SI1440059T1 - Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja - Google Patents

Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja

Info

Publication number
SI1440059T1
SI1440059T1 SI200230688T SI200230688T SI1440059T1 SI 1440059 T1 SI1440059 T1 SI 1440059T1 SI 200230688 T SI200230688 T SI 200230688T SI 200230688 T SI200230688 T SI 200230688T SI 1440059 T1 SI1440059 T1 SI 1440059T1
Authority
SI
Slovenia
Prior art keywords
azabicyclo
receptor antagonists
opioid receptor
hexane derivatives
hexane
Prior art date
Application number
SI200230688T
Other languages
English (en)
Inventor
Stanton Mchardy
Spiros Liras
Steven Donald Heck
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SI1440059T1 publication Critical patent/SI1440059T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200230688T 2001-10-22 2002-09-09 Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja SI1440059T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33851101P 2001-10-22 2001-10-22
EP02765197A EP1440059B1 (en) 2001-10-22 2002-09-09 3-azabicyclo(3.1.0)hexane derivatives as opioid receptor antagonists
PCT/IB2002/003668 WO2003035622A1 (en) 2001-10-22 2002-09-09 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists

Publications (1)

Publication Number Publication Date
SI1440059T1 true SI1440059T1 (sl) 2008-08-31

Family

ID=23325099

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200230688T SI1440059T1 (sl) 2001-10-22 2002-09-09 Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja

Country Status (42)

Country Link
US (3) US7049335B2 (sl)
EP (1) EP1440059B1 (sl)
JP (2) JP4155522B2 (sl)
KR (1) KR100621292B1 (sl)
CN (1) CN100368398C (sl)
AP (1) AP1816A (sl)
AR (1) AR036905A1 (sl)
AT (1) ATE392415T1 (sl)
AU (1) AU2002329557B2 (sl)
BR (1) BR0213464A (sl)
CA (1) CA2463264C (sl)
CR (1) CR7317A (sl)
DE (1) DE60226161T2 (sl)
DK (1) DK1440059T3 (sl)
EA (1) EA006708B1 (sl)
EC (1) ECSP045077A (sl)
ES (1) ES2302839T3 (sl)
GE (1) GEP20084300B (sl)
GT (1) GT200200216A (sl)
HK (1) HK1072052A1 (sl)
HN (1) HN2002000299A (sl)
HR (1) HRP20040288A2 (sl)
HU (1) HUP0401884A2 (sl)
IL (2) IL161157A0 (sl)
IS (1) IS7187A (sl)
MA (1) MA27141A1 (sl)
MX (1) MXPA04003730A (sl)
MY (1) MY136580A (sl)
NO (1) NO329092B1 (sl)
NZ (1) NZ531807A (sl)
OA (1) OA12711A (sl)
PA (1) PA8556701A1 (sl)
PE (1) PE20030610A1 (sl)
PL (1) PL368919A1 (sl)
PT (1) PT1440059E (sl)
RS (1) RS25104A (sl)
SI (1) SI1440059T1 (sl)
SV (1) SV2004001363A (sl)
TN (1) TNSN04071A1 (sl)
UA (1) UA75714C2 (sl)
WO (1) WO2003035622A1 (sl)
ZA (1) ZA200402172B (sl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100352816C (zh) 2001-04-18 2007-12-05 欧罗赛铁克股份有限公司 伤害感受肽类似物
IL161157A0 (en) 2001-10-22 2004-08-31 Pfizer Prod Inc 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
BRPI0409307A (pt) * 2003-04-14 2006-04-25 Pfizer Prod Inc derivados de 3-azabiciclo[3.2.1]octano
US20050043327A1 (en) * 2003-08-21 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) * 2003-10-06 2006-12-26 Pfizer Inc. Purification process for an azabicyclo[3.1.0]hexane compound
GEP20104959B (en) * 2003-10-14 2010-04-26 Pfizer Prod Inc Bicyclic [3.1.0] derivatives as glycine transporter inhibitors
EP1675829A1 (en) * 2003-10-16 2006-07-05 Pfizer Products Inc. Preparation of 3-azabicyclo [3.1.0] hexane derivatives
AR047890A1 (es) 2004-02-23 2006-03-01 Glaxo Group Ltd Derivados de azabiciclo[3.1.0]hexano como moduladores de los receptores de dopamina d3
US7855294B2 (en) * 2004-03-05 2010-12-21 Banyu Pharmaceutical Co., Ltd. Cycloalkanopyridine derivative
EP1837022A4 (en) * 2004-12-14 2009-12-16 Toray Industries INDOLOMORPHINANE DERIVATIVE WITH CARBOXY IN 6 'POSITION
GB0512099D0 (en) * 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
GB0517191D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
MY145633A (en) 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2008075162A2 (en) * 2006-12-15 2008-06-26 Pfizer Limited Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
US7691878B2 (en) * 2007-08-27 2010-04-06 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
EP2185553B1 (en) * 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2009029257A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists
JP2013542929A (ja) 2010-09-28 2013-11-28 パナセア バイオテック リミテッド 新規ビシクロ環化合物
WO2015076310A1 (ja) * 2013-11-20 2015-05-28 株式会社 三和化学研究所 新規３－アザビシクロ［３．１．０］ヘキサン誘導体及びその医薬用途
WO2016186184A1 (ja) * 2015-05-20 2016-11-24 株式会社 三和化学研究所 新規３－アザビシクロ［３．１．０］ヘキサン誘導体の塩の結晶及びその医薬用途
KR20190120212A (ko) 2017-03-02 2019-10-23 가부시키가이샤산와카가쿠켄큐쇼 알코올 사용 장해의 치료약

