MA27141A1 - DERIVES DE 3-AZABICYCLO[3.1.0]HEXANE SERVANT D'ANTAGONISTES DES RECEPTEURS D'OPIOiDES - Google Patents
DERIVES DE 3-AZABICYCLO[3.1.0]HEXANE SERVANT D'ANTAGONISTES DES RECEPTEURS D'OPIOiDESInfo
- Publication number
- MA27141A1 MA27141A1 MA27630A MA27630A MA27141A1 MA 27141 A1 MA27141 A1 MA 27141A1 MA 27630 A MA27630 A MA 27630A MA 27630 A MA27630 A MA 27630A MA 27141 A1 MA27141 A1 MA 27141A1
- Authority
- MA
- Morocco
- Prior art keywords
- receptor antagonists
- azabicyclo
- opioid receptor
- formula
- hexane derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DEPOSANT Société dite: PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 22 Octobre 2001 60/338,511 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés de 3-azabicyclo[3.1.0]hexane servant d'antagonistes des récepteurs d'opioïdes La présente invention propose un composé de formule (I), dans laquelle X, Q, n, R1, R2, R3, R4 R5, R6, R7, R8, R9 et R10 répondent aux définitions. Les composés de formule (I) sont actifs comme antagonistes des récepteurs d'opioïdes. La présente invention propose en outre des compositions pharmaceutiques et des méthodes thérapeutiques comprenant des composés de formule (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33851101P | 2001-10-22 | 2001-10-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27141A1 true MA27141A1 (fr) | 2005-01-03 |
Family
ID=23325099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA27630A MA27141A1 (fr) | 2001-10-22 | 2004-04-15 | DERIVES DE 3-AZABICYCLO[3.1.0]HEXANE SERVANT D'ANTAGONISTES DES RECEPTEURS D'OPIOiDES |
Country Status (42)
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1918279A3 (fr) | 2001-04-18 | 2008-07-16 | Euro-Celtique S.A. | Dérivés de la 1-(4-pipéridinyl)-1,3-dihydro-2h-benzoxazole-2-one et composés similaires en tant que analogues de la nociceptine et ligandes du récepteur resemblant le récepteur opioid pour le traitement de la douleur |
BR0213464A (pt) | 2001-10-22 | 2004-11-09 | Pfizer Prod Inc | Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide |
BRPI0409307A (pt) * | 2003-04-14 | 2006-04-25 | Pfizer Prod Inc | derivados de 3-azabiciclo[3.2.1]octano |
US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
DK1680124T3 (en) * | 2003-10-14 | 2017-08-21 | Pfizer Prod Inc | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors |
JP2007508367A (ja) * | 2003-10-16 | 2007-04-05 | ファイザー・プロダクツ・インク | 3−アザビシクロ[3.1.0]ヘキサン誘導体の製造方法 |
ES2380990T3 (es) * | 2004-02-23 | 2012-05-22 | Glaxo Group Limited | Derivados de azabiciclo[3.1.0]hexano útiles como moduladores de los receptores D3 de dopamina |
EP1726590A4 (fr) * | 2004-03-05 | 2009-07-15 | Banyu Pharma Co Ltd | D riv cycloalkanopyridine |
TW200637553A (en) * | 2004-12-14 | 2006-11-01 | Shionogi & Co | Indlomorphinane derivatives having a carboxy group at 6' position |
GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
GB0517191D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
US7592461B2 (en) * | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
MY145633A (en) * | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
WO2008075162A2 (fr) * | 2006-12-15 | 2008-06-26 | Pfizer Limited | Composés pour le traitement d'un dysfonctionnement sexuel |
TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | 8-氮雜雙環〔3.2.1〕辛烷化合物之結晶型 |
US7691878B2 (en) * | 2007-08-27 | 2010-04-06 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
WO2009029252A1 (fr) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Composés d'amidoalkyle-8-azabicyclo[3.2.1]octane en tant qu'antagonistes du récepteur opioïde mu |
