitrum Ab | New compounds |
EA009902B1 (ru) | 2004-02-13 | 2008-04-28 | УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си | Модуляторы рецепторов андрогенов |
BRPI0509759A (pt) | 2004-04-13 | 2007-10-16 | Warner Lambert Co | moduladores de androgênio |
WO2005102990A1 (en) | 2004-04-22 | 2005-11-03 | Warner-Lambert Company Llc | Androgen modulators |
TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
WO2007098418A1 (en) * | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
NZ573371A (en) | 2006-07-03 | 2011-01-28 | Biovitrum Ab Publ | Indoles as 5-ht6 modulators |
EP2121603A2 (de) * | 2007-02-16 | 2009-11-25 | Memory Pharmaceuticals Corporation | 6'-substituierte indol- und indazol-derivate mit 5-ht6-rezeptoraffinität |
US20100041672A1 (en) * | 2007-03-21 | 2010-02-18 | Glaxo Group Limited | Use of quinoline derivatives in the treatment of pain and irritable bowel syndrome |
AU2008256859A1 (en) * | 2007-05-24 | 2008-12-04 | Memory Pharmaceuticals Corporation | 4' substituted compounds having 5-HT6 receptor affinity |
JP2010536789A (ja) * | 2007-08-15 | 2010-12-02 | メモリー・ファーマシューティカルズ・コーポレイション | 5−ht6受容体親和性を有する3’置換化合物 |
EP2508177A1 (de) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Kombinationen mit 3-phenylsulfonyl-8-piperazinyl-1yl-chinolin |
US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
WO2011088836A1 (en) | 2010-01-25 | 2011-07-28 | H. Lundbeck A/S | NOVEL 4-(ARYL-4-SULFONYL)-6,6a,7,8,9,10-HEXAHYDRO-4H-4,8,10a-TRIAZA-ACEPHENANTHRYLENE AND 3-ARYLSULFONYL-6,6a,7,8,9,10-HEXAHYDRO-3H-3,8,10a-TRIAZA-CYCLOPENTA[C]FLUORENE DERIVATIVES AS SEROTONIN 5-HT6 LIGANDS |
JP6454346B2 (ja) | 2013-12-20 | 2019-01-16 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | 芳香族複素環式化合物及び医薬におけるその応用 |
AU2015286049B2 (en) * | 2014-07-08 | 2018-03-01 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
JP2018516992A (ja) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーAxovant Sciences Gmbh | レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体 |
BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
WO2017052394A1 (en) | 2015-09-23 | 2017-03-30 | Uniwersytet Jagielloński | Imidazopyridine compounds and their use as 5-ht6 receptor ligands |
CN111233737B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
CN111362859B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
CN111362858B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4808581A (en) * | 1986-03-17 | 1989-02-28 | Glaxo Group Limited | Imidazolyl- indolylpropanones as 5-HT3 receptor antagonists |
GB8623819D0 (en) * | 1986-10-03 | 1986-11-05 | Glaxo Group Ltd | Heterocyclic compounds |
US4859662A (en) * | 1986-11-28 | 1989-08-22 | Glaxo Group Limited | Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances |
GB8720693D0 (en) * | 1987-09-03 | 1987-10-07 | Glaxo Group Ltd | Chemical compounds |
US4985422A (en) * | 1988-04-27 | 1991-01-15 | Glaxo Group Limited | Lactam derivatives |
GB8904551D0 (en) * | 1989-02-28 | 1989-04-12 | Glaxo Group Ltd | Chemical compounds |
ZA902794B (en) * | 1989-04-18 | 1991-04-24 | Duphar Int Res | New 3-n substituted carbamoyl-indole derivatives |
US5225407A (en) * | 1990-02-22 | 1993-07-06 | Glaxo Group Limited | 5-HT3 receptor antagonists for the treatment of autism |
FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
US5965574A (en) * | 1996-08-13 | 1999-10-12 | Chen; Yuhpyng Liang | Heteroaryl amines as novel acetylcholinesterase inhibitors |
EP0773942A1 (de) * | 1994-07-26 | 1997-05-21 | Pfizer Inc. | 4-indolderivate als serotonin agonisten und antagonisten |
US6100291A (en) * | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
US6818639B2 (en) * | 2000-07-21 | 2004-11-16 | Biovitrum Ab | Pharmaceutical combination formulation and method of treatment with the combination |
WO2002032863A1 (en) * | 2000-10-20 | 2002-04-25 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
-
2001
- 2001-11-16 DE DE60122767T patent/DE60122767T2/de not_active Expired - Fee Related
- 2001-11-16 AU AU2002220715A patent/AU2002220715A1/en not_active Abandoned
- 2001-11-16 WO PCT/EP2001/013411 patent/WO2002041889A2/en active IP Right Grant
- 2001-11-16 US US10/432,471 patent/US20050176705A1/en not_active Abandoned
- 2001-11-16 JP JP2002544068A patent/JP2004517072A/ja active Pending
- 2001-11-16 EP EP01997304A patent/EP1335722B1/de not_active Expired - Lifetime
- 2001-11-16 AT AT01997304T patent/ATE337780T1/de not_active IP Right Cessation
- 2001-11-16 ES ES01997304T patent/ES2271124T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20050176705A1 (en) | 2005-08-11 |
EP1335722B1 (de) | 2006-08-30 |
WO2002041889A3 (en) | 2003-04-10 |
DE60122767D1 (de) | 2006-10-12 |
EP1335722A2 (de) | 2003-08-20 |
ES2271124T3 (es) | 2007-04-16 |
DE60122767T2 (de) | 2007-09-13 |
WO2002041889A2 (en) | 2002-05-30 |
AU2002220715A1 (en) | 2002-06-03 |
JP2004517072A (ja) | 2004-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |