ES2058265T3 - Piperidinas antagonistas de opiaceos. - Google Patents
Piperidinas antagonistas de opiaceos.Info
- Publication number
- ES2058265T3 ES2058265T3 ES88303302T ES88303302T ES2058265T3 ES 2058265 T3 ES2058265 T3 ES 2058265T3 ES 88303302 T ES88303302 T ES 88303302T ES 88303302 T ES88303302 T ES 88303302T ES 2058265 T3 ES2058265 T3 ES 2058265T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- alkyl
- piperidines
- alquilo
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA INVENCION PRESENTA PIPERIDINAS TRANS-3,4 1-SUSTITTUIDAS-3SUSTITUIDAS-4-METIL-4-(3-FENIL-SUSTIUIDAS) COMO ANTAGONISTAS OPIOIDES CAPACES DE BLOQUEAR LOS RECEPTORES MU Y KAPPA EN EL CEREBRO, DE FORMULA (I) DONDE R1 ES HIDROGENO O ALCANOILO C1-C4; R2 ES HIDROGENO, ALQUILO C1-C4 O ALQUENILO C2-C6; R3 ES CICLOALQUILO C4-C8, CICLOALQUENILO C4-C8, ALQUILO C1-C6,ALQUENILO C2-C6, ALQUILO C1-C4 SUSTITUIDO, CICLOALQUILO C4-C8, ALQUILO C1-C4, CICLOALQUENILO C4-C8 SUSTITUIDO O TIOFENO; Z ES (II), (III) O UN ENLACE; R4 ES HIDROGENO, ALQUILO C1-C6 (IV) O (V) R5 ES ALQUILO, ALQUILO C1-C4 O (VI) N ES 1, 2 O 3, O UNA SAL FARMACOLOGICAMENTE ACEPTABLE DE DELLOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3912187A | 1987-04-16 | 1987-04-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058265T3 true ES2058265T3 (es) | 1994-11-01 |
Family
ID=21903800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88303302T Expired - Lifetime ES2058265T3 (es) | 1987-04-16 | 1988-04-13 | Piperidinas antagonistas de opiaceos. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0287339B1 (es) |
JP (1) | JP2661699B2 (es) |
KR (1) | KR960015087B1 (es) |
CN (1) | CN1017992B (es) |
AR (1) | AR245933A1 (es) |
AT (1) | ATE110057T1 (es) |
AU (1) | AU596290B2 (es) |
CA (1) | CA1321792C (es) |
DE (1) | DE3851081T2 (es) |
DK (1) | DK204388A (es) |
EG (1) | EG18864A (es) |
ES (1) | ES2058265T3 (es) |
HU (1) | HU202492B (es) |
IE (1) | IE64508B1 (es) |
IL (1) | IL86061A (es) |
MX (1) | MX11117A (es) |
NZ (1) | NZ224236A (es) |
PH (1) | PH24752A (es) |
PT (1) | PT87233B (es) |
SU (1) | SU1598869A3 (es) |
ZA (1) | ZA882640B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0299549A3 (en) * | 1987-07-09 | 1989-02-08 | Duphar International Research B.V | Tertiary 2,5-dialkyl-3-phenyl-piperidine derivatives having opiate-antagonistic activity |
ZA922180B (en) * | 1991-03-29 | 1993-09-27 | Lilly Co Eli | Piperidine derivatives |
GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
US5985880A (en) * | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
HU221726B1 (hu) * | 1993-07-30 | 2002-12-28 | Ardent Pharmaceuticals Inc. | Piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
GB9725114D0 (en) * | 1997-11-28 | 1998-01-28 | Pfizer Ltd | Treatment of pruritus |
GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
GB9815618D0 (en) * | 1998-07-18 | 1998-09-16 | Univ Manchester | Treatment of dyskinesia |
TWI244481B (en) | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912416D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912415D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912417D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
