SI1440059T1 - Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja - Google Patents

Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja

Info

Publication number
SI1440059T1
SI1440059T1 SI200230688T SI200230688T SI1440059T1 SI 1440059 T1 SI1440059 T1 SI 1440059T1 SI 200230688 T SI200230688 T SI 200230688T SI 200230688 T SI200230688 T SI 200230688T SI 1440059 T1 SI1440059 T1 SI 1440059T1
Authority
SI
Slovenia
Prior art keywords
azabicyclo
receptor antagonists
opioid receptor
hexane derivatives
hexane
Prior art date
Application number
SI200230688T
Other languages
English (en)
Inventor
Stanton Mchardy
Spiros Liras
Steven Donald Heck
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SI1440059T1 publication Critical patent/SI1440059T1/sl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/04Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200230688T 2001-10-22 2002-09-09 Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja SI1440059T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33851101P 2001-10-22 2001-10-22
EP02765197A EP1440059B1 (en) 2001-10-22 2002-09-09 3-azabicyclo(3.1.0)hexane derivatives as opioid receptor antagonists
PCT/IB2002/003668 WO2003035622A1 (en) 2001-10-22 2002-09-09 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists

Publications (1)

Publication Number Publication Date
SI1440059T1 true SI1440059T1 (sl) 2008-08-31

Family

ID=23325099

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200230688T SI1440059T1 (sl) 2001-10-22 2002-09-09 Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja

Country Status (42)

Country Link
US (3) US7049335B2 (sl)
EP (1) EP1440059B1 (sl)
JP (2) JP4155522B2 (sl)
KR (1) KR100621292B1 (sl)
CN (1) CN100368398C (sl)
AP (1) AP1816A (sl)
AR (1) AR036905A1 (sl)
AT (1) ATE392415T1 (sl)
AU (1) AU2002329557B2 (sl)
BR (1) BR0213464A (sl)
CA (1) CA2463264C (sl)
CR (1) CR7317A (sl)
DE (1) DE60226161T2 (sl)
DK (1) DK1440059T3 (sl)
EA (1) EA006708B1 (sl)
EC (1) ECSP045077A (sl)
ES (1) ES2302839T3 (sl)
GE (1) GEP20084300B (sl)
GT (1) GT200200216A (sl)
HK (1) HK1072052A1 (sl)
HN (1) HN2002000299A (sl)
HR (1) HRP20040288A2 (sl)
HU (1) HUP0401884A2 (sl)
IL (2) IL161157A0 (sl)
IS (1) IS7187A (sl)
MA (1) MA27141A1 (sl)
MX (1) MXPA04003730A (sl)
MY (1) MY136580A (sl)
NO (1) NO329092B1 (sl)
NZ (1) NZ531807A (sl)
OA (1) OA12711A (sl)
PA (1) PA8556701A1 (sl)
PE (1) PE20030610A1 (sl)
PL (1) PL368919A1 (sl)
PT (1) PT1440059E (sl)
RS (1) RS25104A (sl)
SI (1) SI1440059T1 (sl)
SV (1) SV2004001363A (sl)
TN (1) TNSN04071A1 (sl)
UA (1) UA75714C2 (sl)
WO (1) WO2003035622A1 (sl)
ZA (1) ZA200402172B (sl)