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2099214A (en) * 1937-11-16 Process fob forming the sulphuric
US2099216A (en) * 1934-05-04 1937-11-16 Frederick H Nass Metal testing machine
US3004340A (en) * 1959-09-24 1961-10-17 Bernice L Collins Kitchen utensil
US3078282A (en) * 1960-01-02 1963-02-19 Bayer Ag Anthraquinone dyestuffs
EP0287339B1 (en) 1987-04-16 1994-08-17 Eli Lilly And Company Piperidine opioid antagonists
JPH04155522A (ja) * 1990-10-19 1992-05-28 Nec Corp ファースト・イン・ランダム・アウト回路
US5159081A (en) 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
NZ242117A (en) 1991-03-29 1994-11-25 Lilly Co Eli 4-phenylpiperidine derivatives and medicaments containing them
GB9725114D0 (en) * 1997-11-28 1998-01-28 Pfizer Ltd Treatment of pruritus
GB9810671D0 (en) * 1998-05-18 1998-07-15 Pfizer Ltd Anti-pruritic agents
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
GB9912413D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
US20020064825A1 (en) * 2000-05-19 2002-05-30 Lewis Marilyn Evelyn Novel polypeptide
US20030207876A1 (en) * 2000-06-23 2003-11-06 Banks Bernard Joseph 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy
GB0015562D0 (en) * 2000-06-23 2000-08-16 Pfizer Ltd Heterocycles
US20020025948A1 (en) * 2000-06-23 2002-02-28 Banks Bernard Joseph 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
DE10042885A1 (de) * 2000-08-31 2002-03-14 Heidelberger Druckmasch Ag Bogentransportzylinder
IL161157A0 (en) 2001-10-22 2004-08-31 Pfizer Prod Inc 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
US20050222204A1 (en) 2002-05-30 2005-10-06 Mitch Charles H Opioid receptor antagonists
US20040204453A1 (en) * 2003-04-14 2004-10-14 Pfizer Inc 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors
US7056930B2 (en) * 2003-04-14 2006-06-06 Pfizer Inc. 2-Azabicyclo[3.3.1]nonane derivatives
US20050043327A1 (en) * 2003-08-21 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) * 2003-10-06 2006-12-26 Pfizer Inc. Purification process for an azabicyclo[3.1.0]hexane compound