TWI423801B (zh) | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之8-氮雜雙環〔3.2.1〕辛基-2-羥基苯甲醯胺化合物 |
ATE502939T1 (de) * | 2007-08-27 | 2011-04-15 | Theravance Inc | Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten |
BR112013007566A2 (pt) | 2010-09-28 | 2016-08-02 | Panacea Biotec Ltd | novos compostos bicíclicos |
EP3072884B1 (fr) | 2013-11-20 | 2020-01-01 | Sanwa Kagaku Kenkyusho Co., Ltd. | Dérivé 3-azabicyclo[3.1.0]hexane et son utilisation à des fins médicales |
AU2016265801B2 (en) | 2015-05-20 | 2020-10-08 | Ube Corporation | Crystal of salt of novel 3-azabicyclo[3.1.0]hexane derivative and pharmaceutical use thereof |
EP3590511A4 (fr) | 2017-03-02 | 2020-09-02 | Sanwa Kagaku Kenkyusho Co., Ltd | Agent thérapeutique pour troubles liés à la consommation d'alcool |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2099214A (en) * | 1937-11-16 | Process fob forming the sulphuric | ||
US2099216A (en) * | 1934-05-04 | 1937-11-16 | Frederick H Nass | Metal testing machine |
US3004340A (en) * | 1959-09-24 | 1961-10-17 | Bernice L Collins | Kitchen utensil |
US3078282A (en) * | 1960-01-02 | 1963-02-19 | Bayer Ag | Anthraquinone dyestuffs |
PH24752A (en) | 1987-04-16 | 1990-10-01 | Lilly Co Eli | Piperidine opioid antagonists |
JPH04155522A (ja) * | 1990-10-19 | 1992-05-28 | Nec Corp | ファースト・イン・ランダム・アウト回路 |
US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
CZ284993B6 (cs) | 1991-03-29 | 1999-04-14 | Eli Lilly And Company | Derivát piperidinu |
GB9725114D0 (en) * | 1997-11-28 | 1998-01-28 | Pfizer Ltd | Treatment of pruritus |
GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912413D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912415D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
US20020064825A1 (en) * | 2000-05-19 | 2002-05-30 | Lewis Marilyn Evelyn | Novel polypeptide |
US20020025948A1 (en) * | 2000-06-23 | 2002-02-28 | Banks Bernard Joseph | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
US20030207876A1 (en) * | 2000-06-23 | 2003-11-06 | Banks Bernard Joseph | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy |
GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
DE10042885A1 (de) * | 2000-08-31 | 2002-03-14 | Heidelberger Druckmasch Ag | Bogentransportzylinder |
BR0213464A (pt) | 2001-10-22 | 2004-11-09 | Pfizer Prod Inc | Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide |
WO2003101963A1 (fr) | 2002-05-30 | 2003-12-11 | Eli Lilly And Company | Antagonistes de recepteur d'opioides |
US7056930B2 (en) * | 2003-04-14 | 2006-06-06 | Pfizer Inc. | 2-Azabicyclo[3.3.1]nonane derivatives |
US20040204453A1 (en) * | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
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2002
- 2002-09-09 BR BR0213464-0A patent/BR0213464A/pt not_active IP Right Cessation
- 2002-09-09 PL PL02368919A patent/PL368919A1/xx not_active Application Discontinuation
- 2002-09-09 UA UA20040402979A patent/UA75714C2/uk unknown
- 2002-09-09 CN CNB028208854A patent/CN100368398C/zh not_active Expired - Fee Related
- 2002-09-09 SI SI200230688T patent/SI1440059T1/sl unknown
- 2002-09-09 JP JP2003538138A patent/JP4155522B2/ja not_active Expired - Fee Related
- 2002-09-09 IL IL16115702A patent/IL161157A0/xx unknown
- 2002-09-09 DK DK02765197T patent/DK1440059T3/da active
- 2002-09-09 WO PCT/IB2002/003668 patent/WO2003035622A1/fr active IP Right Grant
- 2002-09-09 PT PT02765197T patent/PT1440059E/pt unknown
- 2002-09-09 CA CA002463264A patent/CA2463264C/fr not_active Expired - Fee Related