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BR0213464A (pt) 2001-10-22 2004-11-09 Pfizer Prod Inc Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opiĆ³ide
BRPI0409307A (pt) * 2003-04-14 2006-04-25 Pfizer Prod Inc derivados de 3-azabiciclo[3.2.1]octano
US20050043327A1 (en) * 2003-08-21 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) * 2003-10-06 2006-12-26 Pfizer Inc. Purification process for an azabicyclo[3.1.0]hexane compound
KR20060095865A (ko) * 2003-10-14 2006-09-04 ķ™”ģ“ģž ķ”„ė”œė•ģø  ģøķ¬. źø€ė¦¬ģ‹  ģˆ˜ģ†” ģ–µģ œģ œė”œģ„œģ˜ ė¹„ģ‹œķ“ė¦­ [3.1.0] ģœ ė„ģ²“
AU2004281229A1 (en) * 2003-10-16 2005-04-28 Pfizer Products Inc. Preparation of 3-azabicyclo (3.1.0) hexane derivatives
DK1745040T3 (da) 2004-02-23 2010-04-12 Glaxo Group Ltd Som modulatorer af dopamin-D3-receptorer anvendelige azabicyclo(3.1.0)hexanederivater
AU2005219785B2 (en) * 2004-03-05 2010-05-27 Msd K.K. Cycloalkanopyridine derivative
TW200637553A (en) * 2004-12-14 2006-11-01 Shionogi & Co Indlomorphinane derivatives having a carboxy group at 6' position
GB0512099D0 (en) * 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
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US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-ĪŗB activity and use thereof
MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2008075162A2 (en) * 2006-12-15 2008-06-26 Pfizer Limited Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction
TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ļ¼˜-ę°®é›œé›™ē’°ć€”ļ¼“ļ¼Žļ¼’ļ¼Žļ¼‘ć€•č¾›ēƒ·åŒ–合ē‰©ä¹‹ēµę™¶åž‹
US7691878B2 (en) * 2007-08-27 2010-04-06 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
US7947710B2 (en) * 2007-08-27 2011-05-24 Theravance, Inc. Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作ē‚ŗĪ¼é”žé“‰ē‰‡å—é«”ę‹®ęŠ—åŠ‘ä¹‹ļ¼˜ļ¼ę°®é›œé›™ē’°ć€”ļ¼“ļ¼Žļ¼’ļ¼Žļ¼‘ć€•č¾›åŸŗļ¼ļ¼’ļ¼ē¾„åŸŗč‹Æē”²é†Æčƒŗ化合ē‰©
ES2390195T3 (es) * 2007-08-27 2012-11-07 Theravance, Inc. Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu
WO2012042539A2 (en) 2010-09-28 2012-04-05 Panacea Biotec Ltd Novel bicyclic compounds
KR102305244B1 (ko) 2013-11-20 2021-09-27 ģš°ė²  ź³ ģ‚° ź°€ė¶€ģ‹œķ‚¤ź°€ģ“ģƒ¤ ģ‹ ź·œ 3-ģ•„ģžė¹„ģ‚¬ģ“ķ“ė”œ[3.1.0]ķ—„ģ‚° ģœ ė„ģ²“ ė° ź·ø ģ˜ģ•½ ģš©ė„
JP6087035B1 (ja) * 2015-05-20 2017-03-01 ę Ŗ式会ē¤¾äø‰å’ŒåŒ–å­¦ē ”ē©¶ę‰€ ę–°č¦ļ¼“āˆ’ć‚¢ć‚¶ćƒ“ć‚·ć‚Æ惭ļ¼»ļ¼“ļ¼Žļ¼‘ļ¼Žļ¼ļ¼½ćƒ˜ć‚­ć‚µćƒ³čŖ˜å°Žä½“ć®å”©ć®ēµę™¶åŠć³ćć®åŒ»č–¬ē”Ø途
AU2018229062A1 (en) 2017-03-02 2019-09-26 Ube Industries, Ltd. Therapeutic agent for alcohol use disorders

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BR0213464A (pt) 2001-10-22 2004-11-09 Pfizer Prod Inc Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opiĆ³ide
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Also Published As

Publication number Publication date
MA27141A1 (fr) 2005-01-03
US7049335B2 (en) 2006-05-23
HK1072052A1 (en) 2005-08-12
JP4155522B2 (ja) 2008-09-24
CA2463264C (en) 2009-05-26
HRP20040288A2 (en) 2004-12-31
US20030087898A1 (en) 2003-05-08
HN2002000299A (es) 2002-11-21
IS7187A (is) 2004-03-18
IL161157A0 (en) 2004-08-31
SV2004001363A (es) 2004-02-24
EP1440059B1 (en) 2008-04-16
US20070054950A1 (en) 2007-03-08
GT200200216A (es) 2003-05-23
EP1440059A1 (en) 2004-07-28
MXPA04003730A (es) 2004-07-23
DE60226161D1 (de) 2008-05-29
DE60226161T2 (de) 2009-07-02
PE20030610A1 (es) 2003-07-12
US20050171178A1 (en) 2005-08-04
CN100368398C (zh) 2008-02-13
OA12711A (en) 2006-06-27
NZ531807A (en) 2006-03-31
GEP20084300B (en) 2008-02-11
EA200400467A1 (ru) 2004-08-26
AP1816A (en) 2008-01-04
HUP0401884A2 (hu) 2005-01-28
IL161157A (en) 2009-09-01
PT1440059E (pt) 2008-05-16
KR100621292B1 (ko) 2006-09-13
CR7317A (es) 2006-08-09
AP2004003007A0 (en) 2004-06-30
BR0213464A (pt) 2004-11-09
ECSP045077A (es) 2004-05-28
TNSN04071A1 (fr) 2006-06-01
ES2302839T3 (es) 2008-08-01
NO20041626L (no) 2004-05-26
WO2003035622A1 (en) 2003-05-01
PA8556701A1 (es) 2003-07-28
AR036905A1 (es) 2004-10-13
ZA200402172B (en) 2006-09-27
MY136580A (en) 2008-10-31
NO329092B1 (no) 2010-08-23
AU2002329557B2 (en) 2008-07-31
CA2463264A1 (en) 2003-05-01
DK1440059T3 (da) 2008-07-14
EA006708B1 (ru) 2006-02-24
RS25104A (en) 2007-02-05
KR20040048984A (ko) 2004-06-10
JP2005511545A (ja) 2005-04-28
JP2008069169A (ja) 2008-03-27
PL368919A1 (en) 2005-04-04
CN1610664A (zh) 2005-04-27
UA75714C2 (en) 2006-05-15
ATE392415T1 (de) 2008-05-15

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