Also Published As

Publication number Publication date
CA2463264C (en) 2009-05-26
JP2008069169A (ja) 2008-03-27
HRP20040288A2 (en) 2004-12-31
IL161157A0 (en) 2004-08-31
CN100368398C (zh) 2008-02-13
CR7317A (es) 2006-08-09
IS7187A (is) 2004-03-18
EP1440059B1 (en) 2008-04-16
KR20040048984A (ko) 2004-06-10
PA8556701A1 (es) 2003-07-28
ECSP045077A (es) 2004-05-28
NZ531807A (en) 2006-03-31
AR036905A1 (es) 2004-10-13
PL368919A1 (en) 2005-04-04
US20070054950A1 (en) 2007-03-08
OA12711A (en) 2006-06-27
MA27141A1 (fr) 2005-01-03
PE20030610A1 (es) 2003-07-12
UA75714C2 (en) 2006-05-15
GT200200216A (es) 2003-05-23
DE60226161D1 (de) 2008-05-29
DE60226161T2 (de) 2009-07-02
US20030087898A1 (en) 2003-05-08
EP1440059A1 (en) 2004-07-28
JP2005511545A (ja) 2005-04-28
IL161157A (en) 2009-09-01
MXPA04003730A (es) 2004-07-23
AU2002329557B2 (en) 2008-07-31
ZA200402172B (en) 2006-09-27
EA006708B1 (ru) 2006-02-24
JP4155522B2 (ja) 2008-09-24
NO329092B1 (no) 2010-08-23
US20050171178A1 (en) 2005-08-04
ES2302839T3 (es) 2008-08-01
HUP0401884A2 (hu) 2005-01-28
GEP20084300B (en) 2008-02-11
BR0213464A (pt) 2004-11-09
TNSN04071A1 (fr) 2006-06-01
AP1816A (en) 2008-01-04
CN1610664A (zh) 2005-04-27
PT1440059E (pt) 2008-05-16
AP2004003007A0 (en) 2004-06-30
ATE392415T1 (de) 2008-05-15
WO2003035622A1 (en) 2003-05-01
HN2002000299A (es) 2002-11-21
NO20041626L (no) 2004-05-26
RS25104A (en) 2007-02-05
KR100621292B1 (ko) 2006-09-13
CA2463264A1 (en) 2003-05-01
SV2004001363A (es) 2004-02-24
DK1440059T3 (da) 2008-07-14
EA200400467A1 (ru) 2004-08-26
HK1072052A1 (en) 2005-08-12
US7049335B2 (en) 2006-05-23
MY136580A (en) 2008-10-31

Similar Documents

Publication Publication Date Title
HK1072052A1 (en) 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
PL365377A1 (en) Amide derivatives as nmda receptor antagonists
IL162377A0 (en) 5,6-Diaryl-pyrazine-2-amide derivatives as cb1 antagonists
ZA200408670B (en) Trizole derivatives as tachykinin receptor antagonists.
AU2002367424A1 (en) Androgen receptor antagonists
HK1084394A1 (en) Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use for preparing neurokinin antagonists
MXPA03006991A (es) Derivados de piperidina como antagonistas de neurocinina 1.
PL356990A1 (en) Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
IL153427A0 (en) 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity
AU2002366320A1 (en) Lactams as tachykinin antagonists
HK1079708A1 (zh) 可用作毒蕈碱性受體拮抗劑的3，6-二取代氮雜二環[3．1．10]己烷衍生物
AU2002365655A1 (en) 5-ht7 receptor antagonists
PL370799A1 (en) Aminotetralin derivatives as muscarinic receptor antagonists
EP1359915A4 (en) UROTENSIN-II RECEPTOR ANTAGONISTS
HK1042699A1 (en) N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists.
AU2002216079A1 (en) Bombesin receptor antagonists
AU2673201A (en) Alpha-arylethylpiperazine derivatives as neurokinin antagonists
AU2002217095A1 (en) Bombesin receptor antagonists
GB0203412D0 (en) 5-HT 2B receptor antagonists
AU1100300A (en) Piperidyloxadiazoles as dopamine receptor antagonists
PL370821A1 (en) N-ureido-piperidines as antagonists viii for ccr-3 receptor
PL370367A1 (en) Ccr-3 receptor antagonists v
IL158063A0 (en) Crf receptor antagonists
AU2002351478A1 (en) 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists
AU2002235453A1 (en) Urotensin-ii receptor antagonists