ATE308522T1 - Opioidrezeptorantagonisten - Google Patents

Opioidrezeptorantagonisten

Info

Publication number
ATE308522T1
ATE308522T1 AT03733973T AT03733973T ATE308522T1 AT E308522 T1 ATE308522 T1 AT E308522T1 AT 03733973 T AT03733973 T AT 03733973T AT 03733973 T AT03733973 T AT 03733973T AT E308522 T1 ATE308522 T1 AT E308522T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
opioid receptor
racemate
diastereomers
enantiomer
Prior art date
Application number
AT03733973T
Other languages
English (en)
Inventor
Charles Howard Mitch
Steven James Quimby
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE308522T1 publication Critical patent/ATE308522T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03733973T 2002-05-30 2003-05-22 Opioidrezeptorantagonisten ATE308522T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38460302P 2002-05-30 2002-05-30
PCT/US2003/014540 WO2003101963A1 (en) 2002-05-30 2003-05-22 Opioid receptor antagonists

Publications (1)

Publication Number Publication Date
ATE308522T1 true ATE308522T1 (de) 2005-11-15

Family

ID=29712067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03733973T ATE308522T1 (de) 2002-05-30 2003-05-22 Opioidrezeptorantagonisten

Country Status (7)

Country Link
US (1) US20050222204A1 (de)
EP (1) EP1513813B1 (de)
AT (1) ATE308522T1 (de)
AU (1) AU2003239389A1 (de)
DE (1) DE60302157T2 (de)
ES (1) ES2249722T3 (de)
WO (1) WO2003101963A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2426942C (en) 2000-10-31 2014-06-03 Mark P. Wentland 8-carboxamido-2,6-methano-3-benzazocines
CA2463264C (en) 2001-10-22 2009-05-26 Pfizer Products Inc. 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
US20040204453A1 (en) * 2003-04-14 2004-10-14 Pfizer Inc 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors
ES2318472T3 (es) * 2004-03-15 2009-05-01 Eli Lilly And Company Derivados de 5-(5-(aminoetil)-indol-1-ilmetil)-benzamida y compuestos relacionados como antagonistas del receptor opioide para el tratamiento de la obesidad.
AU2012200919B2 (en) * 2005-10-27 2015-05-28 Merck Sharp & Dohme Llc Novel opioid antagonists
US7538110B2 (en) 2005-10-27 2009-05-26 Adolor Corporation Opioid antagonists
WO2007121916A2 (en) 2006-04-21 2007-11-01 Dsm Ip Assets B.V. Use of opioid receptor antagonists
KR20090051778A (ko) 2006-09-08 2009-05-22 화이자 프로덕츠 인코포레이티드 다이아릴 에터 유도체 및 이의 용도
US8278442B2 (en) 2007-05-22 2012-10-02 Prosidion Limited Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders
WO2009030962A1 (en) 2007-09-07 2009-03-12 Prosidion Limited Bicyclic aryl and heteroaryl receptor modulators
WO2010067233A1 (en) 2008-12-08 2010-06-17 Pfizer Inc. 1,2,4 triazolo [4, 3 -a] [1,5] benzodiazepin-5 (6h) -ones as agonists of the cholecystokinin-1 receptor (cck-ir)
US20100311782A1 (en) * 2009-06-08 2010-12-09 Adolor Corporation Substituted piperidinylpropanoic acid compounds and methods of their use
SI2506712T1 (sl) 2009-12-04 2019-06-28 Alkermes Pharma Ireland Limited, Derivati morfinana za zdravljenje prevelikega odmerka mamil
WO2011119605A2 (en) 2010-03-22 2011-09-29 Rensselaer Polytechnic Institute Carboxamide biosiosteres of opiates
AU2011293502B2 (en) 2010-08-23 2015-03-19 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
PT2725908T (pt) 2011-06-29 2017-08-31 Alkermes Inc Compostos opioides de ação periférica
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
EP3153171B1 (de) 2011-12-15 2018-09-19 Alkermes Pharma Ireland Limited Samidorphan (alks 33) in kombination mit buprenorphin zur behandlung von depressiver störungen
CA2911231C (en) 2013-05-24 2021-12-07 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
EP3003311A2 (de) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Verfahren zur behandlung von symptomen für depression
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4891379A (en) * 1987-04-16 1990-01-02 Kabushiki Kaisha Kobe Seikosho Piperidine opioid antagonists
GB9912411D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy

Also Published As

Publication number Publication date
WO2003101963A1 (en) 2003-12-11
AU2003239389A1 (en) 2003-12-19
EP1513813A1 (de) 2005-03-16
EP1513813B1 (de) 2005-11-02
ES2249722T3 (es) 2006-04-01
DE60302157D1 (de) 2005-12-08
DE60302157T2 (de) 2006-07-27
US20050222204A1 (en) 2005-10-06

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Legal Events

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