AR036905A1 - Derivados del 3-azabiciclo[3.1.0]hexano, composiciones farmaceuticas que los contienen, su uso en un metodo para tratar un trastorno o afeccion en un mamifero, e intermediarios utiles para su sintesis - Google Patents
Derivados del 3-azabiciclo[3.1.0]hexano, composiciones farmaceuticas que los contienen, su uso en un metodo para tratar un trastorno o afeccion en un mamifero, e intermediarios utiles para su sintesisInfo
- Publication number
- AR036905A1 AR036905A1 ARP020103960A ARP020103960A AR036905A1 AR 036905 A1 AR036905 A1 AR 036905A1 AR P020103960 A ARP020103960 A AR P020103960A AR P020103960 A ARP020103960 A AR P020103960A AR 036905 A1 AR036905 A1 AR 036905A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally
- cycloalkyl
- heterocycloalkyl
- halogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto derivado del 3-azabiciclo [3.1.0] hexano de fórmula (1), donde X es H, halógeno, -OH, -CN, -alquilo C1-4 sustituido con 1 a 3 átomos de halógeno ó -O(alquil C1-4), estando el alquilo C1-4 de -O(alquil C1-4) opcionalmente sustituido con 1 a 3 átomos de halógeno; Q es halógeno, -OH, -O-(alquil C1-4) -NH2, -NH(alquil C1-4), -N(alquil C1-4) (alquil C1-4), -C(=O)NH2, -C(=O)NH(alquil C1-4), -C(=O)N(alquil C1-4) (alquil C1-4), -NHS(=O)2H, ó -NHS(=O)2R11; ó Q puede formar un anillo cicloalquilo ó heterocicloalquilo de 5 ó 6 miembros con cualquier átomo de carbono adyacente al átomo de carbono al que está unido, formando así un sistema de anillo bicíclico condensado con el fenilo al que está unido, comprendiendo dicho heterocicloalquilo de 1 a 3 heterorestos seleccionados entre O, S, -C(=O) y N, y conteniendo opcionalmente dicho cicloalquilo o heterocicloalquilo 1 o 2 dobles enlaces; R1 y R2 están conectados, con el carbono al que están unidos, para formar un cicloalquilo C3-7 ó un heterocicloalquilo de 4-7 miembros que comprende de 1 a 3 heterorestos seleccionados entre O, S, -C(=O) y N; y en el que dicho cicloalquilo ó heterocicloalquilo contiene opcionalmente 1 ó 2 dobles enlaces; y estando dicho cicloalquilo ó heterocicloalquilo opcionalmente condensado con un grupo arilo C6-14 ó un heteroarilo de 5-14 miembros; en el que dicho cicloalquilo C3-7 ó el heterocicloalquilo de 4-7 miembros formado por R1 y R2 pueden cada uno opcionalmente estar sustituido con 1 a 3 grupos R12, y cada uno de dichos arilo o heteroarilo opcionalmente condensado pueden estar sustituidos opcional e independientemente con 1 a 6 grupos R12, seleccionándose los grupos R12 entre R13, R16, -alquilo C1-4 que contiene 1 ó 2 enlaces insaturados, halógeno, -OR13, -NO2-CN, -cicloalquilo C3-6, -NR13R14, -NR13C(=O)R14, -C(=O)NR13R14, -OC(=O)R13, -C(=O)OR13, -C(=O)R13, -NR13, -NR13C(=O)R14, -NR13C(=O)ONR14R15, -NR13S(=O)2R14 y -S(=O)2R13; R3 es alquilo C1-4, conteniendo opcionalmente dicho alquilo C1-4 uno o dos enlaces insaturados; R4 es -alquilo C1-4 que puede opcionalmente contener 1 ó 2 enlaces insaturados, -OH, -CN, NO2, -OR16, -NH2, NHR16, NHR16R17 ó -NHC(=O)R16; R5 y R6 son cada uno independientemente H ó metilo; R6, R7, R9 y R10 son H; R11 se selecciona entre alquilo C1-4, -(alquilen C1-4)-O-(alquil C1-4), 4-(1-metilimidazol), -(alquilen C1-4)-NH2, -(alquilen C1-4)-NH(alquil C1-4), -(alquilen C1-4)-N(alquil C1-4) (alquil C1-4); cada R13, R14 y R15 se selecciona independientemente entre H, R16, alquilo C1-4, halógeno, -OH, -SH, -NH2, -NH(alquil C1-4),-N(alquil C1-4) (alquil C1-4), -O(alquil