MXPA02005335A (es) * | 1999-11-29 | 2003-01-28 | Adolor Corp | Metodos y composiciones novedosos que incluyen opioides y antagonistas de los mismos. |
GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
JP4155522B2 (ja) | 2001-10-22 | 2008-09-24 | ファイザー・プロダクツ・インク | オピオイド受容体アンタゴニストとしての3−アザビシクロ(3.1.0)ヘキサン誘導体 |
SI2208727T1 (sl) * | 2002-09-19 | 2012-11-30 | Lilly Co Eli | Diaril etri kot antagonisti opioidnega receptorja |
US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
IN2014DN00137A (es) * | 2011-07-18 | 2015-05-22 | Adolor Corp |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR206937A1 (es) * | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
-
1988
- 1988-04-13 IL IL86061A patent/IL86061A/xx not_active IP Right Cessation
- 1988-04-13 CA CA000563995A patent/CA1321792C/en not_active Expired - Fee Related
- 1988-04-13 PH PH36789A patent/PH24752A/en unknown
- 1988-04-13 ES ES88303302T patent/ES2058265T3/es not_active Expired - Lifetime
- 1988-04-13 AR AR88310556A patent/AR245933A1/es active
- 1988-04-13 DE DE3851081T patent/DE3851081T2/de not_active Expired - Fee Related
- 1988-04-13 NZ NZ224236A patent/NZ224236A/xx unknown
- 1988-04-13 EP EP88303302A patent/EP0287339B1/en not_active Expired - Lifetime
- 1988-04-13 AT AT88303302T patent/ATE110057T1/de not_active IP Right Cessation
- 1988-04-14 IE IE112588A patent/IE64508B1/en not_active IP Right Cessation
- 1988-04-14 ZA ZA882640A patent/ZA882640B/xx unknown
- 1988-04-14 AU AU14624/88A patent/AU596290B2/en not_active Ceased
- 1988-04-14 EG EG21388A patent/EG18864A/xx active
- 1988-04-14 PT PT87233A patent/PT87233B/pt active IP Right Grant
- 1988-04-14 SU SU884355530A patent/SU1598869A3/ru active
- 1988-04-14 DK DK204388A patent/DK204388A/da not_active Application Discontinuation
- 1988-04-14 KR KR1019880004245A patent/KR960015087B1/ko not_active IP Right Cessation
- 1988-04-14 MX MX1111788A patent/MX11117A/es unknown
- 1988-04-15 CN CN88102191A patent/CN1017992B/zh not_active Expired
- 1988-04-15 HU HU881968A patent/HU202492B/hu not_active IP Right Cessation
- 1988-04-15 JP JP63094395A patent/JP2661699B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AR245933A1 (es) | 1994-03-30 |
ATE110057T1 (de) | 1994-09-15 |
DK204388D0 (da) | 1988-04-14 |
JPS63277661A (ja) | 1988-11-15 |
ZA882640B (en) | 1989-12-27 |
DK204388A (da) | 1989-01-05 |
PH24752A (en) | 1990-10-01 |
NZ224236A (en) | 1990-08-28 |
KR960015087B1 (ko) | 1996-10-24 |
IE881125L (en) | 1988-10-16 |
SU1598869A3 (ru) | 1990-10-07 |
DE3851081D1 (de) | 1994-09-22 |
CA1321792C (en) | 1993-08-31 |
EP0287339B1 (en) | 1994-08-17 |
EP0287339A3 (en) | 1991-05-15 |
CN1017992B (zh) | 1992-08-26 |
PT87233A (pt) | 1988-05-01 |
DE3851081T2 (de) | 1995-02-16 |
EP0287339A2 (en) | 1988-10-19 |
JP2661699B2 (ja) | 1997-10-08 |
MX11117A (es) | 1993-11-01 |
PT87233B (pt) | 1992-07-31 |
EG18864A (en) | 1995-06-29 |
IL86061A (en) | 1992-07-15 |
KR880012551A (ko) | 1988-11-28 |
AU1462488A (en) | 1988-10-20 |
IE64508B1 (en) | 1995-08-09 |
CN88102191A (zh) | 1988-11-02 |
IL86061A0 (en) | 1988-09-30 |
HUT46892A (en) | 1988-12-28 |
AU596290B2 (en) | 1990-04-26 |
HU202492B (en) | 1991-03-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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