- 2002-09-09 AU AU2002329557A patent/AU2002329557B2/en not_active Ceased
- 2002-09-09 AT AT02765197T patent/ATE392415T1/de not_active IP Right Cessation
- 2002-09-09 ES ES02765197T patent/ES2302839T3/es not_active Expired - Lifetime
- 2002-09-09 OA OA1200400109A patent/OA12711A/en unknown
- 2002-09-09 DE DE60226161T patent/DE60226161T2/de not_active Expired - Lifetime
- 2002-09-09 AP APAP/P/2004/003007A patent/AP1816A/en active
- 2002-09-09 NZ NZ531807A patent/NZ531807A/xx unknown
- 2002-09-09 EP EP02765197A patent/EP1440059B1/fr not_active Expired - Lifetime
- 2002-09-09 GE GEAP20028173A patent/GEP20084300B/en unknown
- 2002-09-09 EA EA200400467A patent/EA006708B1/ru not_active IP Right Cessation
- 2002-09-09 KR KR1020047006011A patent/KR100621292B1/ko not_active IP Right Cessation
- 2002-09-09 HU HU0401884A patent/HUP0401884A2/hu unknown
- 2002-09-09 MX MXPA04003730A patent/MXPA04003730A/es active IP Right Grant
- 2002-09-09 RS YUP-251/04A patent/RS25104A/sr unknown
- 2002-10-17 PA PA20028556701A patent/PA8556701A1/es unknown
- 2002-10-17 MY MYPI20023878A patent/MY136580A/en unknown
- 2002-10-18 PE PE2002001032A patent/PE20030610A1/es not_active Application Discontinuation
- 2002-10-18 HN HN2002000299A patent/HN2002000299A/es unknown
- 2002-10-21 SV SV2002001363A patent/SV2004001363A/es not_active Application Discontinuation
- 2002-10-21 AR ARP020103960A patent/AR036905A1/es unknown
- 2002-10-22 GT GT200200216A patent/GT200200216A/es unknown
- 2002-10-22 US US10/278,142 patent/US7049335B2/en not_active Expired - Fee Related
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2004
- 2004-03-18 IS IS7187A patent/IS7187A/is unknown
- 2004-03-18 ZA ZA200402172A patent/ZA200402172B/en unknown
- 2004-03-23 HR HRP20040288 patent/HRP20040288A2/hr not_active Application Discontinuation
- 2004-03-29 IL IL161157A patent/IL161157A/en not_active IP Right Cessation
- 2004-04-15 MA MA27630A patent/MA27141A1/fr unknown
- 2004-04-20 CR CR7317A patent/CR7317A/es unknown
- 2004-04-21 NO NO20041626A patent/NO329092B1/no not_active IP Right Cessation
- 2004-04-21 TN TNP2004000071A patent/TNSN04071A1/fr unknown
- 2004-04-22 EC EC2004005077A patent/ECSP045077A/es unknown
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2005
- 2005-02-24 US US11/066,095 patent/US20050171178A1/en not_active Abandoned
- 2005-06-08 HK HK05104840A patent/HK1072052A1/xx not_active IP Right Cessation
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2006
- 2006-03-01 US US11/366,903 patent/US20070054950A1/en not_active Abandoned
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2007
- 2007-10-19 JP JP2007272602A patent/JP2008069169A/ja active Pending
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MA27181A1 (fr) | Derives de thiazole et d'oxazole qui modulent l'activite de ppar. | |
MA26953A1 (fr) | Derives de pipérazine pontés. | |
AP2002002664A0 (en) | Cyclohexylamine derivative as subtype selective NMDA receptor antagonists. | |
MA27135A1 (fr) | Agents antidiabetiques oraux | |
EP1798227A4 (fr) | Agoniste du récepteur 5-ht3 de la sérotonine | |
MX344556B (es) | Agonista de subtipo de receptor 5-ht1a. | |
MXPA04005076A (es) | Derivados de 4-piperidinil alquilamina como antagonistas del receptor muscarinico. | |
MA27010A1 (fr) | Derives d'ethers phenyliques d'heterocyclyle servant d'inhibiteurs selectifs de reabsorption de serotonine | |
IL145645A0 (en) | N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists | |
MXPA04006115A (es) | Derivados de imidazoquinolina. |