C1-4), -S(alquil C1-4), -CN, -NO2, -C(=O) (alquil C1-4), -C(=O)OH, -C(=O)O(alquil C1-4), -NHC(=O) (alquil C1-4), -C(=O)NH2, y -C(=O)N(alquil C1-4) (alquil C1-4), ó R13 y R14 cuando en -NR13R14, pueden estar opcionalmente conectados para formar un grupo heterocicloalquilo o heteroarilo de 4 a 6 miembros, cuyo grupo heteroarilo opcionalmente comprende de 1 a 3 heterorestos adicionales seleccionados entre N, S, O y C(=O); cada R16 y R17 se selecciona independientemente entre arilo C6-14 y heteroarilo de 5-14 miembros, en el que dicho heteroarilo comprende de 1 a 3 heterorestos seleccionados entre O, S, -C(=O) y N, y estando dicho arilo y heteroarilo opcionalmente sustituidos con 1 a 3 sustituyentes seleccionados entre alquilo C1-4 que opcionalmente contiene 1 ó 2 enlaces insaturados, halógeno, -OH -SH, -NH2, -NH(alquil C1-4), -N(alquil C1-4) (alquil C1-4), -O(alquil C1-4), -S(alquil C1-4), -CN, -NO2, -C(=O) (alquil C1-4), -NHC(=O) (alquil C1-4), -C(=O)NH2, y -C(=O)N(alquil C1-4) (alquil C1-4); y n es un número entero seleccionado entre 1, 2, 3, 4 y 5; ó una sal farmacéuticamente aceptable de éste. Los compuestos de fórmula (1) tienen actividad como antagonistas del receptor de opioides. Además se describen composiciones farmacéuticas, procedimientos terapéuticos que comprenden los compuestos de fórmula (1) y compuestos intermediarios útiles para su síntesis. Estos compuestos son de aplicación para tratar trastornos y estados como colon irritable, dependencia ó adicción a drogas y depuración y también ciertos trastornos de la alimentación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33851101P | 2001-10-22 | 2001-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036905A1 true AR036905A1 (es) | 2004-10-13 |
Family
ID=23325099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103960A AR036905A1 (es) | 2001-10-22 | 2002-10-21 | Derivados del 3-azabiciclo[3.1.0]hexano, composiciones farmaceuticas que los contienen, su uso en un metodo para tratar un trastorno o afeccion en un mamifero, e intermediarios utiles para su sintesis |
Country Status (42)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1379246E (pt) | 2001-04-18 | 2009-01-14 | Euro Celtique Sa | Análogos de nociceptina |
| PT1440059E (pt) * | 2001-10-22 | 2008-05-16 | Pfizer Prod Inc | Derivados do 3-azabiciclo(3.1.0)hexano como antagonistas de receptores opióides |
| EP1615894A2 (en) * | 2003-04-14 | 2006-01-18 | Pfizer Products Inc. | 3-azabicyclo 3.2.1 octane derivatives |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
| WO2005037216A2 (en) * | 2003-10-14 | 2005-04-28 | Pfizer Products Inc. | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors |
| CN1867548A (zh) * | 2003-10-16 | 2006-11-22 | 辉瑞产品公司 | 3－氮杂双环[3.1.0]己烷衍生物的制备 |
| PT2060570E (pt) * | 2004-02-23 | 2012-05-07 | Glaxo Group Ltd | Derivados de azabiciclo(3.1.0)-hexano úteis como moduladores dos receptores d3 da dopamina |
| EP1726590A4 (en) * | 2004-03-05 | 2009-07-15 | Banyu Pharma Co Ltd | D RIV CYCLOALKANOPYRIDINE |
| WO2006064779A1 (ja) * | 2004-12-14 | 2006-06-22 | Shionogi & Co., Ltd. | ６’位にカルボキシを有するインドロモルヒナン誘導体 |
| GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
| GB0517191D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| MY145633A (en) * | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2008075162A2 (en) * | 2006-12-15 | 2008-06-26 | Pfizer Limited | Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction |
| TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| EP2185553B1 (en) * | 2007-08-27 | 2012-06-27 | Theravance, Inc. | Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| ATE502939T1 (de) * | 2007-08-27 | 2011-04-15 | Theravance Inc | Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten |
| TWI423801B (zh) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| EP2195313B1 (en) * | 2007-08-27 | 2014-04-02 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| JP2013542929A (ja) | 2010-09-28 | 2013-11-28 | パナセア バイオテック リミテッド | 新規ビシクロ環化合物 |
| MX2016006482A (es) * | 2013-11-20 | 2016-12-09 | Sanwa Kagaku Kenkyusho Co | Derivado novedoso de 3-azabiciclo[3.1.0]hexano y uso del mismo para proposito medico. |
| KR20180004734A (ko) * | 2015-05-20 | 2018-01-12 | 가부시키가이샤산와카가쿠켄큐쇼 | 신규 3-아자비시클로［3.1.0］헥산 유도체의 염의 결정 및 그의 의약 용도 |
| AU2018229062A1 (en) | 2017-03-02 | 2019-09-26 | Ube Industries, Ltd. | Therapeutic agent for alcohol use disorders |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2099214A (en) * | 1937-11-16 | Process fob forming the sulphuric | ||
| US2099216A (en) * | 1934-05-04 | 1937-11-16 | Frederick H Nass | Metal testing machine |
| US3004340A (en) * | 1959-09-24 | 1961-10-17 | Bernice L Collins | Kitchen utensil |
| US3078282A (en) * | 1960-01-02 | 1963-02-19 | Bayer Ag | Anthraquinone dyestuffs |
| DE3851081T2 (de) | 1987-04-16 | 1995-02-16 | Lilly Co Eli | Piperidine als Opioid-Antagoniste. |
| JPH04155522A (ja) * | 1990-10-19 | 1992-05-28 | Nec Corp | ファースト・イン・ランダム・アウト回路 |
| CZ284993B6 (cs) | 1991-03-29 | 1999-04-14 | Eli Lilly And Company | Derivát piperidinu |
| US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| GB9725114D0 (en) * | 1997-11-28 | 1998-01-28 | Pfizer Ltd | Treatment of pruritus |
| GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB9912413D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912415D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US20020064825A1 (en) * | 2000-05-19 | 2002-05-30 | Lewis Marilyn Evelyn | Novel polypeptide |
| GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| US20020025948A1 (en) * | 2000-06-23 | 2002-02-28 | Banks Bernard Joseph | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| US20030207876A1 (en) * | 2000-06-23 | 2003-11-06 | Banks Bernard Joseph | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy |
| DE10042885A1 (de) * | 2000-08-31 | 2002-03-14 | Heidelberger Druckmasch Ag | Bogentransportzylinder |
| PT1440059E (pt) | 2001-10-22 | 2008-05-16 | Pfizer Prod Inc | Derivados do 3-azabiciclo(3.1.0)hexano como antagonistas de receptores opióides |
| EP1513813B1 (en) | 2002-05-30 | 2005-11-02 | Eli Lilly And Company | Opioid receptor antagonists |
| US7056930B2 (en) * | 2003-04-14 | 2006-06-06 | Pfizer Inc. | 2-Azabicyclo[3.3.1]nonane derivatives |
| US20040204453A1 (en) * | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
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2002
- 2002-09-09 PT PT02765197T patent/PT1440059E/pt unknown
- 2002-09-09 AT AT02765197T patent/ATE392415T1/de not_active IP Right Cessation
- 2002-09-09 AP APAP/P/2004/003007A patent/AP1816A/en active
- 2002-09-09 IL IL16115702A patent/IL161157A0/xx unknown
- 2002-09-09 PL PL02368919A patent/PL368919A1/xx not_active Application Discontinuation
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2006
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2007
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